22,410 results match your criteria medical autopsy

Autopsy-Based Pulmonary and Vascular Pathology: Pulmonary Endotheliitis and Multi-Organ Involvement in COVID-19 Associated Deaths.

Respiration 2021 Sep 15:1-11. Epub 2021 Sep 15.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Background: Findings from autopsies have provided evidence on systemic microvascular damage as one of the underlying mechanisms of Coronavirus disease 2019 (CO-VID-19). The aim of this study was to correlate autopsy-based cause of death in SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients with chest imaging and severity grade of pulmonary and systemic morphological vascular pathology.

Methods: Fifteen SARS-CoV-2 positive autopsies with clinically distinct presentations (age 22-89 years) were retrospectively analyzed with focus on vascular, thromboembolic, and ischemic changes in pulmonary and in extrapulmonary sites. Read More

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September 2021

Spectrum of Renal Lesions on Autopsy: Experience of a Tertiary Level Institute Based on Retrospective Histopathological Analysis.

Cureus 2021 Aug 10;13(8):e17064. Epub 2021 Aug 10.

Pathology, Dr Baba Saheb Ambedkar (BSA) Medical College and Hospital, New Delhi, IND.

Introduction: Last few decades have seen a remarkable increase in the elderly population. Aging is an established risk factor for chronic kidney diseases associated with increased mortality and morbidity. The frequency and spectrum of renal pathology on autopsy specimen is not well documented and is often overlooked by physicians as well as forensic pathologists. Read More

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A Cognitive Autopsy Approach Towards Explaining Diagnostic Failure.

Cureus 2021 Aug 9;13(8):e17041. Epub 2021 Aug 9.

Emergency Medicine, Dalhousie University, Halifax, CAN.

Diagnostic failure has emerged as one of the most significant threats to patient safety. It is important to understand the antecedents of such failures both for clinicians in practice as well is those in training. A consensus has developed in the literature that the majority of failures are due to individual or system factors or some combination of the two. Read More

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Phenibut, a GABAB Agonist, Detected in a Fatality.

J Anal Toxicol 2021 Sep 14. Epub 2021 Sep 14.

Harris County Institute of Forensic Sciences, 1861 Old Spanish Trail, Houston, TX 77054, USA.

Phenibut, a GABAB agonist structurally similar to baclofen, is not approved for medical use in the United States, but is available through internet suppliers for recreational use. Calls to poison control centers for phenibut have increased over the last five years, and there are many case reports of severe acute intoxications and withdrawals requiring hospitalization. This case report describes the autopsy and toxicology findings of a 26-year-old male found dead at home with phenibut containers on scene. Read More

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September 2021

Cutting Edge Approaches to Detecting Brain Mosaicism Associated with Common Focal Epilepsies: Implications for Diagnosis and Potential therapies.

Expert Rev Neurother 2021 Sep 14. Epub 2021 Sep 14.

Epilepsy Research Centre, Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Australia.

Introduction: Mosaic variants arising in brain tissue are increasingly being recognized as a hidden cause of focal epilepsy. This knowledge gain has been driven by new, highly sensitive genetic technologies and genome-wide analysis of brain tissue from surgical resection or autopsy in a small proportion of patients with focal epilepsy. Recently reported novel strategies to detect mosaic variants limited to brain have exploited trace brain DNA obtained from cerebrospinal fluid liquid biopsies or stereo-electroencephalography electrodes. Read More

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September 2021

Cholemic Nephrosis: An Autopsy Study of a Forgotten Entity.

Turk Patoloji Derg 2021 May 12. Epub 2021 May 12.

Department of Pathology, Indira Gandhi Medical College and Research Institute, PUDUCHERRY, INDIA.

Objective: The aim of the study is to do a clinicopathologic study of post mortem kidney biopsies with significant deposition of bilirubin pigment within tubular epithelial cells and in the lumen of distal tubules as a bile cast.

Material And Method: All post mortem specimens with acute tubular necrosis, with the presence of bile casts in tubules or bile pigment deposition in the tubular epithelium during the period 2015-2018 were examined for gross and histopathology along with biochemical parameters and viral markers.

Results: Bile casts with sloughed renal tubular epithelial cells and occasional macrophages were present in the distal convoluted tubule in 78. Read More

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Apple Peel Deformity and Malrotation of Gut: Autopsy Findings of a Rare Cause of Mortality in Utero.

Turk Patoloji Derg 2021 Apr 13. Epub 2021 Apr 13.

Department of Pathology, Armed Forces Medical College, PUNE, INDIA.

One-third of all intestinal obstructions in the newborn are caused by atresias. The most common site is the duodenum followed by jejunoileal and colonic locations. Herein we report the autopsy findings of a rare case of jejunoileal atresia associated with malrotation of gut. Read More

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Towards Understanding COVID-19: Molecular Insights, Co-infections, Associated Disorders, and Aging.

Elena L Paley

J Alzheimers Dis Rep 2021 20;5(1):571-600. Epub 2021 Jul 20.

Expert BioMed, Inc. and Nonprofit Public Charity Stop Alzheimers Corp., Miami-Dade, FL, USA.

Background: COVID-19 can be related to any diseases caused by microbial infection(s) because 1) co-infection with COVID-19-related virus and other microorganism(s) and 2) because metabolites produced by microorganisms such as bacteria, fungi, and protozoan can be involved in necrotizing pneumonia and other necrotizing medical conditions observed in COVID-19.

Objective: By way of illustration, the microbial metabolite of aromatic amino acid tryptophan, a biogenic amine tryptamine inducing neurodegeneration in cell and animal models, also induces necrosis.

Methods: This report includes analysis of COVID-19 positivity by zip codes in Florida and relation of the positivity to population density, possible effect of ecological and social factors on spread of COVID-19, autopsy analysis of COVID-19 cases from around the world, serum metabolomics analysis, and evaluation of autoantigenome related to COVID-19. Read More

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Laparoscopic Orthotopic Kidney Transplantation in Swine: A Novel Vascular Prop Device for Venous Anastomoses.

Front Surg 2021 26;8:708449. Epub 2021 Aug 26.

Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

To investigate the safety and efficacy of a vascular prop device for laparoscopic orthotopic kidney transplantation (LOKT) in swine. Twenty swine were randomly divided into two groups. A vascular prop device was used in the observation (VP) group, and the vein beltization technique was used in the control (VB) group. Read More

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Synchronous Total Occlusion of the Celiac Axis and Superior Mesenteric Artery: An Autopsy Case.

Acta Med Okayama 2021 Aug;75(4):523-527

Department of Surgery, National Hospital Organization Nagasaki Medical Center.

Acute mesenteric ischemia (AMI) is often caused by superior mesenteric artery (SMA) embolization. We report a rare case of synchronous celiac axis and SMA embolization in an elderly woman with initially mild abdominal pain. Ultimately, a second contrast-enhanced computed tomography revealed extensive necrosis from the stomach to the transverse colon together with liver ischemia due to hours of occlusion. Read More

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COVID-19 impact on the renal system: Pathophysiology and clinical outcomes.

Best Pract Res Clin Anaesthesiol 2021 Oct 2;35(3):449-459. Epub 2021 Mar 2.

Department of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA. Electronic address:

Coronavirus disease (COVID-19) causes many deleterious effects throughout the body. Prior studies show that the incidence of acute kidney injury in COVID-19 patients could be as high as 25%. There are also autopsy reports showing evidence of viral tropism to the renal system. Read More

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October 2021

Fatal outcome of SARS-CoV-2 infection (B1.1.7) in a 4-year-old child.

Int J Legal Med 2021 Sep 12. Epub 2021 Sep 12.

Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Butenfeld 34, 22529, Hamburg, Germany.

This case report highlights details of a case of critical acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) with B1.1.7 variant in a 4-year-old girl who died due to pneumonia and pulmonary hemorrhage. Read More

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September 2021

Analysis of Pedestrian Fractures in Collisions Between Small Cars and Pedestrians Based on Surveillance Videos.

Am J Forensic Med Pathol 2021 Sep 10. Epub 2021 Sep 10.

From the School of Forensic Medicine Guangdong Provincial Research Center of Traffic Accident Identification Engineering Technology, Centre of Forensic Science Southern Medical University, School of Forensic Medicine, Southern Medical University School of Mechanical & Automotive Engineering, South China University of Technology, Guangzhou, Guangdong, China.

Objective: To discuss the collision relationship and the cause of the fracture caused by traffic accidents in which the front of a small car collides with the side of a pedestrian while braking.

Methods: The surveillance videos of 42 traffic accidents involving the front of a small car colliding with the side of a pedestrian while braking were collected. By analyzing the surveillance videos and the paths, the speed of the collision, the relationship between the vehicle and the pedestrian upon collision, and the movement trajectory of the human body were clearly identified. Read More

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September 2021

Ruptured Splenic Artery Pseudoaneurysm Causing Hemorrhage Into a Pancreatic Pseudocyst.

Am J Forensic Med Pathol 2021 Sep 10. Epub 2021 Sep 10.

From the Volusia County Medical Examiner's Office, Daytona Beach, FL University of South Carolina School of Medicine Departments of Radiology Pathology, Prisma Health, Greenville, SC.

Abstract: This case report describes fatal exsanguination due to splenic artery hemorrhage into a pancreatic pseudocyst with cystogastrostomy in a 46-year-old woman. The decedent had a complicated medical history including necrotizing pancreatitis, giant pseudocyst formation after cystogastrostomy procedure, and coiling of a hemorrhagic splenic artery. While hospitalized, she underwent embolization of a ruptured splenic artery pseudoaneurysm. Read More

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September 2021

Fatal Excipients: An Autopsy Case Series of Excipient Lung Disease.

Am J Forensic Med Pathol 2021 Sep 10. Epub 2021 Sep 10.

From the Department of Pathology, NYU Langone Health, Long Island School of Medicine, Mineola, NY Miami-Dade County Medical Examiner Department, Miami, FL.

Abstract: Crushed oral tablets, when injected intravenously, may induce a foreign body granulomatous reaction in and around pulmonary arterioles, because of the presence of filler materials (excipients). This typically presents as shortness of breath in the context of pulmonary hypertension with arteriolar dilation and centrilobular nodules on imaging modalities. The constellation of findings may be overlooked or misdiagnosed by clinicians and pathologists, ultimately affecting patient care and postmortem assessment. Read More

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September 2021

Fetal Ultrasonic Evaluation of Bronchial Morphology in Fetuses with Isomerism.

Fetal Diagn Ther 2021 Sep 10:1-10. Epub 2021 Sep 10.

Maternal-Fetal Consultation Center of Congenital Heart Disease, Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective: The aim of the study was to evaluate whether fetal ultrasound could determine bronchial isomerism and distinguish left isomerism from right isomerism.

Methods: We identified 110 healthy fetuses and 28 fetuses with isomerism. The outer angle between the tracheal midline and the inner margin of the bronchus is measured. Read More

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September 2021

Group A Streptococcus puerperal sepsis with invasive neonatal infection: A fatal case.

Med J Malaysia 2021 Sep;76(5):731-733

Universiti Sains Malaysia, School of Medical Sciences, Department of Medical Microbiology and Parasitology, Health Campus, Kubang Kerian, Kelantan, Malaysia.

Neonatal invasive Group A Streptococcus (GAS) infection is a rare occurrence nowadays. Prior maternal vaginal colonization is an important factor in early neonatal disease. We report a case of invasive and fatal infection in a neonate. Read More

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September 2021

An autopsy case study of lymphocytic hypophysitis induced by nivolumab treatment for esophageal malignant melanoma.

Pathol Int 2021 Sep 10. Epub 2021 Sep 10.

Department of Pathology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.

Immune checkpoint inhibitors such as anti-cytotoxic T-lymphocyte antigen-4 and anti-programmed death-1 antibodies are effective against malignant tumors. However, they induce unique adverse events known as immune-related adverse events. Hypophysitis is one of the most frequent immune-related adverse events of anti-cytotoxic T-lymphocyte antigen-4 therapies. Read More

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September 2021

Medicolegal Evaluation of an Abandoned Dead Neonate: A Case Report.

JNMA J Nepal Med Assoc 2021 Mar 31;59(235):292-294. Epub 2021 Mar 31.

District Hospital, Palpa, Nepal.

The killing of an illegitimate newborn immediately or within 24 hours of birth is neonaticide which differs from other forms of homicide in terms of diagnosis and motives. Neonaticide is a cognizable offense where mothers are usually the perpetrators. This case reports the autopsy findings of a smothered neonate at a secluded location in rural Nepal. Read More

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De Novo Inverted Duplication Deletion of 4p in a 14-Week-Old Male Fetus Aborted Due to Multiple Anomalies.

J Pediatr Genet 2021 Sep 19;10(3):245-249. Epub 2020 Jun 19.

Department of Medical Genetics, AORN San Pio, PO Gaetano Rummo, Benevento, Italy.

Inverted duplications deletions are rare, complex, and nonrecurrent chromosomal rearrangements associated with a variable phenotype. In this case report, we described the phenotype and genotype of a 14-week-old male fetus, who was aborted after discovery of multiple anomalies (septal cystic hygroma, open abdominal wall, and a nonidentifiable lower limb). At autopsy, fluorescence in situ hybridization and array comparative genomic hybridization identified an inverted duplication with terminal deletion of 4p [46,XY,der(4)del(p16. Read More

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September 2021

Clinical Correlation of Multiple Sclerosis Immunopathologic Subtypes.

Neurology 2021 Sep 9. Epub 2021 Sep 9.

Marcia Applebaum Professor of Neurosciences; Chair, Department of Neurology; Dean for Clinical and Translational Science, Mayo Clinic, College of Medicine

Objective: To compare clinical characteristics across immunopathological subtypes of patients with multiple sclerosis.

Methods: Immunopathological subtyping was performed on specimens from 547 patients with biopsy and/or autopsy confirmed CNS demyelination.

Results: The frequency of immunopathological subtypes were pattern I (23%), II (56%), and III (22%). Read More

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September 2021

Might life-threatening acute pulmonary edema occur after using recombinant tissue plasminogen activator? A case report.

BMC Neurol 2021 Sep 9;21(1):346. Epub 2021 Sep 9.

School of Forensic Medicine, Southern Medical University, 510515, Guangzhou, China.

Background: Recombinant tissue plasminogen activator (rt-pa) is the first-line drug for the treatment of acute ischemic stroke, and can lead to some complications.There were rare reports of death due to acute pulmonary edema during rt-pa thrombolysis treatment.

Case Presentation: This study reports a 30-year-old man was diagnosed with acute ischemic stroke and underwent rt-pa thrombolytic therapy. Read More

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September 2021

Oligodendrocyte-Specific Deletion of Reduces Cerebellar Inflammation and Neurodegeneration in MOG-Induced EAE.

Int J Mol Sci 2021 Aug 31;22(17). Epub 2021 Aug 31.

Experimental Neurology, Department of Neurology, University of Giessen, Klinikstrasse 33, 35385 Giessen, Germany.

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system (CNS). MS commonly affects the cerebellum causing acute and chronic symptoms. Cerebellar signs significantly contribute to clinical disability, and symptoms such as tremor, ataxia, and dysarthria are difficult to treat. Read More

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The effect of the localisation of an underlying ST-elevation myocardial infarction on the VF-waveform: A multi-centre cardiac arrest study.

Resuscitation 2021 Sep 6. Epub 2021 Sep 6.

Department of Cardiology, Amsterdam UMC, location AMC, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.

Introduction: In cardiac arrest, ventricular fibrillation (VF) waveform characteristics such as amplitude spectrum area (AMSA) are studied to identify an underlying myocardial infarction (MI). Observational studies report lower AMSA-values in patients with than without underlying MI. Moreover, experimental studies with 12-lead ECG-recordings show lowest VF-characteristics when the MI-localisation matches the ECG-recording direction. Read More

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September 2021

Sudden death in an adolescent due to undiagnosed classic Hodgkin lymphoma.

J Forensic Sci 2021 Sep 9. Epub 2021 Sep 9.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Few cases of natural sudden death presenting as an undiagnosed lymphoma have been reported in the literature, especially in adolescents. Herein we provide a report of sudden death caused by undiagnosed classic Hodgkin lymphoma (cHL). We describe an 18-year-old female who collapsed after several weeks of weight loss, decreased appetite, and dyspnea. Read More

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September 2021

test profiles and mortality in critically-ill COVID-19 patients.

J Clin Microbiol 2021 Sep 8:JCM0122921. Epub 2021 Sep 8.

Center of Expertise in Mycology Radboudumc/CWZ, Radboud University Medical Center, Nijmegen, The Netherlands.

The literature regarding COVID-19 associated pulmonary aspergillosis (CAPA) has shown conflicting observations, including survival of CAPA patients not receiving antifungal therapy and discrepancy between CAPA diagnosis and autopsy findings. To gain insight into the pathophysiology of CAPA we performed a case-control study, in which we compared test profiles in CAPA patients and controls in relation to ICU-mortality. A multinational case-control study, in which test results, use of antifungal therapy and mortality were collected from critically-ill COVID-19 patients. Read More

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September 2021

Cerebral Microvascular Injury in Patients with Left Ventricular Assist Device: a Neuropathological Study.

Transl Stroke Res 2021 Sep 8. Epub 2021 Sep 8.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue/S80, Cleveland, OH, USA.

Strokes are common among patients with left ventricular devices (LVAD). We hypothesize that there is ongoing cerebral microvascular injury with LVAD support and aim to describe this among LVAD-implanted patients through post-mortem neuropathologic evaluation. We identified and reviewed medical records of LVAD patients who underwent brain autopsy between January 2006 and December 2019 at a tertiary center. Read More

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September 2021

Cardiac myxomas: clinical presentation, diagnosis and management.

Heart 2021 Sep 7. Epub 2021 Sep 7.

Division of Cardiology, Department of Internal Medicine, Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario, Canada.

Cardiac myxomas (CM) are the most common type of primary cardiac tumours in adults, which have an approximate incidence of up to 0.2% in some autopsy series. The purpose of this review is to summarise the literature on CM, including clinical presentation, differential diagnosis, work-up including imaging modalities and histopathology, management, and prognosis. Read More

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September 2021

Mediastinal ectopic thyroid tissue, an imitator of an enlarged lymph node with metastatic pulmonary neoplasia.

Diagn Cytopathol 2021 Sep 7. Epub 2021 Sep 7.

Department of Pathology and Laboratory Medicine, Cooper University Hospital, Camden, New Jersey, USA.

The prevalence of ectopic thyroid tissue, based on autopsy studies, is between 7% and 10%, but there are rare cases reported in the thoracic region. Here, we encountered a case of thoracic ectopic thyroid tissue presenting as a presumed enlarged mediastinal lymph node. A 50-year-old female with a history of lung adenocarcinoma, status post resection, presented with complaints of headache, dizziness, and nausea. Read More

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September 2021

Megacystis in the first trimester of pregnancy: Prognostic factors and perinatal outcomes.

PLoS One 2021 7;16(9):e0255890. Epub 2021 Sep 7.

Maternité Port-Royal, AP-HP, Hôpital Cochin, FHU PREMA, Paris, France.

Objective: To determine whether bladder size is associated with an unfavorable neonatal outcome, in the case of first-trimester megacystis.

Materials And Methods: This was a retrospective observational study between 2009 and 2019 in two prenatal diagnosis centers. The inclusion criterion was an enlarged bladder (> 7 mm) diagnosed at the first ultrasound exam between 11 and 13+6 weeks of gestation. Read More

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September 2021