112,280 results match your criteria mediates

Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2.

PLoS Pathog 2021 Apr 9;17(4):e1009501. Epub 2021 Apr 9.

Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates infection of cells expressing angiotensin-converting enzyme 2 (ACE2). ACE2 is also the viral receptor of SARS-CoV (SARS-CoV-1), a related coronavirus that emerged in 2002-2003. Horseshoe bats (genus Rhinolophus) are presumed to be the original reservoir of both viruses, and a SARS-like coronavirus, RaTG13, closely related to SARS-CoV-2, has been identified in one horseshoe-bat species. Read More

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Differential Association of Spirituality and Religiosity With Rumination: Implications for the Treatment of Depression.

J Nerv Ment Dis 2021 May;209(5):370-377

Division of Translational Epidemiology, New York State Psychiatric Institute.

Abstract: Recent studies have shown that religiosity (R) is associated with lower rates of depression, whereas spirituality (S) is associated with higher rates. Rumination has also been associated with higher rates of depression. Some have hypothesized that rumination mediates the differential association of religiosity and spirituality with depression. Read More

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Overexpression of Efflux Pumps Mediate Pan Resistance of Sequence Type 11.

Microb Drug Resist 2021 Apr 9. Epub 2021 Apr 9.

Department of Clinical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

A clinically isolated pan-resistant strain (ST11), KPN142 was subjected to whole-genome sequencing. Genomic sequence of KPN142 showed that limited antibiotic resistances (β-lactams [], sulfonamides [ and ], bacitracin [], tetracycline [], aminoglycosides [, , , , and ], and chloramphenicol []) were mediated by enzymes, and efflux pumps contributed most to pan resistance. Five types of multidrug resistance efflux pump families were identified, including the resistance nodulation division superfamily (AcrAB-TolC, AcrD, MdtABC, and KexD), the ATP-binding cascade superfamily (MacAB), the small multidrug resistance family (KpnEF), the multidrug and toxic compound extrusion family (KdeA), and the major facilitator superfamily (EmrAB). Read More

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Apple MPK4 Mediates Phosphorylation of MYB1 to Enhance Light-Induced Anthocyanin Accumulation.

Plant J 2021 Apr 9. Epub 2021 Apr 9.

Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing University of Agriculture, Beijing, China.

Anthocyanins are plant pigments with diverse biological functions that contribute to fruit quality and are beneficial to human health. Anthocyanin accumulation can be influenced by environmental signals, such as light, and plants have developed sophisticated systems to receive and transduce these signals. However, the associated molecular mechanisms are not well understood. Read More

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Manifestation of renin angiotensin system modulation in traumatic brain injury.

Metab Brain Dis 2021 Apr 9. Epub 2021 Apr 9.

Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, College of Medicine, 855 Monroe Avenue, Wittenborg Building, Room-231, Memphis, TN, 38163, USA.

Traumatic brain injury (TBI) alters brain function and is a crucial public health concern worldwide. TBI triggers the release of inflammatory mediators (cytokines) that aggravate cerebral damage, thereby affecting clinical prognosis. The renin angiotensin system (RAS) plays a critical role in TBI pathophysiology. Read More

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IL-6 Regulates Hepcidin Expression Via the BMP/SMAD Pathway by Altering BMP6, TMPRSS6 and TfR2 Expressions at Normal and Inflammatory Conditions in BV2 Microglia.

Neurochem Res 2021 Apr 9. Epub 2021 Apr 9.

Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Pécs, Rókus Str. 2, Pécs, 7624, Hungary.

The hormone hepcidin plays a central role in controlling iron homeostasis. Iron-mediated hepcidin synthesis is triggered via the BMP/SMAD pathway. At inflammation, mainly IL-6 pro-inflammatory cytokine mediates the regulation of hepcidin via the JAK/STAT signalling pathway. Read More

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Epigenetic regulations in mammalian spermatogenesis: RNA-mA modification and beyond.

Cell Mol Life Sci 2021 Apr 9. Epub 2021 Apr 9.

Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Emerging evidence shows that mA, one of the most abundant RNA modifications in mammals, is involved in the entire process of spermatogenesis, including mitosis, meiosis, and spermiogenesis. "Writers" catalyze mA formation on stage-specific transcripts during male germline development, while "erasers" remove mA modification to maintain a balance between methylation and demethylation. The different functions of RNA-mA transcripts depend on their recognition by "readers". Read More

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Trait Self-Control Mediates the Association Between Resting-State Neural Correlates and Emotional Well-Being in Late Adolescence.

Soc Cogn Affect Neurosci 2021 Apr 9. Epub 2021 Apr 9.

Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, 400715, China.

Trait self-control (TSC), defined as the capacity to alter predominant response to promote desirable long-term goals, has been found to facilitate emotional well-being (EWB). However, the neural correlates underlying this association remain unclear. The present study estimated resting-state brain activity and connectivity with amplitude of low-frequency fluctuations (ALFF) and functional connectivity (rsFC) among late adolescents. Read More

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Job Characteristics, Emotional Exhaustion, and Work-Family Conflict in Nurses.

Ann Rhéaume

West J Nurs Res 2021 Apr 9:1939459211005712. Epub 2021 Apr 9.

School of Nursing, Université de Moncton, Moncton, New Brunswick, Canada.

The purpose of this study is to identify whether emotional exhaustion, a component of burnout, mediates the relationship between job demands, job resources, and work-family conflict (WFC). A cross-sectional design was used with survey data. A total of 1,202 nurses in eastern Canada participated in this study. Read More

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Struggling Together: Examining the Narratives of Interdependence and Healing Within Romantic Relationships After Stroke.

Qual Health Res 2021 Apr 9:10497323211004101. Epub 2021 Apr 9.

Missouri State University, Springfield, Missouri, USA.

The consequences of a brain injury can introduce ripple effects within a family for years after the initial event. In this study, we focused on the experiences of couples negotiating their relationship after stroke. We specifically concentrated on the changes to couples' interdependence and the relational ramifications of those changes. Read More

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Estrogen receptor 2 mediates intraspecific aggressive behaviors of the female in the estrous cycle.

J Integr Neurosci 2021 Mar;20(1):77-85

College of Life Sciences, Qufu Normal University, Qufu, 273165 Shandong, P. R. China.

The social behavior mechanisms have not been thoroughly reported in the solitary female striped dwarf hamster (). In this study, the handling bag test and neutral arena measurements were used to detect the changes of aggression in the face of rivals of different genders of wild striped dwarf hamsters. We found that female hamsters had the highest aggressive performance in proestrus, followed by estrus, and the lowest in metestrus and the dioestrus, and the increased aggression during the proestrus or estrus period was low-intensity aggression such as intimidation, shock, boxing and counterattack, or even ritualized non-harmful behaviors to drive away opponents. Read More

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Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression.

Gastric Cancer 2021 Apr 8. Epub 2021 Apr 8.

Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: Aberrant activation of the WNT/β-catenin and STAT3 signaling pathways plays a critical role in cancer progression. However, direct targeting of these pathways as an anti-cancer therapeutic approach needs to be reconsidered due to its serious side effects. Here, we demonstrate that overexpression of WNT induces STAT3 activation in a galectin-3-dependent manner. Read More

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Antioxidant, Cytotoxicity and Cytoprotective Potential of Extracts of and Berries.

J Pharmacopuncture 2021 Mar;24(1):24-31

Department of Biological Sciences and Biotechnology, Faculty of Sciences, Botswana International University of Science and Technology, Palapye, Botswana.

Objectives: Accumulation of cellular reactive oxygen species (ROS) leads to oxidative stress. Increased production of ROS, such as superoxide anion, or a deficiency in their clearance by antioxidant defences, mediates cellular pathology. fruits are a source of bioactive compounds and have notable antioxidant activity. Read More

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The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28.

Front Immunol 2021 23;12:639818. Epub 2021 Mar 23.

Department of Surgery, University of California, San Francisco, San Francisco, CA, United States.

Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the transmembrane domain (TMD) between the extracellular antigen-targeting CARs and the intracellular signaling modalities of CARs has not been systemically studied. In this study, a series of 19-CARs differing only by their HD (CD8, CD28, or IgG) and TMD (CD8 or CD28) was generated. Read More

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Intestinal Dysbiosis and Autoimmune Pancreatitis.

Front Immunol 2021 23;12:621532. Epub 2021 Mar 23.

Department of Gastroenterology and Hepatology, Kindai University, Faculty of Medicine, Ohno-Higashi, Osaka-Sayama, Japan.

Autoimmune pancreatitis (AIP) is a chronic fibro-inflammatory disorder of the pancreas. Recent clinicopathological analysis revealed that most cases of AIP are pancreatic manifestations of systemic IgG4-related disease (IgG4-RD), a newly established disease characterized by enhanced IgG4 antibody responses and the involvement of multiple organs. Although the immuno-pathogenesis of AIP and IgG4-RD has been poorly defined, we recently showed that activation of plasmacytoid dendritic cells (pDCs) with the ability to produce large amounts of IFN-α and IL-33 mediates chronic fibro-inflammatory responses in experimental and human AIP. Read More

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Meaning in Life Mediates Between Emotional Deregulation and Eating Disorders Psychopathology: A Research From the Meaning-Making Model of Eating Disorders.

Front Psychol 2021 23;12:635742. Epub 2021 Mar 23.

Personality, Assessment and Treatments, Catholic University of Valencia San Vicente Martyr, Valencia, Spain.

Emotional dysregulation, age, gender, and obesity are transdiagnostic risk factors for the development and maintenance of eating disorders (EDs). Previous studies found that patients with ED had less meaning in life than the non-clinical population, and that meaning in life acted as a buffer in the course of ED; however, to the data, there are no studies about the mediator role of meaning in life in association between the emotional dysregulation and the ED psychopathology. To analyze the mediating role of meaning in life in the relationship between emotional dysregulation and the ED psychopathology in three samples with diverse risk factors for ED. Read More

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Linking Self-Control to Voluntary Behaviors at Workplace: The Mediating Role of Job Satisfaction.

Front Psychol 2021 23;12:530297. Epub 2021 Mar 23.

School of Economics and Management, Guangzhou Huashang College, Guangzhou, China.

Voluntary work behavior (VWB) refers to spontaneous workplace behaviors that extend beyond role norms, including extra-role behaviors that benefit the organization (i. e., organizational citizenship behavior, OCB) and negative behaviors that may harm the organization (i. Read More

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LINC00460 Promotes Cell Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of Head and Neck Squamous Cell Carcinoma via miR-320a/BGN Axis.

Onco Targets Ther 2021 30;14:2279-2291. Epub 2021 Mar 30.

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, People's Republic of China.

Purpose: Long non-coding RNAs (lncRNAs) play critical roles in cancer onset and development, including head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate the biological role of LINC00460 and the mechanisms underlying epithelial-mesenchymal transition (EMT) in HNSCC.

Methods: Aberrantly LINC00460 expression in HNSCC and overall survival outcomes were constructed using the TCGA database. Read More

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CCL8 mediates crosstalk between endothelial colony forming cells and triple-negative breast cancer cells through IL-8, aggravating invasion and tumorigenicity.

Oncogene 2021 Apr 8. Epub 2021 Apr 8.

Duksung Innovative Drug Center, College of Pharmacy, Duksung Women's University, Seoul, Korea.

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a poor prognosis for which no effective therapeutic measures are currently available. The present study aimed to investigate whether interactions with endothelial colony-forming cells (ECFCs) promote aggressive progression of TNBC cells. Herein, using an indirect co-culture system, we showed that co-culture increased the invasive and migratory phenotypes of both MDA-MB-231 TNBC cells and ECFCs. Read More

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Type 1 interferon mediates chronic stress-induced neuroinflammation and behavioral deficits via complement component 3-dependent pathway.

Mol Psychiatry 2021 Apr 8. Epub 2021 Apr 8.

Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, Augusta, GA, USA.

Chronic stress is a major risk factor in the pathophysiology of many neuropsychiatric disorders. Further, chronic stress conditions can promote neuroinflammation and inflammatory responses in both humans and animal models. Type I interferons (IFN-I) are critical mediators of the inflammatory response in the periphery and responsible for the altered mood and behavior. Read More

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Adolescent fluoxetine treatment mediates a persistent anxiety-like outcome in female C57BL/6 mice that is ameliorated by fluoxetine re-exposure in adulthood.

Sci Rep 2021 Apr 8;11(1):7758. Epub 2021 Apr 8.

Department of Psychology, The University of Texas at El Paso, 500 West University Avenue, El Paso, TX, 79968, USA.

The objective of this study was to evaluate whether juvenile fluoxetine (FLX) exposure induces long-term changes in baseline responses to anxiety-inducing environments, and if so, whether its re-exposure in adulthood would ameliorate this anxiety-like phenotype. An additional goal was to assess the impact of adolescent FLX pretreatment, and its re-exposure in adulthood, on serotonin transporters (5-HTT) and brain-derived-neurotrophic-factor (BDNF)-related signaling markers (TrkB-ERK1/2-CREB-proBDNF-mBDNF) within the hippocampus and prefrontal cortex. To do this, female C57BL/6 mice were exposed to FLX in drinking water during postnatal-days (PD) 35-49. Read More

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Identification of critical amino acid residues in the regulatory N-terminal domain of PMEL.

Sci Rep 2021 Apr 8;11(1):7730. Epub 2021 Apr 8.

Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT, 06519, USA.

The pigment cell-specific protein PMEL forms a functional amyloid matrix in melanosomes onto which the pigment melanin is deposited. The amyloid core consists of a short proteolytic fragment, which we have termed the core-amyloid fragment (CAF) and perhaps additional parts of the protein, such as the PKD domain. A highly O-glycosylated repeat (RPT) domain also derived from PMEL proteolysis associates with the amyloid and is necessary to establish the sheet-like morphology of the assemblies. Read More

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Single molecule network analysis identifies structural changes to caveolae and scaffolds due to mutation of the caveolin-1 scaffolding domain.

Sci Rep 2021 Apr 8;11(1):7810. Epub 2021 Apr 8.

Life Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

Caveolin-1 (CAV1), the caveolae coat protein, also associates with non-caveolar scaffold domains. Single molecule localization microscopy (SMLM) network analysis distinguishes caveolae and three scaffold domains, hemispherical S2 scaffolds and smaller S1B and S1A scaffolds. The caveolin scaffolding domain (CSD) is a highly conserved hydrophobic region that mediates interaction of CAV1 with multiple effector molecules. Read More

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Cell-type specific dynamics of calcium activity in cortical circuits over the course of slow wave sleep and rapid eye movement sleep.

J Neurosci 2021 Apr 6. Epub 2021 Apr 6.

Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076 Tübingen, Germany.

Sleep shapes cortical network activity, fostering global homeostatic down-regulation of excitability while maintaining or even up-regulating excitability in selected networks in a manner that supports memory consolidation. Here we used two-photon calcium imaging of cortical layer 2/3 neurons in sleeping male mice to examine how these seemingly opposing dynamics are balanced in cortical networks. During slow-wave sleep (SWS) episodes, mean calcium activity of excitatory pyramidal (Pyr) cells decreased. Read More

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The immediate early gene is not required for hippocampal long-term potentiation.

J Neurosci 2021 Apr 6. Epub 2021 Apr 6.

Department of Neurobiology, University of Utah.

Memory consolidation is thought to occur through protein synthesis-dependent synaptic plasticity mechanisms such as long-term potentiation (LTP). Dynamic changes in gene expression and epigenetic modifications underlie the maintenance of LTP. Similar mechanisms may mediate the storage of memory. Read More

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The inhibitory receptor Tim-3 fails to suppress IFN-γ production via the NFAT pathway in NK-cell, unlike that in CD4 T cells.

BMC Immunol 2021 Apr 9;22(1):25. Epub 2021 Apr 9.

NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, No 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China.

Background: T cell immunoglobulin and mucin domain-containing-3 (Tim-3) is a negative regulator expressed on T cells, and is also expressed on natural killer (NK) cells. The function of Tim-3 chiefly restricts IFNγ-production in T cells, however, the impact of Tim-3 on NK cell function has not been clearly elucidated.

Results: In this study, we demonstrated down-regulation of Tim-3 expression on NK cells while Tim-3 is upregulated on CD4 T cells during HIV infection. Read More

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Cephalosporin antibiotics specifically and selectively target nasopharyngeal carcinoma through HMOX1-induced ferroptosis.

Life Sci 2021 Apr 5:119457. Epub 2021 Apr 5.

Department of Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA. Electronic address:

Aims: Many antibiotics derived from mold metabolites have been found to possess anticarcinogenic properties. We aimed to investigate whether they may elicit anticancer activity, especially against nasopharyngeal carcinoma.

Main Methods: The response of nasopharyngeal and other carcinoma cell lines to cephalosporin antibiotics was evaluated in vitro and in vivo. Read More

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LEUNIG_HOMOLOG Mediates MYC2-Dependent Transcriptional Activation in Cooperation with the Coactivators HAC1 and MED25.

Plant Cell 2019 Sep;31(9):2187-2205

State Key Laboratory of Plant Genomics, National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

Groucho/Thymidine uptake 1 (Gro/Tup1) family proteins are evolutionarily conserved transcriptional coregulators in eukaryotic cells. Despite their prominent function in transcriptional repression, little is known about their role in transcriptional activation and the underlying mechanism. Here, we report that the plant Gro/Tup1 family protein LEUNIG_HOMOLOG (LUH) activates MYELOCYTOMATOSIS2 (MYC2)-directed transcription of JAZ2 and LOX2 via the Mediator complex coactivator and the histone acetyltransferase HAC1. Read More

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September 2019

The F-Box Protein SAGL1 and ECERIFERUM3 Regulate Cuticular Wax Biosynthesis in Response to Changes in Humidity in Arabidopsis.

Plant Cell 2019 Sep;31(9):2223-2240

Department of Life Science, Sogang University, Seoul 04107, Republic of Korea.

Cuticular waxes, which cover the aboveground parts of land plants, are essential for plant survival in terrestrial environments. However, little is known about the regulatory mechanisms underlying cuticular wax biosynthesis in response to changes in ambient humidity. Here, we report that the Arabidopsis (Arabidopsis thaliana) Kelch repeat F-box protein SMALL AND GLOSSY LEAVES1 (SAGL1) mediates proteasome-dependent degradation of ECERIFERUM3 (CER3), a biosynthetic enzyme involved in the production of very long chain alkanes (the major components of wax), thereby negatively regulating cuticular wax biosynthesis. Read More

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September 2019

Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages.

FEBS Open Bio 2021 Apr 8. Epub 2021 Apr 8.

Clinical Medical Research Center, Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.

Apolipoprotein M (ApoM) exhibits various anti-atherosclerotic functions as a component of high-density lipoprotein (HDL) particles. Scavenger receptor class B type I (SR-BI) is a classic HDL receptor that mediates selective cholesterol uptake and enhances the efflux of cellular cholesterol to HDL. However, the effect of ApoM on cholesterol transport in macrophages remains unclear. Read More

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