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Autoantibodies against apolipoprotein A-1 after COVID-19 predict symptoms persistence.

Eur J Clin Invest 2022 May 22:e13818. Epub 2022 May 22.

Division of Laboratory Medicine, Department of Diagnostics and of Medical Specialties, Geneva University Hospitals and Geneva University, Geneva, Switzerland.

Background: SARS-CoV-2 infection triggers different auto-antibodies, including anti-apolipoprotein A-1 IgGs (AAA1), which could be of concern as mediators of persistent symptoms. We determined the kinetics of AAA1 response over after COVID-19, and the impact of AAA1 on the inflammatory response and symptoms persistence.

Methods: All serologies were assessed at one, three, six, and twelve months in 193 hospital employees with COVID-19. Read More

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Continuous metabolic syndrome severity score and the risk of CVD and all-cause mortality.

Eur J Clin Invest 2022 May 22:e13817. Epub 2022 May 22.

Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: The dualistic diagnostic criteria for metabolic syndrome overlooked the severity of metabolic syndrome, and the relationships between the severity of metabolic syndrome and adverse health conditions are poorly characterized. We therefore aimed to investigate the associations of metabolic syndrome severity with incident cardiovascular disease (CVD)/all-cause mortality.

Methods: A total of 116772 participants from the Kailuan study were followed up biennially between 2006 and 2018. Read More

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Global Longitudinal Strain by CMR Improves Prognostic Stratification in Acute Myocarditis presenting with Normal LVEF.

Eur J Clin Invest 2022 May 22:e13815. Epub 2022 May 22.

Centre for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI) and University of Trieste, Trieste, Italy.

Background: Prognostic stratification of acute myocarditis (AM) presenting with normal left ventricular ejection fraction (LVEF) relies mostly on late gadolinium enhancement (LGE) characterization. Left ventricular peak global longitudinal strain (LV-GLS) measured by feature tracking analysis might improve prognostication of AM presenting with normal LVEF.

Methods: Data of patients undergoing cardiac magnetic resonance (CMR) for clinically suspected AM in seven European Centres (2013-2020) were retrospectively analysed. Read More

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TAZ Reduces UVA-mediated Photoaging through Regulates Cell Proliferation in Skin Fibroblasts.

Photochem Photobiol 2022 May 22. Epub 2022 May 22.

National Innovation and Attracting Talents "111" base, Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, China.

The transcriptional co-activator with PDZ-binding motif (TAZ) is a significant transcription factor downstream of the Hippo pathway regulating organ size, tissue regeneration, cell proliferation, and apoptosis. Here we report on TAZ in response to photoaging mediated by repeated UVA irradiation in skin fibroblasts. Continuous UVA irradiation caused a decrease in TAZ and targeted CTGF mRNA and protein expression in fibroblasts, accompanied by reduced cell proliferation, DNA damage, and a cell cycle arrest in G1 phase and S phase reduction. Read More

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Nasopharyngeal cancer cell-derived exosomal PD-L1 inhibits CD8+ T cell activity and promotes immune escape.

Cancer Sci 2022 May 22. Epub 2022 May 22.

Department of Radiation Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, P. R. China.

Programmed cell death ligand 1 (PD-L1) is an immune surface protein that binds to programmed cell death 1 (PD-1) and allows tumors to evade T cell immunity. This study aims to define the role of PD-L1 shuttled by tumor cell-derived exosomes in the immune escape of nasopharyngeal carcinoma (NPC). PD-L1 expression was determined in the exosomes isolated from the plasma of NPC patients or from NPC cells. Read More

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A single immunization with cellular vaccine confers dual protection against SARS-CoV-2 and cancer.

Cancer Sci 2022 May 22. Epub 2022 May 22.

Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Science, Yokohama, Kanagawa, Japan.

The efficacy of current coronavirus disease 2019 (COVID-19) vaccines has been demonstrated; however, emerging evidence suggests insufficient protection in certain immunocompromised cancer patients. We previously developed a cell-based anti-cancer vaccine platform involving artificial adjuvant vector cells (aAVCs) capable of inducing a strong adaptive response by enhancing innate immunity. aAVCs are target antigen-transfected allogenic cells that simultaneously express the natural killer T cell ligand-CD1d complex on their surface. Read More

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Left atrial disease and left atrial reverse remodeling across different stages of heart failure development and progression: a new target for prevention and treatment.

Eur J Heart Fail 2022 May 22. Epub 2022 May 22.

ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

The left atrium is a dynamic chamber with peculiar characteristics. Stressors and disease mechanisms may deeply modify its structure and function, leading to left atrial remodeling and disease. Left atrial disease is a predictor of poor outcomes. Read More

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Personality disorder and mild traumatic brain injury.

Personal Ment Health 2022 May 22. Epub 2022 May 22.

Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH.

Mild traumatic brain injury (mTBI) poses risk to the neurocognitive, emotional, and financial well-being of affected individuals. While aggression and impulsivity have been examined in relation to mTBI, little work has been done to evaluate the relationship between history of mTBI and personality disorder (PD). The authors examined the associations between history of mTBI and PD in a control group without history of mTBI (N = 1189) and individuals with history of mTBI (N = 267). Read More

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Antigen targeting to dendritic cells: still a place in future immunotherapy?

Eur J Immunol 2022 May 22. Epub 2022 May 22.

Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.

The hallmark of dendritic cells (DCs) is their potent and outstanding capacity to activate naive resting T cells. As such, DCs are the sentinels of the immune system and instrumental for the induction of immune responses. This is one of the reasons, why DCs became the focus of immunotherapeutical strategies to fight infections, cancer and autoimmunity. Read More

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Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure with Preserved Ejection Fraction: Early Results of the REBALANCE-HF Trial Roll-in Cohort.

Eur J Heart Fail 2022 May 22. Epub 2022 May 22.

Northwestern University Feinberg School of Medicine, Chicago, IL.

Background: In heart failure with preserved ejection fraction (HFpEF), excessive redistribution of blood volume into the central circulation leads to elevations of intracardiac pressures with exercise limitations. Splanchnic ablation for volume management (SAVM) has been proposed as a therapeutic intervention.

Aims: Here we present preliminary safety and efficacy data from the initial roll-in cohort of the REBALANCE-HF trial. Read More

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Gaze tracker parameters have little association with visual field metrics of intrasession frontloaded SITA-Faster 24-2 visual field results.

Ophthalmic Physiol Opt 2022 May 22. Epub 2022 May 22.

Centre for Eye Health, University of New South Wales, Kensington, New South Wales, Australia.

Purpose: To determine the usefulness of Humphrey Field Analyser (HFA) SITA-Faster 24-2 gaze tracker outputs on interpreting intra-visit visual field (VF) result pairs.

Methods: Analysis of 1380 right-left eye pairs and 1432 pairs of test 1-test 2 intrasession VF results of patients seen within a university-based glaucoma service was undertaken to understand gaze deviation distributions. Output gaze tracker results were aggregated into total ticks, sum of amplitudes and average amplitudes. Read More

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Prediction of visual field defects from macular optical coherence tomography in glaucoma using cluster analysis.

Ophthalmic Physiol Opt 2022 May 22. Epub 2022 May 22.

School of Optometry and Vision Science, University of New South Wales (UNSW), Sydney, New South Wales, Australia.

Purpose: To assess the accuracy of cluster analysis-based models in predicting visual field (VF) defects from macular ganglion cell-inner plexiform layer (GCIPL) measurements in glaucomatous and healthy cohorts.

Methods: GCIPL measurements were extracted from posterior pole optical coherence tomography (OCT), from locations corresponding to central VF test grids. Models incorporating cluster analysis methods and corrections for age and fovea to optic disc tilt were developed from 493 healthy participants, and 5th and 1st percentile limits of GCIPL thickness were derived. Read More

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Treatment zone decentration promotes retinal reshaping in Chinese myopic children wearing orthokeratology lenses.

Ophthalmic Physiol Opt 2022 May 22. Epub 2022 May 22.

Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.

Purpose: To investigate whether the treatment zone (TZ) decentration in orthokeratology (OK) lenses affects retinal expansion in Chinese children with myopia.

Methods: Children aged 8 to 13 years (n = 30) were assessed over 13 months comprising 12 months of OK lens wear followed by discontinuation of lens wear for 1 month. Corneal topography was measured at 0, 1, 3, 6, 9, 12 and 13 months. Read More

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Covid-19 Induced Myopathy and Encephalopathy in the Same Patient.

J Assoc Physicians India 2022 May;70(5):11-12

Ex-HOD Medicine, Medical College, Kolkata, West Bengal.

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COVID-19 and Mucormycosis in India a Study on Implicated Risk Factors.

J Assoc Physicians India 2022 May;70(5):11-12

Post Graduate in Internal Medicine, Gandhi Medical College, Secunderabad, Telangana.

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Hepatocellular Carcinoma Evaluation and Management for Physicians: Joint Gastroenterology Research Society and Association of Physicians of India Guidelines.

J Assoc Physicians India 2022 May;70(5):11-12

Department of Gastroenterology, TNMC and Nair Hospital, Mumbai, Maharashtra.

Hepatocellular carcinoma (HCC) is the most common cause of, and accounts for almost 90% of all liver cancers. Data from India is limited especially due to cancer not being a reportable disease and in view of wide variation in diagnostic modalities. This document is a result of a consensus meeting comprising Hepatologists, Interventional Radiologists, Hepatobiliary surgeons, medical and surgical Oncologists nominated by the Association of Physicians of India and Gastroenterology Research Society of Mumbai. Read More

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Rare Disease Day.

J Assoc Physicians India 2022 May;70(5):11-12

Professor of Medicine (Retd.), TN Medical College, Hon. Physician, Bhatia Hospital, Mumbai, Maharashtra.

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Autoimmune Hemolytic Anemia in Chronic Liver Disease following COVID-19 Episode.

J Assoc Physicians India 2022 May;70(5):11-12

Professor & Head, Department of Medicine, Mount Zion Medical College, Chayalode, Kerala.

This report describes a case of Autoimmune Hemolytic Anemia that was possibly induced by COVID-19 in a patient with history of Chronic Liver Disease and Diabetes Mellitus. Autoimmune responses like hemolytic anemia are known to be triggered by viral infections. COVID-19 is reported to be inducing Autoimmune Hemolytic Anemia in susceptible individuals. Read More

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Spectrum of Neurological Illnesses in Pregnancy - An Observational Study from a Tertiary Care Centre of Eastern India.

J Assoc Physicians India 2022 May;70(5):11-12

Professor, Bangur Institute of Neurosciences IPGMER & SSKM Hospital Annex-1, , Kolkata, West Bengal; * Corresponding Author.

Introduction: Neurological disorders in pregnancy may be observed in patients with a pre-existing neurological disorder; patients developing a primary neurological disorder during the course of pregnancy or puerperium; and in patients with primary medical disorders presenting with neurological manifestations.

Objectives: The objectives of the study were to find out the magnitude of neurological disorders in pregnancy in a tertiary care hospital along with assessment of proportion of women with particular disorders among total number of neurological disorders during the course of pregnancy or puerperium (6 weeks after child birth) and also to elicit the effect of neurological disorders on pregnancy outcome, if any.

Methods: A prospective observational longitudinal study was carried out in a tertiary care centre of Eastern India from July 2018 to June 2020 including all pregnant women attending the department of Obstetrics and Gynaecology. Read More

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A Clinical Profile of Patients with Hyperuricemia and the Relationship between Hyperuricemia and Metabolic Syndrome: A Cross-sectional Study at a Tertiary Hospital in the Indian Population.

J Assoc Physicians India 2022 05;70(5):11-12

Assistant Professor, Department of General Medicine, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra.

Introduction: Metabolic syndrome is a constellation of interrelated risk factors that increase the risk of cardiovascular diseases (CVD) and diabetes mellitus. The increase in prevalence of hyperuricemia was considered to be directly related to increasing incidence of obesity and Metabolic Syndrome in developing and developed countries. Hyperuricemia is defined as serum uric acid of 6. Read More

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Indian Reality of Clinical Practice and Patient Profile in Diabetes Care: Lessons from the IMPACT survey.

J Assoc Physicians India 2022 May;70(5):11-12

Dr. Mohan's Diabetes Specialities Centre, Chennai, Tamil Nadu.

India shoulders a heavy burden of diabetes mellitus (DM), the management of which is suboptimal globally.& Objectives: Insulin Management: Practical Aspects in Choice of Therapy (IMPACT) survey was designed to gain insight into the ground (in-clinic) reality of DM management by physicians in India.

Methods: A survey consisting of 12 multiple-choice questions was conducted by SurveyMonkey® , focusing on practice profile, patient profile, and other aspects of DM management. Read More

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Assessment of Fluid Responsiveness by Changes in End Tidal Carbon Dioxide During Passive Leg Raising Test and Fluid Challenge.

J Assoc Physicians India 2022 May;70(5):11-12

Senior Resident, Department of Medicine, TN Medical College & BYL Nair Ch Hospital, Mumbai, Maharashtra.

Purpose: It is rationale to predict fluid responsiveness for optimum hemodynamic management. Passive Leg Raising (PLR) causes reversible increase in cardiac output (CO) and changes in end-tidal CO2& pressure (ETCO2 ) can be considered surrogate for CO variations. We aimed to assess the variations in EtCO2 with PLR and fluid challenge (FC) and also compared it with systolic arterial pressure (SAP), mean arterial pressure (MAP), heart rate (HR) and central venous pressure (CVP). Read More

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Retino-Renal Dissociation in Type 2 Diabetes Mellitus: An Observational Cross Sectional Study at a Tertiary Care Center of Sub-Himalayan Region.

J Assoc Physicians India 2022 May;70(5):11-12

Professor Rtd., Indira Gandhi Medical College, Shimla, Himachal Pradesh.

Introduction: Diabetic retinopathy, the diabetes-specific long-term microvascular complication is an important predictor of diabetic nephropathy. Diabetes induced retinopathy mostly proceeds nephropathy in patients with Type1 diabetes; however, this sequence is not consistent in patients with Type 2 diabetes and has significant discordance.

Methods: It was a hospital-based prospective, observational study conducted at Indira Gandhi Medical College, Shimla Himachal Pradesh a tertiary care center in the sub-Himalayan region of India from July 2016 to June 2017. Read More

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Mannose Binding Lectin Levels and its Association with Systemic Lupus Erythematosus Disease Severity: An Indian Report.

J Assoc Physicians India 2022 May;70(5):11-12

Department of Clinical & Experimental Immunology, National Institute of Immunohaematology, Indian Council of Medical Research, King Edward Memorial Hospital, Mumbai, Maharashtra Corresponding Author.

Background: Dysregulated serum levels of Mannan binding lectin (MBL) has a probable role in Systemic Lupus Erythematosus (SLE) pathogenesis.

Objective: To evaluate the association between serum MBL levels in SLE patients from western India with the severity of disease Methods: SLE patients (n=70) from Western India were included. Based on MBL levels, patients were classified into four categories, viz. Read More

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Circulatory Cytokine Levels as a Predictor of Disease Severity in COVID-19: A Study from Western India.

J Assoc Physicians India 2022 May;70(5):11-12

Assistant Professor, Department of General Medicine, SMS Medical College and Hospital, Jaipur, Rajasthan.

Inflammatory response in COVID-19 responsible for acute respiratory distress syndrome (ARDS) and multiorgan failure and play a major role in morbidity and mortality of patients. The present study was undertaken to assess serum level of cytokines and its association with other inflammatory markers and disease severity in COVID-19 and hence their prognostic significance.

Methods: This was a retrospective observational study of 175 admitted COVID-19 patients. Read More

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Neuroborreliosis in India - A Diagnostic Challenge and a Great Mimicker: A Case Series.

J Assoc Physicians India 2022 May;70(5):11-12

Consultant Neurologist, Manipal Hospitals, Goa.

Objectives: Neuroborreliosis is generally known to be a disease confined to the Western part of the globe. It is not commonly encountered in this part of the world. Interestingly, we recently came across a series of cases of Lyme's disease with a plethora of neurological presentations. Read More

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Evaluation of Teneligliptin a DPP4 Inhibitor in Terms of Efficacy and Safety with Respect to QT/QTc Prolongation in Patients with Type II Diabetes Mellitus (T2DM).

J Assoc Physicians India 2022 May;70(5):11-12

Tutor, Department of Pharmacology, MGM Medical College, Aurangabad, Maharashtra.

Introduction: Low risk of hypoglycemia and weight neutrality have increased the administration of dipeptidyl peptidase 4 (DPP-4) inhibitors in patients with T2DM in clinical practice. Currently Teneligliptin is prescribed as a second or third add on to the standard treatment with other classes of oral hypoglycemic agents (OHAs) to achieve targeted glycemic control in type 2 DM patients.

Methods: An open label, interventional, single arm, 12 weeks study was conducted on160 patients with type 2 DM at MGM Medical College, Aurangabad with Teneligliptin 20 mg once a day as add on to the ongoing standard treatment with other classes of OHAs. Read More

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Physicians' Knowledge, Attitudes, Practices and Perceived Needs Regarding Specialised Geriatric Healthcare: A Nation-wide Survey in India.

J Assoc Physicians India 2022 May;70(5):11-12

Fourth Year Undergraduate Student, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra.

Background& : The geriatric population in India is projected to increase from 8% to a staggering 20% by 2050. The combination of a population boom along with advances in medicine resulting has resulted in an increase in life span, leaving India with a potential geriatric healthcare crisis in its hands leaves India with a potential geriatric healthcare crisis in its hands. India currently produces as few as 20 geriatricians per year due to limited PG seats and has only a handful of fully functioning Geriatric Departments in the public healthcare sector. Read More

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