975,122 results match your criteria medications

Pulmonary Support of Infants with Tracheotomies in a Regional Neonatal Intensive Care Unit.

Am J Perinatol 2021 May 11. Epub 2021 May 11.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan.

Objective:  We evaluate patient characteristics, hospital course, and outcome by type discharge pulmonary support; mechanical ventilation (MV) or with tracheotomy masks (TM).

Study Design:  We reviewed records of infants admitted to the neonatal intensive care unit (NICU) that underwent tracheotomy within their first year of life between 2006 and 2017. We evaluated patient characteristics, referral pattern, destination of discharge, and outcome by type of pulmonary support at discharge (MV vs. Read More

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Prevalence of Polypharmacy and Risks of Potentially Inappropriate Medication Use in the Older Population in a Developing Country: A Systematic Review and Meta-Analysis.

Gerontology 2021 May 11:1-10. Epub 2021 May 11.

Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czechia.

Background And Aim: Polypharmacy and potentially inappropriate medication (PIM) use in older populations (65+ years) have not yet been investigated by meta-analyses in developing countries. This systematic literature review and meta-analysis aimed to investigate the prevalence of polypharmacy and PIM use and major risk factors associated with PIM prescribing in older adults in Ethiopia.

Methods: We searched PubMed/MEDLINE, Scopus, Embase, and Google Scholar databases to identify relevant studies published between January 1990 and October 2020. Read More

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Criticality index conducted in pediatric emergency department triage.

Am J Emerg Med 2021 May 6;48:209-217. Epub 2021 May 6.

Children's Hospital of Orange County, Orange, CA, United States.

Objective: To develop and analyze the performance of a machine learning model capable of predicting the disposition of patients presenting to a pediatric emergency department (ED) based on triage assessment and historical information mined from electronic health records.

Methods: We retrospectively reviewed data from 585,142 ED visits at a pediatric quaternary care institution between 2013 and 2020. An extreme gradient boosting machine learning model was trained on a randomly selected training data set (50%) to stratify patients into 3 classes: (1) high criticality (patients requiring intensive care unit [ICU] care within 4 h of hospital admission, patients who died within 4 h of admission, and patients who died in the ED); (2) moderate criticality (patients requiring hospitalization without the need for ICU care); and (3) low criticality (patients discharged home). Read More

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The intertwined expansion of telehealth and buprenorphine access from a prescriber hub.

Prev Med 2021 May 8:106603. Epub 2021 May 8.

VA Connecticut Healthcare System, West Haven, CT, United States of America; Yale University, School of Medicine, Department of Psychiatry, New Haven, CT, United States of America.

In this manuscript, we describe how efforts to increase access to buprenorphine for Opioid Use Disorder (OUD) through a telemedicine hub before and since the COVID-19 pandemic have played out in the Veterans Healthcare Administration (VHA) in New England. We look at how the COVID-19 pandemic and subsequent spike in opioid overdoses tilted the risk: benefit calculation for tele-prescribing a controlled substance such as buprenorphine toward expanding access to tele-buprenorphine. We conclude that there is a need for tele-buprenorphine hubs that can fill gaps in geographically dispersed healthcare systems. Read More

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Client satisfaction and experience of telemedicine and home use of mifepristone and misoprostol for abortion up to 10 weeks' gestation at British Pregnancy Advisory Service: a cross-sectional evaluation.

Contraception 2021 May 8. Epub 2021 May 8.

British Pregnancy Advisory Service, 20 Timothy's Bridge Road, Stratford Enterprise Park, Stratford-upon-Avon, Warwickshire, CV37 9BF, UK. Electronic address:

Objective: Evaluate satisfaction and experience with telemedicine consultation and home use of mifepristone and misoprostol for abortion to 10 weeks' gestation.

Study Design: Cross-sectional evaluation of British Pregnancy Advisory Service (BPAS) clients who used mifepristone and misoprostol at home from 11 May to 10 July 2020. We sent a text message with a link to a web-survey 2-3 weeks postabortion. Read More

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Cancer Disparities and Black American Representation in Clinical Trials Leading to the Approval of Oral Chemotherapy Drugs in the United States Between 2009 and 2019.

JCO Oncol Pract 2021 May;17(5):e623-e628

Department of Pharmacy Practice and Clinical Health Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX.

Purpose: Over the past 10 years, oral chemotherapy made up about half (45.6%) of all US Food and Drug Administration (FDA)-approved oncolytic and hematologic medications. Given the disparity in incidence and mortality rate because of certain cancers among Black Americans (BAs) in the United States, a review of BA's representation in the clinical trials that lead to the development and FDA approval of oral chemotherapy drugs becomes imperative. Read More

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Pharmacotherapy for Management of 'Kratom Use Disorder': A Systematic Literature Review With Survey of Experts.

WMJ 2021 Apr;120(1):54-61

Ascension All Saints Hospital, Racine, Wisconsin,

Objectives: An increasing number of Americans are turning to kratom for self-management of various pain, anxiety, and mood states and as an opioid substitute. Addiction to this unique botanical develops and carries a high relapse risk and, to date, there are no guidelines on how to maintain long-term abstinence. The aim of this article is to compile all available information on management of "kratom use disorder" (KUD)-as coined here-from the literature, with evidence from the clinical practice of expert addictionologists in an attempt to develop a standard of care consensus. Read More

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Rate of glycemic control and associated factors among type two diabetes mellitus patients in Ethiopia: A cross sectional study.

PLoS One 2021 11;16(5):e0251506. Epub 2021 May 11.

Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.

Objective: To assess the rate of glycemic control and associated factors among type 2 diabetes mellitus patients at Dilchora Referral Hospital, Dire Dawa, Eastern Ethiopia.

Methods: A cross-sectional study was conducted from 13 May to 16 August 2019. Type 2 diabetic patients on follow up at Dilchora Referral Hospital who fulfilled the inclusion criteria of the study were included. Read More

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Perioperative Approach to Reducing Hematoma during Rhytidectomy: What Does the Evidence Show?

Plast Reconstr Surg 2021 May 10. Epub 2021 May 10.

From the Duke University Medical Center; and the Dallas Plastic Surgery Institute.

Background: Postoperative hematoma remains the most common complication in rhytidectomy, prompting surgeons to use a multitude of adjunctive measures to prevent its occurrence. The goal of this systematic review was to determine which of these measures are supported by strong evidence, and to highlight those that remain unsubstantiated and require further investigation.

Methods: A systematic search was performed of the PubMed and Embase databases for English literature from 1975 to March of 2020 containing designated keywords, and focusing specifically on adjunctive measures aimed at preventing hematoma in rhytidectomy. Read More

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How a Medication for Opioid Use Disorder Curriculum Translates into Experiences and Internal Medicine Residents' Understanding of Patients with Opioid Use Disorder.

Teach Learn Med 2021 May 11:1-8. Epub 2021 May 11.

VA HSRD Center for Health Information and Communication, Roudebush VAMC, Roudebush, Indiana, USA.

Problem: The number of people with an Opioid Use Disorder (OUD) continues to outpace access to associated medication. Ninety-six percent of states report higher rates of OUD than access to medications, and, despite being the standard of care, only 3% of physicians currently prescribe medication for opioid use disorder (MOUD). Prior studies have shown that decreasing barriers, such as a lack of knowledge about MOUD, increased physicians' willingness to prescribe. Read More

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Impact of COVID-19 and Partial Lockdown on Access to Care, Self-Management and Psychological Well-being among People with Diabetes: A Cross-sectional Study.

Int J Clin Pract 2021 May 11:e14319. Epub 2021 May 11.

Saw Swee Hock School of Public Health, National University of Singapore, Singapore.

Background: The impact of lockdown measures can be widespread, affecting both clinical and psychosocial aspects of health. This study aims to assess changes in health services access, self-care, behavioral and psychological impact of COVID-19 and partial lockdown amongst diabetes patients in Singapore.

Methods: We conducted a cross-sectional online survey amongst people with diabetes with the Diabetes Health Profile-18 (DHP-18). Read More

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A review and perspective on the assessment, management and prevention of fragility fractures in patients with osteoporosis and chronic kidney disease.

Endocrine 2021 May 11. Epub 2021 May 11.

Department of Medicine, Holbæk Hospital, Holbæk, Denmark.

This article aims to review the methods used for the assessment of fracture risk and the use of osteoporosis medications for fracture prevention in the population with CKD, and highlights the difficulties faced by clinicians in the management of these patients and the latest recommendations and guidelines. Chronic kidney disease (CKD) and osteoporosis often co-exist in older adults, and they present a major healthcare challenge. CKD mineral and bone disorder (CKD-MBD) occurs as renal function declines and this syndrome affects most patients in CKD stages 4 and 5. Read More

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Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity.

Brian A Baldo

Arch Toxicol 2021 May 11. Epub 2021 May 11.

Molecular Immunology Unit, Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney, Sydney, NSW, 2070, Australia.

Opioid-induced respiratory depression is potentially life-threatening and often regarded as the main hazard of opioid use. Main cause of death is cardiorespiratory arrest with hypoxia and hypercapnia. Respiratory depression is mediated by opioid μ receptors expressed on respiratory neurons in the CNS. Read More

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Provider and Patient-panel Characteristics Associated With Initial Adoption and Sustained Prescribing of Medication for Opioid Use Disorder.

J Addict Med 2021 May 10. Epub 2021 May 10.

Department of Internal Medicine, University of Utah, City, UT (GC, AJG), Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA (ESC, MS, DN, TB, CD, JD), School of Medicine, University of Pittsburgh, Pittsburgh, PA (WFG, C-CH), Program Evaluation Research Unit, University of Pittsburgh, Pittsburgh, PA (JP, JW), School of Pharmacy, University of Pittsburgh, Pittsburgh, PA (JP), Pennsylvania Department of Drug and Alcohol Programs, Harrisburg, PA (ED), Pennsylvania Department of Human Services, Harrisburg, PA (DK).

Objectives: Limited information is available regarding provider- and patient panel-level factors associated with primary care provider (PCP) adoption/prescribing of medication for opioid use disorder (MOUD).

Methods: We assessed a retrospective cohort from 2015 to 2018 within the Pennsylvania Medicaid Program. Participants included PCPs who were Medicaid providers, with no history of MOUD provision, and who treated ≥10 Medicaid enrollees annually. Read More

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A practical approach to peripheral autonomic neuropathies.

Curr Opin Neurol 2021 May 11. Epub 2021 May 11.

Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

Purpose Of The Review: The review focuses on the practical evaluation and management of patients with autonomic neuropathies.

Recent Findings: Autonomic neuropathies are complex disorders and result in diverse clinical manifestations that affect the cardiovascular, gastrointestinal, urogenital, and sudomotor systems. The autonomic medical history is key when seeing a patient with suspected autonomic neuropathy. Read More

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Three-year effectiveness and safety of the XEN gel stent as a solo procedure or in combination with phacoemulsification in open-angle glaucoma: a multicentre study.

Acta Ophthalmol 2021 May 10. Epub 2021 May 10.

Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.

Purpose: To assess the 3-year effectiveness and safety of the XEN gel stent implanted ab interno in open-angle glaucoma (OAG).

Methods: This study was a multicentre, retrospective chart review of consecutive patients with OAG who underwent ab-interno gel stent placement alone or combined with phacoemulsification between 1 January 2014 and 1 October 2015. Outcome measures included mean changes in intraocular pressure (IOP) and IOP-lowering medication count from medicated baseline at 1, 2, 3 (primary outcome) and 4 years (if available) postimplantation. Read More

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Long-Term Outcomes of Transforaminal Epidural Steroid Injection in Patients with Lumbosacral Radicular Pain according to the Location, Type, and Size of Herniated Lumbar Disc.

Pain Pract 2021 May 11. Epub 2021 May 11.

Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea.

Objectives: Transforaminal epidural steroid injection (TFESI) is widely used to manage lumbosacral radicular pain due to herniated lumbar disc (HLD).

Objectives: We evaluated the long-term outcomes of TFESI in patients with lumbosacral radicular pain due to a HLD by the location, type, and size of the HLD.

Methods: In total, 114 patients who received the initial TFESI at least 4 years ago completed a phone interview. Read More

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Potentially Inappropriate Medications in Chinese Older Outpatients in tertiary hospitals according to Beers Criteria: A Cross-sectional Study.

Int J Clin Pract 2021 May 10:e14348. Epub 2021 May 10.

Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, China.

Objectives: Multimorbidity and polypharmacy in older adults always increase the prevalence of potentially inappropriate medications (PIMs) and affect the quality of life of older adults. Currently, the data of PIMs on Chinese geriatric outpatients based on Beers criteria 2015 and 2019 has not been studied. The purposes of this study were aimed to investigate the prevalence of PIMs prescription and the most frequent PIMs among outpatients according to the two criteria, and to explore related risk factors for PIMs. Read More

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Distributive health literacy and medication management: A longitudinal qualitative study with Bhutanese former-refugees in Tasmania.

Health Promot J Austr 2021 May 11. Epub 2021 May 11.

School of Medicine, University of Tasmania, Hobart, Australia.

Issue Addressed: Tasmania, Australia is home to a population of Bhutanese former-refugees who have resettled since 2007. Their refugee journey and disrupted education opportunities has resulted in gaps in literacy in their primary language (Nepali), and many suffer one or more chronic conditions (ongoing communicable or non-communicable diseases (NCDs)). This research explored how this community perceives chronic conditions and managed their medication using the concept of distributed health literacy. Read More

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sFlt-1/PlGF ratio as a predictive and prognostic marker for preeclampsia.

J Obstet Gynaecol Res 2021 May 10. Epub 2021 May 10.

Department of Obstetrics and Gynecology, Gachon University of Gil Medical Center, Incheon, South Korea.

Objective: Preeclampsia is clinically unpredictable and associated with adverse outcomes. Pregnant women with suspected preeclampsia require intensive monitoring or hospitalization for elevated sFlt-1 (soluble fms-like tyrosine kinase-1) to PlGF (placental growth factor) ratios before symptoms arise. We aimed to determine the sFlt-1/PlGF ratio's usefulness in predicting adverse pregnancy outcomes in preeclampsia. Read More

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Pharmacist's Role and Pharmaceutical Care During the COVID-19 Pandemic.

Adv Exp Med Biol 2021 ;1318:605-622

Research Group on Pharmaceutical Promotion and Prevention, University of Antioquia, Medellín, Colombia.

Pharmacists play a vital role in public health during the COVID-19 pandemic. In this chapter, we present the most significant contributions that pharmacists could make to communitarian and hospital settings. It includes the provision of essential services, such as continuous access to medication and supplies, support to medical services, education and information to the population and the health team to reduce the misuse of medications, patient monitoring and follow-up, and the detection and referral of suspected cases of COVID-19. Read More

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January 2021

Genetic investigations of 100 inherited cardiac disease-related genes in deceased individuals with schizophrenia.

Int J Legal Med 2021 May 11. Epub 2021 May 11.

Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Cardiac diseases and sudden cardiac death (SCD) are more prevalent in individuals diagnosed with schizophrenia compared to the general population, with especially coronary artery disease (CAD) as the major cardiovascular cause of death. Antipsychotic medications, genetics, and lifestyle factors may contribute to the increased SCD in individuals with schizophrenia. The role of antipsychotic medications and lifestyle factors have been widely investigated, while the genetic predisposition to inherited cardiac diseases in schizophrenia is poorly understood. Read More

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Quality of life in cancer patients with or without medication-related osteonecrosis of the jaw.

Support Care Cancer 2021 May 10. Epub 2021 May 10.

Postgraduate Program in Dentistry, Universidade Federal Do Paraná, Curitiba, Paraná, Brazil.

Purpose: Cancer and its therapies can have a significant impact on general and oral health and, therefore, cause a reduction in patients' quality of life (QoL). The study aimed to evaluate the QoL of cancer patients who use antiresorptive and anti-angiogenic medications with or without the development of medication-related osteonecrosis of the jaws (MRONJ).

Methods: Sixty-two patients diagnosed with cancer under antiresorptive therapy answered three instruments from the European Organization for Cancer Research and Treatment (EORTC). Read More

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Retinal Migraine: Evaluation and Management.

Curr Neurol Neurosci Rep 2021 May 11;21(7):35. Epub 2021 May 11.

Division of Neurology, University of Toronto, Toronto, Canada.

Purpose Of Review: This review aims to summarize the last 15 years of literature and case reports detailing retinal migraine-an uncommon and somewhat poorly understood migraine variant.

Recent Findings: In the last 15 years, only 12 cases of retinal migraine have been outlined. Similar to other migraine statistics, retinal migraine appears to affect women more so than men and presents with unilateral headache which tends to be ipsilateral to the side of vision loss. Read More

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Controversial cardiovascular and hematologic comorbidities in atopic dermatitis.

Arch Dermatol Res 2021 May 10. Epub 2021 May 10.

Department of Dermatology, Wake Forest School of Medicine, Center for Dermatology Research, Medical Center Boulevard, Winston-Salem, NC, 27157-1071, USA.

Atopic dermatitis' (AD) systemic involvement is wide-reaching. The cardiovascular and hematological comorbidities of AD have potential for considerable economic and physical burden; however, data surrounding the association between these comorbidities and AD is controversial. This review discusses the cardiovascular and hematological comorbidities of AD, detailing the conflicting evidence, pathophysiology, and connection to medications. Read More

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Oral Lactulose vs. Polyethylene Glycol for Bowel Preparation in Colonoscopy: A Randomized Controlled Study.

Cureus 2021 Apr 8;13(4):e14363. Epub 2021 Apr 8.

Department of Surgery, Maulana Azad Medical College, New Delhi, IND.

Background Colonoscopy is the method of choice to evaluate colonic mucosa and the distal ileum, allowing the diagnosis and treatment of many diseases. Appropriate bowel preparation necessitates the use of laxative medications, preferentially by oral administration. These include polyethylene glycol (PEG), sodium picosulfate, and sodium phosphate (NaP). Read More

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Opioid Prescribing Practices and Quality Improvements Within an Outpatient Orthopedic Practice.

Cureus 2021 Apr 6;13(4):e14332. Epub 2021 Apr 6.

Statistics, Twin Cities Orthopedics, Golden Valley, USA.

Background During the last several decades, the opioid epidemic throughout the United States has been recognized as an increasing problem. The aim of this study was to identify and implement processes throughout a single private orthopedic practice and managed ambulatory surgery centers to reduce opioid prescription pill quantity and strength, while also reducing consumption. Methodology A baseline assessment along with the development of four separate phases was implemented. Read More

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From Precision Metapharmacology to Patient Empowerment: Delivery of Self-Care Practices for Epilepsy, Pain, Depression and Cancer Using Digital Health Technologies.

Front Pharmacol 2021 23;12:612602. Epub 2021 Apr 23.

Department of Pharmacotherapy, Skaggs Pharmacy Institute, University of Utah, Salt Lake City, UT, United States.

To improve long-term outcomes of therapies for chronic diseases, health promotion and lifestyle modifications are the most promising and sustainable strategies. In addition, advances in digital technologies provide new opportunities to address limitations of drug-based treatments, such as medication non-adherence, adverse effects, toxicity, drug resistance, drug shortages, affordability, and accessibility. Pharmaceutical drugs and biologics can be combined with digital health technologies, including mobile medical apps (digital therapeutics), which offer additional clinical benefits and cost-effectiveness. Read More

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Prevention of Covid-19 affected patient using multi robot cooperation and Q-learning approach: a solution.

Qual Quant 2021 May 6:1-29. Epub 2021 May 6.

Department of Computer Science and Engineering, GIET University, Gunupur, India.

Combat with the novel corona virus (COVID-19) has become challenging for all the frontline warriors like, medic people, police and other service provider. Many technology and intelligent algorithms have been developed to set the boundary in its incremental growth. This paper proposed a concept to set the boundary on spreading of this disease among the medic people, who are directly exposed to the COVID-19 patient. Read More

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RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor.

Cell Mol Immunol 2021 May 10. Epub 2021 May 10.

Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

The NLRP3 inflammasome plays a crucial role in innate immune-mediated inflammation and contributes to the pathogenesis of multiple autoinflammatory, metabolic and neurodegenerative diseases, but medications targeting the NLRP3 inflammasome are not available for clinical use. RRx-001 is a well-tolerated anticancer agent currently being investigated in phase III clinical trials, but its effects on inflammatory diseases are not known. Here, we show that RRx-001 is a highly selective and potent NLRP3 inhibitor that has strong beneficial effects on NLRP3-driven inflammatory diseases. Read More

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