1,559,633 results match your criteria medical devices

Flow Structure and Particle Deposition Analyses for Optimization of a Pressurized Metered Dose Inhaler (pMDI) in a Model of Tracheobronchial Airway.

Eur J Pharm Sci 2021 Jun 12:105911. Epub 2021 Jun 12.

Institute of Lung Biology and Disease, Helmholtz Zentrum Muenchen, Neuherberg 85764, Germany; Comprehensive Pneumology Center, Member of the German Center for Lung Research, Max-Lebsche-Platz 31, Munich 81377, Germany. Electronic address:

Inhalation therapy plays an important role in management or treatment of respiratory diseases such asthma and chronic obstructive pulmonary diseases (COPDs). For decades, pressurized metered dose inhalers (pMDIs) have been the most popular and prescribed drug delivery devices for inhalation therapy. The main objectives of the present computational work are to study flow structure inside a pMDI, as well as transport and deposition of micron-sized particles in a model of human tracheobronchial airways and their dependence on inhalation air flow rate and characteristic pMDI parameters. Read More

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Identification and validation of selective deubiquitinase inhibitors.

Cell Chem Biol 2021 Jun 2. Epub 2021 Jun 2.

Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Deubiquitinating enzymes (DUBs) are a class of isopeptidases that regulate ubiquitin dynamics through catalytic cleavage of ubiquitin from protein substrates and ubiquitin precursors. Despite growing interest in DUB biological function and potential as therapeutic targets, few selective small-molecule inhibitors and no approved drugs currently exist. To identify chemical scaffolds targeting specific DUBs and establish a broader framework for future inhibitor development across the gene family, we performed high-throughput screening of a chemically diverse small-molecule library against eight different DUBs, spanning three well-characterized DUB families. Read More

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Clinical Characteristics and Predictors of In-Hospital Mortality in Patients With Cardiogenic Shock: Results From the RESCUE Registry.

Circ Heart Fail 2021 Jun 15;14(6):e008141. Epub 2021 Jun 15.

Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center (J.H.Y., K.H.C., T.K.P., J.M.L., Y.B.S., J.-Y.H., S.-H.C., H.-C.G.), Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: In the current era of mechanical circulatory support, limited data are available on prognosis of cardiogenic shock (CS) caused by various diseases. We investigated the characteristics and predictors of in-hospital mortality in Korean patients with CS.

Methods: The RESCUE study (Retrospective and Prospective Observational Study to Investigate Clinical Outcomes and Efficacy of Left Ventricular Assist Device for Korean Patients With CS) is a multicenter, retrospective, and prospective registry of patients that presented with CS. Read More

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Contemporary ICD Use in Patients with Heart Failure.

Cardiol Ther 2021 Jun 15. Epub 2021 Jun 15.

1St Department of Cardiology, Medical School, Hippokration Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Despite constant breakthroughs in heart failure (HF) therapy, the population of HF patients resume to grow and is linked to increased mortality and morbidity. Ventricular arrhythmias (VA) are one of the leading causes of mortality in HF subjects. Implantable cardioverter-defibrillators (ICDs) are currently the gold standard in treatment, preventing arrhythmic sudden cardiac death (SCD) episodes. Read More

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Nickel Hypersensitivity to Atrial Septal Occluders: Smoke Without Fire?

Clin Rev Allergy Immunol 2021 Jun 15. Epub 2021 Jun 15.

First Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital, Athens, Greece.

Nickel is one of the most common contact allergens worldwide; it is used as the main component of the devices used for atrial septal defects (ASDs) and patent foramen ovale (PFO) closure. Developing nickel hypersensitivity after PFO/ASD occlusion is significantly rarer described in medical literature than typical nickel contact sensitization. The exact pathophysiological mechanism of this "device syndrome" remains unknown, and many question the real incidence or even the existence of this clinical entity. Read More

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Robotic-assisted percutaneous iliac screw fixation for destructive lumbosacral metastatic lesions: an early single-institution experience.

Acta Neurochir (Wien) 2021 Jun 15. Epub 2021 Jun 15.

Division of Spine, Department of Neurosurgery, Duke University Medical Center, 200 Trent Drive, Durham, NC, 27710, USA.

Background: Robotic-assisted surgery is becoming more widely applied in surgical subspecialties due to its intraoperative and postoperative advantages such as minimally invasive approach, reduced blood loss, shorter hospital stay, and decreased incidence of postoperative complications. However, robotic devices were only recently introduced in the field of spinal surgery. Specifically, percutaneous approaches involving computer-assisted image guidance are relatively new in iliac screw fixation. Read More

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Comparison of intragastric pressure between endotracheal tube and supraglottic airway devices in laparoscopic hepatectomy: A randomized, controlled, non-inferiority study.

Medicine (Baltimore) 2021 Jun;100(24):e26287

Department of Anaesthesiology and Pain Medicine.

Background: Supraglottic airway (SGA) devices do not definitively protect the airway from regurgitation of gastric contents. Increased gastric pressure and long operation time are associated with development of complications such as aspiration pneumonia. The aim of this study was to compare intragastric pressure between second-generation SGA and endotracheal tube (ETT) devices during long-duration laparoscopic hepatectomy. Read More

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Transient Permeation Enhancer® (TPE®) technology for oral delivery of octreotide: a technological evaluation.

Expert Opin Drug Deliv 2021 Jun 15. Epub 2021 Jun 15.

School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland.

Introduction: : The FDA approval of oral semaglutide for type 2 diabetes (2019) and oral octreotide for acromegaly (2020) is evidence that selected niche peptides can be administered orally if formulated with selected intestinal permeation enhancers.

Areas Covered: We evaluated the oral octreotide formulation, MYCAPSSA® (Chiasma Pharmaceuticals, Needham, MA, USA). An outline of the current standard of care in acromegaly and the benefits of oral octreotide versus depot injections is provided. Read More

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J Endourol 2021 Jun 15. Epub 2021 Jun 15.

Scott and White Healthcare, 293755, Urology, Temple, Texas, United States;

Purpose: Holmium laser enucleation of the prostate (HoLEP) entails both enucleation and morcellation. Only three popular prostate morcellation devices (PMDs) are available for this procedure. In this study, a retrospective review was done to compare the Wolf and Storz morcellators. Read More

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The Impact of Instrumentation and Implant Surface Technology on Cervical and Thoracolumbar Fusion.

Oper Neurosurg (Hagerstown) 2021 Jun;21(Supplement_1):S12-S22

Duke University Medical Center Department of Neurological Surgery, Durham, North Carolina, USA.

Spinal fusion has undergone significant evolution and improvement over the past 50 yr. Historically, spine fusion was noninstrumented and arthrodesis was based entirely on autograft. Improved understanding of spinal anatomy and materials science ushered in a new era of spinal fusion equipped with screw-based technologies and various interbody devices. Read More

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Conventional glaucoma implants and the new MIGS devices: a comprehensive review of current options and future directions.

Eye (Lond) 2021 Jun 14. Epub 2021 Jun 14.

Microsystems Research Section, Department of Mechanical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.

Glaucoma is a progressive optic neuropathy that is the second leading cause of preventable blindness worldwide, after cataract formation. A rise in the intraocular pressure (IOP) is considered to be a major risk factor for glaucoma and is associated with an abnormal increase of resistance to aqueous humour outflow from the anterior chamber. Glaucoma drainage devices have been developed to provide an alternative pathway through which aqueous humour can effectively exit the anterior chamber, thereby reducing IOP. Read More

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'Ice' flavoured e-cigarette use among young adults.

Tob Control 2021 Jun 14. Epub 2021 Jun 14.

Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

Background: 'Ice' e-cigarette flavours-marketed as a combination of fruity/sweet and cooling flavours (eg, 'blueberry ice' or 'melon ice')-recently entered the US market. The prevalence and correlates of ice flavoured e-cigarette use in young adults are unknown.

Methods: This cross-sectional study of a Los Angeles, California, USA, cohort analysed data from the past 30-day e-cigarette (current) users (n=344; M (SD)=21. Read More

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Comparative safety of percutaneous ventricular assist device and intra-aortic balloon pump in acute myocardial infarction-induced cardiogenic shock.

Open Heart 2021 Jun;8(1)

Cardiology, Detroit Medical Center, Detroit, Michigan, USA

Background: The relative safety of percutaneous left ventricular assist device (pVAD) and intra-aortic balloon pump (IABP) in patients with cardiogenic shock after acute myocardial infarction remain unknown.

Methods: Multiple databases were searched to identify articles comparing pVAD and IABP. An unadjusted OR was used to calculate hard clinical outcomes and mortality differences on a random effect model. Read More

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Primary care professionals' attitudes towards digital health interventions for common mental disorders: study protocol for a mixed methods systematic review.

BMJ Open 2021 06 14;11(6):e045657. Epub 2021 Jun 14.

Institute of General Practice, University of Frankfurt, Frankfurt am Main, Germany

Introduction: Mental disorders such as depression are common, and an estimated 264 million people are affected by them throughout the world. In recent years, studies on digital health interventions to treat mental disorders have shown evidence of their efficacy, and interest in using them has increased as a result. In the primary care setting, depression and anxiety are the two most frequently diagnosed and treated mental disorders. Read More

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Perceptions of anonymised data use and awareness of the NHS data opt-out amongst patients, carers and healthcare staff.

Res Involv Engagem 2021 Jun 14;7(1):40. Epub 2021 Jun 14.

PIONEER, HDR-UK Health Data Research Hub in Acute Care, Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2GW, UK.

Background: England operates a National Data Opt-Out (NDOO) for the secondary use of confidential health data for research and planning. We hypothesised that public awareness and support for the secondary use of health data and the NDOO would vary by participant demography and healthcare experience. We explored patient/public awareness and perceptions of secondary data use, grouping potential researchers into National Health Service (NHS), academia or commercial. Read More

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Hospital Pharmacy Response to Covid-19 Pandemic in Italy: What We Learned From the First Outbreak Wave.

J Pharm Pract 2021 Jun 15:8971900211023643. Epub 2021 Jun 15.

SIFaCT President, Italian Society for Clinical Pharmacy and Therapeutics, Milan, Italy.

Background: When COVID-19 pandemic started, Italian hospital pharmacists faced multiple challenges and change their work practices.

Objectives: The aim of this study was to describe the impact of COVID-19 emergency on pharmaceutical care provided by pharmacists during the first wave of the pandemic. Issues related to pharmacist's involvement in the pandemic management were: changes in activities, support received by authorities and pharmacists' own perceived role in the Health System. Read More

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Comparison of intravascular access methods applied by nurses wearing personal protective equipment in simulated COVID-19 resuscitation: A randomized crossover simulation trial.

Am J Emerg Med 2021 Jun 3;49:189-194. Epub 2021 Jun 3.

Polish Society of Disaster Medicine, Warsaw, Poland; Maria Sklodowska-Curie Bialystok Oncology Center, Bialystok, Poland. Electronic address:

Background: Prehospital emergency care of children is challenging. In the era of the COVID-19 pandemic, when medical personnel should use personal protective equipment against aerosol-generating procedures, the efficiency of medical procedures may decrease. The study objective was to evaluate the effectiveness of different intravascular access methods applied by nurses wearing biosafety Level-2 suits in simulated paediatric COVID-19 resuscitation. Read More

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Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and standardisation.

J Control Release 2021 Jun 11. Epub 2021 Jun 11.

Department of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway.

Nanotechnology-based health products are providing innovative solutions in health technologies and the pharmaceutical field, responding to unmet clinical needs. However, suitable standardised methods need to be available for the assessment of quality and safety of these innovative products prior to their translation into the clinic and for monitoring it when manufacturing processes are changed. The question arises which technological solutions are currently available within the scientific community to support the requested characterisation of nanotechnology-based products, and which methodological developments should be prioritized to support product developers in their regulatory assessment. Read More

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Cost-effectiveness of the i-gel Supraglottic Airway Device compared to Tracheal Intubation During Out-of-Hospital Cardiac Arrest: Findings from the AIRWAYS-2 Randomised Controlled Trial.

Resuscitation 2021 Jun 11. Epub 2021 Jun 11.

Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK; Oxford NIHR Biomedical Research Centre, Oxford, UK. Electronic address:

Aim: Optimal airway management during out-of-hospital cardiac arrest (OHCA) is uncertain. Complications from tracheal intubation (TI) may be avoided with supraglottic airway (SGA) devices. The AIRWAYS-2 cluster randomised controlled trial (ISRCTN08256118) compared the i-gel SGA with TI as the initial advanced airway management (AAM) strategy by paramedics treating adults with non-traumatic OHCA. Read More

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Five-Year Outcomes with Conformable GORE® TAG® endoprosthesis used in traumatic aortic transections.

Ann Thorac Surg 2021 Jun 11. Epub 2021 Jun 11.

W.L. Gore & Associates, Inc., Flagstaff, Arizona.

Background: The Conformable GORE® TAG® thoracic endoprosthesis (CTAG) device (W.L. Gore and Associates, Flagstaff, AZ) seeks to optimize thoracic endovascular repair (TEVAR) of blunt aortic injuries (BAI) by better apposing to the aortic arch. Read More

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Endovascular thrombectomy and intra-arterial interventions for acute ischaemic stroke.

Cochrane Database Syst Rev 2021 Jun 14;6:CD007574. Epub 2021 Jun 14.

University Hospital of North Norway, Tromsø, Norway.

Background: Most disabling strokes are due to a blockage of a large artery in the brain by a blood clot. Prompt removal of the clot with intra-arterial thrombolytic drugs or mechanical devices, or both, can restore blood flow before major brain damage has occurred, leading to improved recovery. However, these so-called endovascular interventions can cause bleeding in the brain. Read More

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Multiresponsive 2D TiCT MXene Implanting Molecular Properties.

ACS Nano 2021 Jun 14. Epub 2021 Jun 14.

Future Energy and Innovation Laboratory, Central European Institute of Technology, Brno University of Technology (CEITEC-BUT), Purkyňova 123, 61200 Brno, Czech Republic.

The design and fabrication of active nanomaterials exhibiting multifunctional properties is a must in the so-called global "Fourth Industrial Revolution". In this sense, molecular engineering is a powerful tool to implant original capabilities on a macroscopic scale. Herein, different bioinspired 2D-MXenes have been developed a versatile and straightforward synthetic approach. Read More

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Tricuspid clip implantation using the MitraClip system-A step-by-step guide.

Catheter Cardiovasc Interv 2021 Jun 14. Epub 2021 Jun 14.

Department of Cardiovascular Surgery, Mount Sinai Medical Center, New York, New York, USA.

Many novel percutaneous interventions are being developed for application in the tricuspid valve position. At the present time, there are no commercially available devices for this application. There has been mounting evidence supporting the safety and efficacy of using the MitraClip system on the tricuspid valve. Read More

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A picture is worth a thousand words: exploring the roles of caregivers and the home environment of ventricular assist device patients.

Eur J Cardiovasc Nurs 2021 Jun 14. Epub 2021 Jun 14.

Johns Hopkins University School of Nursing, 525 N Wolfe St., Baltimore, MD 21205, USA.

Aims: Caregivers of persons living with ventricular assist devices (VADs) are integrally involved in both medical and non-medical care. We sought to understand tasks caregivers perform after surgical recovery, ways the home is adapted for those tasks, and presence of home safety hazards.

Methods And Results: We conducted semi-structured interviews with persons living with a VAD and their caregivers. Read More

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Ultrasound Hypotension Protocol Time-motion Study Using the Multifrequency Single Transducer Versus a Multiple Transducer Ultrasound Device.

West J Emerg Med 2021 Apr 8;22(3):775-781. Epub 2021 Apr 8.

Denver Health Medical Center, Department of Emergency Medicine, Denver, Colorado.

Introduction: Ultrasound hypotension protocols (UHP) involve imaging multiple body areas, each with different transducers and imaging presets. The time for task switching between presets and transducers to perform an UHP has not been previously studied. A novel hand-carried ultrasound (HCU) has been developed that uses a multifrequency single transducer to image areas of the body (lung, heart, abdomen, superficial) that would typically require three transducers using a traditional cart-based ultrasound (CBU) system. Read More

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Sternal Intraosseous Devices: Review of the Literature.

West J Emerg Med 2021 Mar 24;22(3):690-695. Epub 2021 Mar 24.

Medical Command, Texas Army National Guard, Austin, Texas.

Introduction: The intraosseous (IO) route is one of the primary means of vascular access in critically ill and injured patients. The most common sites used are the proximal humerus, proximal tibia, and sternum. Sternal IO placement remains an often-overlooked option in emergency and prehospital medicine. Read More

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Audiologic outcomes and complications of active middle ear implantation in older adults.

Acta Otolaryngol 2021 Jun 14:1-5. Epub 2021 Jun 14.

Department of Otorhinolaryngology, Head & Neck Surgery, Veterans Health Service Medical Centre, Seoul, Republic of Korea.

Background: A few studies have reported the use of middle ear implants (MEIs) in older adults.

Objectives: To evaluate the audiologic outcomes and postoperative complications of MEIs in older adults.

Methods: This retrospective study reviewed audiologic data and medical records from a single referral centre. Read More

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US Guided Si.La.D. A new technique for minimally invasive pilonidal disease treatment, using ultrasound guided laser ablation.

Expert Rev Med Devices 2021 Jun 14. Epub 2021 Jun 14.

3rd Department of Surgery, ``AHEPA`` University Hospital, Aristotle University of Thessaloniki, Medical School of Health Sciences, Thessaloniki,Greece.

Background: The destruction of the pilonidal sinus with a radial laser probe has been suggested as a safe procedure with good results and low morbidity. Nevertheless the drawbacks of this technique are: a blind technique, if the sinus has some ramifications, or e non-linear development we cannot be sure for their destruction.

Methods: 17: patients (12 men, 5 women) were operated with US guided laser destruction- US guided Si. Read More

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Substrate-Induced Growth of Micro/Nanostructured Zn(OH)F Arrays for Highly Sensitive Microfluidic Fluorescence Assays.

ACS Appl Mater Interfaces 2021 Jun 14. Epub 2021 Jun 14.

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai 200032, China.

To date, ZnO array-based microfluidic fluorescence assays have been widely investigated and have exhibited excellent performance in the detection of cancer biomarkers. However, the requirements of highly sensitive detection necessitate further improvement of current Zn-based fluorescence detection devices. Here, a rhombus-like Zn(OH)F array-based microfluidic fluorescence detection device is proposed. Read More

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