236,031 results match your criteria median time


Telemedicine for adult congenital heart disease patients during the first wave of COVID-19 era: a single center experience.

J Cardiovasc Med (Hagerstown) 2021 Apr 20. Epub 2021 Apr 20.

Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico Universitario A. Gemelli IRCCS Catholic University of the Sacred Heart Department of Pediatric Cardiology and Cardiac Surgery - Bambino Gesù Hospital, Rome, Italy.

Aim: To summarize our experience on the implementation of a telemedicine service dedicated to adult congenital heart disease (ACHD) patients during the lockdown for the first wave of COVID-19.

Methods: This is a prospective study enrolling all ACHD patients who answered a questionnaire dedicated telematic cardiovascular examination.

Results: A total of 289 patients were enrolled, 133 (47%) were male, 25 (9%) were affected by a genetic syndrome. Read More

View Article and Full-Text PDF

Surgeon Factors Have a Larger Effect on Vascular Access Type and Outcomes than Patient Factors.

J Surg Res 2021 Apr 18;265:33-41. Epub 2021 Apr 18.

Division of Vascular Surgery, Department of Surgery, University of California, Los Angeles, California. Electronic address:

Background And Objectives: Though patient factors are frequently linked to hemodialysis vascular access selection and outcomes, variability by surgeon and surgeon specialty may play a role as well. The objective of this study is to examine the extent to which individual surgeons influence selection of vascular access type, removal of tunneled hemodialysis catheter (THC), and repeat vascular access.

Design, Setting, Participants, & Measurements: A national claims database was used to identify patients initiating hemodialysis via a THC between 2011 and 2017. Read More

View Article and Full-Text PDF

Thoracic Surgery Foundation Research Awards: Leading the Way to Excellence.

Ann Thorac Surg 2021 Apr 18. Epub 2021 Apr 18.

Background: Combining clinical and research excellence has become an increasingly difficult endeavor for thoracic surgeons, with typical success rates for the NHLBI and NCI being 25.1% and 11.3% respectively. Read More

View Article and Full-Text PDF

Timeliness and content of retraction notices for publications by a single research group.

Account Res 2021 Apr 21. Epub 2021 Apr 21.

Department of Medicine, University of Auckland.

Publications of expressions of concern and retractions should be timely, accurate and comprehensive. We assessed these characteristics for 292 publications by a research group about which we submitted concerns about publication integrity to 77 journals and 29 publishers between March 2013 and February 2020. By October 2020, 115 publications were corrected (3), had expressions of concern (18), or were retracted (94). Read More

View Article and Full-Text PDF

Correlates of variability in endurance shuttle walk test time in patients with chronic obstructive pulmonary disease.

PLoS One 2021 21;16(4):e0249786. Epub 2021 Apr 21.

Department of Pulmonary Diseases, Dekkerswald Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Background: The endurance shuttle walk test (ESWT) is used to evaluate exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). The recommended pre-intervention tolerated duration (Tlim) is between 3-8 minutes for optimal interpretation of treatment effects. However, this window may be exceeded and factors determining ESWT Tlim are not completely understood. Read More

View Article and Full-Text PDF

The Perme Mobility Index: A new concept to assess mobility level in patients with coronavirus (COVID-19) infection.

PLoS One 2021 21;16(4):e0250180. Epub 2021 Apr 21.

Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil.

Introduction: The Coronavirus Disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. Data on the mobility level of patients with COVID-19 in the intensive care unit (ICU) are needed.

Objective: To describe the mobility level of patients with COVID-19 admitted to the ICU and to address factors associated with mobility level at the time of ICU discharge. Read More

View Article and Full-Text PDF

Long-term medical imaging use in children with central nervous system tumors.

PLoS One 2021 21;16(4):e0248643. Epub 2021 Apr 21.

The Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Children with central nervous system (CNS) tumors undergo frequent imaging for diagnosis and follow-up, but few studies have characterized longitudinal imaging patterns. We described medical imaging in children before and after malignant CNS tumor diagnosis.

Procedure: We conducted a retrospective cohort study of children aged 0-20 years diagnosed with CNS tumors between 1996-2016 at six U. Read More

View Article and Full-Text PDF

In neonatal onset surgical short bowel syndrome survival is high, and enteral autonomy is related to residual bowel length.

JPEN J Parenter Enteral Nutr 2021 Apr 21. Epub 2021 Apr 21.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.

Background: In an era of improved management and treatment options, this study aims to describe the long-term outcomes and factors predictive of outcomes of neonatal-onset intestinal failure (IF) due to surgical short bowel syndrome (SBS).

Materials And Methods: Retrospective, single-center cohort study of infants born between January 2011 and December 2018 with inclusion criteria: <44 weeks postmenstrual age at SBS diagnosis, <28 days on admission, parenteral nutrition dependence >60 days, and documented intestinal resection. Primary outcomes included survival and achievement of enteral autonomy (EA). Read More

View Article and Full-Text PDF

A systematic review of craniospinal irradiation for leptomeningeal disease: past, present, and future.

Clin Transl Oncol 2021 Apr 21. Epub 2021 Apr 21.

Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Purpose: Leptomeningeal disease (LMD) is a rare but deadly complication of cancer in which the disease spreads to the cerebrospinal fluid and seeds the meninges of the central nervous system (CNS). Craniospinal irradiation (CSI) involves treatment of the entire CNS subarachnoid space and is occasionally used as a last-resort palliative therapy for LMD.

Methods: This review examined literature describing the role of CSI for LMD from solid and hematologic malignancies in adults. Read More

View Article and Full-Text PDF

Molecular aspects and long-term outcome of patients with primary distal renal tubular acidosis.

Pediatr Nephrol 2021 Apr 21. Epub 2021 Apr 21.

Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.

Background: Primary distal renal tubular acidosis (dRTA) is a rare genetic disorder caused by impaired distal mechanisms of urinary acidification. Most cases are secondary to pathogenic variants in ATP6V0A4, ATP6V1B1, and SLC4A1 genes, which encode transporters regulating acid-base balance in the collecting duct.

Methods: Retrospective study of molecular and clinical data from diagnosis and long-term follow-up (10, 20, and 40±10 years) of 16 patients with primary dRTA diagnosed in childhood. Read More

View Article and Full-Text PDF

Absolute lymphocyte count proliferation kinetics after CAR T-cell infusion impact response and relapse.

Blood Adv 2021 Apr;5(8):2128-2136

Division of Hematopathology, The Children's Hospital of Philadelphia, Philadelphia, PA.

CD19-directed chimeric antigen receptor (CAR) T cells show characteristic proliferation kinetics after infusion that correlate with response. Clearance of circulating disease, B-cell aplasia (BCA), and cytokine release syndrome (CRS) are used to observe CAR T-cell function, given the lack of commercial CAR T-cell measurement assays. We investigated the utility of common hematology laboratory parameters in 166 patients with B-cell acute lymphoblastic leukemia (B-ALL) who were treated with CAR T-cell therapy targeting CD19. Read More

View Article and Full-Text PDF

Caplacizumab prevents refractoriness and mortality in acquired thrombotic thrombocytopenic purpura: integrated analysis.

Blood Adv 2021 Apr;5(8):2137-2141

Medical Affairs, Sanofi, Diegem, Belgium.

The efficacy and safety of caplacizumab in individuals with acquired thrombotic thrombocytopenic purpura (aTTP) have been established in the phase 2 TITAN and phase 3 HERCULES trials. Integrated analysis of data from both trials was conducted to increase statistical power for assessing treatment differences in efficacy and safety outcomes. Caplacizumab was associated with a significant reduction in the number of deaths (0 vs 4; P < . Read More

View Article and Full-Text PDF

Oxygenated End-Hypothermic Machine Perfusion in Expanded Criteria Donor Kidney Transplant: A Randomized Clinical Trial.

JAMA Surg 2021 Apr 21. Epub 2021 Apr 21.

Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.

Importance: Continuous hypothermic machine perfusion during organ preservation has a beneficial effect on graft function and survival in kidney transplant when compared with static cold storage (SCS).

Objective: To compare the effect of short-term oxygenated hypothermic machine perfusion preservation (end-HMPo2) after SCS vs SCS alone on 1-year graft survival in expanded criteria donor kidneys from donors who are brain dead.

Design, Setting, And Participants: In a prospective, randomized, multicenter trial, kidneys from expanded criteria donors were randomized to either SCS alone or SCS followed by end-HMPo2 prior to implantation with a minimum machine perfusion time of 120 minutes. Read More

View Article and Full-Text PDF

Clinical Characterization of Mogamulizumab-Associated Rash During Treatment of Mycosis Fungoides or Sézary Syndrome.

JAMA Dermatol 2021 Apr 21. Epub 2021 Apr 21.

Department of Dermatology, Stanford University School of Medicine, Palo Alto, California.

Importance: Mogamulizumab is a monoclonal antibody against CCR4 approved for treatment for mycosis fungoides (MF) and Sézary syndrome (SS). Mogamulizumab-associated rash (MAR) is difficult to differentiate from cutaneous MF or SS, which can lead to unnecessary discontinuation of drug use because of concern for severe drug reaction or incorrect presumption of disease relapse or progression in the skin.

Objective: To examine the most common clinical presentations of MAR in patients with MF or SS and the diagnostic and management challenges. Read More

View Article and Full-Text PDF

[Contribution of Real-Time PCR in the Diagnosis of Cutaneous Leishmaniasis: Experience of the Pasteur Institute of Tunis].

Bull Soc Pathol Exot 2020 ;113(5):251-253

Laboratoire de parasitologie médicale, biotechnologies et biomolécules, LR 16-IPT-06, institut Pasteur de Tunis, université Tunis-El-Manar, Tunisie.

The aim of this study was to assess the performance of real-time PCR (qPCR) in the diagnosis of cutaneous leishmaniasis (CL). Culture, direct microscopic examination (DE) and qPCR were performed on dermal exudate samples collected from 235 confirmed CL cases. The qPCR was found to be more sensitive than other diagnostic techniques and was able to correct the diagnosis in 49 patients (20. Read More

View Article and Full-Text PDF
January 2020

Memory outcomes of temporal lobe surgery in adults aged over 45 years.

Acta Neurol Scand 2021 Apr 21. Epub 2021 Apr 21.

First Department of Neurology and Department of Neurosurgery, Brno Epilepsy Center, St. Anne's Hospital and School of Medicine, Brno, Czech Republic.

Objective: It is assumed that temporal lobe resection in older people is associated with worse seizure outcomes and potential postsurgical memory decline. We studied postsurgical memory development and surgical efficacy in patients over 45 years of age compared with younger patients.

Methods: We studied 88 patients (51 male and 37 female) after temporal lobe surgery, which involved hippocampal resection. Read More

View Article and Full-Text PDF

Acellular Nerve Allografts in Major Peripheral Nerve Repairs: An Analysis of Cases Presenting With Limited Recovery.

Hand (N Y) 2021 Apr 21:15589447211003175. Epub 2021 Apr 21.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.

Background: Acellular nerve allografts have been used successfully and with increasing frequency to reconstruct nerve injuries. As their use has been expanded to treat longer gap, larger diameter nerve injuries, some failed cases have been reported. We present the histomorphometry of 5 such cases illustrating these limitations and review the current literature of acellular nerve allografts. Read More

View Article and Full-Text PDF

First-line methadone for cancer pain: titration time analysis.

Support Care Cancer 2021 Apr 21. Epub 2021 Apr 21.

Programa de Bioética, Facultad Latinoamericana de Ciencias Sociales (FLACSO), Buenos Aires, Argentina.

Background: Methadone is a low-cost, strong opioid that is increasingly used as a first-line treatment for pain in palliative care (PC). Its long and unpredictable half-life and slow elimination phase can make titration challenging. Evidence for titration modalities is scarce. Read More

View Article and Full-Text PDF

Macular holes following vitrectomy for rhegmatogenous retinal detachment: epiretinal proliferation and spontaneous closure of macular holes.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

Department of Ophthalmology, Kagoshima University Graduate School of Medicine and Dental Sciences, Kagoshima, Japan.

Purpose: To describe the characteristics and management of full-thickness macular holes (MHs) that develop after pars plana vitrectomy for rhegmatogenous retinal detachment (RD).

Methods: Retrospective, interventional, consecutive case series. Patients who developed secondary full-thickness MHs after prior pars plana vitrectomy for RD over a 6-year period were included. Read More

View Article and Full-Text PDF

Causes of death after emergency general surgical admission: population cohort study of mortality.

BJS Open 2021 Mar;5(2)

Division of Acute Care Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: A substantial number of patients treated in emergency general surgery (EGS) services die within a year of discharge. The aim of this study was to analyse causes of death and their relationship to discharge diagnoses, in patients who died within 1 year of discharge from an EGS service in Scotland.

Methods: This was a population cohort study of all patients with an EGS admission in Scotland, UK, in the year before death. Read More

View Article and Full-Text PDF

Right ventricular remodelling after endo-exclusion during pulmonary valve replacement: evaluation by cardiac magnetic resonance.

Eur J Cardiothorac Surg 2021 Apr 20. Epub 2021 Apr 20.

Congenital Heart Surgery, La Timone Children Hospital, APHM, Aix Marseille Univ, Marseille, France.

Objectives: Pulmonary valve replacement (PVR) performed for pulmonary valve regurgitation is the most common indication for reoperation during mid-to-long-term follow-up after tetralogy of Fallot repair. An aneurysmal dilation of the infundibulum is often associated secondary to the infundibulotomy performed in the first operation. The right ventricular outflow tract reconstruction with endo-exclusion aims to exclude the non-contractile segments of the dilated right ventricular. Read More

View Article and Full-Text PDF

A Retrospective Study Assessing the Effect of Diabetes on Mortality in Patients With COVID-19 at a Teaching Hospital in the United Kingdom.

Cureus 2021 Mar 15;13(3):e13902. Epub 2021 Mar 15.

Diabetes and Endocrinology, Brighton and Sussex County Hospitals NHS Trust, Brighton, GBR.

Aim The aim of the study was to compare the clinical characteristics and outcomes (mortality, intensive care admission, mechanical ventilation, and length of stay, LoS) of patients with and without diabetes with confirmed COVID-19.  Methods This retrospective study evaluated clinical and laboratory variables in adult inpatients from Brighton and Sussex University Hospitals NHS Trust with laboratory-confirmed COVID-19 between March 10, 2020, and June 30, 2020. Univariate and multivariate analyses were performed to compare the outcomes of patients with and without diabetes. Read More

View Article and Full-Text PDF

Early Experience of Reverse Total Shoulder Arthroplasty in a Public Hospital in Malaysia.

Malays Orthop J 2021 Mar;15(1):119-123

Department of Orthopaedics, International Medical University, Seremban, Malaysia.

Introduction: Reverse total shoulder arthroplasty provides a surgical alternative to standard total shoulder arthroplasty for the treatment of cuff tear arthropathy, arthritis and fracture sequelae. This study aimed to assess the short-term outcomes following reverse total shoulder arthroplasty for patients in a large public hospital in Malaysia.

Materials And Methods: We identified and performed five primary reverse total shoulder arthroplasties between 1 May 2019 and 1 June 2020. Read More

View Article and Full-Text PDF

Can Paediatric Femoral Fracture Hip Spica Application be Done in the Outpatient Setting?

Malays Orthop J 2021 Mar;15(1):105-112

Department of Orthopaedic Surgery, KK Women's and Children's Hospital, Singapore.

Introduction: Hip spica casting is a standard treatment for children with femur fractures. This study compares the outcomes of spica cast application, in terms of quality of fracture reduction and hospital charges when performed in operating theatre versus outpatient clinics at a local institution.

Materials And Methods: A total of 93 paediatric patients, aged between 2 months to 8 years, who underwent spica casting for an isolated femur fracture between January 2008 and March 2019, were identified retrospectively. Read More

View Article and Full-Text PDF

Health-Related Quality of Life and Its Associated Factors Among Burn Patients at Governmental Referral Hospitals of Amhara Regional State, Northwest Ethiopia, 2020: Institutional-Based Cross-Sectional Study.

Clin Cosmet Investig Dermatol 2021 13;14:367-375. Epub 2021 Apr 13.

Department of Adult Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.

Introduction: Burns can have a considerable negative impact on physical and psychosocial functioning that affects the quality of life. The physical and psychological manifestations may compromise the quality of life of burned patients. The aim is to assess health-related quality of life and associated factors among burn patients at Amhara regional state governmental referral hospitals, Northwest Ethiopia, 2020. Read More

View Article and Full-Text PDF

Perception of Stigma in Patients with Neuromyelitis Optica Spectrum Disorder.

Patient Prefer Adherence 2021 12;15:713-719. Epub 2021 Apr 12.

Medical Department, Roche Farma, Madrid, Spain.

Background: Perception of stigma was associated with low self-esteem, psychological problems, and decreased health-seeking behavior among patients with different neurological disorders. The purpose of this study was to assess stigmatization and its impact in patients with neuromyelitis optica spectrum disorder (NMOSD).

Methods: A non-interventional study was conducted at thirteen neuroimmunology clinics in Spain. Read More

View Article and Full-Text PDF

Retinal Detachment After Endophthalmitis: Risk Factors and Outcomes.

Clin Ophthalmol 2021 13;15:1529-1537. Epub 2021 Apr 13.

Department of Ophthalmology and Visual Sciences, University of Michigan W.K. Kellogg Eye Center, Ann Arbor, MI, USA.

Purpose: To analyze the risk factors, clinical course, and visual and anatomic outcomes of retinal detachment (RD) after endophthalmitis.

Patients And Methods: This retrospective study included 108 patients diagnosed with endophthalmitis between August 2014 and May 2019 at a single tertiary referral center. Sixteen patients developed RD after endophthalmitis. Read More

View Article and Full-Text PDF

Trends in Opioid Prescriptions after Laparoscopic Sterilization.

JSLS 2021 Jan-Mar;25(1)

Department of Obstetrics and Gynecology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY.

Background And Objectives: Examine trends in opioid prescriptions after laparoscopic sterilization over time, and identify any individual patient, provider, or procedural factors influencing prescribing.

Methods: A retrospective observational cohort analysis of laparoscopic sterilizations between January 1, 2016 and December 31, 2019 at Montefiore Medical Center. A review of the medical records was performed and information on patient demographics, comorbid conditions, and surgical characteristics were collected. Read More

View Article and Full-Text PDF

Laparoscopic Nephrectomy for Massive Kidneys in Polycystic Kidney Disease.

JSLS 2021 Jan-Mar;25(1)

UO Chirurgia Trapianti Renali, Azienda Ospedaliero-Universitaria Senese, Viale Bracci 14, 53100 Siena, Italy.

Background And Objectives: Laparoscopic nephrectomy is now considered a feasible surgical approach, even for large kidneys. In the case of massive kidneys, laparoscopy can be problematic, so that some authors suggest an open approach. However, previous studies have shown that hand-assisted laparoscopic nephrectomy (HALN) may represent a useful compromise. Read More

View Article and Full-Text PDF

[Clinical value of inflammatory biomarkers in predicting prognosis of patients with ureteral urothelial carcinoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Mar;53(2):302-307

Department of Urology, the First Affiliated Hospital, Hebei North Univercity, Zhangjiakou 075061, Hebei, China.

Objective: To evaluate the clinical value of inflammation-related markers in predicting the prognosis of patients with ureteral urothelial carcinoma.

Methods: 200 patients with ureteral urothelial carcinoma were randomly divided into two groups by split sample validation: modeling group and validation group. Paraffin embedded pathological specimens of the patients were reviewed. Read More

View Article and Full-Text PDF