7,674 results match your criteria mediates association

Adoptees facing adolescence: What accounts for their psychological well-being?

J Adolesc 2021 Apr 7;89:10-17. Epub 2021 Apr 7.

Universidad de Seville, Spain.

Introduction: In accordance with the "resilience paradigm", this study was aimed at exploring the role of the parent-child relationship in supporting internationally adopted adolescents' ability to develop a strong adoptive identity and a feeling of satisfaction with their own life.

Methods: Participants were 105 Italian adopted adolescents (13-17 years) asked to complete a self-report questionnaire.

Results: Results showed that adolescents generally feel fairly comfortable discussing adoption-related issues (especially with their mothers), have a medium-high level of adoptive identity, and appear to be quite satisfied with their life. Read More

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Differential Association of Spirituality and Religiosity With Rumination: Implications for the Treatment of Depression.

J Nerv Ment Dis 2021 May;209(5):370-377

Division of Translational Epidemiology, New York State Psychiatric Institute.

Abstract: Recent studies have shown that religiosity (R) is associated with lower rates of depression, whereas spirituality (S) is associated with higher rates. Rumination has also been associated with higher rates of depression. Some have hypothesized that rumination mediates the differential association of religiosity and spirituality with depression. Read More

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Trait Self-Control Mediates the Association Between Resting-State Neural Correlates and Emotional Well-Being in Late Adolescence.

Soc Cogn Affect Neurosci 2021 Apr 9. Epub 2021 Apr 9.

Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, 400715, China.

Trait self-control (TSC), defined as the capacity to alter predominant response to promote desirable long-term goals, has been found to facilitate emotional well-being (EWB). However, the neural correlates underlying this association remain unclear. The present study estimated resting-state brain activity and connectivity with amplitude of low-frequency fluctuations (ALFF) and functional connectivity (rsFC) among late adolescents. Read More

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Meaning in Life Mediates Between Emotional Deregulation and Eating Disorders Psychopathology: A Research From the Meaning-Making Model of Eating Disorders.

Front Psychol 2021 23;12:635742. Epub 2021 Mar 23.

Personality, Assessment and Treatments, Catholic University of Valencia San Vicente Martyr, Valencia, Spain.

Emotional dysregulation, age, gender, and obesity are transdiagnostic risk factors for the development and maintenance of eating disorders (EDs). Previous studies found that patients with ED had less meaning in life than the non-clinical population, and that meaning in life acted as a buffer in the course of ED; however, to the data, there are no studies about the mediator role of meaning in life in association between the emotional dysregulation and the ED psychopathology. To analyze the mediating role of meaning in life in the relationship between emotional dysregulation and the ED psychopathology in three samples with diverse risk factors for ED. Read More

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Perceived Physical Vulnerability Promotes Prosocial Behavior.

Pers Soc Psychol Bull 2021 Apr 8:1461672211005879. Epub 2021 Apr 8.

The Hebrew University of Jerusalem, Israel.

Our research examines the association between perceived physical vulnerability and prosocial behavior. Studies 1 to 4 establish a positive association between individuals' vulnerability and their prosociality. To increase generality, these studies looked at different behaviors (volunteering vs. Read More

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Child marriage, maternal serum metal exposure, and risk of preterm birth in rural Bangladesh: evidence from mediation analysis.

J Expo Sci Environ Epidemiol 2021 Apr 6. Epub 2021 Apr 6.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.

Background: The prevalence of preterm birth in Bangladesh is estimated to be 19.1%, the highest in the world. Although prenatal exposure to several metals has been linked with preterm birth, fewer prospective studies have investigated the socioeconomic factors that affect metal exposure, leading to preterm birth risk. Read More

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p53 mediates target gene association with nuclear speckles for amplified RNA expression.

Mol Cell 2021 Mar 29. Epub 2021 Mar 29.

Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

Nuclear speckles are prominent nuclear bodies that contain proteins and RNA involved in gene expression. Although links between nuclear speckles and gene activation are emerging, the mechanisms regulating association of genes with speckles are unclear. We find that speckle association of p53 target genes is driven by the p53 transcription factor. Read More

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Structure-Function Analysis of SMAX1 Reveals Domains That Mediate Its Karrikin-Induced Proteolysis and Interaction with the Receptor KAI2.

Plant Cell 2020 Aug;32(8):2639-2659

Department of Botany and Plant Sciences, University of California, Riverside, California 92521.

Karrikins (KARs) are butenolides found in smoke that can influence germination and seedling development of many plants. The KAR signaling mechanism is hypothesized to be very similar to that of the plant hormone strigolactone (SL). Both pathways require the F-box protein MORE AXILLARY GROWTH2 (MAX2), and other core signaling components have shared ancestry. Read More

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Thalamic volume mediates associations between cardiorespiratory fitness (VOmax) and cognition in Parkinson's disease.

Parkinsonism Relat Disord 2021 Mar 29;86:19-26. Epub 2021 Mar 29.

Department of Neurology, University of Southern California, 1520 San Pablo St., HCC-2, Suite 3000, Los Angeles, CA, 90033, USA.

Introduction: Cognitive deficits occur in Parkinson's disease (PD). Cardiorespiratory fitness (CRF) is associated with better cognitive performance in aging especially in executive function (EF) and memory. The association between CRF and cognitive performance is understudied in people with PD. Read More

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Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound.

J Allergy Clin Immunol 2021 Apr 2. Epub 2021 Apr 2.

Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. Electronic address:

Background: IL-31 is a major pruritogen associated with atopic dermatitis (AD). Although a specific antibody for IL-31 receptor has been shown to alleviate pruritus in patients with AD, therapeutic approaches to inhibit IL-31 production remain unexploited. IL-31 production by helper T cells critically depends on the transcription factor EPAS1, which mediates IL31 promoter activation in collaboration with SP1. Read More

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Hyperglycemia-Induced miR-467 Drives Tumor Inflammation and Growth in Breast Cancer.

Cancers (Basel) 2021 Mar 16;13(6). Epub 2021 Mar 16.

Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, 9500 Euclid Avenue NB50, Cleveland, OH 44195, USA.

The tumor microenvironment contains the parenchyma, blood vessels, and infiltrating immune cells, including tumor-associated macrophages (TAMs). TAMs affect the developing tumor and drive cancer inflammation. We used mouse models of hyperglycemia and cancer and specimens from hyperglycemic breast cancer (BC) patients to demonstrate that miR-467 mediates the effects of high blood glucose on cancer inflammation and growth. Read More

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Meaning in Life Mediates the Association between Environmental Engagement and Loneliness.

Int J Environ Res Public Health 2021 Mar 12;18(6). Epub 2021 Mar 12.

Department of Psychology, Wilfrid Laurier University, Waterloo, ON N2L 3C5, Canada.

Although the positive outcomes of human-environment interactions have been established, research examining the motivation between engagement in pro-environmental activities and psychological well-being is limited. In this mixed-methods study, the relationship between pro-environmental engagement, meaning in life, and well-being, including loneliness and depression, were investigated in a sample of 112 young adults in Canada. It was found that engaging in pro-environmental activities was negatively associated with loneliness. Read More

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Annexin A2 Flop-Out Mediates the Non-Vesicular Release of DAMPs/Alarmins from C6 Glioma Cells Induced by Serum-Free Conditions.

Cells 2021 Mar 5;10(3). Epub 2021 Mar 5.

Pharmacology and Therapeutic Innovation, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan.

Prothymosin alpha (ProTα) and S100A13 are released from C6 glioma cells under serum-free conditions via membrane tethering mediated by Ca-dependent interactions between S100A13 and p40 synaptotagmin-1 (Syt-1), which is further associated with plasma membrane syntaxin-1 (Stx-1). The present study revealed that S100A13 interacted with annexin A2 (ANXA2) and this interaction was enhanced by Ca and p40 Syt-1. Amlexanox (Amx) inhibited the association between S100A13 and ANXA2 in C6 glioma cells cultured under serum-free conditions in the in situ proximity ligation assay. Read More

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The Loneliness-Life Satisfaction Relationship: The Parallel and Serial Mediating Role of Hopelessness, Depression and Ego-Resilience among Young Adults in South Africa during COVID-19.

Int J Environ Res Public Health 2021 03 31;18(7). Epub 2021 Mar 31.

Department of Psychology, University of the Western Cape, Cape Town 7535, South Africa.

Recently, with the onset of the COVID-19 pandemic, several lockdown and stay-at-home regulations have been implemented worldwide. In this regard, loneliness has been identified as the signature mental health consequence of this pandemic. The aim of this study is to explore the associations among loneliness, hopelessness, depression, ego-resilience and life satisfaction in a random sample of young adults ( = 337) at a university in the Western Cape of South Africa. Read More

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Pain Sensitivity, Negative Affect, and Alcohol Use Disorder Status: A Moderated Mediation Study of Emotion Dysregulation.

J Clin Med 2021 Mar 23;10(6). Epub 2021 Mar 23.

Department of Psychiatry, Medical University of Warsaw, 00-665 Warsaw, Poland.

Previous work suggests that the association between pain and emotional processes among individuals with alcohol use disorder (AUD) may differ from healthy controls. This study investigates whether pain sensitivity mediates the association between negative affect and emotional dysregulation and whether this association differs across AUD status using moderated mediation. The sample included 165 individuals diagnosed with AUD and 110 healthy controls. Read More

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Copper-Associated Oxidative Stress Contributes to Cellular Inflammatory Responses in Cystic Fibrosis.

Biomedicines 2021 Mar 24;9(4). Epub 2021 Mar 24.

Institut National de la Santé et de la Recherche Médicale U1292, Biologie et Biotechnologie Pour la Santé, 38000 Grenoble, France.

Cystic fibrosis (CF) is caused by mutations in the gene encoding the CF Transmembrane Conductance Regulator (CFTR), an apical chloride channel. An early inflammation (EI) in the lung of CF patients occurring in the absence of any bacterial infection has been reported. This EI has been proposed to be associated with oxidative stress (OX-S), generated by deregulations of the oxidant/antioxidant status. Read More

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NOX4 Mediates -Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium.

Antioxidants (Basel) 2021 Mar 17;10(3). Epub 2021 Mar 17.

Departments of Pharmacology & Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

() infection increases reactive oxygen species (ROS), and earlier, we have shown a role for NADPH oxidase-derived ROS in -mediated lung inflammation and injury. Here, we show a role for the lung epithelial cell (LEpC) NOX4 in -mediated chromatin remodeling and lung inflammation. Intratracheal administration of to Nox4 mice for 24 h caused lung inflammatory injury; however, epithelial cell-deleted Nox4 mice exhibited reduced lung inflammatory injury, oxidative stress, secretion of pro-inflammatory cytokines, and decreased histone acetylation. Read More

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Impact of HBV infection on the association between HOTAIR SNPs and the risk of hepatocellular carcinoma: A mediation and interaction analysis.

Neoplasma 2021 Mar 23;68(2):375-381. Epub 2020 Oct 23.

Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.

Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) rs12427129 and rs3816153 in HOX transcript antisense intergenic RNA (HOTAIR) might interact with hepatitis B virus (HBV) infection to increase the risk of hepatocellular carcinoma (HCC). However, it is unclear whether HBV infection is a potential mediator between HOTAIR rs12427129, rs3816153, and HCC. This study, including 1262 HCC cases and 1559 controls, aimed to use a four-way decomposition method to quantify the interaction and mediation effects of HBV infection in the association between rs12427129, rs3816153, and HCC. Read More

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Personality and Insomnia Symptoms in Older Adults: The Baltimore Longitudinal Study of Aging.

Sleep 2021 Apr 1. Epub 2021 Apr 1.

Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Study Objective: To examine associations of personality dimensions and facets with insomnia symptoms in a community sample of older adults.

Methods: We studied 1,049 participants aged 60-97 years in the Baltimore Longitudinal Study of Aging. Personality was assessed by the Revised NEO Personality Inventory (NEO-PI-R), and insomnia symptom severity was measured by the Women's Health Initiative Insomnia Rating Scale (WHIIRS). Read More

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Lipid binding by the N-terminal motif mediates plasma membrane localization of Bordetella effector protein BteA.

J Biol Chem 2021 Mar 28:100607. Epub 2021 Mar 28.

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address:

The respiratory pathogens Bordetella pertussis and Bordetella bronchiseptica employ a type III secretion system (T3SS) to inject a 69-kDa BteA effector protein into host cells. This effector is known to contain two functional domains, including an N-terminal lipid raft-targeting (LRT) domain, and a cytotoxic C-terminal domain that induces non-apoptotic and caspase-1-independent host cell death. However, the exact molecular mechanisms underlying the interaction of BteA with plasma membrane as well as its cytotoxic activity in the course of Bordetella infections remain poorly understood. Read More

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The Triglyceride-Glucose Index and Obesity-Related Risk of End-Stage Kidney Disease in Austrian Adults.

JAMA Netw Open 2021 Mar 1;4(3):e212612. Epub 2021 Mar 1.

Agency for Preventive and Social Medicine, Bregenz, Austria.

Importance: It is unknown whether the triglyceride-glucose (TyG) index as a measure of insulin resistance is associated with the risk of developing end-stage kidney disease (ESKD). Because individuals who are overweight or obese often develop insulin resistance, mediation of the association between body mass index (BMI) and ESKD risk through the TyG index seems plausible but has not been investigated.

Objective: To evaluate whether the TyG index is associated with ESKD risk and, if so, to what extent the TyG index mediates the association between BMI and ESKD. Read More

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Oxoglaucine mediates Ca influx and activates autophagy to alleviate osteoarthritis through the TRPV5/Calmodulin/CAMK-II pathway.

Br J Pharmacol 2021 Mar 30. Epub 2021 Mar 30.

Center for Materials Synthetic Biology, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

Background And Purpose: Stimulation of calcium influx and suppression of autophagy play important roles in the pathogenesis of osteoarthritis (OA). In this study, we use a novel TRPV5 inhibitor - oxoglaucine to attenuate progression of deterioration and pathological changes on OA patient-derived chondrocytes and OA animal model by activating autophagy.

Experimental Approach: The inhibition by oxoglaucine on calcium channel was detected in vitro. Read More

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The Truncated Splice Variant of the Granulocyte-Macrophage-Colony-Stimulating Factor Receptor β- Chain in Peripheral Blood Serves as Severity Biomarker of Respiratory Failure in Newborns.

Neonatology 2021 Mar 30:1-7. Epub 2021 Mar 30.

Department of Pediatrics, Division of Neonatology, Klinikum rechts der Isar, Technical University of Munich School of Medicine, Munich, Germany.

Background: The granulocyte-macrophage-colony-stimulating factor (GM-CSF) plays an important role in surfactant homeostasis. βC is a subunit of the GM-CSF receptor (GM-CSF-R), and its activation mediates surfactant catabolism in the lung. βIT is a physiological, truncated isoform of βC and is known to act as physiological inhibitor of βC. Read More

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Multiple copies of a novel amphipathic α-helix forming segment in Physcomitrella patens dehydrin play a key role in abiotic stress mitigation.

J Biol Chem 2021 Mar 26:100596. Epub 2021 Mar 26.

Plant Functional Genomics Laboratory, Department of Botany, University of Calcutta, 35 Ballygunge Circular Road, Kolkata-700019, India. Electronic address:

Plants use a diverse set of proteins to mitigate various abiotic stresses. The intrinsically disordered protein dehydrin is an important member of this repertoire of proteins, characterized by a canonical amphipathic K-segment. It can also contain other stress-mitigating non-canonical segments - a likely reflection of the extremely diverse nature of abiotic stress encountered by plants. Read More

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Dysfunctional coping mediates the relationship between stress and mental health in health care staff working amid COVID-19 pandemic.

Med Princ Pract 2021 Mar 29. Epub 2021 Mar 29.

Objective: The cross-sectional study aimed to assess the stress outcomes in health care staff working during the Covid-19 pandemic and to explore the role of coping in the relationship between stress outcomes and mental health dimensions with Preacher & Hayes's mediation analysis.

Subjects And Methods: 170 participants including physicians (n=41; 24.1%), nurses (n=114, 67. Read More

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Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein.

Elife 2021 Mar 29;10. Epub 2021 Mar 29.

Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, United States.

The downregulation of sclerostin in osteocytes mediates bone formation in response to mechanical cues and parathyroid hormone (PTH). To date, the regulation of sclerostin has been attributed exclusively to the transcriptional downregulation of the gene hours after stimulation. Using mouse models and rodent cell lines, we describe the rapid, minute-scale post-translational degradation of sclerostin protein by the lysosome following mechanical load and PTH. Read More

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Novel AXL-targeted agents overcome FLT3 inhibitor resistance in FLT3-ITD acute myeloid leukemia cells.

Oncol Lett 2021 May 18;21(5):397. Epub 2021 Mar 18.

Department of Hematology, Chinese PLA Medical School, Beijing 100853, P.R. China.

AXL receptor tyrosine kinase (AXL) upregulation mediates drug resistance in several types of human cancer and has become a therapeutic target worthy of exploration. The present study investigated AXL antigen expression and the effects of novel AXL-targeted agents in acute myeloid leukemia (AML) cells. AXL antigen expression in drug-sensitive and drug-resistant human AML cell lines, and AML blast cells from 57 patients with different clinical characteristics, was analyzed by flow cytometry and compared. Read More

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Affective Benefits of Nature Contact: The Role of Rumination.

Front Psychol 2021 10;12:643866. Epub 2021 Mar 10.

Department of Psychology, Stanford University, Stanford, CA, United States.

Mounting evidence shows that nature contact is associated with affective benefits. However, the psychological mechanisms responsible for these effects are not well understood. In this study, we examined whether more time spent in nature was associated with higher levels of positive affect in general, and lower levels of negative affect and rumination in general. Read More

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MiR-93/HMGB3 regulatory axis exerts tumor suppressive effects in colorectal carcinoma cells.

Exp Mol Pathol 2021 Mar 24:104635. Epub 2021 Mar 24.

Center for Laboratory Medicine, the Affiliated Zhuzhou Hospital Xiangya Medical College CSU, Zhuzhou 412000, China. Electronic address:

Objective: MicroRNA (miR)-93 has been proven to mediate the initiation and progression of colorectal carcinoma (CRC); however, the mechanisms by which miR-93 mediates CRC development need deeper elucidation. The present study is designed to investigate the association between miR-93 and high mobility group box 3 (HMGB3), as well as the functions of miR-93, in CRC.

Methods: miR-93 expression was quantified by RT-qPCR. Read More

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How psychological inflexibility mediates the association between general feelings of shame with body image-related shame and eating psychopathology severity?

Appetite 2021 Mar 23;163:105228. Epub 2021 Mar 23.

Center for Research in Neuropsychology and Cognitive and Behavioral Intervention (CINEICC), Faculty of Psychology and Educational Sciences, University of Coimbra, Portugal.

Adolescence is considered a transitional stage characterized by several physical, psychological and social changes. During this period, there is an increased propensity for the emergence of emotional difficulties, especially those related to body image and eating attitudes and behaviours. In particular, shame has been pointed out as a key risk factor for body image and eating-related difficulties. Read More

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