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Autophagic defects observed in fibroblasts from a patient with β-propeller protein-associated neurodegeneration.

Am J Med Genet A 2021 Jul 29. Epub 2021 Jul 29.

Neural Circuit Research Group, Korea Brain Research Institute, Daegu, South Korea.

Beta-propeller protein-associated neurodegeneration (BPAN) is associated with mutations in the autophagy gene WDR45. The aim of this study was to demonstrate autophagic defects in a patient with BPAN. We assayed autophagic markers using western blot analysis and immunocytochemistry and applied transmission electron microscopy (TEM) to visualize the autophagic structures in fibroblasts from a 7-year-old Korean female with WDR45 splice-site mutation (c. Read More

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Surgery for Degenerative Cervical Myelopathy: A Nationwide Registry-Based Observational Study With Patient-Reported Outcomes.

Neurosurgery 2021 Jul 29. Epub 2021 Jul 29.

Department of Neurosurgery, University Hospital of North Norway, Norwegian Registry for Spine Surgery, Tromsø, Norway.

Background: Indications and optimal timing for surgical treatment of degenerative cervical myelopathy (DCM) remain unclear, and data from daily clinical practice are warranted.

Objective: To investigate clinical outcomes following decompressive surgery for DCM.

Methods: Data were obtained from the Norwegian Registry for Spine Surgery. Read More

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Microvascular Decompression for Trigeminal Neuralgia: A Prospective, Multicenter Study.

Neurosurgery 2021 Jul 29. Epub 2021 Jul 29.

Seikei-kai Chiba Medical Center, Chiba, Japan.

Background: Microvascular decompression (MVD) is the most effective procedure for the long-term management of trigeminal neuralgia (TGN). However, retrospective and single-center studies are inherently biased, and there are currently no prospective, multicenter studies.

Objective: To evaluate the short- and long-term outcomes and complications in patients with TGN who underwent MVD at specialized Japanese institutions. Read More

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AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.

J Exp Med 2021 Sep 29;218(9). Epub 2021 Jul 29.

Department of Dermatology, University of Massachusetts Medical School, Worcester, MA.

The STING and absent in melanoma 2 (AIM2) pathways are activated by the presence of cytosolic DNA, and STING agonists enhance immunotherapeutic responses. Here, we show that dendritic cell (DC) expression of AIM2 within human melanoma correlates with poor prognosis and, in contrast to STING, AIM2 exerts an immunosuppressive effect within the melanoma microenvironment. Vaccination with AIM2-deficient DCs improves the efficacy of both adoptive T cell therapy and anti-PD-1 immunotherapy for "cold tumors," which exhibit poor therapeutic responses. Read More

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September 2021

Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair.

J Exp Med 2021 Sep 29;218(9). Epub 2021 Jul 29.

Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Hypoxia-inducible factors (HIFs) are activated in parenchymal cells in response to low oxygen and as such have been proposed as therapeutic targets during hypoxic insult, including myocardial infarction (MI). HIFs are also activated within macrophages, which orchestrate the tissue repair response. Although isoform-specific therapeutics are in development for cardiac ischemic injury, surprisingly, the unique role of myeloid HIFs, and particularly HIF-2α, is unknown. Read More

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September 2021

A review on management of caesarean scar pregnancy.

Curr Opin Obstet Gynecol 2021 Jul 28. Epub 2021 Jul 28.

Department of Obstetrics and Gynaecology Professor of Obstetrics and Gynaecology, Department of Obstetrics and Gynaecology, Azienda di Rilievo Nazionale e di Alta Specializzazione (ARNAS) Garibaldi Nesima, Catania, Italy.

Purpose Of Review: To review the current literature on management of cesarean scar pregnancy.

Recent Findings: Caesarean scar pregnancy (CSP) is a complex pathologic condition, which is strictly related to a previous caesarean section. It is an iatrogenic disorder, that has had an exponential increase over the last few years linked to the parallel increase in the number of caesarean sections. Read More

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A Novel Topical Treatment for Keratosis Obturans.

Otol Neurotol 2021 Jul 28. Epub 2021 Jul 28.

Department of Otorhinolaryngology, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands.

Objective: To present and evaluate the treatment of keratosis obturans (KO) using miconazole/triamcinolone 0.1% crème gauzes.

Study Design: A retrospective clinical capsule report. Read More

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Reconstruction of the Anterior External Auditory Canal With Mastoid Cortex Autologous Bone Graft.

Otol Neurotol 2021 Jul 28. Epub 2021 Jul 28.

Georgetown University School of Medicine Department of Otolaryngology and Head and Neck Surgery, Medstar Georgetown University Hospital, Washington DC.

Objective: To describe the surgical management of temporomandibular joint (TMJ) herniation with external auditory canal (EAC) reconstruction using autologous bone grafting from the mastoid cortex.

Study Design: Retrospective case series.

Setting: A tertiary university medical center. Read More

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Factors That Drive Annual Variation in Pediatric Elbow Fracture Occurrence, Severity, and Resource Utilization.

J Pediatr Orthop 2021 Jul 29. Epub 2021 Jul 29.

Vanderbilt University School of Medicine Division of Pediatric Orthopaedics, Monroe Carell Jr. Children's Hospital at Vanderbilt Department of Orthopaedics, Vanderbilt University Medical Center Departments of Pharmacology Pediatrics Pathology, Microbiology, and Immunology Center for Bone Biology, Nashville, TN The Wharton School at the University of Pennsylvania, Philadelphia, PA.

Background: Elbow fractures are the most common pediatric fractures requiring operative treatment. To date, few studies have examined what annual factors drive pediatric elbow fracture incidence and no studies have examined which annual factors drive elbow fracture severity or resource utilization. The goal of this study was to not only document the annual patterns of pediatric elbow fracture incidence and severity but also the impact of these patterns on resource utilization in the emergency department, emergency medical service transportation, and the operating room (OR). Read More

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The development of artificial livers.

Curr Opin Organ Transplant 2021 Jul 28. Epub 2021 Jul 28.

Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Purpose Of Review: While liver transplantation is an established treatment for liver failure, the number of patients with liver failure amenable to such intervention far outnumbers the donor supply of livers. Technologies serving to bridge this gap are required. Artificial livers may serve as an alternative. Read More

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A Cross-Sectional Evaluation of Outcomes of Pediatric Thyroglossal Duct Cyst Excision.

ORL J Otorhinolaryngol Relat Spec 2021 Jul 29:1-8. Epub 2021 Jul 29.

Pediatric Otolaryngology, Lehigh Valley Health Children's Hospital, Allentown, Pennsylvania, USA.

Introduction: Thyroglossal duct cysts (TGDCs) are the most common form of congenital neck cysts. They may become infected causing dysphagia or respiratory distress. Accordingly, the treatment is always surgical removal. Read More

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ultra-small lipid carriers with adjustable release profiles for synergistic treatment of drug-resistant ovarian cancer.

Nanotechnology 2021 Jul 29. Epub 2021 Jul 29.

Department of Pharmaceutics, Harbin Medical University, 157, Baojian Road, Nangang District, Harbin City, China, Harbin, 150086, CHINA.

The combined application of paclitaxel (PTX) and tetrandrine (TET) is a promising avenue in drug-resistant cancer therapy. However, poor drug release and limited intracellular accumulation greatly impede the combinatorial antitumor practices. To address this problem, we successfully developed a tunable controlled release lipid platform for coordinated drug delivery. Read More

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NUDCD1 knockdown inhibits the proliferation, migration, and invasion of pancreatic cancer via the EMT process.

Aging (Albany NY) 2021 Jul 29;13(undefined). Epub 2021 Jul 29.

School of Stomatology, Wenzhou Medical University, Wenzhou 110013, China.

NudC domain containing 1 (NUDCD1) is an oncoprotein frequently activated or upregulated in various human cancers, but its role in pancreatic cancer (PC) remains unknown. Thus, we aimed to determine the function and mechanism of NUDCD1 in PC. We employed Western blot and quantitative real-time polymerase chain reaction to assess NUDCD1 expression in cells and PC tissues. Read More

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White matter alterations in Parkinson's disease with levodopa-induced dyskinesia.

Parkinsonism Relat Disord 2021 Jul 24;90:8-14. Epub 2021 Jul 24.

Department of Neurology, Faculty of Medicine, Juntendo University, Tokyo, Japan. Electronic address:

Introduction: Levodopa-induced dyskinesia is a complication of levodopa therapy and negatively impacts the quality of life of patients. We aimed to elucidate white matter alterations in Parkinson's disease with levodopa-induced dyskinesia using advanced diffusion magnetic resonance imaging techniques.

Methods: The enrolled subjects included 26 clinically confirmed Parkinson's disease patients without levodopa-induced dyskinesia, 25 Parkinson's disease patients with levodopa-induced dyskinesia, and 23 healthy controls. Read More

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Cerebral aneurysm image segmentation based on multi-modal convolutional neural network.

Comput Methods Programs Biomed 2021 Jul 17;208:106285. Epub 2021 Jul 17.

Department of Neurosurgery, The Third People's Hospital of Hefei, Hefei Third Clinical College of Anhui Medical University, Hefei 230022, China. Electronic address:

Background And Objective: Accurate segmentation of cerebral aneurysms in computed tomography angiography (CTA) can provide an essential reference for diagnosis and treatment. This study aimed to evaluate a more helpful image segmentation method for cerebral aneurysms.

Methods: Firstly, the original CTA images were filtered by Gaussian and Laplace, and both the processed image and original image constitute multi-modal images as input. Read More

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Rice bran-derived protein fractions enhance sulforaphane-induced anti-oxidative activity in gingival epithelial cells.

Arch Oral Biol 2021 Jul 24;129:105215. Epub 2021 Jul 24.

Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. Electronic address:

Objective: Food-derived bioactive peptides have been reported to exhibit various beneficial effects, including anti-microbial, anti-inflammatory, and anti-oxidant properties. Oxidative stress has been implicated in the development of several inflammatory diseases such as periodontal disease. However, the anti-oxidative effect of food-derived bioactive peptides in gingival epithelial cells (GECs) is unknown. Read More

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Thymoma-associated autoimmune encephalitis with positive Titin antibodies: A case report.

J Neuroimmunol 2021 Jul 22;358:577670. Epub 2021 Jul 22.

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address:

We report a case of thymoma-associated autoimmune encephalitis with positive Titin antibodies. The patient had cognitive dysfunction, psychiatric symptoms and symptomatic epilepsy. PET-CT indicated space-occupied lesion at the thoracic entrance. Read More

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Effects of purified exosome product on rotator cuff tendon-bone healing in vitro and in vivo.

Biomaterials 2021 Jul 23;276:121019. Epub 2021 Jul 23.

Department of Orthopedic Surgery, Mayo Clinic Rochester, Rochester, MN, USA. Electronic address:

Exosomes have multiple therapeutic targets, but the effects on healing rotator cuff tear (RCT) remain unclear. As a circulating exosome, purified exosome product (PEP) has the potential to lead to biomechanical improvement in RCT. Here, we have established a simple and efficient approach that identifies the function and underlying mechanisms of PEP on cell-cell interaction using a co-culture model in vitro. Read More

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Immunopolarization-regulated 3D printed-electrospun fibrous scaffolds for bone regeneration.

Biomaterials 2021 Jul 23;276:121037. Epub 2021 Jul 23.

Department of Orthopedics, The First Affiliated Hospital of Soochow University, Medical College of Soochow University, Orthopedic Institute of Soochow University, 708 Renmin Road, Suzhou, Jiangsu, 215007, PR China. Electronic address:

Three-dimension (3D)-printed bioscaffolds are precise and personalized for bone regeneration. However, customized 3D scaffolds may activate the immune response in vivo and consequently impede bone formation. In this study, with layer-by-layer deposition and electrospinning technology to control the physical structure, 3D-printed PCL scaffolds with PLLA electrospun microfibrous (3D-M-EF) and nanofibrous (3D-N-EF) composites were constructed, and their immunomodulatory effect and the subsequent osteogenic effects were explored. Read More

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Angioplasty alone versus acute stenting for acute tandem occlusions due to internal carotid artery atherosclerotic.

Clin Neurol Neurosurg 2021 Jul 10;208:106818. Epub 2021 Jul 10.

Department of Neurology, First Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China. Electronic address:

Objective: The aim of the study is to compare the efficacy and safety of angioplasty alone with acute stenting for acute tandem occlusions (TO) due to internal carotid artery atherosclerotic.

Methods: We identified 112 patients who underwent an endovascular treatment (EVT) for acute tandem internal carotid artery occlusions from the prospectively maintained registries 5 comprehensive stroke centers. The study cohort included 75 patients with underlying atherosclerotic lesion of the extracranial internal carotid artery, forty-five in the balloon angioplasty (BA) alone group and 30 in the acute stenting (AS) group. Read More

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Isolation of primary human B lymphocytes from tonsils compared to blood as alternative source for ex vivo application.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jul 7;1179:122853. Epub 2021 Jul 7.

Process Biotechnology, University of Bayreuth, Germany. Electronic address:

B lymphocytes ('B cells') are components of the human immune system with obvious potential for medical and biotechnological applications. Here, we discuss the isolation of primary human B cells from both juvenile and adult tonsillar material using a two-step procedure based on gradient centrifugation followed by separation on a nylon wool column as alternative to the current gold standard, i.e. Read More

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A novel humanized cutaneous lupus erythematosus mouse model mediated by IL-21-induced age-associated B cells.

J Autoimmun 2021 Jul 26;123:102686. Epub 2021 Jul 26.

Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, 410011, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, Jiangsu, 210042, China; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, 210042, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, 210042, China. Electronic address:

Cutaneous lupus erythematosus (CLE) is a relapsing autoimmune disease, but key elements that drive disease initiation and progression remain elusive. To date, the lack of ideal murine model which resemble human cutaneous lupus makes it extremely challenging for moving mechanistic discoveries and novel therapeutics. Here, we prompt a humanized murine model to develop an inducible rapid-onset murine that performs cutaneous rather than systemic lupus, depending on the successful human immune system reconstruction from active lupus patients and UVB irradiation as for essentially pathogenic triggers. Read More

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Metabolic benefits of novel histamine H receptor ligands in the model of excessive eating: The importance of intrinsic activity and pharmacokinetic properties.

Biomed Pharmacother 2021 Jul 26;142:111952. Epub 2021 Jul 26.

Department of Pharmacological Screening, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland. Electronic address:

Aims: One of the therapeutic approaches in the treatment of obesity is the use of histamine H receptor ligands. Histamine plays a significant role in eating behavior because it causes a loss of appetite and is considered to be a satiety signal released during food intake.

Material And Methods: Histamine ligands were selected based on the preliminary studies which included determination of intrinsic activity and selected pharmacokinetic parameters. Read More

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Monitoring of pesticides in surface water, pesticides removal efficiency in drinking water treatment plant and potential health risk to consumers using Monte Carlo simulation in Behbahan City, Iran.

Chemosphere 2021 Jul 23;286(Pt 1):131667. Epub 2021 Jul 23.

Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Environmental Health Engineering, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Excessive application of pesticides to control pests and weeds leads to contaminating bodies of water and health problems for consumers. The present study was designed to investigate the concentration of pesticides in raw water originated from the Marun River as well as the treated water of the drinking water treatment plant in Behbahan City. The efficiency of each treatment process was evaluated. Read More

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Characteristics of discharge prescriptions for patients with schizophrenia or major depressive disorder: Real-world evidence from the Effectiveness of Guidelines for Dissemination and Education (EGUIDE) psychiatric treatment project.

Asian J Psychiatr 2021 Jul 15;63:102744. Epub 2021 Jul 15.

Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.

Background: Monopharmacy with antipsychotics and antidepressants is the first-line treatment for schizophrenia and major depressive disorder (MDD) in most clinical guidelines, while polypharmacy with psychotropic agents in the treatment of schizophrenia is common in clinical practice. There are no detailed data on the prescription patterns for inpatients with mental illness with reliable diagnoses made by treating psychiatrists.

Methods: We gathered prescription data at discharge from 2177 patients with schizophrenia and 1238 patients with MDD from October 2016 to March 2018. Read More

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Chemical profiling of Houttuynia cordata Thunb. by UPLC-Q-TOF-MS and analysis of its antioxidant activity in C2C12 cells.

J Pharm Biomed Anal 2021 Jul 16;204:114271. Epub 2021 Jul 16.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Houttuynia cordata Thunb. ("Yu-Xing-Cao"), a traditional Chinese medicinal herb, has long been used to treat various diseases. However, detailed information regarding the chemical constituents of H. Read More

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MSDS-UNet: A multi-scale deeply supervised 3D U-Net for automatic segmentation of lung tumor in CT.

Comput Med Imaging Graph 2021 Jul 24;92:101957. Epub 2021 Jul 24.

Amii, University of Alberta, Edmonton, Alberta, Canada.

Lung cancer is one of the most common and deadly malignant cancers. Accurate lung tumor segmentation from CT is therefore very important for correct diagnosis and treatment planning. The automated lung tumor segmentation is challenging due to the high variance in appearance and shape of the targeting tumors. Read More

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The impact of carbon and nitrogen catabolite repression in microorganisms.

Microbiol Res 2021 Jul 23;251:126831. Epub 2021 Jul 23.

Department of Biotechnology, School of Engineering and Applied Sciences, Bennett University, Greater Noida, Uttar Pradesh, India. Electronic address:

Organisms have cellular machinery that is focused on optimum utilization of resources to maximize growth and survival depending on various environmental and developmental factors. Catabolite repression is a strategy utilized by various species of bacteria and fungi to accommodate changes in the environment such as the depletion of resources, or an abundance of less-favored nutrient sources. Catabolite repression allows for the rapid use of certain substrates like glucose over other carbon sources. Read More

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