321,669 results match your criteria medical history

[Cardiac diagnostics after ischemic stroke or transitory ischemic attack].

Dtsch Med Wochenschr 2021 Jun 15;146(12):801-808. Epub 2021 Jun 15.

Stroke is the most common cause of permanent disability and one of the most common causes of death. Cardio-embolic strokes are associated with a poor prognosis and a high risk of recurrence compared to other stroke etiologies. The most common source of cardiac embolism is atrial fibrillation which must be quickly identified to optimize secondary stroke prevention. Read More

View Article and Full-Text PDF

Clusters of comorbidities in idiopathic pulmonary fibrosis.

Respir Med 2021 Jun 1;185:106490. Epub 2021 Jun 1.

Center for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.

Introduction: Comorbidities are common in patients with idiopathic pulmonary fibrosis (IPF) and negatively impact health-related quality of life, health-care costs and mortality. Retrospective studies have focused on individual comorbidities, but clusters of multiple comorbidities have rarely been analysed. This study aimed to comprehensively and prospectively assess comorbidities in a multicentre, real-world cohort of patients with IPF, including prespecified conditions of special interest and to analyse clusters of comorbidities and examine characteristics, disease course and mortality of the clusters. Read More

View Article and Full-Text PDF

Influence of current and previous smoking on current phenotype in Parkinson's disease.

J Neurol Sci 2021 Jun 8;427:117534. Epub 2021 Jun 8.

Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical and Health Sciences, Hiroshima, Japan; Epilepsy Center, Hiroshima University Hospital, Hiroshima, Japan.

Introduction: Although an inverse correlation between smoking and Parkinson's disease (PD) has been reported, research into the effect of smoking on current clinical progression remains limited for PD patients. Elucidation of a specific PD population who would benefit from smoking is challenging.

Methods: We evaluated 110 consecutive PD patients (mean age; 71. Read More

View Article and Full-Text PDF

From hospital unit to intestinal failure center: Twenty years of history.

Clin Nutr 2021 Apr 27;40(6):3787-3792. Epub 2021 Apr 27.

Department of Clinical Nursing, Institute of Nursing and Midwifery, Faculty of Health Care, Jagiellonian University, Krakow, Poland.

Aim: Home parenteral nutrition (HPN) is one of the most demanding medical therapies as it is the only option for patients for intestinal failure (IF). No unequivocal policy on how to start and progress with HPN has ever been presented. The IF Center at the Stanley Dudrick's Memorial Hospital in Skawina is one of the biggest centers in Poland, celebrating its twentieth birthday last year. Read More

View Article and Full-Text PDF

Eradicating micrometastases with immune checkpoint blockade: Strike while the iron is hot.

Cancer Cell 2021 Jun;39(6):738-742

Department of Surgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.

Immune checkpoint blockade (ICB) is transforming treatment for many cancers. While ICB alone initially demonstrated efficacy in patients with metastatic melanoma, it has expanded to other types and to earlier-stage cancers. We describe ICB history, mechanisms underlying variation in response, and how ICB is being integrated into adjuvant and neoadjuvant treatment approaches. Read More

View Article and Full-Text PDF

Sperm parameters and mitochondrial DNA sequence variants among patients at a fertility clinic in Ghana.

PLoS One 2021 15;16(6):e0252923. Epub 2021 Jun 15.

Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Accra, Ghana.

Purpose: The present study sought to investigate the common abnormalities and mtDNA mutations in the sperm of Ghanaian men attending the fertility Clinic at the Korle-Bu Teaching Hospital (KBTH). The study therefore provides a baseline data mtDNA mutations in a cross-section of Ghanaian men on referral to the fertility clinic at the KBTH.

Materials And Methods: The semen of 55 men attending the fertility clinic were collected from the Urology and the Obstetrics and Gynaecology Departments of the KBTH. Read More

View Article and Full-Text PDF

Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study.

PLoS One 2021 15;16(6):e0253257. Epub 2021 Jun 15.

Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea.

Tooth loss is closely associated with suboptimal oral care. Suboptimal oral care can facilitate local infections. These can lead to systemic inflammation and endothelial dysfunction, which are important pathological mechanisms of hypertension. Read More

View Article and Full-Text PDF

Correlation between reported dengue illness history and seropositivity in rural Thailand.

PLoS Negl Trop Dis 2021 Jun 15;15(6):e0009459. Epub 2021 Jun 15.

State University of New York Upstate Medical University, Syracuse, New York, United States of America.

In the latest World Health Organization (WHO) recommendation for Dengvaxia implementation, either serological testing or a person's history of prior dengue illness may be used as supporting evidence to identify dengue virus (DENV)-immune individuals eligible for vaccination, in areas with limited capacity for laboratory confirmation. This analysis aimed to estimate the concordance between self-reported dengue illness histories and seropositivity in a prospective cohort study for dengue virus infection in Kamphaeng Phet province, a dengue-endemic area in northern Thailand. The study enrolled 2,076 subjects from 516 multigenerational families, with a median age of 30. Read More

View Article and Full-Text PDF

Tension-Sided Femoral Neck Stress Fracture in an Adolescent with Vitamin D Deficiency and Osteomalacia: A Case Report.

JBJS Case Connect 2021 06 15;11(2). Epub 2021 Jun 15.

Department of Pediatric Orthopaedics, Phoenix Children's Hospital, Phoenix, Arizona.

Case: An adolescent girl presented with groin pain without any history of trauma. Imaging showed a tension-sided stress fracture of the femoral neck. Vitamin D deficiency (VDD), and raised alkaline phosphatase and parathyroid hormone levels were found. Read More

View Article and Full-Text PDF

Exploiting Causality for Improved Prediction of Patient Volumes by Gaussian Processes.

IEEE J Biomed Health Inform 2021 Jun 15;PP. Epub 2021 Jun 15.

Estimating and surveillance volumes of patients are of great importance for public health and resource allocation. In many situations, the change of these volumes is correlated with many factors, e.g. Read More

View Article and Full-Text PDF

Neuropathic Corneal Pain Following LASIK Surgery: A Retrospective Case Series.

Ophthalmol Ther 2021 Jun 15. Epub 2021 Jun 15.

HDR Research Center, Hoopes Vision, University of Utah Health Sciences Center, 11820 S. State Street Suite #200, Draper, UT, 84020, USA.

Introduction: Transient dry eye symptoms have been reported following laser in situ keratomileusis (LASIK). Very rarely, patients may present with debilitating symptoms of dry eye syndrome (DES) with limited or no evidence of ocular surface disease. These patients are diagnosed with a form of DES known as neuropathic corneal pain (NCP). Read More

View Article and Full-Text PDF

Can Autologous Adipose-Derived Mesenchymal Stem Cell Transplantation Improve Sexual Function in People with Sexual Functional Deficiency?

Stem Cell Rev Rep 2021 Jun 15. Epub 2021 Jun 15.

Vinmec Research Institute of Stem Cell and Gene Technology (VRISG), Vinmec Health Care System, Hanoi, Vietnam.

Background: Sexual functional deficiency occurs at some point in life and becomes a problematic issue in middle-aged adulthood. Regenerative medicine, especially mesenchymal stem cell (MSC) transplantation, has developed extensively, with preclinical and clinical trials emphasizing the benefits of stem cell therapy for restoration of sexual deficiency. This study was designed to develop a new therapeutic stem cell treatment for people with sexual functional deficiency. Read More

View Article and Full-Text PDF

Aberrant expression of multiple T cell markers on diffuse large B cell lymphoma: a case report.

J Egypt Natl Canc Inst 2021 Jun 15;33(1):14. Epub 2021 Jun 15.

Department of Laboratory and Transfusion Services, Rajiv Gandhi Cancer Institute & Research Centre, Sector 5, Rohini, Delhi, 110085, India.

Background: Aberrant T cell antigen expression has been well documented in diffuse large B cell lymphomas. However, co-expression of multiple T cell antigens including CD3, which has been considered a specific marker for T cells is extremely rare. Awareness about such aberrant expression is important so as not to misdiagnose or wrongly classify a lymphoma. Read More

View Article and Full-Text PDF

Clinical triage of patients on kidney replacement therapy presenting with COVID-19: an ERACODA registry analysis.

Nephrol Dial Transplant 2021 Jun 15. Epub 2021 Jun 15.

Department Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands.

Rationale & Objective: Patients on kidney replacement therapy (KRT) are at a very high risk of COVID-19. Triage pathway for KRT patients presenting with varying severity of COVID-19 illness remains ill-defined. We studied clinical characteristics of patients at initial and subsequent hospital presentations and its impact on patient outcomes. Read More

View Article and Full-Text PDF

Effects of Intravenous Eptinezumab vs Placebo on Headache Pain and Most Bothersome Symptom When Initiated During a Migraine Attack: A Randomized Clinical Trial.

JAMA 2021 Jun;325(23):2348-2356

Lundbeck La Jolla Research Center, San Diego, California.

Importance: Intravenous eptinezumab, an anti-calcitonin gene-related peptide antibody, is approved for migraine prevention in adults. It has established onset of preventive efficacy on day 1 after infusion.

Objective: To evaluate the efficacy of and adverse events related to eptinezumab when initiated during a migraine attack. Read More

View Article and Full-Text PDF

Chronic Pelvic Pain in Women: A Review.

JAMA 2021 Jun;325(23):2381-2391

Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles.

Importance: Chronic pelvic pain (CPP) is a challenging condition that affects an estimated 26% of the world's female population. Chronic pelvic pain accounts for 40% of laparoscopies and 12% of hysterectomies in the US annually even though the origin of CPP is not gynecologic in 80% of patients. Both patients and clinicians are often frustrated by a perceived lack of treatments. Read More

View Article and Full-Text PDF

Antibodies to SARS-CoV-2 in All of Us Research Program Participants, January 2-March 18, 2020.

Clin Infect Dis 2021 Jun 15. Epub 2021 Jun 15.

All of Us Research Program, National Institutes of Health, Bethesda, MD.

Background: With limited SARS-CoV-2 testing capacity in the US at the start of the epidemic (January - March), testing was focused on symptomatic patients with a travel history throughout February, obscuring the picture of SARS-CoV-2 seeding and community transmission. We sought to identify individuals with SARS-CoV-2 antibodies in the early weeks of the US epidemic.

Methods: All of Us study participants in all 50 US states provided blood specimens during study visits from January 2 to March 18, 2020. Read More

View Article and Full-Text PDF

The spectrum, prevalence and in-hospital outcomes of cardiovascular diseases in a South African district hospital: a retrospective study.

Cardiovasc J Afr 2021 Jun 10;32:1-6. Epub 2021 Jun 10.

Cardiac Clinic, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Introduction: The increasing prevalence of cardiovascular risk factors in South African rural communities is well reported. However, the prevalence of cardiovascular disease (CVD) leading to hospital admission and related in-hospital mortality in rural and semi-rural hospitals is unknown.

Methods: We conducted a retrospective review of hospital records for patients admitted to the Department of Internal Medicine at Dora Nginza Hospital in Port Elisabeth, South Africa between 1 April and 31 October 2016. Read More

View Article and Full-Text PDF

What Is the Risk of Intraoperative Cerebral Oxygen Desaturation in Patients Undergoing Shoulder Surgery in the Beach Chair Position?

Clin Orthop Relat Res 2021 06 15. Epub 2021 Jun 15.

Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Previous studies have shown that intraoperative cerebral desaturation in patients undergoing shoulder surgery in the beach chair position varies widely, from 0% to 80%. To our knowledge, the risk of intraoperative cerebral desaturation is not known after all identified intraoperative modifiable physiologic parameters that influence cerebral blood flow have been controlled for.

Questions/purposes: (1) What is the risk of intraoperative cerebral desaturation during shoulder surgery with the patient in the beach chair position when patients received combined general anesthesia and an interscalene block, and what other factors associated with intraoperative cerebral desaturation can be identified? (2) Is intraoperative cerebral desaturation associated with 24-hour cognitive decline? (3) What factors are associated with intraoperative hypotension?

Methods: Between April and December 2020, 51 patients underwent elective shoulder surgery in the beach chair position at one center. Read More

View Article and Full-Text PDF

Correlation between single nucleotide polymorphisms in the 3 primer untranslated region of PTX3 and the risk of essential hypertension: A case-control study.

Medicine (Baltimore) 2021 Jun;100(24):e25937

Department of Clinical Laboratory, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Abstract: The aim of this study was to investigate the correlation between single-nucleotide polymorphisms (SNPs) in the 3 primer of untranslated region (3'UTR) of the Pentraxin 3 (PTX3) gene and the risk of essential hypertension (EHT).PTX3 genotypes, rs2614, rs111451363, and rs73158510 locus, were found in 260 patients with EHT and 260 healthy controls. Quantitative real-time polymerase chain reaction was used to detect plasma hsa-miR-4766-5p levels. Read More

View Article and Full-Text PDF

Clinical Characteristics of Patients with Adrenal Insufficiency and Fever.

J Korean Med Sci 2021 Jun 14;36(23):e152. Epub 2021 Jun 14.

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Background: Because persistent fever often occurs in adrenal insufficiency, it might be confused with infectious diseases. This study aimed to identify clinical characteristics and risk factors of patients with adrenal insufficiency and fever.

Methods: All adult patients (n = 150) admitted to a tertiary care hospital in South Korea and diagnosed with adrenal insufficiency between 1 March 2018, and 30 June 2019, were recruited. Read More

View Article and Full-Text PDF

Systematic review: Incidence and prevalence of mucous membrane pressure injury in adults admitted to acute hospital settings.

Int Wound J 2021 Jun 14. Epub 2021 Jun 14.

College of Dentistry, Hawler Medical University, Erbil, Iraq.

Mucous membrane pressure injury (MMPI) is associated with a history of medical device use at the site of injury. The current international guideline recommends they should be reported in incidence and prevalence studies. The aim of this systematic review was to analyse the incidence and prevalence of hospital-acquired MMPI in adults admitted to acute hospital settings. Read More

View Article and Full-Text PDF

A population-based psychometric analysis of the insomnia severity index in black women with and without a history of cancer.

J Sleep Res 2021 Jun 14:e13421. Epub 2021 Jun 14.

Slone Epidemiology Center at Boston University, Boston, MA, USA.

Black women are under-represented in insomnia research. Further, cancer treatments increase the risk of late effects, thus affecting the sleep of psychologically and medically vulnerable cancer survivors. The Insomnia Severity Index (ISI) is widely used, but has not been researched in black women, and research in cancer survivors is limited. Read More

View Article and Full-Text PDF

Relations between left atrial appendage contrast retention and thromboembolic risk in patients with atrial fibrillation.

J Thromb Thrombolysis 2021 Jun 15. Epub 2021 Jun 15.

Department of Cardiology, the Sixth Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.

Left atrial appendage (LAA), a blind pouch, accounts for more than 90% of the source of cardiac thrombus formation. Contrast retention (CR) in the LAA has been frequently observed during left atrial appendage occlusion (LAAO) procedures, especially in patients with stroke history. This study was designed to assess the relations between LAA contrast retention and thrombogenesis risk of the LAA in patients with non-valvular atrial fibrillation. Read More

View Article and Full-Text PDF

Preliminary evidence of blunted humoral response to SARS-CoV-2 mRNA vaccine in multiple sclerosis patients treated with ocrelizumab.

Neurol Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

Objectives: Several concerns regard the immunogenicity of SARS-CoV-2 vaccines in people with multiple sclerosis (pwMS), since the majority of them is treated with immunomodulating/immunosuppressive disease modifying therapies. Here we report the first data on the humoral response to mRNA SARS-CoV-2 vaccine in a case series of 4 pwMS treated with ocrelizumab (OCR) as compared to a group of healthy subjects (HS).

Methods: We collected serum samples at 0, 14, 21 days after the first dose and 7 days after the second dose of BNT162b2-mRNA-Covid-19 vaccine from 55 health-care workers and 4 relapsing pwMS on OCR, with no history of Covid-19 infection. Read More

View Article and Full-Text PDF

New-onset atrial fibrillation in patients with worsening heart failure and coronary artery disease: an analysis from the COMMANDER-HF trial.

Clin Res Cardiol 2021 Jun 14. Epub 2021 Jun 14.

Centre D'Investigation Clinique 1433 Module Plurithématique, CHRU Nancy - Hopitaux de Brabois, CHRU de Nancy, FCRIN INI-CRCT, Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu, Université de Lorraine, Nancy, France.

Background: Atrial fibrillation (AF) in the presence of heart failure (HF) is associated with poor outcomes including a high-risk of stroke and other thromboembolic events. Identifying patients without AF who are at high-risk of developing this arrhythmia has important clinical implications.

Aims: To develop a risk score to identify HF patients at high risk of developing AF. Read More

View Article and Full-Text PDF

Myocardial infarction complicated by cardiac arrest revealing SARS-COV-2 infection: Case report.

Ann Med Surg (Lond) 2021 Jul 9;67:102484. Epub 2021 Jun 9.

Intensive Care Unit, Mohammed VI University Hospital Center, Oujda, Morocco.

Introduction: COVID19 infection is most often reveled by pulmonary symptoms, however cardiovascular manifestations has been observed revealing this infection with absence of respiratory symptoms.

Clinical Case: A 62 year old female patient, with no medical history, admitted to the emergency room for epigastric pain, with no respiratory signs, the exploration revealed myocardial infarction with COVID 19 infection.

Conclusion: COVID19 infection manifest mainly with respiratory symptoms but it can also be revealed by cardiac manifestations with absence of respiratory symptoms. Read More

View Article and Full-Text PDF

Identification of transdiagnostic psychiatric disorder subtypes using unsupervised learning.

Neuropsychopharmacology 2021 Jun 14. Epub 2021 Jun 14.

Max Planck Institute of Psychiatry, Munich, Germany.

Psychiatric disorders show heterogeneous symptoms and trajectories, with current nosology not accurately reflecting their molecular etiology and the variability and symptomatic overlap within and between diagnostic classes. This heterogeneity impedes timely and targeted treatment. Our study aimed to identify psychiatric patient clusters that share clinical and genetic features and may profit from similar therapies. Read More

View Article and Full-Text PDF

Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology.

NPJ Genom Med 2021 Jun 14;6(1):47. Epub 2021 Jun 14.

Cardiology department, Health In Code. As Xubias s/n, Edificio El Fortín, 15006, A Coruña, Spain.

The cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history of sudden cardiac death or familial cardiomyopathy. Given the disparity in patient outcomes and therapy options, we investigated the impact of variations on the intermolecular interactions across the thin filament complex as an example of an unbiased systems biology method to better define clinical prognosis to aid future management options. We present a novel unbiased dynamic model to define and analyse the functional, structural and physico-chemical consequences of genetic variations among the troponins. Read More

View Article and Full-Text PDF