253,352 results match your criteria mechanisms control

[Development of a Psychosocial Online Self-Help Program for Cancer Patients: A Patient-Oriented Approach].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):132-141. Epub 2021 Apr 15.

Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz.

Aim Of The Study: Involving potential end users in the development process of digital interventions makes it possible to ensure that these programs meet the needs, requirements and expectations of future users, which in turn has a positive impact on acceptance and adherence. This contribution presents a participatory development approach for the patient-centered design of the psycho-oncological online self-help , which aims to provide support in coping with cancer.

Methods: Patients were involved in the developmental process at two points. Read More

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Pharmacologically Induced Ventilatory Depression in the Postoperative Patient: A Sleep-Wake State-Dependent Perspective.

Anesth Analg 2021 May;132(5):1274-1286

Department of Anesthesiology and Perioperative Medicine, College of Medicine, Mayo Clinic, Rochester, Minnesota.

Pharmacologically induced ventilatory depression (PIVD) is a common postoperative complication with a spectrum of severity ranging from mild hypoventilation to severe ventilatory depression, potentially leading to anoxic brain injury and death. Recent studies, using continuous monitoring technologies, have revealed alarming rates of previously undetected severe episodes of postoperative ventilatory depression, rendering the recognition of such episodes by the standard intermittent assessment practice, quite problematic. This imprecise description of the epidemiologic landscape of PIVD has thus stymied efforts to understand better its pathophysiology and quantify relevant risk factors for this postoperative complication. Read More

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A comparison of the mechanisms and performances of Acorus calamus, Pontederia cordata and Alisma plantagoaquatica in removing nitrogen from farmland wastewater.

Bioresour Technol 2021 Apr 6;332:125105. Epub 2021 Apr 6.

College of Resources and Environment, Hunan Agricultural University, Changsha 410128, PR China; Hunan Provincial Key Laboratory of Farmland Pollution Control and Agricultural Resources Use, Hunan Provincial Key Laboratory of Nutrition in Common University, National Engineering Laboratory on Soil and Fertilizer Resources Efficient Utilization, Changsha 410128, PR China. Electronic address:

This study examined the performances of Acorus calamus, Pontederia cordata, and Alisma plantagoaquatica in removing nitrogen (N) from farmland wastewater. P. cordata showed the fastest rate of N removal, followed by A. Read More

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Toxicity and deleterious impacts of selenium nanoparticles at supranutritional and imbalance levels on male goldfish (Carassius auratus) sperm.

J Trace Elem Med Biol 2021 Apr 8;66:126758. Epub 2021 Apr 8.

Leibniz Institute for Natural Product Research and Infection Biology e.V. Hans-Knöll-Institute (HKI), Jena, Germany.

Background: Selenium has a major role in male reproduction and antioxidative mechanisms. Although deficiency of this element can result in damages to the body's organs, this metalloid can induce deleterious effects in organisms by causing oxidative stress. This study assessed the spermatotoxicity of selenium nanoparticles (SeNPs) in goldfish (Carassius auratus) based on genotoxicity, antioxidant status, sperm quality, and histopathology. Read More

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Mechanisms by which different polar fractions of dissolved organic matter affect sorption of the herbicide MCPA in ferralsol.

J Hazard Mater 2021 Mar 31;416:125774. Epub 2021 Mar 31.

Institute of Environment and Plant Protection, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China; Danzhou Scientific Observing and Experimental Station of Agro-Environment, Ministry of Agriculture, Danzhou 571737, PR China; Hainan Key Laboratory of Tropical Eco-Circuling Agriculture, Haikou 571101, PR China. Electronic address:

Exogenous dissolved organic matter (DOM) modifies the sorption of 4-chloro-2-methylphenoxyacetic acid (MCPA, a polar herbicide) in soil. However, how the chemodiversity and diverse fractions of DOM affect MCPA sorption is still unknown. Here, DOM was extracted from compost and rice straw; the structure-activity correlations between DOM chemodiversity and their effects on MCPA sorption were investigated by redundancy analysis. Read More

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Evidence for dissociable cognitive and neural pathways from poverty versus maltreatment to deficits in emotion regulation.

Dev Cogn Neurosci 2021 Apr 8;49:100952. Epub 2021 Apr 8.

Department of Psychological & Brain Sciences at Washington University in St. Louis, United States; Department of Psychiatry at Washington University in St. Louis, United States; Department of Radiology at Washington University in St. Louis, United States.

Poverty and threat exposure (TE) predict deficits in emotion regulation (ER). Effective cognitive ER (i.e. Read More

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Affective dysregulation in children is associated with difficulties in response control in emotional ambiguous situations.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 Apr 12. Epub 2021 Apr 12.

Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Germany. Electronic address:

Background: Affective dysregulation (AD) or synonymously "irritability" is a transdiagnostic construct that serves as a diagnostic criterion in various childhood mental disorders. It is characterized by severe or persistent outbursts of anger and aggression. Emotional self-regulation is highly dependent on the ability to process relevant and ignore conflicting emotional information. Read More

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Development of Species-Specific IgM Antibodies and Elevation of Mucosal Immune Response in Labeo rohita Using Recombinant Bicistronic Nano DNA Vaccine Priming.

Fish Shellfish Immunol 2021 Apr 12. Epub 2021 Apr 12.

ICAR-Central Institute of Fisheries Education, Mumbai, 400061, India. Electronic address:

Immunoglobulin (IgM) is the primary immunoglobulin essential for defense mechanisms in fish. It is difficult to reliably quantify IgM because a lack of standardization in methodology and limited availability of commercially reagents. In the present study, a polyclonal antibody was developed for the specific detection and quantification of IgM in Labeo rohita. Read More

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Immuno-protective efficiency of feed-based whole-cell inactivated bivalent vaccine against Streptococcus and Aeromonas infections in red hybrid tilapia (Oreochromis niloticus × Oreochromis mossambicus).

Fish Shellfish Immunol 2021 Apr 12. Epub 2021 Apr 12.

Department of Aquaculture, Faculty of Agriculture, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia; Aquatic Animal Health and Therapeutics Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia. Electronic address:

Streptococcosis and motile aeromonad septicemia (MAS) are well-known diseases in tilapia culture, which cause mass mortality with significant economic losses. The development of feed-based bivalent vaccines in controlling these diseases has been initiated, however, the mechanisms of immunities and cross-protection in fish remain unclear. This study was conducted to assess the immuno-protective as well as the cross-protective efficacy of a newly developed feed-based bivalent vaccine against Streptococcus and Aeromonas infections in red hybrid tilapia. Read More

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Similar Activation Patterns in the Bilateral Dorsal Inferior Frontal Gyrus for Monolingual and Bilingual Contexts in Second Language Production.

Neuropsychologia 2021 Apr 12:107857. Epub 2021 Apr 12.

Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education; School of Psychology, South China Normal University, 510631, Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, 510631, Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631, Guangzhou, China. Electronic address:

Language production is a vital process of communication. Although many studies have devoted to the neural mechanisms of language production in bilinguals, they mainly focused on the mechanisms of cognitive control during language switching. Therefore, it is not clear how naming context influences the neural representations of linguistic information during language production in bilinguals. Read More

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Human plasmacytoid dendritic cells at the crossroad of type I interferon-regulated B cell differentiation and antiviral response to tick-borne encephalitis virus.

PLoS Pathog 2021 Apr 15;17(4):e1009505. Epub 2021 Apr 15.

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

The Tick-borne encephalitis virus (TBEV) causes different disease symptoms varying from asymptomatic infection to severe encephalitis and meningitis suggesting a crucial role of the human host immune system in determining the fate of the infection. There is a need to understand the mechanisms underpinning TBEV-host interactions leading to protective immunity. To this aim, we studied the response of human peripheral blood mononuclear cells (PBMC) to the whole formaldehyde inactivated TBEV (I-TBEV), the drug substance of Encepur, one of the five commercially available vaccine. Read More

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Single START-domain protein Mtsp17 is involved in transcriptional regulation in Mycobacterium smegmatis.

PLoS One 2021 15;16(4):e0249379. Epub 2021 Apr 15.

School of Medicine, Foshan University, Foshan, Guangdong, China.

Tuberculosis caused by the pathogen Mycobacterium tuberculosis (MTB), remains a significant threat to global health. Elucidating the mechanisms of essential MTB genes provides an important theoretical basis for drug exploitation. Gene mtsp17 is essential and is conserved in the Mycobacterium genus. Read More

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Language switching training modulates the neural network of non-linguistic cognitive control.

PLoS One 2021 15;16(4):e0247100. Epub 2021 Apr 15.

State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P. R. China.

Bilingual language experience, such as switching between languages, has been shown to shape both cognitive and neural mechanisms of non-linguistic cognitive control. However, the neural adaptations induced by language switching remain unclear. Using fMRI, the current study examined the impact of short-term language switching training on the neural network of domain-general cognitive control for unbalanced Chinese-English bilinguals. Read More

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Local Anesthetics Inhibit Transient Receptor Potential Vanilloid Subtype 3 Channel Function in Xenopus Oocytes.

Anesth Analg 2021 Apr 15. Epub 2021 Apr 15.

From the Department of Anesthesiology, School of Medicine.

Background: The transient receptor potential vanilloid subtype 3 (TRPV3) channel is activated by innocuous temperature and several chemical stimuli. It is proposed to be involved in pathological pain development and is therefore considered a potential target for treating pain. Local anesthetics have been used for patients with both acute and chronic pain. Read More

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Less is more: Depleting cognitive resources enhances language learning abilities in adults.

J Exp Psychol Gen 2021 Apr 15. Epub 2021 Apr 15.

Department of Experimental Psychology, Ghent University.

It is still an unresolved question why adults do not learn languages as effortlessly as children do. We tested the hypothesis that the higher cognitive control abilities in adults interfere with implicit learning mechanisms relevant for language acquisition. Across 2 days, Dutch-speaking adults were asked to rapidly recite novel syllable strings in which, unannounced to the participants, the allowed position of a phoneme depended on another adjacent phoneme. Read More

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Facile, Smart, and Degradable Metal-Organic Framework Nanopesticides Gated with Fe-Tannic Acid Networks in Response to Seven Biological and Environmental Stimuli.

ACS Appl Mater Interfaces 2021 Apr 15. Epub 2021 Apr 15.

Key Laboratory of Mesoscopic Chemistry (Ministry of Education), State Key Laboratory of Coordination Chemistry, and School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, People's Republic of China.

Nanopesticides were selected as one of the top 10 emerging technologies in chemistry that will change our world in 2019. Facile, smart, and degradable metal-organic framework MIL-101(Fe) nanopesticides gated with Fe-tannic acid (TA) networks are created using a universal strategy. The capping of the Fe-TA network gatekeepers is instinctively oriented by the coordinatively unsaturated Fe sites on the surfaces of the MIL-101(Fe) nanocarriers; thus, their combination is perfectly matched. Read More

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Antifungal effects of lycorine on Botrytis cinerea and possible mechanisms.

Biotechnol Lett 2021 Apr 15. Epub 2021 Apr 15.

Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources, College of Tropical Crops, Hainan University, Haikou, 570228, China.

Botrytis cinerea cause postharvest diseases on fruit and lead economic losses. Application of environment-friendly natural compounds is an alternative for synthetic fungicides to control postharvest disease. Lycorine is an indolizidine alkaloid which is widely used for human drug design, however, application of lycorine in controlling postharvest disease and the underlying mechanisms have not been reported. Read More

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Classical Phenotyping and Deep Learning Concur on Genetic Control of Stomatal Density and Area in Sorghum.

Plant Physiol 2021 Apr 15. Epub 2021 Apr 15.

Department of Agronomy, Kansas State University, Manhattan, KS, 66506, USA.

Stomatal density (SD) and stomatal complex area (SCA) are important traits that regulate gas exchange and abiotic stress response in plants. Despite sorghum (Sorghum bicolor) adaptation to arid conditions, the genetic potential of stomata-related traits remains unexplored due to challenges in available phenotyping methods. Hence, identifying loci that control stomatal traits is fundamental to designing strategies to breed sorghum with optimized stomatal regulation. Read More

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's Response to Antagonism Bacterial Stress Sheds Light on a Regulation and Metabolic Trade-Off Mechanism for Adversity Survival.

J Agric Food Chem 2021 Apr 15. Epub 2021 Apr 15.

Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430061, People's Republic of China.

Biocontrol to combat the menace of has gained considerable attention. However, the molecular mechanisms of 's response to antagonism biotic stress are poorly deciphered. Here, we discovered that switches an adaptive metabolic reprogramming to ensure its adversity survival by multiomics analyses (including four omics platform). Read More

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Bacterial and Microfauna Mechanisms for Sludge Reduction in Carrier-Enhanced Anaerobic Side-Stream Reactors Revealed by Metagenomic Sequencing Analysis.

Environ Sci Technol 2021 Apr 15. Epub 2021 Apr 15.

Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China.

Packing carriers into the anaerobic side-stream reactor (ASSR) can enhance sludge reduction and save footprint by investigating ASSR-coupled membrane bioreactors (AP-MBRs) under different hydraulic residence times of the ASSR (HRT). Three AP-MBRs and an anoxic-aerobic MBR (AO-MBR) showed efficient chemical oxygen demand (>94.2%) and ammonium nitrogen removal (>99. Read More

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The BBSome: a nexus controlling energy metabolism in the brain.

J Clin Invest 2021 Apr;131(8)

Institute of Innate Immunity, Department of Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany.

Bardet-Biedl syndrome (BBS) is a syndromic ciliopathy that has obesity as a cardinal feature. BBS is caused by mutations in BBS genes. BBS proteins control primary cilia function, and BBS mutations therefore lead to dysfunctional primary cilia. Read More

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Evaluation of the Ameliorative Effect of Zinc Nanoparticles against Silver Nanoparticle-Induced Toxicity in Liver and Kidney of Rats.

Biol Trace Elem Res 2021 Apr 14. Epub 2021 Apr 14.

Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Silver nanoparticles (Ag-NPs) have various pharmaceutical and biomedical applications owing to their unique physicochemical properties. Zinc (Zn) is an essential trace element, a strong antioxidant, and has a primary role in gene expression, enzymatic reactions, and protein synthesis. The present study aims to explore the toxic effects of Ag-NPs (50 nm) on the liver and kidney of rats and also to evaluate the potential protective effect of Zn-NPs (100 nm) against these adverse effects. Read More

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High-fructose diet initially promotes increased aortic wall thickness, liver steatosis, and cardiac histopathology deterioration, but does not increase body fat index.

J Public Health Res 2021 Apr 14;10(2). Epub 2021 Apr 14.

Nutrition Department, Polytechnic of Health, Malang.

Background: Dietary fats and fructose have been responsible for inducing obesity and body tissues damage due to the consequence of metabolic syndrome through several mechanisms. The body fat index (BFI) is one of the anthropometric measures used to detect obesity in rats. This study aims to examine the correlation between high-fat high-fructose diet and liver steatosis cell count, early atherosclerosis characteristics, and BFI in Sprague Dawley Rats. Read More

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The rapid effects of sleeve gastrectomy on glucose homeostasis and resolution of diabetes mellitus.

Endocrinol Diabetes Metab 2021 Apr 30;4(2):e00182. Epub 2020 Aug 30.

Deparment of General Surgery University of Health Sciences Sisli Hamidiye Etfal Education and Research Hospital İstanbul Turkey.

Aims: Type 2 diabetes caused by obesity is increasing globally. Bariatric surgical procedures are known to have positive effects on glucose homeostasis through neurohormonal action mechanisms. In the present study, we aimed to investigate the factors influencing glucose homeostasis independent of weight loss after the laparoscopic sleeve gastrectomy (LSG). Read More

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Reinforcement of Self-Regulated Brain Activity in Schizophrenia Patients Undergoing Rehabilitation.

Biomed Res Int 2021 26;2021:8030485. Epub 2021 Mar 26.

Department of Management in Nursing, Faculty of Health Sciences, Medical University of Lublin, 20-081 Lublin, Poland.

The experiment was aimed to compare the effects of different forms of rehabilitation applied in patients with schizophrenia. Verification of the obtained results was based on the analysis of the level of cognitive and social functioning of the subjects. For this purpose, the following clinical tools were used: Positive and Negative Syndrome Scale (PANSS), Beck Cognitive Insight Scale (BCIS), Color Trial Test (CTT-1, CTT-2), d2 psychological tests, Acceptance of Illness Scale (AIS), Self-efficacy Scale (GSES), Quantitative Electroencephalogram Biofeedback (QEEG-BF), auditory event-related potentials (ERPs), and serum levels of brain-derived neurotrophic factor (BDNF). Read More

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Descending and Ascending Signals That Maintain Rhythmic Walking Pattern in Crickets.

Front Robot AI 2021 29;8:625094. Epub 2021 Mar 29.

Research Institute for Electronic Science, Hokkaido University, Sapporo, Japan.

The cricket is one of the model animals used to investigate the neuronal mechanisms underlying adaptive locomotion. An intact cricket walks mostly with a tripod gait, similar to other insects. The motor control center of the leg movements is located in the thoracic ganglia. Read More

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COVID-19 in Children: Respiratory Involvement and Some Differences With the Adults.

Front Pediatr 2021 29;9:622240. Epub 2021 Mar 29.

Department of Pediatric Pulmonology, Neumocenter, Valledupar, Colombia.

The coronavirus disease 2019 (COVID-19) represents a health problem with multidimensional impacts and heterogeneous respiratory involvement in children, probably due to the interaction between different and complex mechanisms that could explain its variable degrees of severity. Although the majority of reports reveal that children develop less severe cases, the number of patients is increasing with more morbidity. Most serious respiratory manifestations are acute respiratory distress syndrome (ARDS) and pneumonia. Read More

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Cognitive improvement effect of gintonin might be associated with blood-brain barrier permeability enhancement: dynamic contrast-enhanced MRI pilot study.

Transl Clin Pharmacol 2021 Mar 10;29(1):21-32. Epub 2021 Mar 10.

Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.

Along with the multiple neuroprotective effect, recent studies suggest that gintonin might increase the blood brain barrier permeability. We evaluated the effect of gintonin on the vascular permeability changes in different brain segments, using dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). In this 8-week, randomized, open label pilot study, ten participants with subjective memory impairment but preserved cognitive function assigned to gintonin-enriched fraction (GEF) 300 mg/day or placebo groups. Read More

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Astragalus manna abortifacient risk and effects on sex hormones in BALB/c mice.

Biomedicine (Taipei) 2020 1;10(4):11-17. Epub 2020 Dec 1.

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Background: manna is used to treat different diseases. Because pregnant women tend to use and Iranian traditional medicine emphasizes the abortifacient potential of this plant, this study aimed to investigate manna abortifacient property and effects on estrogen, progesterone, LH and FSH levels in BALB/c mice.

Method: This experimental study was conducted with 70 female BALB/c mice assigned to seven groups: Nonpregnant, untreated; nonpregnant, extract (400 mg/kg)-treated; pregnant, extract (400, 800 and 1200 mg/kg)-treated; and two pregnant control groups. Read More

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December 2020

Characterization of the first vaginal genomes isolated in Brazil.

PeerJ 2021 10;9:e11079. Epub 2021 Mar 10.

Department of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Background: is the dominant species in the vaginal microbiota associated with health and considered a homeostasis biomarker. Interestingly, some strains are even used as probiotics. However, the genetic mechanisms of involved in the control of the vaginal microbiome and protection against bacterial vaginosis (BV) are not entirely known. Read More

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