Neurochem Res 2021 Jul 26. Epub 2021 Jul 26.
Department of Neurology, Kangda College of Nanjing Medical University Affiliated Lianshui County People's Hospital, 6 Hongri Avenue East, Lianshui County, Huai'an, 223400, Jiangsu, People's Republic of China.
Sinensetin (SIN) is an important active compound that exists widely in citrus plants, and has been reported to exhibit various pharmacological properties, including anti-oxidative, anti-inflammatory, and anti-tumor. This study was designed to examine whether SIN can protect against amyloid beta (Aβ)-induced neurotoxicity and to elucidate the underlying mechanism. Our results showed that pretreatment with SIN for 1 h, followed by co-treatment with Aβ plus SIN for 24 h, attenuated Aβ-induced cell viability reduction, oxidative stress, inflammation, and apoptosis in a dose-dependent manner. Read More