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Analysis of Heritability Across the Clinical Phenotypes of Frontotemporal Dementia and the Frequency of the C9ORF72 in a Colombian Population.

Front Neurol 2021 30;12:681595. Epub 2021 Aug 30.

Fundación Santa Fé de Bogotá, Bogotá, Colombia.

Frontotemporal dementia (FTD) is a highly heritable condition. Up to 40% of FTD is familial and an estimated 15% to 40% is due to single-gene mutations. It has been estimated that the G4C2 hexanucleotide repeat expansions in the C9ORF72 gene can explain up to 37. Read More

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Prevention and control strategies for the post-pandemic era: finding a balance between COVID-19 and reviving medical service.

J Infect Dev Ctries 2021 08 31;15(8):1074-1079. Epub 2021 Aug 31.

Department of Hospital-Acquired Infection Control, Beijing Jishuitan Hospital, Beijing, China.

Introduction: Public life in China is gradually returning to normal with strong measures in coronavirus 2019 (COVID-19) control. Because of the long-term effects of COVID-19, medical institutions had to make timely adjustments to control policies and priorities to balance between COVID-19 prevention and daily medical services.

Methodology: The framework for infection prevention and control in the inpatient department was effectively organized at both hospital and department levels. Read More

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Development and Validation of a Model Including Distinct Vascular Patterns to Estimate Survival in Hepatocellular Carcinoma.

JAMA Netw Open 2021 Sep 1;4(9):e2125055. Epub 2021 Sep 1.

Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.

Importance: Because of tumor heterogeneity, traditional clinical variables remain insufficient to predict recurrence, which impairs long-term survival among patients undergoing radical hepatectomy for hepatocellular carcinoma (HCC). Vessels encapsulating tumor clusters (VETC) constitute a novel vascular pattern distinct from microvascular invasion (MVI), representing biological aggressiveness of HCC.

Objective: To establish a model to estimate individualized recurrence-free survival (RFS) in HCC by integrating VETC and MVI. Read More

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September 2021

Pre-existing comorbidities are associated with the mortality rate as well as the pre-dialysis adverse events in incident dialysis patients.

Kidney Res Clin Pract 2021 Aug 13. Epub 2021 Aug 13.

Department of Nephrology, Ajou University School of Medicine, Suwon, Republic of Korea.

Background: Optimal estimated glomerular filtration rate (eGFR) to start maintenance dialysis is controversial. Observational studies have reported that initiation of dialysis at high eGFRs is associated with worse postdialysis survival.

Methods: We retrospectively investigated 1,038 incident dialysis patients who started maintenance dialysis during 2010-2015. Read More

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Derivation of the Buffalo Concussion Physical Examination risk of delayed recovery (RDR) score to identify children at risk for persistent postconcussive symptoms.

Br J Sports Med 2021 Sep 11. Epub 2021 Sep 11.

Orthopaedics and Sports Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.

Objective: The Buffalo Concussion Physical Examination (BCPE) is a brief, but pertinent physical examination designed for the subacute, outpatient assessment of concussion. The purpose of this study was to perform the BCPE on a larger sample and derive a scoring system to identify children at risk for Persistent Post-Concussive Symptoms (PPCS, recovery ≥30 days).

Methods: This prospective, observational cohort study from September 2016 to March 2019 was performed at three university-affiliated concussion clinics. Read More

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September 2021

Identification of Regorafenib Prognostic Index (REP Index) via Recursive Partitioning Analysis in Patients with Advanced Hepatocellular Carcinoma Receiving Systemic Treatment: A Real-World Multi-Institutional Experience.

Target Oncol 2021 Sep 7. Epub 2021 Sep 7.

Unit of Oncology, IRCCS-San Raffaele Scientific Institute, Università Vita-Salute, Milan, Italy.

Background: The results of the pivotal RESORCE trial led to the approval of the tyrosine kinase inhibitor regorafenib as second-line treatment in advanced hepatocellular carcinoma (HCC) after sorafenib failure. Data about prognostic factors in a second-line HCC setting are scarce.

Objective: The aim of the present study was to investigate prognostic factors in a cohort of patients with advanced HCC treated with regorafenib after progressing on sorafenib. Read More

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September 2021

Environmental risk assessment of parabens in surface water from a Brazilian river: the case of Mogi Guaçu Basin, São Paulo State, under precipitation anomalies.

Environ Sci Pollut Res Int 2021 Sep 7. Epub 2021 Sep 7.

São Carlos Institute of Chemistry, University of São Paulo, Avenida do Trabalhador São Carlense 400, CEP 13.560-970, São Carlos, São Paulo, Brazil.

Parabens are preservatives widely used by industry since these compounds have antifungal properties, relative low cost, and stability over a wide pH range. This study aims to quantify and assess the environmental risks of methylparaben (MP), ethylparaben (EP), propylparaben (PP), and butylparaben (BP) in surface water from a Brazilian River, Mogi Guaçu. The State of São Paulo, including the Mogi Guaçu River region, suffered from a period of intense drought and high temperatures, which caused anomalies in river flows and water supply problems. Read More

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September 2021

Robust Discovery of Mild Cognitive Impairment Subtypes and Their Risk of Alzheimer's Disease Conversion Using Unsupervised Machine Learning and Gaussian Mixture Modeling.

Curr Alzheimer Res 2021 Aug 31. Epub 2021 Aug 31.

Tecnologico de Monterrey Ringgold standard institution - medical school Monterrey, new Leon. Mexico.

Background: Alzheimer's disease (AD) is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills. The ability to correctly predict the diagnosis of Alzheimer's disease in its earliest stages can help physicians make more informed clinical decisions on therapy plans.

Objective: This study aimed to determine whether the unsupervised discovering of latent classes of subjects with mild cognitive impairment (MCI) may be useful in finding different prodromal AD stages and/or subjects with a low MCI to AD conversion risk. Read More

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Perceived Risk of Infection Linked to Changes in Comfort in Social Situations From Before to During the COVID-19 Pandemic.

Front Psychiatry 2021 13;12:678072. Epub 2021 Aug 13.

Social Neuroscience Lab at the Translational Psychiatry Unit (TPU), Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.

Social lives have significantly changed since social distancing measures have been implemented to prevent the spread of the coronavirus disease 2019 (COVID-19). This study aimed to investigate how our appraisal of social situations changed during the pandemic. In two online surveys, conducted in October 2019 and April 2020, 58 participants rated their personal level of comfort for sketches depicting social situations. Read More

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Real-world evaluation of costs of illness for pneumonia in adult patients in Dubai-A claims database study.

PLoS One 2021 1;16(9):e0256856. Epub 2021 Sep 1.

Real World Evidence, IQVIA, Dubai, UAE.

Background: Pneumonia is a significant cause of morbidity and mortality among adults globally. This retrospective cohort analysis assessed the pneumonia burden and related healthcare resource utilization and costs in the at-risk (low, medium, and high-risk) adult patients in Dubai, United Arab Emirates (UAE).

Methods: The claims data from January 1, 2014 to June 30, 2019 were extracted from the Dubai Real-World Claims Database for patients, aged ≥18 year, having at least 1 pneumonia claim. Read More

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September 2021

An early warning risk prediction tool for patients diagnosed with COVID-19: the statistical analysis plan for RECAP V1.

JMIR Res Protoc 2021 Jul 5. Epub 2021 Jul 5.

Department of Surgery and Cancer, Imperial College London, Queen Elisabeth the Queen Mother Building (10th Floor/1091), St Mary's HospitalPraed Street, London, GB.

Background: Since the start of the COVID-19 pandemic efforts have been made to develop early warning risk scores to help clinicians decide which patient is likely to deteriorate and require hospitalisation. The RECAP (Remote COVID-19 Assessment in Primary Care) study investigates the predictive risk of hospitalisation, deterioration, and death of patients with confirmed COVID-19, based on a set of parameters chosen through a Delphi process done by clinicians. We aim to use rich data collected remotely through the use of electronic data templates integrated in the electronic health systems of a number of general practices across the UK to construct accurate predictive models that will use pre-existing conditions and monitoring data of a patient's clinical parameters such as blood oxygen saturation to make reliable predictions as to the patient's risk of hospital admission, deterioration, and death. Read More

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Identification of WHO II/III gliomas by 16 prognostic-related gene signatures using machine learning methods.

Curr Med Chem 2021 Aug 26. Epub 2021 Aug 26.

Department of Biomedical Engineering, Tianjin Key Lab of BME Measurement, Tianjin University, Tianjin. China.

Background: It is found that the prognosis of gliomas of the same grade has large differences among World Health Organization(WHO) grade II and III in clinical observation. Therefore, a better understanding of the genetics and molecular mechanisms underlying WHO grade II and III gliomas is required, with the aim of developing a classification scheme at the molecular level rather than the conventional pathological morphology level.

Method: We performed survival analysis combined with machine learning methods of Least Absolute Shrinkage and Selection Operator using expression datasets downloaded from the Chinese Glioma Genome Atlas as well as The Cancer Genome Atlas. Read More

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A Comparative Study of the Ergonomic Risk to the Surgeon During Vesicoscopic and Robotic Cross-Trigonal Ureteric Reimplantation.

J Laparoendosc Adv Surg Tech A 2021 Aug 27. Epub 2021 Aug 27.

Department of Anaesthesiology, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Andheri West, Mumbai, India.

Maintenance of the body posture and precise repetitive movements during minimally invasive surgeries predispose the surgeons to the risk of musculoskeletal disorders (MSDs). The present study was designed to estimate the ergonomic risk of MSDs in a single surgeon while performing vesicoscopic ureteric reimplantation. All children with primary vesicoureteric reflux (VUR) undergoing vesicoscopic ureteric reimplantation through the laparoscopic (Group 1) or robotic (Group 2) approaches from July 2015 to October 2019 were included. Read More

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[Antibody Screening and Risk Assessment of Healthcare Professionals in the COVID-19 Pandemic].

Mikrobiyol Bul 2021 Jul;55(3):357-373

Baskent University Faculty of Medicine, Adana Dr. Turgut Noyan Teaching and Research Hospital, Department of Emergency Medicine, Adana, Turkey.

Globally 364102 healthcare professionals have been infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and 1253 of them died until 15 January 2021. Healthcare professionals serving at the forefront of combating the pandemic are in the high risk group. In our country, the data about coronavirus-2019 (COVID-19) among healthcare professionals are limited. Read More

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Comprehensive risk assessment of marine radioactivity in the Beibu Gulf of Guangxi.

Mar Pollut Bull 2021 Aug 11;172:112795. Epub 2021 Aug 11.

Laboratory of Marine Isotopic Technology and Environmental Risk Assessment, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China.

In this paper, a marine environmental sensitivity index system was constructed based on three factors: the marine biological species sensitivity, the marine ecological value sensitivity and the social and economic sensitivity. Combined with numerical simulations of Cs in the Beibu Gulf under the condition of a level-7 nuclear accident, a comprehensive risk assessment of marine radioactivity under the simulated accident in the Beibu Gulf was carried out. The results show that the areas at high risk and medium-to-high risk to marine radioactivity are mainly concentrated within 30 km of the Fangchenggang Nuclear Power Plant. Read More

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Risk stratification for hydronephrosis in the evaluation of acute kidney injury: a cross-sectional analysis.

BMJ Open 2021 08 13;11(8):e046761. Epub 2021 Aug 13.

Director of Education, Division of Hospital Medicine, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.

Objective: To validate an existing clinical decision support tool to risk-stratify patients with acute kidney injury (AKI) for hydronephrosis and compare the risk stratification framework with nephrology consultant recommendations.

Setting: Cross-sectional study of hospitalised adults with AKI who had a renal ultrasound (RUS) ordered at a large, tertiary, academic medical centre.

Participants: Two hundred and eighty-one patients were included in the study cohort. Read More

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Cardiovascular characteristics of patients initially diagnosed breast cancer.

J Cardiothorac Surg 2021 Aug 12;16(1):231. Epub 2021 Aug 12.

Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400000, China.

Objective: We aimed to explore the cardiovascular characteristics of patients who were initially diagnosed with breast cancer.

Methods: A total of 600 patients who were diagnosed with primary breast cancer were included in this retrospective study. The data of fasting blood glucose, total cholesterol, total triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, lipoprotein (a) (LP (a)) and serum uric acid were collected. Read More

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Risk for short-term undesirable outcomes in older emergency department users: Results of the ER2 observational cohort study.

PLoS One 2021 11;16(8):e0249882. Epub 2021 Aug 11.

Department of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis-Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada.

Background: The "Emergency Room Evaluation and Recommendations" (ER2) is a clinical tool designed to determine prognosis for the short-term Emergency Department (ED) undesirable outcomes including long length of stay (LOS) in ED and in hospital, as well as the likelihood of hospital admission during an index ED visit. It is also designed to guide appropriate and timely tailor-made geriatric interventions. This study aimed to examine whether ER2 assessment part was: 1) usable by ED healthcare workers (e. Read More

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Validation of computed tomography angiography as a complementary test in the assessment of renal artery stenosis: a comparison with digital subtraction angiography.

Pediatr Radiol 2021 Aug 10. Epub 2021 Aug 10.

Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.

Background: Renal artery stenosis is an important cause of hypertension in children, accounting for 5-10% of cases. When suspected, noninvasive imaging options include ultrasound (US), computed tomography (CT) angiography and magnetic resonance (MR) angiography. However, digital subtraction angiography (DSA) remains the gold standard. Read More

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Risk Assessment for the Establishment of Vespa mandarinia (Hymenoptera: Vespidae) in the Pacific Northwest, United States.

J Insect Sci 2021 Jul;21(4)

Department of Land Resources and Environmental Sciences, Montana State University, 334 Leon Johnson Hall, Bozeman, MT 59717-3120, USA.

The recent introduction of the Asian giant hornet, Vespa mandarinia Smith, in the United States in late 2019 has raised concerns about its establishment in the Pacific Northwest and its potential deleterious effects on honey bees, Apis spp., and their pollination services in the region. Therefore, we conducted a risk assessment of the establishment of V. Read More

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[The Clinical Characteristics and Prognosis of Patients with Acute Myeloid Leukemia Combine Paroxysmal Nocturnal Hemoglobinuria].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Aug;29(4):1080-1084

Department of Hematology, Xi'an Central Hospital Affiliated to Xi'an Jiaotong University,Xi'an 710003, Shaanxi Province,

Objective: To investigate the clinical characteristics and prognosis of patients with acute myeloid leukemia(AML) combined with paroxysmal nocturnal hemoglobinuria(PNH).

Methods: The clinical data of 13 AML combined with PNH patients treated in our hospital from January 2017 to May 2019 were collected and retrospective analyzed. The complete remission(CR) rate for induction chemotherapy was analyzed. Read More

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A concise prognostic score system for diffuse large B-cell lymphoma: a retrospective study with long-term follow-up.

Future Oncol 2021 Aug 5. Epub 2021 Aug 5.

Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, China.

To identify risk factors and establish a concise prognostic scoring system in patients with diffuse large B-cell lymphoma (DLBCL). A total of 131 DLBCL patients were enrolled with long-term follow-up who were treated in Shengjing Hospital of the China Medical University. The relationship between clinical parameters and outcomes was analyzed. Read More

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Using the aMAP Risk Score to Predict Late Recurrence Following Radiofrequency Ablation for Hepatocellular Carcinoma in Chinese Population: A Multicenter Study.

J Hepatocell Carcinoma 2021 28;8:837-850. Epub 2021 Jul 28.

Department of Hepatobiliary and Pancreatic Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, Henan Province, People's Republic of China.

Objective: This study was conducted to explore the application of age-male-ALBI-platelets (aMAP) score for predicting late recurrence of hepatocellular carcinoma (HCC) following radiofrequency ablation (RFA) and develop an aMAP score based-nomogram to predict prognosis in Chinese population.

Materials And Methods: HCC patients who developed late recurrence following RFA at National Cancer Center (NCC) of China, First Hospital of Shanxi Medical University and Beijing Hospital of Traditional Chinese Medicine from January 2011 to December 2016 were included as a training cohort, and patients who were treated at Affiliated Cancer Hospital of Zhengzhou University between January 2012 and December 2016 were included as an external validation cohort. The optimal cut-off value for aMAP score was determined using X-tile software to discriminate the performance of recurrence-free survival (RFS). Read More

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Continuous input of organic ultraviolet filters and benzothiazoles threatens the surface water and sediment of two major rivers in the Pearl River Basin.

Sci Total Environ 2021 Jul 27;798:149299. Epub 2021 Jul 27.

Environmental Research Institute, School of Environment, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety, MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China.

The extensive usage of organic ultraviolet filters (UV filters) and benzothiazoles (BTs) has caused continuous and widespread pollution in the aquatic environment. This study investigated the occurrence of nine organic UV filters and eight BTs in the surface water and sediment of two major drinking water source rivers in the Pearl River Basin (PRB). The detection frequencies of six organic UV filters and seven BTs were above 50% in surface water, while eight target compounds were as high as 100%. Read More

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Risk Stratification of Patients Undergoing Percutaneous Repair of Mitral and Tricuspid Valves Using a Multidimensional Geriatric Assessment.

Circ Cardiovasc Qual Outcomes 2021 Aug 30;14(8):e007624. Epub 2021 Jul 30.

Division of Cardiology, Pneumology, Angiology, and Intensive Care, Department III of Internal Medicine (M.S., M.I.K., R.V., V.M., C.I., C.M., H.t.F., S.B., R.P.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany.

Background: Given their advanced age and high comorbidity, individual risk assessment is crucial in patients undergoing transcatheter mitral and tricuspid valve repair. Therefore, we evaluated the use of a comprehensive geriatric assessment score, the multidimensional prognostic index (MPI), for risk stratification in these patients.

Methods: We conducted a prospective, observational single-center study, including 226 patients undergoing percutaneous repair for mitral or tricuspid regurgitation. Read More

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Fear Language in a Warning Is Beneficial to Risk Perception in Lower-Risk Situations.

Hum Factors 2021 Jul 28:187208211029444. Epub 2021 Jul 28.

6243 University of Central Florida, Orlando, USA.

Objective: The goal was to examine the effectiveness of fear language in the protective action recommendation of an emergency warning, which instructs people how to prepare and stay safe.

Background: Past work is limited because it has focused on describing the severity of the weather crisis, not improving the recommendation. Likewise, other research has examined fear appeals that overemphasize death, which leads to poor risk perceptions. Read More

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[Clinical study on new risk assessment and prediction system for early osteonecrosis of the femoral head].

Zhongguo Gu Shang 2021 Jul;34(7):617-22

Department of Orthopaedics, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.

Objective: To establish a risk assessment and prediction system for early osteonecrosis of the femoral head (ONFH) in order to predict the collapse risk.

Methods: The risk assessment system for early necrosis and collapse of femoral head was established based on the combination of Steinberg stage, ABC typing and the proportion of the proximal sclerotic rim. Firstly, Steinberg stage system was applied. Read More

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A TTP-incorporated scoring model for predicting mortality of solid tumor patients with bloodstream infection caused by Escherichia coli.

Support Care Cancer 2021 Jul 24. Epub 2021 Jul 24.

Department of Cell Biology, School of Medicine, Nankai University, 94 Weijin Road, Nankai District, Tianjin, 300071, People's Republic of China.

Background: Few mortality-scoring models are available for solid tumor patients who are predisposed to develop Escherichia coli-caused bloodstream infection (ECBSI). We aimed to develop a mortality-scoring model by using information from blood culture time to positivity (TTP) and other clinical variables.

Methods: A cohort of solid tumor patients who were admitted to hospital with ECBSI and received empirical antimicrobial therapy was enrolled. Read More

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