3,017,965 results match your criteria medicine treatment

Role of Lipogenesis Rewiring in Hepatocellular Carcinoma.

Semin Liver Dis 2021 Jul 26. Epub 2021 Jul 26.

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.

Metabolic rewiring is one of the hallmarks of cancer. Altered de novo lipogenesis is one of the pivotal metabolic events deregulated in cancers. Sterol regulatory element-binding transcription factor 1 (SREBP1) controls the transcription of major enzymes involved in de novo lipogenesis, including ACLY, ACACA, FASN, and SCD. Read More

View Article and Full-Text PDF

Nasal Opioid Agonist Treatment in Patients with Severe Opioid Dependence: A Case Series.

Eur Addict Res 2021 Jul 26:1-6. Epub 2021 Jul 26.

Outpatient Addiction Treatment, ZOPA, Zug, Switzerland.

Introduction: Opioid agonist treatment (OAT) is the first-line treatment for opioid dependence. Currently available OAT options comprise oral (methadone and morphine) and sublingual (buprenorphine) routes of administration. In Switzerland and some other countries, severely opioid-dependent individuals with insufficient response to oral or sublingual OAT are offered heroin-assisted treatment (HAT), which involves the provision of injected or oral medical heroin (diacetylmorphine [DAM]). Read More

View Article and Full-Text PDF

Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses.

Dermatology 2021 Jul 26:1-13. Epub 2021 Jul 26.

Dermatology Service, Memorial Sloan Kettering, New York, New York, USA.

Seborrheic keratoses (SKs) are ubiquitous, generally benign skin tumors that exhibit high clinical variability. While age is a known risk factor, the precise roles of UV exposure and immune abnormalities are currently unclear. The underlying mechanisms of this benign disorder are paradoxically driven by oncogenic mutations and may have profound implications for our understanding of the malignant state. Read More

View Article and Full-Text PDF

Contralateral Stenosis and Echolucent Plaque Morphology are Associated with Elevated Stroke Risk in Patients Treated with Asymptomatic Carotid Artery Stenosis within a Controlled Clinical Trial (SPACE-2).

J Stroke Cerebrovasc Dis 2021 Jul 23;30(9):105940. Epub 2021 Jul 23.

Department of Neurology, University Hospital of Heidelberg, Heidelberg, Germany. Electronic address:

Background: Asymptomatic carotid artery stenosis (ACS) has a low risk of stroke. To achieve an advantage over noninterventional best medical treatment (BMT), carotid endarterectomy (CEA) or carotid artery stenting (CAS) must be performed with the lowest possible risk of stroke. Therefore, an analysis of risk-elevating factors is essential. Read More

View Article and Full-Text PDF

Dual-region radiomics signature: Integrating primary tumor and lymph node computed tomography features improves survival prediction in esophageal squamous cell cancer.

Comput Methods Programs Biomed 2021 Jul 16;208:106287. Epub 2021 Jul 16.

Department of Radiology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China. Electronic address:

Background: Preoperative prognostic biomarkers to guide individualized therapy are still in demand in esophageal squamous cell cancer (ESCC). Some studies reported that radiomic analysis based on CT images has been successfully performed to predict individual survival in EC. The aim of this study was to assess whether combining radiomics features from primary tumor and regional lymph nodes predicts overall survival (OS) better than using single-region features only, and to investigate the incremental value of the dual-region radiomics signature. Read More

View Article and Full-Text PDF

Snake venom proteomics and antivenomics of two Sundaic lance-headed pit vipers: Trimeresurus wiroti (Malaysia) and Trimeresurus puniceus (Indonesia).

Comp Biochem Physiol Part D Genomics Proteomics 2021 Jul 5;40:100875. Epub 2021 Jul 5.

Venom Research & Toxicology Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

Envenomation by two medically important Sundaic pit vipers, Trimeresurus wiroti (Malaysia) and Trimeresurus puniceus (Indonesia), causes hemotoxic syndrome with a potentially fatal outcome. Research on the compositions and antigenicity of these pit viper venoms is however lacking, limiting our understanding of the pathophysiology and treatment of envenomation. This study investigated the venom proteomes of both species through a protein decomplexation strategy, applying C reverse-phase high-performance liquid chromatography followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and protein identification through nano-electrospray ionization liquid chromatography-tandem mass spectrometry (nano-ESI-LCMS/MS) of trypsin-digested peptides. Read More

View Article and Full-Text PDF

Comparative analysis of peracetic acid (PAA) and permaleic acid (PMA) in disinfection processes.

Sci Total Environ 2021 Jul 21;797:149206. Epub 2021 Jul 21.

Department of Medicine Surgery and Dentistry, University of Salerno, via S. Allende, 84081 Baronissi, SA, Italy.

The growing demand to reduce chlorine usage and control disinfection byproducts increased the development of new strategies in wastewater treatments. Organic peracids are increasingly attracting interest in disinfection activities as a promising alternative to chlorine and chlorine-based agents. In this study, we assessed the antimicrobial properties against Escherichia coli (E. Read More

View Article and Full-Text PDF

MicroRNA-based host response to toxicant exposure is influenced by the presence of gut microbial populations.

Sci Total Environ 2021 Jul 20;797:149130. Epub 2021 Jul 20.

Center for Microbial Ecology, Michigan State University, East Lansing, MI 48824, USA; Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI 48824, USA; Department of Civil and Environmental Engineering, East Lansing, MI 48824, USA. Electronic address:

Segmented filamentous bacteria (SFB) and Bacteroides fragilis are known to interact with the host immune response through the aryl hydrocarbon receptor (Ahr). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an environmental toxicant and a high-affinity Ahr ligand has the potential to modify the effect of SFB and B. fragilis. Read More

View Article and Full-Text PDF

Clinical utility of next-generation sequencing-based ctDNA testing for common and novel ALK fusions.

Lung Cancer 2021 Jul 17;159:66-73. Epub 2021 Jul 17.

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York NY, USA.

Objectives: Liquid biopsy for plasma circulating tumor DNA (ctDNA) next-generation sequencing (NGS) can detect ALK fusions, though data on clinical utility of this technology in the real world is limited.

Materials And Methods: Patients with lung cancer without known oncogenic drivers or who had acquired resistance to therapy (n = 736) underwent prospective plasma ctDNA NGS. A subset of this cohort (n = 497) also had tissue NGS. Read More

View Article and Full-Text PDF

Veliparib in combination with carboplatin/paclitaxel-based chemoradiotherapy in patients with stage III non-small cell lung cancer.

Lung Cancer 2021 Jul 21;159:56-65. Epub 2021 Jul 21.

Department of Medicine, University of Chicago, 5801 South Ellis Avenue, Chicago, IL 60637, USA. Electronic address:

Objectives: Veliparib is a potent poly(ADP)-ribose polymerase (PARP) 1 and 2 inhibitor that impedes repair of DNA damage induced by cytotoxic and radiation therapies. This phase 1 study evaluated veliparib in combination with chemoradiotherapy in patients with unresectable stage III non-small cell lung cancer (NSCLC).

Materials And Methods: Patients received veliparib orally twice daily (BID) in escalating doses (60-240 mg, Day -3 to 1 day after last dose of radiation) combined with weekly carboplatin (area under the curve [AUC] 2 mg/mL/min), paclitaxel (45 mg/m), and daily radiation therapy (60 Gy in 30 fractions), followed by two cycles of veliparib (120-240 mg BID, Days -2 through 5 of each 21-day cycle), carboplatin (AUC 6 mg/mL/min, Day 1 of each cycle), and paclitaxel (200 mg/m, Day 1 of each cycle) consolidation. Read More

View Article and Full-Text PDF

Prognostic value of inflammatory response biomarkers using peripheral blood and [18F]-FDG PET/CT in advanced NSCLC patients treated with first-line chemo- or immunotherapy.

Lung Cancer 2021 Jul 20;159:45-55. Epub 2021 Jul 20.

Department of Nuclear Medicine, Institut Curie, 92210 Saint-Cloud, France; Laboratoire d'Imagerie Translationnelle en Oncologie, Inserm, Institut Curie, 91401, Orsay, France.

Objectives: We aimed to compare the prognostic value of inflammatory biomarkers extracted from pretreatment peripheral blood and [18F]-FDG PET for estimating outcomes in non-small cell lung cancer (NSCLC) patients treated with first-line immunotherapy (IT) or chemotherapy (CT).

Materials And Methods: In this retrospective multicenter study, we evaluated 111 patients with advanced NSCLC who underwent baseline [18F]-FDG PET/CT before IT or CT between 2016 and 2019. Several blood inflammatory indices were evaluated: derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP) and systemic immune-inflammation index (SII). Read More

View Article and Full-Text PDF

Female primary urethral carcinoma: A rare case report.

Int J Surg Case Rep 2021 Jun 10;85:106100. Epub 2021 Jun 10.

Urology Department, Faculty of Medicine, Universitas Syiah Kuala, General Hospital dr. Zainoel Abidin, Banda Aceh, Indonesia.

Introduction: Primary tumors of the female urethra are exceedingly rare and account for <0.02% of the malignant disease occurring in women. This disease usually presents late and, hence, has a poor outcome. Read More

View Article and Full-Text PDF

Predicting clinically significant response to primary care treatment for depression from electronic health records of veterans.

J Affect Disord 2021 Jul 16;294:337-345. Epub 2021 Jul 16.

VA Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

Objective: To reduce delays in referral to specialty mental health care, we evaluated clinical prediction models estimating the likelihood of response to primary care treatment of depression in the VA healthcare system.

Methods: We included patients with a primary care depression diagnosis between October 1, 2015 and December 31, 2017, an initial PHQ-9 score ≥ 10 within 30 days, a follow-up PHQ-9 score within 2-8 months, and no specialty mental health care within three months prior to depression diagnosis. We evaluated eight ordinary least squares regression models, each with a different procedure for selecting predictors of percentage change in PHQ-9 score from baseline to follow-up. Read More

View Article and Full-Text PDF

Elucidating posttraumatic stress symptom dimensions and health correlates among postpartum women.

J Affect Disord 2021 Jul 18;294:314-321. Epub 2021 Jul 18.

Department of Psychology, University of California, Los Angeles, CA, United States.

Background: Posttraumatic stress disorder (PTSD) is associated with interpersonal dysfunction and adverse maternal health during the perinatal period (extending from conception through one year postpartum). However, PTSD is a heterogeneous disorder, and little is known about which aspects of this disorder may be particularly deleterious to the health of new mothers. Such data may inform more personalized approaches to PTSD prevention and treatment among postpartum women. Read More

View Article and Full-Text PDF

Clear the fog of negative emotions: A new challenge for intervention towards drug users.

J Affect Disord 2021 Jul 17;294:305-313. Epub 2021 Jul 17.

School of Public Health, Peking University, Beijing, China; Center for Intelligent Public Health, Institute for Artificial Intelligence, Peking University, Beijing, China; Center for Drug Abuse Control and Prevention, National Institute of Health Data Science, Peking University, Beijing, China. Electronic address:

Background: The psychological and emotional problems of drug users are a focus of research. However, quick and effective emotion assessment tools were scarce. We aimed to use facial expression recognition to assess the emotional states of drug users. Read More

View Article and Full-Text PDF

SARS-CoV-2 activates lung epithelial cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients.

EBioMedicine 2021 Jul 23;70:103500. Epub 2021 Jul 23.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

Background: The outbreak of Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection has become a global health emergency. We aim to decipher SARS-CoV-2 infected cell types, the consequent host immune response and their interplay in lung of COVID-19 patients.

Methods: We analyzed single-cell RNA sequencing (scRNA-seq) data of bronchoalveolar lavage fluid (BALF) samples from 10 healthy donors, 6 severe COVID-19 patients and 3 mild recovered patients. Read More

View Article and Full-Text PDF

Effect of supplemental acid-etching on the early stages of osseointegration: A preclinical model.

J Mech Behav Biomed Mater 2021 Jul 13;122:104682. Epub 2021 Jul 13.

Department of Biomaterials, New York University College of Dentistry, New York, NY, USA; Department of Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn, NY, USA. Electronic address:

Purpose: To evaluate the effect of two surface modifications on early osseointegration parameters of conical implants in a translational pre-clinical model.

Materials And Methods: Conical implants with progressive trapezoidal threads and healing chambers were evaluated consisting of two different surface conditions: 1) Implacil surface (IMP Sur), and 2) Implacil surface + Supplemental Acid-etching (IMP Sur + AE). Surface characterization comprised of the evaluation of roughness parameters (S, S and S), surface energy and contact angle. Read More

View Article and Full-Text PDF

Comparative immunogenicity of decellularized wild type and alpha 1,3 galactosyltransferase knockout pig lungs.

Biomaterials 2021 Jul 15;276:121029. Epub 2021 Jul 15.

Department of Medicine, University of Vermont College of Medicine, Burlington, VT, 05405, USA. Electronic address:

Decellularized pig lungs recellularized with human lung cells offer a novel approach for organ transplantation. However, the potential immunogenicity of decellularized pig lungs following exposure to human tissues has not been assessed. We found that exposure of native lungs from wildtype and transgenic pigs lacking alpha (1,3)-galactosyltransferase (α-gal KO) to sera from normal healthy human volunteers demonstrated similar robust IgM and IgG immunoreactivity, comparably decreased in decellularized lungs. Read More

View Article and Full-Text PDF

The effect that pathologic and radiologic interpretation of invasive and non-invasive areas in lung adenocarcinoma has on T-stage and treatment.

Ann Diagn Pathol 2021 Jul 20;54:151799. Epub 2021 Jul 20.

Department of Pathology and Laboratory Medicine Rhode Island Hospital, The Warren Alpert School of Medicine, Brown University, United States of America. Electronic address:

Lung adenocarcinoma is currently staged based on invasive tumor size, excluding areas of lepidic (in situ) growth. Invasive tumor size may be determined by pathologic assessment of a surgical specimen or radiographic assessment on computerized tomography (CT) scan. When invasive tumor size is the primary stage determinate, radiographic-pathologic discordance or discordant interpretation among pathologists may alter tumor stage and treatment. Read More

View Article and Full-Text PDF

Randomized phase II study of docetaxel versus paclitaxel in patients with esophageal squamous cell carcinoma refractory to fluoropyrimidine- and platinum-based chemotherapy: OGSG1201.

Eur J Cancer 2021 Jul 23;154:307-315. Epub 2021 Jul 23.

Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan. Electronic address:

Background: There is no standard chemotherapy for esophageal squamous cell carcinoma (ESCC) refractory to first-line fluoropyrimidine- and platinum-based chemotherapy. We therefore performed a randomized, selection-design phase II trial to compare docetaxel (DTX) and paclitaxel (PTX) in this setting.

Patients And Methods: Eligible patients were randomly assigned to receive either DTX (70 mg/m on day 1 of each 21-day cycle) or PTX (100 mg/m on days 1, 8, 15, 22, 29 and 36 of each 49-day cycle). Read More

View Article and Full-Text PDF

Efficacy and adverse events of selective serotonin noradrenaline reuptake inhibitors in the management of postoperative pain: A systematic review and meta-analysis.

J Clin Anesth 2021 Jul 23;75:110451. Epub 2021 Jul 23.

Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, BG-Universitätsklinikum Bergmannsheil gGmbH, Medical Faculty of Ruhr University Bochum, Bürkle-de-la-Camp-Platz 1, Bochum, Germany.

Study Objective: Selective-serotonin-noradrenaline-reuptake inhibitors (SSNRI) might be an interesting option for postoperative pain treatment. Objective was to investigate postoperative pain outcomes of perioperative SSNRI compared to placebo or other additives in adults undergoing surgery.

Design: Systematic review of randomised controlled trials (RCT) with meta-analysis and GRADE assessment. Read More

View Article and Full-Text PDF

Urinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women's Health Across the Nation.

Environ Int 2021 Jul 23;157:106781. Epub 2021 Jul 23.

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, United States. Electronic address:

Background: Exposure to metals and metal mixtures may influence ovarian aging. However, epidemiologic evidence of their potential impact is lacking.

Objective: We prospectively examined the associations of 15 urinary metal concentrations and their mixtures with natural menopause in the Study of Women's Health Across the Nation Multi-Pollutant Study. Read More

View Article and Full-Text PDF

Prognostic effect of low-level HER2 expression in patients with clinically negative HER2 status.

Eur J Cancer 2021 Jul 23;155:1-12. Epub 2021 Jul 23.

Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany.

Purpose: Assessment of HER2 overexpression using immunohistochemistry (IHC) and/or in situ hybridisation (ISH) for the detection of HER2 amplifications is standard to identify patients for established HER2-directed treatments. Patients with lower HER2 expression levels have recently also become candidates for novel therapies targeting HER2. This study aimed to assess tumour and patient characteristics and prognosis in patients with advanced breast cancer (aBC), relative to low HER2 expression levels. Read More

View Article and Full-Text PDF

Factors associated with obtaining employment among opioid use disorder patients enrolled in a therapeutic workplace intervention.

Drug Alcohol Depend 2021 Jul 21;226:108907. Epub 2021 Jul 21.

Johns Hopkins University School of Medicine, USA.

Background: Unemployment is a common problem among adults who have substance use disorder that often persists during treatment and recovery. We identified patient characteristics that were associated with obtaining employment among unemployed adults in opioid use disorder treatment.

Methods: This analysis used data from participants (N = 91) who were enrolled in a randomized controlled trial evaluating the effectiveness of a therapeutic workplace in promoting drug abstinence and employment. Read More

View Article and Full-Text PDF

Contribution of altered corticospinal microstructure to gait impairment in children with cerebral palsy.

Clin Neurophysiol 2021 Jul 15;132(9):2211-2221. Epub 2021 Jul 15.

Medical Physics and Biomedical Engineering Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Physical Medicine and Rehabilitation Department, Northwestern University, USA. Electronic address:

Objective: Corticospinal tract (CST) injury may lead to motor disorders in children with Cerebral Palsy (CP). However, the precise underlying mechanisms are still ambiguous. We aimed to characterize the CST structure and function in children with CP and determine their contributions to balance and gait impairments. Read More

View Article and Full-Text PDF

Significant treatment gap and co-morbidities identified in an epidemiological survey of pediatric epilepsy in rural suburbs of India.

Seizure 2021 Jul 18;91:417-424. Epub 2021 Jul 18.

State Health Systems Resource Center, Pune, Maharashtra, India.

Purpose: A cross-sectional epidemiological survey of children was conducted in two rural clusters to estimate the point prevalence and study various aspects of childhood epilepsy.

Material And Methods: In the first stage, a house-to-house survey was conducted by health workers using a screening questionnaire, which was pre-validated in a pilot study. All screen positive houses were visited by pediatric neurologist for detailed evaluation. Read More

View Article and Full-Text PDF

Dicalcin suppresses in vitro trophoblast attachment in human cell lines.

Biochem Biophys Res Commun 2021 Jul 23;570:206-213. Epub 2021 Jul 23.

Department of Physiology, Saitama Medical University, 38 Moro-hongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan. Electronic address:

Implantation is a highly organized process that involves an interaction between a competent blastocyst and a receptive uterus. Despite significant research efforts, the molecular mechanisms governing this complex process remain elusive. Here, we investigated the effect of dicalcin, an S100-like Ca-binding protein, on the attachment of choriocarcinoma cells (BeWo cells) onto a monolayer of endometrial carcinoma cells (Ishikawa cells). Read More

View Article and Full-Text PDF

Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy.

Epilepsy Behav 2021 Jul 23;122:108205. Epub 2021 Jul 23.

Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD, USA.

Recent approval of Epidiolex® (pharmaceutical cannabidiol/CBD) for the treatment of Lennox Gastaut syndrome (LGS) and Dravet syndrome highlights a therapeutic efficacy of CBD in the treatment of epilepsy. However, a large number of patients with epilepsy elect to use alternative artisanal CBD products due to cost or access constraints. Despite widespread availability and variety of these artisanal CBD products, studies evaluating their safety or efficacy are rare, making conclusions about clinical utility uncertain. Read More

View Article and Full-Text PDF

Knee strength outcomes in adolescents by age and sex during late-stage rehabilitation after anterior cruciate ligament reconstruction.

Phys Ther Sport 2021 Jul 18;51:102-109. Epub 2021 Jul 18.

Connecticut Children's, Sports Physical Therapy, Farmington, CT, United States.

Objective: To determine if knee strength differences exist according to age group and sex among adolescents during late-stage anterior cruciate ligament reconstruction (ACLR) rehabilitation.

Design: Retrospective cohort study.

Methods: Consecutive patients who had undergone ACLR with a hamstring autograft completed isokinetic knee strength assessment. Read More

View Article and Full-Text PDF