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Impact of self-reported walking habit on slower decline in renal function among the general population in a longitudinal study: the Japan Specific Health Checkups (J-SHC) Study.

J Nephrol 2021 Apr 30. Epub 2021 Apr 30.

Department of Nephrology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.

Background: Association between physical activity and decline in renal function among the general population is not fully understood.

Methods: This is a longitudinal study on subjects who participated in the Japanese nationwide Specific Health Checkup program between 2008 and 2014. The exposure of interest was baseline self-reported walking habit. Read More

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Effect of Neighborhood and Individual-Level Socioeconomic Factors on Colorectal Cancer Screening Adherence.

Int J Environ Res Public Health 2021 Apr 21;18(9). Epub 2021 Apr 21.

Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

Despite the effectiveness of screenings in reducing colorectal cancer (CRC) mortality, ~25% of US adults do not adhere to screening guidelines. Prior studies associate socioeconomic status (SES) with low screening adherence and suggest that neighborhood deprivation can influence CRC outcomes. We comprehensively investigated the effect of neighborhood SES circumstances (nSES), individual SES, and race/ethnicity on adherence to CRC screening in a multiethnic cross-sectional study. Read More

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Ocular manifestation of rickettsial disease in South Indian population.

Indian J Ophthalmol 2021 May;69(5):1167-1171

Prasad Netralaya, Udupi, Karnataka, India.

Purpose: The aim of this work was to study the ocular manifestations and its management in spotted fever and typhus group of rickettsial disease.

Methods: A retrospective analysis of 50 patients with serologically confirmed Rickettsial disease. In all patients, relevant history, investigations and treatment details were collected and they underwent complete ophthalmic evaluation including measurement of best-corrected visual acuity, anterior segment examination and dilated fundus examination. Read More

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Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness.

BMC Cardiovasc Disord 2021 Apr 27;21(1):216. Epub 2021 Apr 27.

Health Management Centre, Kaifeng Central Hospital, Kaifeng, 475000, Henan, China.

Aim: To investigate the relationship of small dense low-density lipoprotein cholesterol (sdLDL-C) to carotid artery intima-media thickness (CA-IMT) and carotid plaque (CAP) in Chinese general population, and to evaluate whether sdLDL-C could be an independent risk factor for individuals with subclinical atherosclerosis.

Methods: A total of 729 subjects were randomly collected from consecutive individuals from April 2019 to April 2020 for an annual health checkup. CA-IMT > 1. Read More

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Possible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study.

Sci Rep 2021 Apr 26;11(1):8999. Epub 2021 Apr 26.

Steering Committee of Research on "Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based On the Individual Risk Assessment By Specific Health Checkup", Fukushima Medical University, Fukushima, Japan.

Hyperuricaemia is a risk for premature death. This study evaluated the burden of hyperuricaemia (serum urate > 7 mg/dL) for all-cause and cardiovascular mortality in 515,979 health checkup participants using an index of population attributable fraction (PAF). Prevalence of hyperuricaemia at baseline was 10. Read More

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Risk prediction for new-onset atrial fibrillation using the Minnesota code electrocardiography classification system.

Int J Cardiol Heart Vasc 2021 Jun 31;34:100762. Epub 2021 Mar 31.

Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: Few risk models are available to predict future onset of atrial fibrillation (AF) in workers. We aimed to develop risk prediction models for new-onset AF, using annual health checkup (HC) data with electrocardiogram findings.

Methods And Results: We retrospectively included 56,288 factory or office workers (mean age = 51. Read More

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Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects.

Sci Rep 2021 Apr 21;11(1):8606. Epub 2021 Apr 21.

Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan.

A potential link between chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) has been suggested. We investigated the relationship between fatty liver index (FLI), a noninvasive and simple predictor of NAFLD, and the development of CKD defined as estimated glomerular filtration rate < 60 mL/min/1.73 m or positive for urinary protein during a 10-year follow-up period in subjects who received annual health examinations (n = 28,890). Read More

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Changes in health-related quality of life and the associated factors among Myanmar migrants with tuberculosis: a cohort study.

BMC Infect Dis 2021 Apr 21;21(1):377. Epub 2021 Apr 21.

Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Background: Migrants are known to be predominantly poor population which are predisposing to social and health problems, particularly infectious diseases including tuberculosis (TB). TB itself and effect of treatment may further result in substantial morbidity and lowering the quality of life. This study aimed to assess the changes in health-related quality of life (HRQOL) within six months of anti-TB treatment initiation, and the associated factors in Myanmar migrants under anti-TB treatment within this border area. Read More

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Preserving inferior right hepatic vein enabled bisegmentectomy 7 and 8 without venous congestion: a case report.

Surg Case Rep 2021 Apr 21;7(1):101. Epub 2021 Apr 21.

Department of Surgery, National Center for Global Health and Medicine, Hepato-Biliary-Pancreatic Surgery Division, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Background: In hepatectomy, the preservation of portal perfusion and venous drainage in the remnant liver is important for securing postoperative hepatic function. Right hepatectomy is generally indicated when a hepatic tumor involves the right hepatic vein (RHV). However, if a sizable inferior RHV (IRHV) exists, hepatectomy with preservation of the IRHV territory may be another option. Read More

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Mobile Application for Scoliosis Screening Using a Standard 2D Digital Camera.

Cureus 2021 Mar 17;13(3):e13944. Epub 2021 Mar 17.

Department of Orthopaedic Surgery, St. Marianna University School of Medicine, Kawasaki, JPN.

Several scoliosis detection systems, using three-dimensional (3D) cameras or sensors, have been developed in recent years. Because these systems require specific 3D digital cameras or sensors, and the equipment is expensive, they are rarely used in many countries and regions. The development of a scoliosis screening system that uses standard two-dimensional (2D) digital cameras that come with tablet personal computers (PCs) and smartphones will facilitate the efforts made to detect scoliosis patients on a global scale. Read More

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Dietary salt intake increases with age in Japanese adults.

Nutr Res 2021 May 21;89:1-9. Epub 2021 Mar 21.

Department of Internal Medicine, Faculty of Rehabilitation Sciences, Nagoya Gakuin University, Nagoya, Japan.

Excess salt intake is linked to cardiovascular disease as well as hypertension, but whether individual salt intake increases with age has not been studied. The present study was designed to test the hypothesis that individual salt intake increases with age in Japanese adults. In this retrospective observational follow-up study, men and women age ≥30 years who participated in a baseline health checkup (2008-2009) at our center and had a health checkup 10 years later (n = 2598) were enrolled and salt intake was estimated by spot urine analysis. Read More

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SARS-CoV-2 seroprevalence in healthcare workers at a frontline hospital in Tokyo.

Sci Rep 2021 04 16;11(1):8380. Epub 2021 Apr 16.

Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo, Japan.

Healthcare workers (HCWs) are highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The actual coronavirus disease (COVID-19) situation, especially in regions that are less affected, has not yet been determined. This study aimed to assess the seroprevalence of SARS-CoV-2 in HCWs working in a frontline hospital in Tokyo, Japan. Read More

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Validation of Tools for Predicting Incident Adenocarcinoma of the Esophagus or Esophagogastric Junction.

Am J Gastroenterol 2021 05;116(5):949-957

Kaiser Permanente, Northern California, Oakland, California, USA.

Introduction: Guidelines suggest screening of individuals who are at increased risk of esophageal adenocarcinoma (EAC). Tools for identifying patients at risk of Barrett's esophagus have been validated. Here, we aimed to compare and validate the tools for the primary outcomes of interest: EAC and esophagogastric junction adenocarcinoma (EGJAC). Read More

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Prospective nursing care certification using the 25-question Geriatric Locomotive Function Scale.

Geriatr Gerontol Int 2021 Apr 13. Epub 2021 Apr 13.

Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Aim: The 25-question Geriatric Locomotive Function Scale (hereafter, "GLFS-25") is a simple screening tool to detect elderly individuals at high risk of locomotive syndrome and promote interventions. This cohort study aimed to clarify if it can predict the need for nursing care certification in the near future.

Methods: Participants were 531 Japanese adults aged ≥65 years who had undergone a healthcare checkup in 2012 and never received nursing care certification until 2012. Read More

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Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men.

Sci Rep 2021 Apr 13;11(1):8026. Epub 2021 Apr 13.

Department of Family medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Low serum bilirubin levels have been associated with increased risk of cardiovascular disease (CVD) and metabolic syndrome. Testosterone deficiency could also contribute to increased risk of CVD and metabolic syndrome. Therefore, this study aimed to examine the relationship between serum bilirubin level and testosterone deficiency in 1284 Korean men aged 45 to 70 years. Read More

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Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China.

Hereditas 2021 Apr 12;158(1):12. Epub 2021 Apr 12.

Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P.R. China.

Background: Coronary artery disease (CAD) is the leading cause of death worldwide. In this study, we aimed to explore whether some genetic variants of the human IDOL gene were associated with CAD among Chinese population in Xinjiang.

Methods: We designed two independent case-control studies. Read More

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Gender differences in risk factors for high plasma homocysteine levels based on a retrospective checkup cohort using a generalized estimating equation analysis.

Lipids Health Dis 2021 Apr 12;20(1):31. Epub 2021 Apr 12.

Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China.

Background: Hyperhomocysteinemia (HHcy) is associated with various health problems, but less is known about the gender differences in risk factors for high plasma homocysteine (Hcy) levels.

Methods: In this study, a retrospective study was carried out on 14,911 participants (7838 males and 7073 females) aged 16-102 years who underwent routine checkups between January 2012 and December 2017 in the Health Management Department of Xuanwu Hospital, China. Anthropometric measurements, including body mass index (BMI) and waist-to-hip ratio, were collected. Read More

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Left Atrial Appendage Ostial Stenosis: A Case Report and Literature Review.

Am J Case Rep 2021 Apr 9;22:e930510. Epub 2021 Apr 9.

Department of Cardiology, Osaka Medical College, Takatsuki, Osaka, Japan.

BACKGROUND Left atrial appendage (LAA) ostial stenosis is a rare cardiac condition usually identified by transesophageal echocardiography (TEE). LAA ostial stenosis can be classified into 2 types: one is idiopathic and the other is a complication after incomplete surgical LAA ligation. The former one is even rarer and only 12 cases have previously been reported. Read More

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H. pylori negative gastric MALT lymphoma with API2-MALT1 translocation treated by endoscopic submucosal dissection: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e24371

Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan.

Rationale: API2-MALT1 positive gastric mucosa-associated lymphoid tissue (MALT) lymphomas are considered to have favorable prognosis. We report a case of API2-MALT1 positive gastric MALT lymphoma, treated by endoscopic submucosal dissection (ESD).

Patient Concerns: A 51-year-old man underwent esophagogastroduodenoscopy (EGD) for the annual health checkup examination. Read More

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[Ectopic Adrenocorticotropic Hormone-Producing Pulmonary Carcinoid Presenting as Cushing's Syndrome after Intrapleural Hyperthermic Chemotherapy].

Kyobu Geka 2021 Mar;74(3):197-201

Department of Surgery, Okinawa National Hospital, Ginowan, Japan.

The patient was a woman in her 70's was referred to our hospital because of an abnormal shadow on chest roentgenogram at an annual medical checkup. Since preoperative examinations suggested lung cancer in the right middle lobe, thoracoscopic right middle lobectomy was planned. However, pleural dissemination was detected at surgery and we changed the treatment plan to the intrapleural hyperthermic chemotherapy. Read More

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Relationship between locomotive syndrome, frailty and sarcopenia: Locomotive syndrome overlapped in the majority of frailty and sarcopenia patients.

Geriatr Gerontol Int 2021 Apr 6. Epub 2021 Apr 6.

Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Aim: The relationship between locomotive syndrome (LS), frailty and sarcopenia is unclear. This cohort study investigates the epidemiology of the three conditions and examines the relationship between them.

Methods: The participants were 337 Japanese adults aged ≥60 years who had undergone a healthcare checkup. Read More

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Gender-Dependent Reference Range of Serum Calcitonin Levels in Healthy Korean Adults.

Endocrinol Metab (Seoul) 2021 Apr 7;36(2):365-373. Epub 2021 Apr 7.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Serum calcitonin measurement contains various clinical and methodological aspects. Its reference level is wide and unclear despite sensitive calcitonin kits are available. This study aimed to identify the specific reference range in the healthy Korean adults. Read More

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Close Association between Awareness of Teeth-Alignment Disorder and Systemic Disorders in Late Adolescence.

Healthcare (Basel) 2021 Mar 26;9(4). Epub 2021 Mar 26.

Division for Health Service Promotion, The University of Tokyo, Tokyo 113-0033, Japan.

Background: Oral diseases are associated with various systemic disorders. Our previous research revealed new insights into the close relationship between occlusal disorder (functional disorder) and systemic disorders (allergic rhinitis, asthma, and arrhythmia) in late adolescence. Here, we investigated whether there was an association between the awareness of teeth-alignment disorder (morphological disorder) and common systemic disorders. Read More

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Association between Serum Concentration of Carotenoid and Visceral Fat.

Nutrients 2021 Mar 11;13(3). Epub 2021 Mar 11.

Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.

Consumption of fruits and vegetables rich in carotenoids has been widely reported to prevent cardiovascular diseases. However, the relationship between serum carotenoid concentrations and visceral fat area (VFA), which is considered a better predictor of cardiovascular diseases than the body-mass index (BMI) and waist circumference, remains unclear. Therefore, we examined the relationship in healthy individuals in their 20s or older, stratified by sex and age, to compare the relationship between serum carotenoid concentrations and VFA and BMI. Read More

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Identification of Hepatic Steatosis in Premenopausal and Postmenopausal Women Based on Phenotypes Combining Triglyceride Levels and Anthropometric Indices: A Cross-Sectional Study.

Diabetes Metab Syndr Obes 2021 23;14:1339-1347. Epub 2021 Mar 23.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, People's Republic of China.

Background: The hypertriglyceridemic waist phenotype (HWP) has exhibited a strong association with metabolic syndrome, a condition closely linked with nonalcoholic fatty liver disease (NAFLD). However, no study has investigated whether the HWP can accurately predict NAFLD among premenopausal and postmenopausal women or whether alternative anthropometric indexes could replace waist circumference (WC) in the HWP. We examined the power of phenotypes combining triglyceride (TG) levels with anthropometric indexes such as body mass index (BMI), WC, waist-to-hip ratio, waist-to-height ratio, and percent body fat, to detect NAFLD among premenopausal and postmenopausal women. Read More

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Impact of incentives for health-care workers wearing personal protective equipment while dealing with coronavirus disease in Japan.

J Occup Health 2021 Jan;63(1):e12213

Department of Acute Critical Care and Disaster Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

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January 2021

Chronic Kidney Disease Risk of Isolated Systolic or Diastolic Hypertension in Young Adults: A Nationwide Sample Based-Cohort Study.

J Am Heart Assoc 2021 Apr 31;10(7):e019764. Epub 2021 Mar 31.

Department of Internal Medicine Chonnam National University Medical School Gwangju Korea.

Background Hypertension among young adults is common. However, the effect of isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), or systolic and diastolic hypertension (SDH) among young adults on chronic kidney disease (CKD) development is unknown. Methods and Results From a nationwide health screening database, we included 3 030 884 participants aged 20 to 39 years who were not taking antihypertensives at baseline examination in 2009 to 2010. Read More

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Quality Improvement of Bowel Preparation for Screening Colonoscopies: A Study of Hospital Team Resource Management in Taiwan.

Qual Manag Health Care 2021 Apr-Jun 01;30(2):127-134

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei, Taiwan, Republic of China (Dr Chung); College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan, Republic of China (Dr Chung); Department of Healthcare Information and Management, Ming Chuan University, Taoyuan, Taiwan, Republic of China (Dr Lin); and Department of Healthcare Administration, Oriental Institute of Technology, New Taipei, Taiwan, Republic of China (Dr Chen).

Background And Objectives: This study aimed to investigate the impact of patient education using a medical team resource management (TRM) method on the adequacy of bowel preparation.

Methods: The study setting was a single hospital in northern Taiwan, and a total of 2104 (884 female, 1220 male) healthy subjects who underwent a health checkup colonoscopy screening were enrolled before and after the application of the TRM program intervention. The efficacy of the TRM intervention and the factors affecting bowel preparation were estimated using multivariate logistic regression. Read More

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Changes in Cardiovascular Health Status and Risk of Sudden Cardiac Death in Older Adults.

Yonsei Med J 2021 Apr;62(4):298-305

Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Cardiovascular health (CVH) status is associated with several cardiovascular outcomes; however, correlations between changes in CVH status and risk of sudden cardiac death (SCD) are unknown. We aimed to evaluate associations between changes in CVH status and risk of SCD and all-cause death in older adults.

Materials And Methods: We used data from the Korea National Health Insurance Service-Senior cohort database (2005-2012). Read More

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Author Correction: Meta-analytic research of the dose-response relationship between salt intake and risk of heart failure.

Hypertens Res 2021 Mar 25. Epub 2021 Mar 25.

Department of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

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