76 results match your criteria mediated sdb

Reversible Electroactive Behavior in a Zn-Based Metal-Organic Framework via Mild Oxidation Potential.

Inorg Chem 2021 Jul 23. Epub 2021 Jul 23.

Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan.

This work describes the synthesis and characterization of a Zn-based metal-organic framework, [Zn(TTPA)(SDB)·(DMF)(HO)] (, TTPA = tris(4-(1-1,2,4-triazol-1-yl)phenyl)amine, SDB = 4,4'-sulfonyldibenzoate). A newly designed strategy with a redox-active linker, TTPA, and mediated by a V-shaped carboxylic linker with Zn metal ions resulted in an electroactive framework. The V-shaped carboxylic linker with Zn metal ions forms linear struts interlinked by two of the side-arms of the TTPA ligands to form a square grid network. Read More

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A preliminary study on the relationship between sleep, depression and cardiovascular dysfunction in a 4 sample population.

Int J Cardiol Heart Vasc 2021 Aug 25;35:100814. Epub 2021 Jun 25.

Department of Psychology, University of Michigan, Ann Arbor, MI, USA.

Background: Major Depressive Disorder (MDD) has been linked in the literature to poorer prognosis in patients with cardiovascular dysfunction, although the mechanisms of this relationship remain unclear. Underlying Sleep Disordered Breathing (SDB) serves as a potential candidate to explain this effect due to its downstream effects on inflammatory activation and decreased nitric oxide (NO) bioavailability, both of which have been shown to contribute to the pathophysiology of both MDD and cardiovascular disease (CVD).

Methods: This study utilizes overnight polysomnography and an inflammation panel to examine the links between cardiovascular dysfunction and sleep difficulties in control participants and patients diagnosed with SDB only, MDD only, and both SDB and MDD. Read More

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Controlled breathing and pain: Respiratory rate and inspiratory loading modulate cardiovascular autonomic responses, but not pain.

Psychophysiology 2021 Jul 6:e13895. Epub 2021 Jul 6.

Laboratory for Brain-Gut Axis Studies, Translational Research Center for Gastrointestinal Disorders, Department of Chronic Diseases, Metabolism, and Ageing, KU Leuven, Leuven, Belgium.

Slow, deep breathing (SDB) is a common pain self-management technique. Stimulation of the arterial baroreceptors and vagal modulation are suggested, among others, as potential mechanisms underlying the hypoalgesic effects of SDB. We tested whether adding an inspiratory load to SDB, which results in a stronger baroreceptor stimulation and vagal modulation, enhances its hypoalgesic effects. Read More

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Sluggish Cognitive Tempo and Daytime Sleepiness Mediate Relationships Between Sleep and Academic Performance.

J Dev Behav Pediatr 2021 Jun 1. Epub 2021 Jun 1.

Departments of Psychology, Women's and Children's Health, University of Otago, Dunedin, New Zealand.

Objective: Sleep difficulties, daytime sleepiness, and sluggish cognitive tempo (SCT) are associated with impairments in academic performance. SCT refers to symptoms of sluggishness, tiredness/lethargy, and slowed thinking/processing, but despite symptom overlap with sleepiness, research examining interrelations of SCT with sleep and daytime sleepiness is limited. The aims of this study were to evaluate the relationship between SCT and daytime sleepiness and to examine pathways between sleep, daytime sleepiness, SCT, and academic performance. Read More

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Hypoxia activates SUMO-1-HIF-1α signaling pathway to upregulate pro-inflammatory cytokines and permeability in human tonsil epithelial cells.

Life Sci 2021 Jul 29;276:119432. Epub 2021 Mar 29.

Department of Pediatrics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address:

Background: Adenoid hypertrophy (AH) can cause harmful effects on untreated children, which include mouth breathing, chronic intermittent hypoxia, sleep disordered breathing (SDB), and even some behavioral problems. However, the molecular mechanisms underlying this pathophysiological process have remained poorly understood.

Methods: In this study, SUMO was induced silencing and overexpression using RNAi and lentiviral-mediated vector. Read More

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Leptin: Master Regulator of Biological Functions that Affects Breathing.

Compr Physiol 2020 07 8;10(3):1047-1083. Epub 2020 Jul 8.

Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Obesity is a global epidemic in developed countries accounting for many of the metabolic and cardiorespiratory morbidities that occur in adults. These morbidities include type 2 diabetes, sleep-disordered breathing (SDB), obstructive sleep apnea, chronic intermittent hypoxia, and hypertension. Leptin, produced by adipocytes, is a master regulator of metabolism and of many other biological functions including central and peripheral circuits that control breathing. Read More

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Predictors of Behavioral Changes After Adenotonsillectomy in Pediatric Obstructive Sleep Apnea: A Secondary Analysis of a Randomized Clinical Trial.

JAMA Otolaryngol Head Neck Surg 2020 10;146(10):900-908

Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore.

Importance: Adenotonsillectomy (AT) is associated with improved behavior in children with obstructive sleep apnea (OSA). However, it is unknown whether polysomnographic parameters are superior to the parent-reported severity of sleep-disordered breathing (SDB) in predicting behavioral changes after AT.

Objective: To ascertain whether polysomnographic parameters vs parent-reported severity of SDB are better predictors of treatment-related behavioral changes in children with OSA. Read More

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October 2020

Sleep-Disordered Breathing and Free Fatty Acid Metabolism.

Chest 2020 11 18;158(5):2155-2164. Epub 2020 Jun 18.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

Background: Sleep-disordered breathing (SDB) is independently associated with insulin resistance, glucose intolerance, and type 2 diabetes mellitus. However, data on whether SDB alters the metabolism of free fatty acids (FFAs) are lacking.

Research Question: The primary objective of the current study was to characterize alterations in FFA metabolism across the spectrum of SDB severity. Read More

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November 2020

Atractylon treatment prevents sleep-disordered breathing-induced cognitive dysfunction by suppression of chronic intermittent hypoxia-induced M1 microglial activation.

Biosci Rep 2020 06;40(6)

Department of Pediatrics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wan-Ping Road, Shanghai 200065, China.

Chronic intermittent hypoxia (CIH) induced by sleep-disordered breathing (SDB) is a key factor involved in cognitive dysfunction (CD). Increasing evidence has shown that atractylon (ATR) has anti-inflammatory effects. However, it remains unclear if ATR has a protective effect against SDB-induced nerve cell injury and CD. Read More

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Accumulated nocturnal hypoxemia predict arterial endothelial function in patients with sleep-disordered breathing with or without chronic heart failure.

Heart Vessels 2020 Jun 21;35(6):800-807. Epub 2020 Jan 21.

Sleep Apnea Center, Kyushu University Hospital, 3-1-1 Maidashi, Higashiku, Fukuoka, 812-8582, Japan.

Abtsract: Sleep-disordered breathing (SDB) is often accompanied with the chronic heart failure (CHF). Hypoxemia due to pulmonary congestion from CHF and concurrent SDB might synergistically impair endothelial function and worsen the prognosis. However, the main factors affecting deterioration of endothelial function are unknown and whether the influence of hypoxemia differs in SDB patients with and without CHF remains unclear. Read More

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Differential IL-17A response to S. pneumoniae in adenoid tissue of children with sleep disordered breathing and otitis media with effusion.

Sci Rep 2019 12 27;9(1):19839. Epub 2019 Dec 27.

Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Streptococcus pneumonia, one of the major colonizers in nasopharyngeal adenoids, has been the predominant pathogen causing acute otitis media (AOM) in children. Recent evidence suggests an association between IL-17A-mediated immune response and the clearance of pneumococcal colonization in nasopharyngeal adenoids. Here, we evaluated the expressions of IL-17A and associated genes in hypertrophic adenoid tissues of children with sleep-disordered breathing (SDB) and otitis media with effusion (OME) and their association with pneumococcal carriage. Read More

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December 2019

The Impact of Obstructive Sleep Apnea and Positive Airway Pressure Therapy on Metabolic Peptides Regulating Appetite, Food Intake, Energy Homeostasis, and Systemic Inflammation: A Literature Review.

J Clin Sleep Med 2019 07 15;15(7):1037-1050. Epub 2019 Jul 15.

Department of Internal Medicine, Wayne State University, Detroit, Michigan.

Introduction: Sleep-related breathing disorders are very common and highly associated with many comorbid diseases. They have many metabolic consequences that impact appetite, energy expenditure, and systemic inflammation. These consequences are mediated through peptides (eg, ghrelin, leptin, adiponectin, resistin, apelin, obestatin, and neuropeptide Y). Read More

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Pathophysiological changes associated with sleep disordered breathing and supine sleep position in pregnancy.

Sleep Med Rev 2019 08 16;46:1-8. Epub 2019 Apr 16.

Mater Research Institute-University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia; Mater Mothers' Hospital, Raymond Terrace, South Brisbane, Queensland 4101, Australia; Faculty of Medicine, The University of Queensland, Australia. Electronic address:

Sleep is a complex and active physiological process that if disrupted, can result in adverse outcomes both within and outside of pregnancy. Sleep disordered breathing (SDB) occurs in 10-32% of pregnancies. Substantial physiological changes occur during pregnancy that impact on maternal sleep, which typically deteriorates with advancing gestation. Read More

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IL-17A expression in the adenoid tissue from children with sleep disordered breathing and its association with pneumococcal carriage.

Sci Rep 2018 11 13;8(1):16770. Epub 2018 Nov 13.

Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Tonsil and adenoid-tissue hypertrophy (AH) is the most common cause of pediatric sleep-disordered breathing (SDB), with AH possibly initiated by repeated exposure to infectious agents or allergens. Here, we evaluated IL-17A activity in adenoid tissue from children with SDB and its association with AH and pneumococcal carriage. Thirty-five children (aged 3-12 years) with SDB and receiving adenoidectomy and tonsillectomy were enrolled. Read More

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November 2018

A critical evaluation of the use of gas chromatography- and high performance liquid chromatography-mass spectrometry techniques for the analysis of microbial metabolites in human urine after consumption of orange juice.

J Chromatogr A 2018 Nov 9;1575:100-112. Epub 2018 Sep 9.

Department of Food Science and Health, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA), Avenida Menéndez-Pidal, SN, 14004, Córdoba, Spain.

The present study compared and validated two analytical methods, HPLC-HRMS, and GC-MS using MSTFA as derivatization agent, for the analysis of microbiota-derived phenolic acids and aromatic compounds accumulating in urine, collected over a 24 h period after the consumption of 500 mL of orange juice. In addition, purification procedures using SDB-L and HLB solid phase cartridges were compared when HPLC-HRMS technique was used. Both HPLC-HRMS and GC-MS methodologies were successfully validated in terms of specificity, sensitivity, limit of detection and quantification, recovery and matrix effects. Read More

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November 2018

Sleep-disordered breathing, neuroendocrine function, and clinical SUDEP risk in patients with epilepsy.

Epilepsy Behav 2018 10 31;87:78-82. Epub 2018 Aug 31.

Comprehensive Epilepsy and Sleep Center, Department of Neurology, Columbia University Medical Center New York, NY, United States.

Introduction: Sudden unexpected death in epilepsy (SUDEP) is a major contributor to epilepsy-related mortality. It is associated with nocturnal seizures and centrally mediated postictal cardiorespiratory dysfunction (CRD), but mechanisms and contributors remain poorly understood.

Methods: We performed a prospective, cross-sectional, observational pilot study in the Columbia University Medical Center (CUMC) adult epilepsy monitoring unit (EMU) to explore relationships between periictal CRD, sleep-disordered breathing (SDB), neuroendocrine function, and clinical SUDEP risk. Read More

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October 2018

Inhibition of Biofilm and Virulence Factors of Candida albicans by Partially Purified Secondary Metabolites of Streptomyces chrestomyceticus Strain ADP4.

Curr Top Med Chem 2018 ;18(11):925-945

Division of Biological Sciences and Engineering, Netaji Subhas Institute of Technology, Dwarka, New Delhi 110078, India.

Background: Despite several advancements in antifungal drug discovery, fungal diseases like Invasive Candidiasis (IC) still remain associated with high rates of morbidity and mortality worldwide. Thus there is an enormous need for anti-Candida drugs.

Objective: The main objectives of the work included: 1. Read More

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September 2018

Correlation between gonial angle and dynamic tongue collapse in children with snoring/sleep disordered breathing - an exploratory pilot study.

J Otolaryngol Head Neck Surg 2018 Jun 4;47(1):41. Epub 2018 Jun 4.

University of Alberta, Edmonton, AB, Canada.

Background: Drug induced sleep endoscopy (DISE) is hoped to identify reasons of failure of adenotonsillectomy (AT) in treating pediatric sleep disordered breathing (SDB). Maxillomandibular disproportion has been studied as another association which may explain alternative pathogenesis of SDB. We aimed to explore the relation between the size of the gonial angle and inclination of the epiglottis measured from cone beam CT (CBCT) and tongue base collapse based on DISE in children with SDB. Read More

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Impact of sleep characteristics and obesity on diabetes and hypertension across genders and menopausal status: the Nagahama study.

Sleep 2018 07;41(7)

Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Study Objectives: The individual prevalence of sleep-disordered breathing (SDB), short sleep duration, and obesity is high and increasing. The study aimed to investigate potential associations between SDB, objective sleep duration, obesity, diabetes and hypertension across genders, and the effect of pre- or post-menopausal status.

Methods: A cross-sectional study evaluated 7051 community participants with wrist actigraphy for a week, and nocturnal oximetry ≥ 2 nights. Read More

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Global Distribution of Invasive Serotype 35D Streptococcus pneumoniae Isolates following Introduction of 13-Valent Pneumococcal Conjugate Vaccine.

J Clin Microbiol 2018 07 25;56(7). Epub 2018 Jun 25.

Infection Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

A newly recognized pneumococcal serotype, 35D, which differs from the 35B polysaccharide in structure and serology by not binding to factor serum 35a, was recently reported. The genetic basis for this distinctive serology is due to the presence of an inactivating mutation in , which encodes an O-acetyltransferase responsible for O-acetylation of a galactofuranose. Here, we assessed the genomic data of a worldwide pneumococcal collection to identify serotype 35D isolates and understand their geographical distribution, genetic background, and invasiveness potential. Read More

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Effect-based monitoring of the Danube River using mobile passive sampling.

Sci Total Environ 2018 Sep 10;636:1608-1619. Epub 2018 Mar 10.

Masaryk University, Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Kamenice 753/5, 625 00 Brno, Czech Republic. Electronic address:

Many aquatic pollutants can be present at low concentrations, but their mixtures can still affect health or behavior of exposed organisms. In this study, toxicological and chemical analyses were combined for spatial contamination profiling using an innovative passive sampling approach. A novel Dynamic Passive Sampler (DPS) was employed as a mobile sampler from a ship cruising along 2130km of the Danube river during the Joint Danube Survey 3 (JDS3). Read More

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September 2018

Sleep disorder prevalence in at-risk adolescents and potential effects of nightmare triad syndrome.

Int J Adolesc Med Health 2018 Feb 17;32(1). Epub 2018 Feb 17.

Robert F. Kennedy Charter School, Albuquerque, NM 87121, USA.

Objective At-risk high school students, those considered to have a higher probability for academic failure or dropping out, were assessed for various sleep disorders. Effects were compared between students with and without the nightmare triad syndrome (NTS+), the sleep disorders' cluster of frequent nightmares, insomnia disorder and suspected sleep-disordered breathing (SDB). Methods Data were gathered at a charter school for at-risk youth using: computer based surveys, physical airway exams, and mental health interviews by school social worker. Read More

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February 2018

Fitness, Sleep-Disordered Breathing, Symptoms of Depression, and Cognition in Inactive Overweight Children: Mediation Models.

Public Health Rep 2017 Nov/Dec;132(2_suppl):65S-73S

5 Georgia Prevention Institute, Augusta University, Augusta, GA, USA.

Objectives: We used mediation models to examine the mechanisms underlying the relationships among physical fitness, sleep-disordered breathing (SDB), symptoms of depression, and cognitive functioning.

Methods: We conducted a cross-sectional secondary analysis of the cohorts involved in the 2003-2006 project PLAY (a trial of the effects of aerobic exercise on health and cognition) and the 2008-2011 SMART study (a trial of the effects of exercise on cognition). A total of 397 inactive overweight children aged 7-11 received a fitness test, standardized cognitive test (Cognitive Assessment System, yielding Planning, Attention, Simultaneous, Successive, and Full Scale scores), and depression questionnaire. Read More

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December 2017

The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study.

Contemp Clin Trials 2018 01 31;64:101-111. Epub 2017 Oct 31.

The ASPREE Study Group, Australia, USA.

Purpose: Sleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3years. Read More

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January 2018

Dorsolateral prefrontal cortex GABA deficit in older adults with sleep-disordered breathing.

Proc Natl Acad Sci U S A 2017 09 5;114(38):10250-10255. Epub 2017 Sep 5.

Laboratory for Advanced MRS Research, Department of Radiology, Weill Cornell Medicine, New York, NY 10065;

Sleep-disordered breathing (SDB) is a common disorder in aging that is associated with cognitive decline, including significant executive dysfunction, for which the neurobiological underpinnings remain poorly understood. Using proton magnetic resonance spectroscopy (1H MRS), this study assessed whether dysregulation of the homeostatic balance of the major inhibitory and excitatory amino acid neurotransmitter systems of γ-aminobutyric acid (GABA) and glutamate, respectively, play a role in SDB. Levels of GABA and those of the combined resonances of glutamate and glutamine (Glx), were measured by 1H MRS in the left dorsolateral prefrontal cortex (l-DLPFC) and bilateral hippocampal regions of 19 older adults (age ± SD: 66. Read More

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September 2017

Amidoalkylindoles as Potent and Selective Cannabinoid Type 2 Receptor Agonists with in Vivo Efficacy in a Mouse Model of Multiple Sclerosis.

J Med Chem 2017 08 3;60(16):7067-7083. Epub 2017 Aug 3.

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, China.

Selective CB agonists represent an attractive therapeutic strategy for the treatment of a variety of diseases without psychiatric side effects mediated by the CB receptor. We carried out a rational optimization of a black market designer drug SDB-001 that led to the identification of potent and selective CB agonists. A 7-methoxy or 7-methylthio substitution at the 3-amidoalkylindoles resulted in potent CB antagonists (27 or 28, IC = 16-28 nM). Read More

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Hearing loss mediates executive function impairment in sleep-disordered breathing.

Sleep Med 2017 Jun 7;34:18-23. Epub 2017 Mar 7.

Cognitive Neuroscience & Psychiatry, University College London Great Ormond St Institute of Child Health, UK; Department of Anaesthetics, Addenbrookes Hospital, Cambridge University Hospitals Trust, Cambridge, UK.

Background: Sleep-disordered breathing (SDB) is often co-morbid with conductive hearing loss in early childhood due to a shared aetiology of adenotonsillar hypertrophy. Hearing loss is independently associated with impairment of executive function and behavioural difficulties. We hypothesised that these impairments in children with SDB may be mediated through hearing loss. Read More

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Sleep-disordered breathing is associated with blood pressure and carotid arterial stiffness in obese children.

J Hypertens 2017 01;35(1):125-131

aDepartment of Medicine, Section of General Medicine and Hypertension bDepartment of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Division cDepartment of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Diabetes and Metabolic Disorders Unit, University of Verona, Verona, Italy.

Introduction: Both sleep-disordered breathing (SDB) and high blood pressure (BP) occur more frequently among obese children than among normal weight children, and this may be due to endothelial dysfunction and worsened arterial stiffness. The aim of this study was to evaluate the possible association between SDB and BP, and the possible role of endothelial function and local and systemic arterial stiffness in a sample of obese children asymptomatic for sleep disturbances.

Materials And Methods: Thirty-nine obese children were included in the study. Read More

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January 2017

Sleep-disordered breathing, impaired cardiac adrenergic innervation and prognosis in heart failure.

Heart 2016 Nov 23;102(22):1813-1819. Epub 2016 Jun 23.

Department of Advanced Biomedical Sciences, Section of Cardiology, Federico II University, Naples, Italy.

Objective: Unfavourable effects of sleep-disordered breathing (SDB) in heart failure (HF) are mainly mediated by impaired sympathetic activity. Few data are available on SDB and cardiac adrenergic impairment evaluated at myocardial level. The aim of the study was to assess the relationship between SDB, cardiac sympathetic innervation assessed by I-metaiodobenzylguanidine (I-MIBG) imaging and prognosis in HF. Read More

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November 2016

Sleep disordered breathing symptoms and daytime sleepiness are associated with emotional problems and poor school performance in children.

Psychiatry Res 2016 Aug 24;242:218-225. Epub 2016 May 24.

University of Pennsylvania, School of Education, Philadelphia, PA, USA.

This study examined the prevalence of sleep disordered breathing (SDB) symptoms and their associations with daytime sleepiness, emotional problems, and school performance in Chinese children. Participants included 3979 children (10.99±0. Read More

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