1,317,309 results match your criteria mechanisms


Georgian Med News 2021 Mar(312):157-163

3Donetsk Law Institute of the Ministry of Internal Affairs of Ukraine, Kryvyi Rih, Ukraine.

This article aims to analyse the implementation of public procurement procedures in the context of national governments' fight against the COVID-19 pandemic and find solutions for adapting those public procurement procedures that are currently used in the healthcare sector to new challenges. For this above purpose, we have applied both theoretical methods such as analysis, synthesis, generalization, and empirical methods such as observation, etc. The research has yielded the following findings: 1) there are no one-size-fits-all solutions in the national governments' fight against the COVID-19 pandemic through the public procurement mechanism, except that national policies in this field intend to speed up the organisation of the public procurement procedures, which would shorten the time for the delivery of medical goods to healthcare facilities; 2) due to the current emergency conditions caused by the COVID-19 pandemic, public procurements of medical supplies are taking place under the non-competitive procedure, i. Read More

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Georgian Med News 2021 Mar(312):82-87

Tbilisi State Medical University, Department of Peadiatric Neurology; Iashvili Children's Central Hospital, Tbilisi, Georgia.

The purpose of this review is study of literature for the development of biological effect of Kalcipherol (D vitamin group) on children population. Different factors seem, that D- vitamin deficiency disbalance elevated, children specifically negative effect, which have a major impact on health, growth and development of infants, children and adolescents. Vitamin D and calcium deficiencies are preventable global public health problems in pediatric medicine. Read More

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A review on nitrogen dynamics and mitigation strategies of food waste digestate composting.

Bioresour Technol 2021 Mar 24;334:125032. Epub 2021 Mar 24.

Institute of Bioresource and Agriculture, Sino-Forest Applied Research Centre for Pearl River Delta Environment and Department of Biology, Hong Kong Baptist University, Hong Kong; School of Technology, Huzhou University, Huzhou 311800, China. Electronic address:

Food waste digestate is a by-product of the anaerobic digestion of food waste. Presence of high ammonium nitrogen content significantly increase the nitrogen loss upon direct application on soil or by conventional composting. In this review, a comprehensive discussion regarding the effective management of food waste digestate is outlined, in which global food waste digestate production, characteristics, and composting are discussed. Read More

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Multiple drivers, interaction effects, and trade-offs of efficient and cleaner combustion of torrefied water hyacinth.

Sci Total Environ 2021 Apr 23;786:147278. Epub 2021 Apr 23.

School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China.

Developing cleaner and affordable alternatives to the sole reliance on fossil fuels has intensified efforts to improve the thermochemical conversion property of the second-generation lignocellulosic biomass. This study aimed to explore the effects of the two torrefaction temperatures (200 and 300 °C), the two reaction atmospheres (N/O and CO/O), and the three heating rates (5, 10, and 15 °C/min) on the combustion regime of water hyacinth (WH). Decomposition behaviors, reaction kinetics, thermodynamics, and mechanisms, evolved emissions and functional groups, and fuel microstructure properties were quantified. Read More

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Position-specific isotope effects during alkaline hydrolysis of 2,4-dinitroanisole resolved by compound-specific isotope analysis, C NMR, and density-functional theory.

Chemosphere 2021 May 1;280:130625. Epub 2021 May 1.

Department of Earth Sciences, University of Delaware, Newark, DE, 19716, USA. Electronic address:

Compound-specific isotope analysis (CSIA), position-specific isotope analysis (PSIA), and computational modeling (e.g., quantum mechanical models; reactive-transport models) are increasingly being used to monitor and predict biotic and abiotic transformations of organic contaminants in the field. Read More

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Low-temperature oxidation of monobromobenzene: Bromine transformation and yields of phenolic species.

Chemosphere 2021 Apr 26;280:130621. Epub 2021 Apr 26.

Charles Darwin University, Office of Deputy Vice-Chancellor and Vice-President, Research & Innovation, Darwin, NT, 0909, Australia.

Brominated benzenes and phenols constitute direct precursors in the formation of bromine-bearing pollutants; most notably PBDD/Fs and other dioxin-type compounds. Elucidating accurate mechanisms and constructing robust kinetic models for the oxidative transformation of bromobenzenes and bromophenols into notorious Br-toxicants entail a comprehensive understanding of their initial oxidation steps. However, pertinent mechanistic studies, based on quantum chemical calculations, have only focused on secondary condensation reactions into PBDD/Fs and PBDEs. Read More

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Graphene oxide nanocomposites based room temperature gas sensors: A review.

Chemosphere 2021 Apr 29;280:130641. Epub 2021 Apr 29.

Department of Physics, VIT-AP University, Amaravati, Guntur, 522501, Andhra Pradesh, India. Electronic address:

Over the last few decades, various volatile organic compounds (VOCs) have been widely used in the processing of building materials and this practice adversely affected the environment i.e. both indoor and outdoor air quality. Read More

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Pediatric Autoimmune Encephalitis and Its Relationship With Infection.

Pediatr Neurol 2021 Apr 7;120:27-32. Epub 2021 Apr 7.

Department of Pediatrics, Peking University People's Hospital, Beijing, P.R. China. Electronic address:

Autoimmune encephalitis (AE) is an increasingly recognized inflammatory disorder of the central nervous system and is most often characterized by antibodies against intracellular and neuronal surface antigens. AE is a devastating disease that may result in developmental delay or regression in children. However, the pathogenesis of AE is not clear, and immune system disorders after infection likely play an important role in AE. Read More

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Multi-omics analyses on the response mechanisms of 'Shine Muscat' grapevine to low degree of excess copper stress (Low-ECS).

Environ Pollut 2021 Apr 30;286:117278. Epub 2021 Apr 30.

Department of Horticulture, Nanjing Agricultural University, Nanjing, Jiangsu Province, 210095, China; Fruit Crop Genetic Improvement and Seedling Propagation Engineering Center of Jiangsu Province, Nanjing, 210095, China.

Copper stress is one of the most severe heavy metal stresses in plants. Grapevine has a relatively higher copper tolerance than other fruit crops. However, there are no reports regarding the tolerance mechanisms of the 'Shine Muscat' ('SM') grape to a low degree of excess copper stress (Low-ECS). Read More

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Investigation of the skin lesions in lightning strike death.

Leg Med (Tokyo) 2021 Apr 30;52:101896. Epub 2021 Apr 30.

Section Legal Medicine, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Via del Vespro, 129, 90127, Italy. Electronic address:

Lightning strike-related deaths are unusual, and the victim bodies can present different lesions due to the different injury mechanisms associated with this event. Since the post mortem assessment can be challenging, the evaluation of the characteristics of the skin lesions becomes fundamental to reconstruct the event. Due to the paucity of literature on this topic, the authors report the case of a 59-year-old man found dead near his home after a thunderstorm. Read More

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Mass spectrometry informs the structure and dynamics of membrane proteins involved in lipid and drug transport.

Curr Opin Struct Biol 2021 May 5;70:53-60. Epub 2021 May 5.

Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3QZ, UK; The Kavli Institute for Nanoscience Discovery, 3 South Parks Road, Oxford, OX1 3QU, UK. Electronic address:

Membrane proteins are important macromolecules that play crucial roles in many cellular and physiological processes. Over the past two decades, the use of mass spectrometry as a biophysical tool to characterise membrane proteins has grown steadily. By capturing these dynamic complexes in the gas phase, many unknown small molecule interactions have been revealed. Read More

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Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents.

Eur J Med Chem 2021 Apr 28;221:113480. Epub 2021 Apr 28.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, 250012, China. Electronic address:

With the increasing incidence of antibiotic resistance, new antibacterial agents having novel mechanisms of action hence are in an urgent need to combat infectious diseases caused by multidrug-resistant (MDR) pathogens. Four novel series of substituted 9-arylalkyl-10-methylacridinium derivatives as FtsZ inhibitors were designed, synthesized and evaluated for their antibacterial activities against various Gram-positive and Gram-negative bacteria. The results demonstrated that they exhibited broad-spectrum activities with substantial efficacy against MRSA and VRE, which were superior or comparable to the berberine, sanguinarine, linezolid, ciprofloxacin and vancomycin. Read More

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Evaluation of the chemopreventive effects of Hypericum perforatum L on DMBA-applied rat oral mucosa.

Arch Oral Biol 2021 Apr 30;127:105139. Epub 2021 Apr 30.

Ankara University, Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey.

Objective: Hypericum perforatum L also known as St. John's wort is known to have many beneficial properties for the organism including its antioxidant and anticancer activities. It is also known to have shown antiproliferative and cytotoxic effects against various cancer cell lines. Read More

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Expanding the versatility of natural and de novo designed coiled coils and helical bundles.

Curr Opin Struct Biol 2021 May 5;68:224-234. Epub 2021 May 5.

Department of Protein Evolution, Max Planck Institute for Developmental Biology, Max-Planck-Ring 5, Tübingen, 72076, Germany. Electronic address:

Natural helical bundles (HBs) constitute a ubiquitous class of protein folds built of two or more longitudinally arranged α-helices. They adopt topologies that include symmetric, highly regular assemblies all the way to asymmetric, loosely packed domains. The diverse functional spectrum of HBs ranges from structural scaffolds to complex and dynamic effectors as molecular motors, signaling and sensing molecules, enzymes, and molecular switches. Read More

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Efficient removal of arsenite by a composite of amino modified silica supported MnO/Fe-Al hydroxide (SNMFA) prepared from biotite.

J Environ Manage 2021 May 5;291:112678. Epub 2021 May 5.

School of Minerals Processing and Bioengineering, Central South University, Changsha, 410083, China.

Developing materials from natural minerals to efficiently remove arsenite (As(Ⅲ)) from solution is vital important for resources comprehensive utilization and environment protection. In this study, biotite containing minerals was used to prepare a novel composite of amino modified silica supported MnO/Fe-Al hydroxide (SNMFA composite), which was then applied to remove arsenite. Scanning electron microscope (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) results indicated that many amorphous MnO and Fe-Al hydroxide nano sheets were loaded on the surface of layered silica structure. Read More

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Plumbagin Inhibits Proliferation, Migration, and Invasion of Retinal Pigment Epithelial Cells Induced by FGF-2.

Tissue Cell 2021 Apr 28;72:101547. Epub 2021 Apr 28.

Department of Ophthalmology, The second Hospital of Hebei Medical University, Shijiazhuang, 05000, China. Electronic address:

Proliferative vitreoretinopathy (PVR) is a serious ophthalmic disease and characterized by the formation of proliferative membranes by retinal pigment epithelial (RPE) cells. In PVR, the contraction and traction of the fibrocellular membranes cause retinal detachment, which can cause reduction surgery for retinal detachment to fail. Fibroblast growth factor-2 (FGF-2) causes RPE cells to form extracellular matrix (ECM), promotes chemotaxis, mitosis, and positively promotes the disease process of PVR. Read More

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Out of balance: the role of evolutionary mismatches in the sex disparity in autoimmune disease.

Med Hypotheses 2021 Mar 29;151:110558. Epub 2021 Mar 29.

Department of Anthropology, University College London, UK.

Over the past century autoimmune disease incidence has increased rapidly in (post-) industrialised, affluent societies, suggesting that changes in ecology and lifestyle are driving this development. Epidemiological studies show that (i) 80% of autoimmune disease patients are female, (ii) autoimmune diseases co-occur more often in women, and (iii) the incidence of some autoimmune diseases is increasing faster in women than in men. The female preponderance in autoimmunity is most pronounced between puberty and menopause, suggesting that diverging sex hormone levels during the reproductive years are implicated in autoimmune disease development. Read More

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Facial first impressions form two clusters representing approach-avoidance.

Cogn Psychol 2021 May 5;126:101387. Epub 2021 May 5.

School of Psychology, University of Lincoln, UK.

Existing models of facial first impressions indicate between two and four factors that underpin all social trait judgements. Here, we submitted several large databases of these first impression ratings to unsupervised learning algorithms with the aim of clustering together faces, rather than traits, to examine the ways in which impressions may be grouped together. Experiment 1 revealed two clusters of faces that exist in both a full-dimensional, and two- or three-factor representations, of social impressions, while Experiment 2 indicated that these clusters also emerged in additional datasets. Read More

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Multiple metal exposure and obesity: A prospective cohort study of adults living along the Yangtze River, China.

Environ Pollut 2021 Apr 30;285:117150. Epub 2021 Apr 30.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China; Laboratory for Environmental Toxicology, Anhui Medical University, Hefei, Anhui, 230032, China. Electronic address:

Association between long-term exposure to multiple metals and obesity remains inconclusive, and prospective evidence on the region along the Yangtze River was limited. Thus, our study aimed to examine the association of multiple metal exposure and obesity. We measured baseline urine levels of 22 metals of 982 adults living along the Yangtze River, incidence of obesity was calculated from body mass index (BMI) and waist circumference (WC) measured at follow-up survey. Read More

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Predictive Factors of Perioperative Stroke-Related Mortality Following Vascular Surgery: A Retrospective Analysis.

J Stroke Cerebrovasc Dis 2021 May 4;30(7):105833. Epub 2021 May 4.

Departments of Neurology and Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States. Electronic address:

Objective: Vascular surgical procedures have one of the highest risks of perioperative stroke and stroke-related mortality, yet the independent risk factors contributing to this increased mortality have not been described. Perioperative strokes are thought to result from a combination of embolism and hypoperfusion mechanisms. The purpose of this study is to describe the independent predictors of perioperative stroke-related mortality in the vascular surgical population using the Pennsylvania Health Care Cost Containment Council (PHC4) database which collects cause of death data. Read More

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A semiological marker of emotional insulo-cingulate network activation in epileptic human brain.

Epilepsy Behav 2021 May 5;120:107970. Epub 2021 May 5.

Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing 100053, China. Electronic address:

There are limited reports on the "chapeau de gendarme" (CDG) sign, which is considered reliable evidence for the verification of frontal epilepsy. However, several recent reports of scattered cases of extra-frontal epilepsy suggest the complexity of the cortical networks underlying CDG generation. The present study aimed to investigate the anatomo-electro-clinical correlations and explore the cortical mechanisms of the generation of CDG via video-stereoelectroencephalography (SEEG). Read More

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Differential DNA Methylation is associated with Hippocampal Abnormalities in Pediatric Posttraumatic Stress Disorder.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 May 5. Epub 2021 May 5.

Department of Child and Adolescent Psychiatry, The Netherlands; De Bascule, Academic Centre for Child and Adolescent Psychiatry, Amsterdam, The Netherlands.

Background: Recent findings in neuroimaging and epigenetics offer important insights into brain structures and biological pathways of altered gene expression associated with posttraumatic stress disorder (PTSD). However, it is unknown to what extent epigenetic mechanisms are associated with PTSD and its neurobiology in youth.

Methods: In this study we combined a methylome-wide association study and structural neuroimaging measures in a Dutch cohort of youth with PTSD (ages 8-18 years). Read More

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Loss of FOXO Transcription Factors in the Liver Mitigates Stress-Induced Hyperglycemia.

Mol Metab 2021 May 5:101246. Epub 2021 May 5.

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Physiology, Perelman School of Medicine, University of Pennsylvania. Electronic address:

Objective: Stress-induced hyperglycemia is associated with poor outcomes in nearly all critical illnesses. This acute elevation in glucose after injury or illness is associated with increased morbidity and mortality including multiple organ failure. Stress-induced hyperglycemia is often attributed to insulin resistance as controlling glucose levels via exogenous insulin improves outcomes, but mechanisms are unclear. Read More

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Clinical characteristics and outcome of bacteremia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences.

J Glob Antimicrob Resist 2021 May 5. Epub 2021 May 5.

Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBiS), University of Seville/CSIC/ Virgen del Rocío University Hospital, Seville, Spain.

Introduction: The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter species were those of the Enterobacter cloacae complex and Enterobacter aerogenes. In 2019, E. Read More

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Quantitative proteomic analysis of scleras in guinea pig exposed to wavelength defocus.

J Proteomics 2021 May 5:104248. Epub 2021 May 5.

Department of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China; Clinical Research Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China. Electronic address:

Myopia is the most common optical disorder in the world, and wavelength defocus induced ametropia and myopia have attracted great attention. The objective was to identify and quantify scleral proteins involved in the response to the wavelength defocus. Guinea pigs were randomly divided into 3 groups that received different lighting conditions for 8 weeks: white light, short wavelength light, and long wavelength light. Read More

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Ginsenosides in vascular remodeling: cellular and molecular mechanisms of their therapeutic action.

Pharmacol Res 2021 May 5:105647. Epub 2021 May 5.

The Second Xiangya Hospital of Central South University Shenzhen Hospital, Shenzhen, Guangdong 518067, China. Electronic address:

Evidence is mounting that abnormal vascular remodeling (VR) is a vital pathological event that precedes many cardiovascular diseases (CVD). This provides us with a new research perspective that VR can be a pivotal target for CVD treatment and prevention. However, the current drugs for treating CVD does not fundamentally reverse VR and repair vascular function. Read More

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Plumbagin suppresses non-small cell lung cancer progression through downregulating ARF1 and by elevating CD8 cells.

Pharmacol Res 2021 May 5:105656. Epub 2021 May 5.

Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research. Electronic address:

Non-small cell lung cancer (NSCLC) is one of the most frequently diagnosed cancers and the leading causes of cancer death worldwide. Therefore, new therapeutic agents are urgently needed to improve patient outcomes. Plumbagin (PLB), a natural sesquiterpene present in many Chinese herbal medicines, has been reported for its anti-cancer activity in various cancer cells. Read More

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Biological effect of PM on airway epithelium-focus on obstructive lung diseases.

Clin Immunol 2021 May 5:108754. Epub 2021 May 5.

Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Poland. Electronic address:

Recently, a continuous increase in environmental pollution has been observed. Despite wide-scale efforts to reduce air pollutant emissions, the problem is still relevant. Exposure to elevated levels of airborne particles increased the incidence of respiratory diseases. Read More

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A basic helix-loop-helix transcription factor CabHLH113 positively regulate pepper immunity against Ralstonia solanacearum.

Microb Pathog 2021 May 5:104909. Epub 2021 May 5.

Innovative Institute for Plant Health, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, People's Republic of China; College of Agriculture and Biology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, People's Republic of China. Electronic address:

Pepper's (Capsicum annum) response to bacterial pathogen Ralstonia solanacearm inoculation (RSI) and abiotic stresses is known to be synchronized by transcriptional network; however, related molecular mechanisms need extensive experimentation. We identified and characterized functions of CabHLH113 -a basic helix-loop-helix transcription factor-in pepper immunity to R. solanacearum infection. Read More

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Identification of hub genes and signaling pathways related to gastric cells infected by Helicobacter pylori.

Microb Pathog 2021 May 5:104932. Epub 2021 May 5.

Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China; Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China; Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. Electronic address:

Background: Helicobacter pylori is a pathogen involved in several gastroduodenal diseases, whose infection mechanisms have not been completely confirmed. To study the specific mechanism of gastropathy caused by H. pylori, we analyzed the gene microarray of gastric mucosa and gastric cells infected by H. Read More

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