8,992 results match your criteria mel

Broad and ultra-potent cross-clade neutralization of HIV-1 by a vaccine-induced CD4 binding site bovine antibody.

Cell Rep Med 2022 May;3(5):100635

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection Immunity, University of Melbourne, Melbourne, VIC 3000, Australia. Electronic address:

Human immunodeficiency virus type 1 (HIV-1) vaccination of cows has elicited broadly neutralizing antibodies (bNAbs). In this study, monoclonal antibodies (mAbs) are isolated from a clade A (KNH1144 and BG505) vaccinated cow using a heterologous clade B antigen (AD8). CD4 binding site (CD4bs) bNAb (MEL-1872) is more potent than a majority of CD4bs bNAbs isolated so far. Read More

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Association between serum estradiol level on day of progesterone start and outcomes from frozen blastocyst transfer cycles utilizing oral estradiol.

J Assist Reprod Genet 2022 May 18. Epub 2022 May 18.

Department of Obstetrics & Gynecology, Center for Infertility and Reproductive Surgery, Brigham & Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Purpose: Supraphysiologic serum estradiol levels may negatively impact the likelihood of conception and live birth following IVF. The purpose of this study is to determine if there is an association between serum estradiol level on the day of progesterone start and clinical outcomes following programmed frozen blastocyst transfer cycles utilizing oral estradiol.

Methods: This is a retrospective cohort study at an academic fertility center analyzing 363 patients who underwent their first autologous single (SET) or double frozen embryo transfer (DET) utilizing oral estradiol and resulting in blastocyst transfer from June 1, 2012, to June 30, 2018. Read More

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TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genes.

PLoS Genet 2022 May 17;18(5):e1010207. Epub 2022 May 17.

Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.

In developing melanocytes and in melanoma cells, multiple paralogs of the Activating-enhancer-binding Protein 2 family of transcription factors (TFAP2) contribute to expression of genes encoding pigmentation regulators, but their interaction with Microphthalmia transcription factor (MITF), a master regulator of these cells, is unclear. Supporting the model that Tfap2 facilitates MITF's ability to activate expression of pigmentation genes, single-cell seq analysis of zebrafish embryos revealed that pigmentation genes are only expressed in the subset of mitfa-expressing cells that also express Tfap2 paralogs. To test this model in SK-MEL-28 melanoma cells we deleted the two TFAP2 paralogs with highest expression, TFAP2A and TFAP2C, creating TFAP2 knockout (TFAP2-KO) cells. Read More

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Anti-CSF-1R emactuzumab in combination with anti-PD-L1 atezolizumab in advanced solid tumor patients naïve or experienced for immune checkpoint blockade.

J Immunother Cancer 2022 May;10(5)

Drug Development Department, Gustave Roussy Institute, Villejuif, France.

Background: This phase 1b study (NCT02323191) evaluated the safety, antitumor activity, pharmacokinetics, and pharmacodynamics of colony-stimulating factor-1 receptor-blocking monoclonal antibody (mAb) emactuzumab in combination with the programmed cell death-1 ligand (PD-L1)-blocking mAb atezolizumab in patients with advanced solid tumors naïve or experienced for immune checkpoint blockers (ICBs).

Methods: Emactuzumab (500-1350 mg flat) and atezolizumab (1200 mg flat) were administered intravenously every 3 weeks. Dose escalation of emactuzumab was conducted using the 3+3 design up to the maximum tolerated dose (MTD) or optimal biological dose (OBD). Read More

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Melatonin Ingestion Prevents Liver Damage and Improves Biomarkers of Renal Function Following a Maximal Exercise.

Res Q Exerc Sport 2022 May 16:1-11. Epub 2022 May 16.

University of Sfax.

While the promotion of the beneficial effects of melatonin (MEL) ingestion on the modulation of oxidative stress is widespread, less attention is given to the biological influence that it could exert on the results of hematology and clinical chemistry parameters. This study was undertaken to assess the effects of acute MEL ingestion on these parameters during a maximal running exercise. In double blind randomized design, 12 professional soccer players [age: 17. Read More

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A Hybrid Time-Distributed Deep Neural Architecture for Speech Emotion Recognition.

Int J Neural Syst 2022 May 12:2250024. Epub 2022 May 12.

Computational Intelligence Group, University of the Basque Country (UPV), San Sebastian, Spain.

In recent years, speech emotion recognition (SER) has emerged as one of the most active human-machine interaction research areas. Innovative electronic devices, services and applications are increasingly aiming to check the user emotional state either to issue alerts under some predefined conditions or to adapt the system responses to the user emotions. Voice expression is a very rich and noninvasive source of information for emotion assessment. Read More

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Vocal Acoustic Features as Potential Biomarkers for Identifying/Diagnosing Depression: A Cross-Sectional Study.

Front Psychiatry 2022 28;13:815678. Epub 2022 Apr 28.

Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China.

Background: At present, there is no established biomarker for the diagnosis of depression. Meanwhile, studies show that acoustic features convey emotional information. Therefore, this study explored differences in acoustic characteristics between depressed patients and healthy individuals to investigate whether these characteristics can identify depression. Read More

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Endometriosis diagnosis, staging and typology and adverse pregnancy outcome history.

Paediatr Perinat Epidemiol 2022 May 16. Epub 2022 May 16.

Department of Obstetrics and Gynecology University of Utah Health, Salt Lake City, Utah, USA.

Background: Women with endometriosis may have an increased risk of adverse pregnancy outcomes. Research has focused on infertility clinic populations limiting generalisability. Few studies report differences by endometriosis severity. Read More

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Comparison of fludarabine-melphalan and fludarabine-treosulfan as conditioning prior to allogeneic hematopoietic cell transplantation-a registry study on behalf of the EBMT Acute Leukemia Working Party.

Bone Marrow Transplant 2022 May 14. Epub 2022 May 14.

Sorbonne University, Saint-Antoine Hospital, AP-HP, INSERM UMRs 938, Paris, France.

In recent years considerable variations in conditioning protocols for allogeneic hematopoietic cell transplantation (allo-HCT) protocols have been introduced for higher efficacy, lower toxicity, and better outcomes. To overcome the limitations of the classical definition of reduced intensity and myeloablative conditioning, a transplantation conditioning intensity (TCI) score had been developed. In this study, we compared outcome after two frequently used single alkylator-based conditioning protocols from the intermediate TCI score category, fludarabine/melphalan 140 mg/m (FluMel) and fludarabine/treosulfan 42 g/m (FluTreo) for patients with acute myeloid leukemia (AML) in complete remission (CR). Read More

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Day Vs. Night Melatonin and Corticosterone Modulation By LPS in Distinct Tissues of Toads (Rhinella Icterica).

Integr Comp Biol 2022 May 14. Epub 2022 May 14.

Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo, São Paulo, Brasil.

Pathogen-associated molecular patterns modulate melatonin (MEL) production in the pineal and extra-pineal sites and corticosterone (CORT) synthesis in the adrenal/interrenal and other tissues. Both MEL and CORT play essential and complex immunomodulatory roles, controlling the inflammatory response. Given that most of what we know about these interactions is derived from mammalian studies, discovering how MEL and CORT are modulated following an immune challenge in anurans would increase understanding of how conserved these immune-endocrine interactions are in vertebrates. Read More

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Proliferation and Invasion of Melanoma Are Suppressed by a Plant Protease Inhibitor, Leading to Downregulation of Survival/Death-Related Proteins.

Molecules 2022 May 5;27(9). Epub 2022 May 5.

Departamento de Bioquímica, Universidade Federal de São Paulo (UNIFESP), São Paulo 04044-020, Brazil.

Cell adhesion and migration are crucial for cancer progression and malignancy. Drugs available for the treatment of metastatic melanoma are expensive and unfit for certain patients. Therefore, there is still a need to identify new drugs that block tumor cell development. Read More

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High GILT Expression Is Associated with Improved Survival in Metastatic Melanoma Patients Treated with Immune Checkpoint Inhibition.

Cancers (Basel) 2022 Apr 28;14(9). Epub 2022 Apr 28.

College of Medicine-Phoenix, University of Arizona, Phoenix, AZ 85004, USA.

Gamma-interferon-inducible lysosomal thiol reductase (GILT) is critical for MHC class II restricted presentation of multiple melanoma antigens. There is variable GILT protein expression in malignant melanocytes in melanoma specimens. High GILT mRNA expression in melanoma specimens is associated with improved overall survival, before the advent of immune checkpoint inhibitors (ICI). Read More

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IFN-γ and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma.

Cells 2022 Apr 30;11(9). Epub 2022 Apr 30.

Institute of Physiology I, Department of Vegetative and Clinical Physiology, University of Tuebingen, 72074 Tuebingen, Germany.

Immune checkpoint blockade (ICB) therapy is a central pillar of melanoma treatment leading to durable response rates. Important mechanisms of action of ICB therapy include disinhibition of CD4 and CD8 T cells. Stimulated CD4 T helper 1 cells secrete the effector cytokines interferon-gamma (IFN-γ) and tumor necrosis factor alpha (TNF), which induce senescence in tumor cells. Read More

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Glycemic Index, Glycemic Load, Fiber, and Gluten Intake and Risk of Laparoscopically-Confirmed Endometriosis in Premenopausal Women.

J Nutr 2022 May 12. Epub 2022 May 12.

Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center.

Background: The etiology of endometriosis is not well understood. Limited evidence suggests that dietary factors influence risk, but prospective data related to carbohydrate, fiber, and gluten consumption are scarce. Despite this, recommendations concerning fiber, gluten intake and endometriosis are pervasive in the lay literature. Read More

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A temporal dependency feature in lower dimension for lung sound signal classification.

Sci Rep 2022 May 12;12(1):7889. Epub 2022 May 12.

Department of Applied Artificial Intelligence, College of Computing, Hanyang University, Ansan, 15588, Korea.

Respiratory sounds are expressed as nonlinear and nonstationary signals, whose unpredictability makes it difficult to extract significant features for classification. Static cepstral coefficients such as Mel-frequency cepstral coefficients (MFCCs), have been used for classification of lung sound signals. However, they are modeled in high-dimensional hyperspectral space, and also lose temporal dependency information. Read More

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School-supervised Asthma Therapy is Associated with Improved Long-Term Asthma Outcomes for Underrepresented Minority Children.

J Sch Nurs 2022 May 12:10598405221100470. Epub 2022 May 12.

Department of Population and Quantitative Health Sciences, 12262University of Massachusetts Chan Medical School, Worcester, MA, USA.

Asthma morbidity disproportionately impacts children from low-income and racial/ethnic minority communities. School-supervised asthma therapy improves asthma outcomes for up to 15 months for underrepresented minority children, but little is known about whether these benefits are sustained over time. We examined the frequency of emergency department (ED) visits and hospital admissions for 83 children enrolled in Asthma Link, a school nurse-supervised asthma therapy program serving predominantly underrepresented minority children. Read More

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Orchestrating Non-muscle myosin II filament assembly at the onset of cytokinesis.

Mol Biol Cell 2022 May 11:mbcE21120599. Epub 2022 May 11.

Biotechnology Centre, Technische Universität, Tatzberg 47/49, Dresden 01307.

Contractile forces in the actomyosin cortex are required for cellular morphogenesis. This includes the invagination of the cell membrane during division, where filaments of non-muscle myosin II (NMII) are responsible for generating contractile forces in the cortex. However, how NMII heterohexamers form filaments is not well understood. Read More

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Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1/NF-kB/NLRP3 and PERK/TGF-β1 axis activation.

Life Sci 2022 May 7:120622. Epub 2022 May 7.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Aims: Nickel(Ni) accumulates in the environment due to human activities such as electroplating, alloy production, stainless steel, Ni‑cadmium batteries and industrial production. Ni enriched in humans and animals through food chains, poses a serious health threat. Txnrd3, as a member of the thioredoxin reductase family, has long been thought to be testicular specific and involved in sperm maturation. Read More

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Visual and Refractive Outcomes Following Laser Blended Vision With Non-linear Aspheric Micro-anisometropia (PRESBYOND) in Myopic and Hyperopic Patients.

J Refract Surg 2022 May 1;38(5):288-297. Epub 2022 May 1.

Purpose: To report 6-month visual and refractive outcomes following PRESBYOND Laser Blended Vision (Carl Zeiss Meditec) treatment using non-linear aspheric micro-anisometropia laser in situ keratomileusis (LASIK) for the correction of myopic and hyperopic presbyopia.

Methods: A retrospective, non-comparative study of 139 consecutive patients with a mean age of 53.13 ± 5. Read More

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ICU organization and disparities in clinical trajectories and outcomes during the pandemic.

Intensive Care Med 2022 May 9. Epub 2022 May 9.

D'Or Institute for Research and Education, Rio de Janeiro, Brazil.

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Long-Term Follow-Up of Multiple Myeloma Patients Treated with Tandem Autologous Transplantation Following Melphalan and Upon Recovery, Total Marrow Irradiation.

Transplant Cell Ther 2022 May 6. Epub 2022 May 6.

Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA. Electronic address:

Background: Total body irradiation in combination with melphalan for multiple myeloma (MM), was shown to be prohibitively toxic. To ameliorate toxicity, total marrow irradiation (TMI), was given as the sole ablative modality during the second cycle of tandem autologous stem cell transplant (TASCT) for MM patients on a phase I-II trial.

Study Design: Patients with MM in response or with stable disease and ≤ 18 months from diagnosis received melphalan (MEL) 200 mg/m and ASCT (Cycle 1), and, after recovery, TMI and ASCT (Cycle 2) followed by maintenance with an IMiD and dexamethasone for up to 12 months. Read More

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Temperature variability associations with cardiovascular and respiratory emergency department visits in Dhaka, Bangladesh.

Environ Int 2022 May 2;164:107267. Epub 2022 May 2.

Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA; Department of Population Health, New York University School of Medicine, New York, NY, USA.

Background: Greenhouse gas emissions are changing the Earth's climate, most directly by modifying temperatures and temperature variability (TV). Residents of low- and middle-income countries (LMICs) are likely more adversely affected, due to lack of air conditioning to compensate. To date, there is no local epidemiological evidence documenting the cardio-respiratory health effects of TV in Dhaka, Bangladesh, one of the most climate change vulnerable cities in the world. Read More

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Melatonin attenuates cerebral hypoperfusion-induced hippocampal damage and memory deficits in rats by suppressing TRPM7 channels.

Saudi J Biol Sci 2022 Apr 18;29(4):2958-2968. Epub 2022 Jan 18.

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, and the Centre of Biomedical Sciences Research (CBSR), Taif University, Taif, Saudi Arabia.

This study was conducted to examine if modulating transporters like transient receptor potential cation channels, subfamily M, member 7 (TRPM7) underlies the hippocampal neuroprotection afforded by melatonin (Mel) in rats exposed to cerebral hypoperfusion (CHP). Experimental groups included control, Mel-treated (1.87 g/kg), CHP, and CHP + Mel (1. Read More

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Proc IEEE Int Conf Acoust Speech Signal Process 2022 May 27;2022:6267-6271. Epub 2022 Apr 27.

Dept. of Electrical and Computer Engineering, University of California, Los Angeles, USA.

In this paper, a data augmentation method is proposed for depression detection from speech signals. Samples for data augmentation were created by changing the frame-width and the frame-shift parameters during the feature extraction process. Unlike other data augmentation methods (such as VTLP, pitch perturbation, or speed perturbation), the proposed method does not explicitly change acoustic parameters but rather the time-frequency resolution of frame-level features. Read More

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An Analytical Study of Speech Pathology Detection Based on MFCC and Deep Neural Networks.

Comput Math Methods Med 2022 4;2022:7814952. Epub 2022 Apr 4.

Department of Computer Science and Engineering, United International University, Dhaka, Bangladesh.

Diseases of internal organs other than the vocal folds can also affect a person's voice. As a result, voice problems are on the rise, even though they are frequently overlooked. According to a recent study, voice pathology detection systems can successfully help the assessment of voice abnormalities and enable the early diagnosis of voice pathology. Read More

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Lipofuscin labelling through biorthogonal strain-promoted azide-alkyne cycloaddition for the detection of senescent cells.

FEBS J 2022 May 8. Epub 2022 May 8.

Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Camino de Vera s/n, 46022, Valencia, Spain.

A new method for senescent cell detection, based on lipofuscin labeling with a fluorescent reporter through a biorthogonal strain-promoted azide-alkyne cycloaddition (SPAAC), is described. The sensing protocol involves a first step where the interaction of lipofuscin with a Sudan Black B derivative containing an azide moiety (SBB-N3) is carried out. In the final step, the azide moiety reacts with a fluorophore containing a cyclooctine ring (BODIPY). Read More

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Melatonin and zinc supplements with physical and mental activities subside neurodegeneration and hepatorenal injury induced by aluminum chloride in rats: Inclusion of GSK-3β-Wnt/β-catenin signaling pathway.

Neurotoxicology 2022 May 5;91:69-83. Epub 2022 May 5.

Pharmacology and Toxicology Department, Faculty of Pharmacy, October 6 University, Giza, Egypt. Electronic address:

Alzheimer's disease (AD) is an irreversible, progressive cognitive dysfunction. Inflammaging is the greatest common factor between AD and hepatorenal malfunction. This study aimed to use melatonin (MEL) and zinc sulfate (Zn) in addition to physical and mental activities (PMA) to ameliorate AlCl-induced AD as well as investigate their impact on the associated hepatorenal impairment. Read More

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Overview on Glycosylated Lipids Produced by Bacteria and Fungi: Rhamno-, Sophoro-, Mannosylerythritol and Cellobiose Lipids.

Adv Biochem Eng Biotechnol 2022 May 9. Epub 2022 May 9.

Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Wide ranges of microorganisms produce glycosylated lipids (GL), which are characterized by their tensio-active properties. Therefore, they can be used in different industrial applications as biosurfactants, such as food, agriculture, cosmetics, and health products among others. Two GL biosurfactants, rhamnolipids (RL) and sophorolipids (SL), are now commercially available and share a significant part of the biosurfactant market that in 2017 represented about 2. Read More

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Photonic crystal sensor for melamine based on magnetic molecularly imprinted nanoparticles self-assembled with an amphiphilic random copolymer.

Mikrochim Acta 2022 05 7;189(6):215. Epub 2022 May 7.

School of Chemical and Material Engineering, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, China.

Magnetic molecularly imprinted nanoparticles (MMINPs) were obtained with a one-step process through miniemulsion self-assembly using an amphiphilic random copolymer as both an emulsifier and MMINP coating, oleic acid-modified magnetite nanoparticles as magnetic cores, and melamine (MEL) as the template molecule. MMINPs were assembled under an external magnetic field to construct photonic crystal (PC) sensor for naked-eye detection of MEL. The MMINPs were characterized by FT-IR, TEM, TGA, and VSM. Read More

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