865,079 results match your criteria medicinal products


Quantitative Removal of Pyrrolizidine Alkaloids from Essential Oils by the Hydrodistillation Step in Their Manufacturing Process.

Planta Med 2021 Jul 22. Epub 2021 Jul 22.

G. Pohl-Boskamp GmbH & Co. KG, Hohenlockstedt, Germany.

Pyrrolizidine alkaloids are naturally occurring toxins produced by certain weeds that can, if accidentally co-harvested, contaminate plant-based food, feed, and herbal medicinal products. Focusing on herbal medicinal products, the presence of pyrrolizidine alkaloids is restricted by regulatory prescribed thresholds to assure patient safety. Among the multitude of different herbal active substances utilized in herbal medicinal products, the class of pharmaceutically effective essential oils is considered to exhibit a negligible contribution to pyrrolizidine alkaloid contamination. Read More

View Article and Full-Text PDF

The European Medicines Agency Review of Luspatercept for the Treatment of Adult Patients With Transfusion-dependent Anemia Caused by Low-risk Myelodysplastic Syndromes With Ring Sideroblasts or Beta-thalassemia.

Hemasphere 2021 Aug 19;5(8):e616. Epub 2021 Jul 19.

Oncology and Haematology Office, European Medicines Agency, Amsterdam, The Netherlands.

Luspatercept is a recombinant fusion protein that selectively binds to ligands belonging to the transforming growth factor-beta superfamily, resulting in erythroid maturation and differentiation. On June 25, 2020, a marketing authorization valid through the European Union (EU) was issued for luspatercept for the treatment of adult patients with transfusion-dependent anemia caused by very low-, low-, and intermediate-risk myelodysplastic syndromes (MDS) with ring sideroblasts, or those with transfusion-dependent beta thalassemia (BT). Luspatercept was evaluated in 2 separate phase 3, double-blind, placebo-controlled multicentre trials. Read More

View Article and Full-Text PDF

Mesangiogenic Progenitor Cells Are Tissue Specific and Cannot Be Isolated From Adipose Tissue or Umbilical Cord Blood.

Front Cell Dev Biol 2021 5;9:669381. Epub 2021 Jul 5.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Mesangiogenic progenitor cells (MPCs) have been isolated from human bone marrow (BM) mononuclear cells. They attracted particular attention for the ability to differentiate into exponentially growing mesenchymal stromal cells while retaining endothelial differentiative potential. MPC power to couple mesengenesis and angiogenesis highlights their tissue regenerative potential and clinical value, with particular reference to musculoskeletal tissues regeneration. Read More

View Article and Full-Text PDF

Preparing and assessing the physiochemical properties of curcumin niosomes and evaluating their cytotoxicity in 3T3 and MCF-7 cell lines.

Avicenna J Phytomed 2021 Jul-Aug;11(4):417-427

Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Objective: Application of vesicular drug delivery systems has made major progress in pharmaceutical science and technology. Niosomal drug delivery is potentially efficient to improve the pharmacokinetic and pharmacological properties of many compounds. Curcumin (CUR) has several documented anticancer activities; however, it has a low bioavailability that necessitates the development of efficient delivery systems. Read More

View Article and Full-Text PDF

Anti-edema effect of leaf extract following traumatic brain injury: Role of pro-inflammatory cytokines.

Avicenna J Phytomed 2021 Jul-Aug;11(4):380-393

Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Objective: Based on anti-inflammatory effects of , the effect of aqueous extract of this plant on brain edema and changes in some pro-inflammatory cytokines was investigated after traumatic brain injury (TBI).

Materials And Methods: In this study, adult male Wistar rats were divided into 5 groups: Sham, TBI, vehicle (Veh), and low dose (LA) and high dose (HA) . The vehicle and aqueous extract of were injected intraperitoneally 30 min after induction of diffuse TBI by Marmarou's method. Read More

View Article and Full-Text PDF
September 2020

Cytotoxic abietane-type diterpenoids from roots of and their pharmacophore modeling.

Nat Prod Res 2021 Jul 22:1-6. Epub 2021 Jul 22.

Research Group Biosynthesis/NMR, Max Planck Institute for Chemical Ecology, Jena, Germany.

The roots of L. (Lamiaceae) were extracted with hexane, dichloromethane (DCM) and ethyl acetate. The DCM extract exhibited cytotoxic activity (IC 32. Read More

View Article and Full-Text PDF

Guava ( L.): a glorious plant with cancer preventive and therapeutic potential.

Crit Rev Food Sci Nutr 2021 Jul 21:1-32. Epub 2021 Jul 21.

Lake Erie College of Osteopathic Medicine, Bradenton, Florida, USA.

Guava ( L.) tree (Myrtaceae family) bears fruit rich in vitamins, fiber, and other nutrients. While native to Latin America, guava is grown in many tropical and subtropical regions across the globe where it has long been used in traditional medicine to treat a myriad of ailments. Read More

View Article and Full-Text PDF

Co-delivery of paclitaxel and STAT3 siRNA by a multifunctional nanocomplex for targeted treatment of metastatic breast cancer.

Acta Biomater 2021 Jul 18. Epub 2021 Jul 18.

Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China; NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Metastasis is one of the major causes of mortality in patients suffering from breast cancer. The signal transducer and activator of transcription 3 (STAT3) is closely related to cancer metastasis. Herein, a multifunctional nanocomplex was developed to simultaneously deliver paclitaxel (PTX) and STAT3 siRNA (siSTAT3) to inhibit tumor growth and prevent metastasis of breast tumor cells. Read More

View Article and Full-Text PDF

Evolutionary biology and development model of medicines: a necessary "pas de deux" for future successful bacteriophage therapy.

J Evol Biol 2021 Jul 19. Epub 2021 Jul 19.

Centre National de la Recherche Scientifique, Centre Emile Durkheim - UMR5116, Paris, France.

The increase in frequency of multidrug resistant bacteria worldwide is largely the result of the massive use of antibiotics in the second half of the 20th century. These relatively recent changes in human societies revealed the great evolutionary capacities of bacteria towards drug resistance. In this article, we hypothesize that the success of future antibacterial strategies lies in taking into account both these evolutionary processes and the way human activities influence them. Read More

View Article and Full-Text PDF

An ether-linked halogenated phenazine-quinone prodrug model for antibacterial applications.

Org Biomol Chem 2021 Jul 20. Epub 2021 Jul 20.

Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.

Antibiotic-resistant infections present significant challenges to patients. As a result, there is considerable need for new antibacterial therapies that eradicate pathogenic bacteria through non-conventional mechanisms. Our group has identified a series of halogenated phenazine (HP) agents that induce rapid iron starvation that leads to potent killing of methicillin-resistant Staphylococcus aureus biofilms. Read More

View Article and Full-Text PDF

In silico identification of potential Hsp90 inhibitors via ensemble docking, DFT and molecular dynamics simulations.

J Biomol Struct Dyn 2021 Jul 21:1-12. Epub 2021 Jul 21.

Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.

The molecular chaperone heat shock protein 90 (Hsp90) has emerged as one of the most exciting targets for anticancer drug development and Hsp90 inhibitors are potentially useful chemotherapeutic agents in cancer. Within the current study, Hsp90 inhibitors that entered different phases of clinical trials were subjected to Zinc15 structure query to find similar compounds (≥ 78%). Obtained small molecules (-) with defined similarity cut-off were docked into ensemble of Hsp90-α NTDs. Read More

View Article and Full-Text PDF

[Treatment of infection with traditional Chinese medicine: a case report].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Mar;33(3):327-328

Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, China.

This paper reports a case with infections, and summarizes the diagnosis and treatment with traditional Chinese medicine. Read More

View Article and Full-Text PDF

[Molluscicidal activity of the Y6 strain against and its preliminary mechanisms of molluscicidal actions].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2021 Jul;33(3):248-253

Department of Microbiology and Immunology, Wannan Medical College, Wuhu 241002, China.

Objective: To assess the molluscicidal activity of the of Y6 strain against in laboratory, and to preliminarily investigate its mechanisms of molluscicidal actions.

Methods: Biological identification of the Y6 strain was performed based on analysis of its morphological and physiochemical features and homology analysis of the gene sequence. Y6 suspensions were formulated at concentrations of 0. Read More

View Article and Full-Text PDF

Optimization for synthesis of silver nanoparticles through response surface methodology using leaf extract of Boswellia sacra and its application in antimicrobial activity.

Environ Monit Assess 2021 Jul 20;193(8):497. Epub 2021 Jul 20.

Department of Chemistry, Aligarh Muslim University, Uttar Pradesh, Aligarh, 202002, India.

In the present work, leaf extract of Boswellia sacra was used as reductant for synthesis of silver nanoparticles (AgNPs). The variables such as volume of Boswellia sacra leaf extract (1%), volume of silver nitrate (1 mM), and temperature were optimized by response surface methodology via Box-Behnken design for the synthesis of AgNPs. Design-Expert software generated the optimum conditions for the highest yield of silver nanoparticles as 8 mL of 1 mM AgNO, 8 mL of 1% Boswellia sacra leaf extract, and temperature = 55 °C. Read More

View Article and Full-Text PDF

Transferability of a two-strip method for the quality control of technetium-99m mercaptoacetyltriglycine ([Tc]Tc-MAG3).

Eur J Hosp Pharm 2021 Jul 20. Epub 2021 Jul 20.

Department of Pharmacy, CHU Caen, Caen, France

Objectives: Technetium-99m mercapto-acetyl-triglycine ([Tc]Tc-MAG3) is a radiopharmaceutical diagnostic agent used in nuclear medicine intended for the exploration of nephrological and urological disorders. Patient safety and reliability of this imaging procedure especially depend on the radiochemical purity (RCP) of the [Tc]Tc-MAG3 preparation. Recently, the Summary of Product Characteristics (SPC) of NephroMAG, a kit dedicated to [Tc]Tc-MAG3 preparation, proposed a two-strip thin layer chromatography (TLC) based quality control (QC) method. Read More

View Article and Full-Text PDF

[Prospects for the use of drugs with anti-inflammatory properties for the treatment of depression].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(6):124-131

Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

The review briefly summarizes experimental and preclinical data of the role of pro-inflammatory cytokines in triggering pathophysiological changes associated with depression, primarily major depressive disorder (MDD), as well as the possibility of using anti-inflammatory drugs as antidepressants. Read More

View Article and Full-Text PDF

: a review of ethnomedicinal uses, pharmacology and phytochemistry.

Pharm Biol 2021 Dec;59(1):955-963

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

Context: (Schweinf) Harms (Meliaceae) is an important medicinal plant found in tropical and subtropical countries of Africa. Traditionally, is used in the treatment of various diseases including diabetes, malaria, abdominal pain and diarrhoea.

Objective: To provide an overview of traditional medicinal claims, pharmacological properties, and phytochemical principles of as a basis for its clinical applications and further research and development of new drugs. Read More

View Article and Full-Text PDF
December 2021

Processing and extraction methods of medicinal cannabis: a narrative review.

J Cannabis Res 2021 Jul 19;3(1):32. Epub 2021 Jul 19.

Drug Delivery Research Group, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand.

Introduction: As the cannabis industry transitions from a black market to a legal market, product development, and methods of extraction have become a focal point. To date, more than thousands of chemical constituents have been identified from the cannabis plant, all of which possess different chemical properties that require different conditions for preservation during drying and extraction. However, scientific publications that explore these areas for the cannabis plant are currently lacking. Read More

View Article and Full-Text PDF

Efficacy and safety of Suxiao Jiuxin Pill in the treatment of stable angina (Qi stagnation and blood stasis syndrome): study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial.

Trials 2021 Jul 19;22(1):466. Epub 2021 Jul 19.

Cardiovascular Department, Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, No. 528 Zhangheng Road, Pudong New Area, Shanghai, 201203, China.

Background: Coronary heart disease (CHD) has become one of the biggest health problems in the world. Stable angina is a common clinical type of CHD with poor prognosis and high mortality. Although there are various interventions for stable angina, none of them can significantly reduce mortality. Read More

View Article and Full-Text PDF

Facial Mask and Plexiglass Box: a critical overview on the current strategies to protect patients from COVID-19 infection.

J Biol Regul Homeost Agents 2021 Mar-Apr;35(2 Suppl. 1):139-145

Regenerative Medicine and Tissue Engineering, Saint Camillus International University of Health and Medical Science, Rome, Italy.

The route of transmission of SARS-CoV-2 has been understood thanks to the knowledge of previously identified human coronaviruses. According to these studies, the transmission of the virus occurs mainly between humans at close range, through respiratory droplets produced during conversation or coughing, as well as through direct contact of the hands then placed on the mucous membranes or mouth. From the final analysis of studies carried out on protective systems, the validity of plexiglass as a material to be used for the construction of protective devices could be affirmed. Read More

View Article and Full-Text PDF

Clinical efficacy of grape seed extract as an adjuvant to scaling and root planing in treatment of periodontal pockets.

J Biol Regul Homeost Agents 2021 Mar-Apr;35(2 Suppl. 1):89-96

Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.

Grape seed extract (GSE), a naturally producing polyphenolic compound, is found to be a potent hostmodulatory agent and considered for management of periodontal disease. Its anti-bacterial, antioxidant, and anti-inflammatory property may aid in achieving periodontal health. To assess the clinical efficacy of GSE in adjunct to scaling and root planing (SRP) in healing of periodontal pockets. Read More

View Article and Full-Text PDF

Synthesis and characterization of a new two photon excitable acid sphingomyelinase FRET probe.

Bioorg Med Chem 2021 Jul 13;44:116303. Epub 2021 Jul 13.

Institute for Chemistry, Humboldt Universität zu Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany. Electronic address:

Recently, FRET probes for acid sphingomyelinase (ASM) have enabled the observation of enzyme activity in intact cells for the first time. Here we present an ASM FRET probe specifically optimized for 2-photon excitation. To facilitate probe characterization and comparison to the previous probe, we mixed the two intact probes with defined amounts of the probes' ceramide cleavage products and mounted them on lipid beads. Read More

View Article and Full-Text PDF

Adsorption/desorption performance of Pb and Cd with super adsorption capacity of PASP/CMS hydrogel.

Water Sci Technol 2021 Jul;84(1):43-54

College of Material Science and Art Design, Inner Mongolia Agricultural University, Laboratory of Fibrosis and Energy Utilization of Shrubby Resources in Inner Mongolia Autonomous Region, Hohhot 010018, China.

Super-absorbent polyaspartic acid/carboxymethyl Salix psammophila powder (PASP/CMS) hydrogel was prepared by aqueous solution polymerization. PASP/CMS hydrogel was characterized by Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The results showed that PASP/CMS hydrogel is prepared by graft copolymerization of the -COOH of polyaspartic acid (PASP) and the -CHOH of CMS. Read More

View Article and Full-Text PDF

First Report of Downy Mildew on Sweet Basil Caused By Peronospora belbahrii in India.

Plant Dis 2021 Jul 19. Epub 2021 Jul 19.

CSIR-CIMAP, 30083, Plant Pathology, Lucknow, Uttar Pradesh, India;

Sweet basil (Ocimum basilicum L.; Family Lamiaceae) is an annual aromatic and medicinal plant grown in tropical and subtropical regions of the world. In India, it is cultivated as a commercial crop on ~8,000 ha. Read More

View Article and Full-Text PDF

Detection, Isolation, and H NMR Quantitation of the Nitrile Glycoside Sarmentosin from a Hydro-Ethanolic Extract.

J Agric Food Chem 2021 Jul 19. Epub 2021 Jul 19.

Equipe Produits naturels, analyse, synthèse, UMR CNRS 8038, Faculté de Pharmacie, Université Paris Descartes/Université de Paris, 75006 Paris, France.

(Lam) Pers. (Crassulaceae) is widely used in folk medicine as leaf juice, aqueous, or hydro-ethanolic extracts. It is also listed as a medicinal plant in several countries such as France and Brazil. Read More

View Article and Full-Text PDF

Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment.

ACS Nano 2021 Jul 19. Epub 2021 Jul 19.

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Androgenetic alopecia (AGA) is highly prevalent in current society but lacks effective treatments. The dysregulation of the hair follicle niche induced by excessive reactive oxygen species (ROS) and insufficient vascularization in the perifollicular microenvironment is the leading cause of AGA. Herein, we designed a ceria nanozyme (CeNZ)-integrated microneedles patch (Ce-MNs) that can alleviate oxidative stress and promote angiogenesis simultaneously to reshape the perifollicular microenvironment for AGA treatment. Read More

View Article and Full-Text PDF

Genetic Aspects and Immune Responses in Covid-19: Important Organ Involvement.

Adv Exp Med Biol 2021 ;1327:3-22

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

In the last two decades, the world has experienced outbreaks of three major coronaviruses with high morbidity and mortality rates. The most recent of these started in the form of an unusual viral pneumonia in Wuhan, China, and now the world is facing a serious pandemic. This new disease has been called COVID-19 and is caused by the SARS-CoV-2 virus. Read More

View Article and Full-Text PDF

Plants and Natural Products with Activity against Various Types of Coronaviruses: A Review with Focus on SARS-CoV-2.

Molecules 2021 Jul 5;26(13). Epub 2021 Jul 5.

Escuela Superior Politécnica del Litoral, ESPOL, Centro de Investigaciones Biotecnológicas del Ecuador, CIBE, Campus Gustavo Galindo Km. 30.5 vía Perimetral, Guayaquil EC090112, Ecuador.

COVID-19 is a pandemic disease caused by the SARS-CoV-2 virus, which is potentially fatal for vulnerable individuals. Disease management represents a challenge for many countries, given the shortage of medicines and hospital resources. The objective of this work was to review the medicinal plants, foods and natural products showing scientific evidence for host protection against various types of coronaviruses, with a focus on SARS-CoV-2. Read More

View Article and Full-Text PDF

Natural and Conventional Cosmetics-Mercury Exposure Assessment.

Molecules 2021 Jul 5;26(13). Epub 2021 Jul 5.

Department of Bromatology, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, Poland.

Mercury (Hg) can enter the human body through the respiratory tract and digestive system, but also through the skin. Sources of Hg in the environment can be natural processes, but also human activities, including agriculture, chemical, and pharmaceutical industries. Hg can also enter the body through food, but also with cosmetics that are used for a long time. Read More

View Article and Full-Text PDF

Application of Green Algal Biomasses to Modulate Growth of Selected Microbial Species.

Molecules 2021 Jul 1;26(13). Epub 2021 Jul 1.

Bioorganic Technologies sp. z o.o., Sedziszow Malopolski, Sielec 1A, 39-120 Sielec, Poland.

As microalgae are producers of proteins, lipids, polysaccharides, pigments, vitamins and unique secondary metabolites, microalgal biotechnology has gained attention in recent decades. Microalgae can be used for biomass production and to obtain biotechnologically important products. Here, we present the application of a method of producing a natural, biologically active composite obtained from unicellular microalgae of the genus sp. Read More

View Article and Full-Text PDF