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Dairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status: a pooled analysis of 21 cohort studies.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Background: Epidemiologic studies examining the relations between dairy product and calcium intakes and breast cancer have been inconclusive, especially for tumor subtypes.

Objective: To evaluate the associations between intakes of specific dairy products and calcium and risk of breast cancer overall and for subtypes defined by estrogen receptor (ER) status.

Method: We pooled the individual-level data of over 1 million women who were followed for a maximum of 8-20 years across studies. Read More

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Post-diagnostic reliance on plant-compared with animal-based foods and all-cause mortality in omnivorous long-term colorectal cancer survivors.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Institute of Epidemiology, University Hospital Schleswig-Holstein, University of Kiel, Kiel, Germany.

Background: Plant-rich diets are associated with lower cardiometabolic risks and longer survival in the general population, but their association with mortality in cancer survivors is still unclear.

Objectives: We aimed to examine the associations of 3 postdiagnostic plant-based diet indices with all-cause mortality in omnivorous long-term colorectal cancer (CRC) survivors.

Methods: Diet was assessed with FFQs at a median of 6 years after diagnosis in 1404 CRC survivors (56% male; median age, 69 years) in a Northern German prospective cohort study. Read More

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Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.

Background: Elevated plasma homocysteine has been found to be associated with an increased risk of osteoporosis, especially hip and vertebral fractures. The plasma concentration of homocysteine is dependent on the activities of several B vitamin-dependent enzymes, such as methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and cystathionine β-synthase (CBS).

Objectives: We investigated whether genetic variants in some of the genes involved in 1 carbon metabolism modify the association of B vitamin-related measures with bone mineral density (BMD) and strength. Read More

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The associations between individual plasma SFAs, serine palmitoyl-transferase long-chain base subunit 3 gene rs680379 polymorphism, and type 2 diabetes among Chinese adults.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Several individual studies have shown that circulating levels of odd-chain SFAs and very-long-chain SFAs (VLSFAs) may have beneficial effects, but the results are mixed. While the dietary and metabolic factors that may influence VLSFAs are not well-known, a previous study observed associations of VLSFA concentrations with variants in serine palmitoyl-transferase long-chain base subunit 3 (SPTLC3) gene.

Objectives: We investigated the associations of individual plasma SFAs and SPTLC3 gene rs680379 polymorphism with metabolic risk factors and type 2 diabetes (T2D). Read More

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Metabolic risk factors, genetic predisposition, and risk of severe liver disease in Chinese: a prospective study of 0.5 million people.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.

Background: Metabolic risk factors have been shown to be associated with severe liver disease (SLD) in Chinese populations. However, there is limited evidence on the combined impact of these factors, or the genetic variants associated with SLD.

Objectives: We examined the associations of combined metabolic risk factors with risks of SLD, both overall and by genetic predisposition to SLD. Read More

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[CHEMICAL COMPONENTS FROM STEMS ASTRAGALUS FALCATUS, GROWING IN GEORGIA].

Georgian Med News 2021 Mar(312):180-183

Tbilisi State Medical University, I. Kutateladze Institute of Pharmacochemistry, Georgia.

Astragalus falcatus is the source of medicinal remedy Flaroninum, also other biologically active substances. Eight compounds were isolated and identified from the of stems : calycosin-7-O- β -D - glucoside, isoquercitrin (quercetin-3-O - β -D- glucoside), astragalin (kaempferol-3-O - β -D- glicoside), robinin (kaempferol-3- O- β -D- robinobiosyl, 7- O- a-L-rhamnoside), β - sitosterin, p-hydroxibenzoic acid, sulfuretin and isoliquiritigenin. These compounds were described for the first time from the stems of Astragalus falcatus. Read More

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[LEGAL ASPECTS OF THE ORGANIZATION OF MEDICAL PROVISION OF POLICE OFFICERS IN THE REPUBLIC OF ARMENIA].

Authors:
G Adamyan

Georgian Med News 2021 Mar(312):168-172

Police Medical Department, Polyclinic, Yerevan, Republic of Armenia.

The medical support of the Police officers is a complex and multifaceted process, which has two components: the health and medical and legal aspects themselves. We covered the health and medical aspects of the medical care of the RA Police officers in different issues of the "Georgian Medical News" for 2019-2020. The problems of its legal aspects are not fully presented. Read More

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UKRAINE'S INTERNATIONAL LIABILITIES ON INITIATION OF MEASURES FOR PUBLIC HEALTH PROTECTION AND THE ROLE OF LOCAL AUTHORITIES IN IMPLEMENTATION OF HEALTH CARE POLICY.

Georgian Med News 2021 Mar(312):163-168

4Lviv University of Trade and Economics, Ukraine.

The article examines the international obligations of Ukraine to implement measures to protect public health and the role of local governments in implementation of health policy. Emphasis is placed on Ukraine's implementation of the Sustainable Development Goals being a member of the UN, the Association Agreement between Ukraine and the EU, and the commitment to develop cooperation in the field of health care undertaken by Ukraine, radical health care reform and decentralization reform in Ukraine. The purpose of the article is to determine the role of local governments in implementation of health policy in the context of decentralization reform and the second stage of health care reform in Ukraine, to identify shortcomings in Ukrainian legislation and the practice that lead to violations of regional communities residents' rights for health care and medical aid, as well as violations of the rights of medical personnel for labor. Read More

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[STATE PROCUREMENTS: STUDYING THE IMPLEMENTATION OF NATIONAL POLICIES IN TERMS OF PANDEMIC COVID-19].

Georgian Med News 2021 Mar(312):157-163

3Donetsk Law Institute of the Ministry of Internal Affairs of Ukraine, Kryvyi Rih, Ukraine.

This article aims to analyse the implementation of public procurement procedures in the context of national governments' fight against the COVID-19 pandemic and find solutions for adapting those public procurement procedures that are currently used in the healthcare sector to new challenges. For this above purpose, we have applied both theoretical methods such as analysis, synthesis, generalization, and empirical methods such as observation, etc. The research has yielded the following findings: 1) there are no one-size-fits-all solutions in the national governments' fight against the COVID-19 pandemic through the public procurement mechanism, except that national policies in this field intend to speed up the organisation of the public procurement procedures, which would shorten the time for the delivery of medical goods to healthcare facilities; 2) due to the current emergency conditions caused by the COVID-19 pandemic, public procurements of medical supplies are taking place under the non-competitive procedure, i. Read More

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[DEVELOPMENT OF FORMULATIONS FOR THE PRODUCTION OF MEDICINAL - COMETIC PREPARATIONS USING PLANT, MINERAL AND ANIMAL RESOURCES OF GEORGIA].

Georgian Med News 2021 Mar(312):150-156

Tbilisi State Medical University, Institute of Pharmacochemistry I. Kutateladze, Georgia.

The purpose of the study was to develop cosmetic products using the natural resources of Georgia As components, the therapeutic mud of Akhtala, bentonite clay, perlite, liver oil of the sea cartilaginous fish katran, habitat of coastal waters were used. From the Black Sea, oils and extracts from plants in large numbers growing in Georgia. When studying the physicochemical characteristics of the products obtained and their compliance with standards, tests according to GOST 31460-2012 were used. Read More

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COUMARINS FROM DAPHNE AXILLIFLORA (KEISSL.) POBED. AND THE ANATOMICAL CHARACTERISTICS OF ITS LEAVES AND STEMS.

Georgian Med News 2021 Mar(312):145-149

1Tbilisi State Medical University, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi, Georgia; 2Laboratoire LASEVE, Université du Québec à Chicoutimi, Département des Sciences Fondamentales, Chicoutimi, Québec, Canada.

The aim of the study was to determine the stable diagnostic traits of a Caucasian endemic plant Daphne axilliflora (Keissl.) Pobed. and study its phytochemical composition. Read More

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HEPATOPROTECTIVE EFFICIENCY OF G10 SUBSTANCE FROM ZHUZGUN PLANT IN EXPERIMENTAL TOXIC HEPATITIS.

Georgian Med News 2021 Mar(312):138-145

NJCC"Astana Medical University", Department of General Pharmacology, Nur-Sultan, Kazakhstan.

The article presents the results of biochemical studies of blood and morphological characteristics of liver changes in laboratory animals (rats) under experimental conditions of paracetamol hepatitis and intragastric administration of a new substance G10 from the «Zhuzgun» plant in various doses. The obtained data open up prospects for further studies of the pharmacological properties of the substance G10, the possibility of including it as a phytotherapeutic agent in the complex of preventive and therapeutic measures for acute toxic hepatitis. The study of the hepatoprotective properties was conducted in the "Educational and Research Pharmacological Laboratory" of the Department of General Pharmacology of the Astana Medical University. Read More

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FORMULATION THERMORESPONSIVE NANOCOMPOSITE HYDROGELWITH EMBEDDED PLGA NANOPARTICLES CONTAINING CYTOTOXIC AGENT.

Georgian Med News 2021 Mar(312):133-138

Tbilisi State Medical University, Faculty of Pharmacy, 1Department of Pharmaceutical Technology; Georgia.

The aim of the study was to develop and characterize the nanocomposite in-situ hydrogel as local drug delivery system of cytotoxic agent. In-situ hydrogel consisting of 15% thermosensitive (Poloxamer 407) and 1% mucoadhesive (sodium alginate) polymers was selected as the optimal formulation by the conducted studies. The influence of nanoparticle concentration on gelation time and temperature has been experimentally established. Read More

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ANTIHYPERTENSIVE AND CARDIOPROTECTIVE EFFECTS OF EPOXYEICOSATRIENOIC ACID ANALOGS AND SOLUBLE EPOXIDE HYDROLASE INHIBITORS (REVIEW).

Georgian Med News 2021 Mar(312):125-132

Tbilisi State Medical University, Departments of Pharmaceutical Technology and Medical Pharmacology, Georgia.

In the present article is considered antihypertensive and cardioprotective action of epoxieicosatrienoic acids (EETs) analogues and soluble epoxide hydrolase (sEH) inhibitors. Being epoxygenase products of arachidonic acid metabolism EETs provide a wide spectrum of biological activity in different organs implicated in the regulation of arterial pressure, including vascular endothelium (VE), heart and kidney. EETs are acting as autocrine or paracrine agents producing vasodilation, reduction in salt and fluid retention. Read More

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HISTOPATHOLOGICAL, PROLIFERATIVE, APOPTOTIC AND HORMONAL CHARACTERISTICS OF VARIOUS TYPES OF LEIOMYOMAS.

Georgian Med News 2021 Mar(312):119-125

Tbilisi State Medical University, Georgia.

Uterine leiomyomas decrease the quality of life by causing significant morbidity among women of reproductive age. Histologically various types of leiomyoma's can be differentiated. We have analysed the histopathological, proliferation, apoptotic and hormonal profile in different types of leiomyomas. Read More

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UROGENITAL MIXED INFECTIONS IN REPRODUCTIVE AGED WOMEN WITH PELVIC INFLAMMATORY DISEASE.

Georgian Med News 2021 Mar(312):114-118

1Asfendiyarov Kazakh National Medical University, Department of Obstetrics and Gynecology, Almaty, Kazakhstan.

The purpose of our study was to determine the prevalence of urogenital mixed infections and the sensitivity of mycoplasmas and ureaplasmas to antibiotics in reproductive aged women with pelvic inflammatory disease. 4720 samples of biomaterial were obtained by urethral and cervical canal scrapings in 2360 women of reproductive age with pelvic inflammatory disease (2 samples from each woman). In 2360 samples, Chlamydia trachomatis, Trichomonas vaginalis and Gardnerella vaginalis were determined by multiplex PCR. Read More

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MORPHOMETRIC ASSESSMENT OF STRUCTURAL CHANGES IN THE VASCULAR BED OF DUODENUM IN ANIMALS WITH OBSTRUCTIVE CHOLESTASIS.

Georgian Med News 2021 Mar(312):105-113

I. Horbachevsky Ternopil National Medical University, Ukraine.

Aim of the research - comprehensive morphometric assessment of the structural and spatial organization of the circulatory system of the duodenum in obstructive cholestasis in intact animals. Three days after the simulated obstructive cholestasis in 3 experimental animals, on examination of radiographs there is a tendency to reorient the arterial and venous bed of the duodenum. Analysis of morphometric parameters also showed a tendency to constriction of arteries and varicose veins. Read More

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DISTRIBUTION OF STEM CELLS IN DIFFERENT THYROID LESIONS IN PATIENTS OF REPRODUCTIVE, MENOPAUSAL AND POST-MENOPAUSAL AGE.

Georgian Med News 2021 Mar(312):92-99

Tbilisi State Medical University.

Different studies indicate that cancer stem cells (CSCs) play an important role in the progression and therapy resistance in different cancer types. The aim of our study was to analyse the distribution of CSCs in different thyroid lesions, in reproductive, menopausal and post-menopausal women. Study included altogether 200 formalin-fixed and paraffin-embedded tissue material, with the diagnosis of NIFTP, Hashimoto's thyroiditis, papillary thyroid carcinoma (PTC) and PTC and Hashimoto's thyroiditis co-occurred cases. Read More

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INFLAMMATION IN CHILDHOOD EPILEPSY SYNDROMES.

Georgian Med News 2021 Mar(312):88-92

Tbilisi State Medical University, Department of Paediatric Neurology, Georgia.

Epilepsy is one of the most common neurological disorder affecting up to 1% of the world population. It is a heterogeneous disorder and includes genetic, structural, metabolic causes, sometimes reason is unknown. In recent 20 years inflammation has been considered as a possible etiologic factor in angiogenesis and epileptogenesis in experimental models but there is still lack of evidence if inflammation could be seen in clinical cases of children with different forms of epilepsy. Read More

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[MODERN ISSUES OF KALCIPHEROL INFLUENCE ON CHILDREN AND ADULTS' HEALTH (REVIEW)].

Georgian Med News 2021 Mar(312):82-87

Tbilisi State Medical University, Department of Peadiatric Neurology; Iashvili Children's Central Hospital, Tbilisi, Georgia.

The purpose of this review is study of literature for the development of biological effect of Kalcipherol (D vitamin group) on children population. Different factors seem, that D- vitamin deficiency disbalance elevated, children specifically negative effect, which have a major impact on health, growth and development of infants, children and adolescents. Vitamin D and calcium deficiencies are preventable global public health problems in pediatric medicine. Read More

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COMORBIDITY OF TYPE 1 DIABETES MELLITUS WITH OTHER CHRONIC PATHOLOGY IN CHILDREN.

Georgian Med News 2021 Mar(312):78-82

1V. Karazin Kharkiv National University, School of Medicine; 2SI "Institute of Health of Children and Adolescents of the National Academy of Medical Sciences of Ukraine", Kharkiv, Ukraine.

In this study was to investigate the сoexistence of diabetes mellitus type 1 with other chronic pathology in children and adolescents and their impact on the course of diabetes mellitus type 1 (DM1). The 88 children from 3 to 17 years who had DM1 were observed. The study was conducted by survey with the aim of finding risk factors and associated comorbidties with a questionnaire-based, objective-subjective study. Read More

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SOME FEATURES OF THE CLINICAL COURSE OF LICHEN PLANUS IN THE ORAL MUCOSA. A CLINICAL CASE OF GRINSHPAN-POTEKAEV SYNDROME.

Georgian Med News 2021 Mar(312):71-74

Tbilisi State Medical University, department of dermatology and venerology, Georgia.

The clinical picture and course of lichen planus (LP) on the mucous membrane of the oral cavity have significant differences from its manifestations on the skin. In particular, greater resistance to treatment, which is due to the structural features of the mucous membrane, as well as the specificity of biological and physicochemical processes in the oral cavity. There are 6 clinical forms of LP of the red border of the lips and oral mucosa - typical, hyperkeratotic, exudative-hyperemic, erosive - ulcerative, bullous and atypical. Read More

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INFLUENCE OF URSODEOXYCHOLIC ACID ON THE CHOLECYSTOKININ LEVELS IN PATIENTS WITH GASTRO-ESOPHAGEAL REFLUX DISEASE AND TYPE 2 DIABETES MELLITUS.

Georgian Med News 2021 Mar(312):67-71

State Higher Educational Institution «Uzhhorod National University», Medical Faculty, Ukraine.

Of particular interest is the study of the peculiarities of clinical findings and diagnostics of gastroesophageal reflux disease (GERD) in patients with diabetes mellitus (DM). The aim of the research - to study the dynamics of cholecystokinin (CCK) level on the background of complex therapy using the ursodeoxycholic acid (UDCA) drug in patients with GERD with type 2 DM. 68 patients with combination of type 2 DM and GERD were examined. Read More

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[INFLUENCE OF COMBINED ERADICATION AND PROKINETIC THERAPY ON CLINICAL MANIFESTATIONS, PSYCHOLOGICAL STATUS AND QUALITY OF LIFE OF PATIENTS WITH FUNCTIONAL DYSPEPSIA - POSTPRANDIAL DISTRESS SYNDROME: RANDOMIZED PROSPECTIVE STUDY].

Georgian Med News 2021 Mar(312):61-67

1Bogomolets National Medical University, Kyiv; Ukraine.

Functional dyspepsia - postprandial distress-syndrome (FD-PDS) is one of the most common reasons for seeking medical attention of general practitioners, internists and gastroenterologists worldwide. Standard approaches to the treatment of patients with postprandial distress syndrome are only effective in small amount of cases. Aim of the study - comparative assessment of the effectiveness of combined eradication and prokinetic therapy and eradication therapy only in the treatment of FD-PDS by studying their effect on the clinical manifestations of the disease, patients' psychological status and quality of life. Read More

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CLINICAL, PHARMACOTHERAPEUTIC AND BIORHYTHMOLOGICAL PECULIARITIES OF DEPRESSIVE DISORDERS, COMORBID WITH CARDIOVASCULAR PATHOLOGY.

Georgian Med News 2021 Mar(312):57-61

2Communal Еnterprise «Regional Institution for Providing Psychiatric Care of Poltava Regional Council», Ukraine.

The spread of depressive disorders is extra high nowadays. Depressive disorders are widespread mental disorders in the structure of mental pathology, both causes of psychiatrists' visit, and causes of medical aid. The presence of depressive syndrome in patients with cardiovascular system leads to deterioration patient's condition and adaptive abilities and aggravates somatic abnormality. Read More

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CLINICAL AND GENETIC FACTORS OF CARDIOVASCULAR EVENTS DEVELOPMENT AFTER PERCUTANEOUS CORONARY INTERVENTION.

Georgian Med News 2021 Mar(312):52-56

NJSC "Medical University of Karaganda", Kazakhstan.

The new cardiovascular events development remains the main factors limiting its long-term effectiveness despite technological progress and the widespread use of percutaneous coronary intervention (PCI). Objective - to assess the effect of clinical and genetic factors on the development of complication after percutaneous coronary intervention with double antiplatelet therapy (DAT). Case-control. Read More

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[REMODELING OF THE LEFT VENTRICLE, SUBCLINICAL MANIFESTATIONS OF ATHEROSCLEROSIS IN PATIENTS WITH HYPERTONIC DISEASE WITH RHEUMATOID ARTHRITIS BY THE INFLUENCE OF DIFFERENT TREATMENT SCHEMES].

Authors:
Y Ivashchuk

Georgian Med News 2021 Mar(312):46-52

State Institution "Zaporozhye Medical Academy of Postgraduate Education" of the Ministry of Health of Ukraine.

Objective - to determine the features of the daily profile of blood pressure (BP), blood lipid spectrum, features of left ventricular remodeling in patients with hypertension in combination with RA and to evaluate the effectiveness of using medium doses of rosuvastatin to correct dyslipidemia in this group of patients. 70 patients aged 40-65 years were examined (average - M±m - 54.88±0. Read More

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ADIPOCYTOKINES LEPTIN AND ADIPONEСTIN AS PREDICTORS OF GENERALIZED PERIODONTITIS ASSOCIATED WITH OBESITY.

Georgian Med News 2021 Mar(312):42-46

Bogomolets National Medical University, Institute of Postgraduate Education, Department of Dentistry, Kyiv, Ukraine.

In recent years, according to the WHO, more than 1,9 billion people over the age of 18 are overweight, of whom more than 650 million are obese, with an annual trend. Studies in recent decades have shown that obese young people with generalized periodontitis have abnormalities in protein, fat and carbohydrate metabolism, which contributes to the early destruction of the periodontal tissue complex and rapid tooth loss. The aim of our study was to examine changes in serum leptin and adiponectin in patients with generalized periodontitis on the background of obesity. Read More

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[TELOMERASE ACTIVITY AS A POTENTIAL BIOMARKER FOR PREOPERATIVE DIFFERENTIAL DIAGNOSIS OF CYSTIC NEOPLASMS OF THE LIVER].

Georgian Med News 2021 Mar(312):31-36

I.M. Sechenov First State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation.

The goal of the study was to find ways to improve the quality of preoperative diagnosis of mucinous cystic liver neoplasms using such tumor markers as CA 19-9 and telomerase activity. We conducted a retrospective analysis and a prospective study that included the results of treatment of 80 patients with cystic neoplasm of the liver (31 with MCNL, 36 with multichamber non-parasitic cysts (NPC), 13 with stage II (WHO classification) echinococcus liver cysts. Our study showed the presence of telomerase activity in 29 (93. Read More

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