8,822 results match your criteria mechanism quinone


Lycopene attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2/NF-κB balance in sulfamethoxazole-induced neurotoxicity in grass carp (Ctenopharyngodon Idella).

Fish Shellfish Immunol 2022 Jan 12. Epub 2022 Jan 12.

College of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, Heilongjiang, PR China. Electronic address:

All drugs that can penetrate the blood-brain barrier (BBB) may lead to mental state changes, including the widely used anti-infective drug sulfamethoxazole (SMZ). Herein, we investigated whether lycopene (LYC) could ameliorate SMZ-induced brain injury and the postulated mechanisms involved. A total of 120 grass carps were exposed under SMZ (0. Read More

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January 2022

Interaction of membrane-embedded cytochrome b-complexes with quinols: Classical Q-cycle and murburn model.

Cell Biochem Funct 2022 Jan 13. Epub 2022 Jan 13.

Karel de Grote University College, Antwerp University Association, Campus Hoboken, Hoboken, Belgium.

We recently proposed a diffusible reactive (oxygen) species (DRS/DROS) based function for cytochrome b complexes (CBC) and quinones (Q)/quinols (QH ) in the murburn model of bioenergetics. This proposal is in direct conflict with the classical purview of Q-cycle. Via extensive analyses of the structure-function correlations of membrane-quinones/quinols and proteins, we present qualitative and quantitative arguments to infer that the classical model cannot explain the energetics, kinetics, mechanism and probabilistic considerations. Read More

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January 2022

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis the protection of vascular endothelial cells from oxidative stress.

J Adv Res 2021 Dec 6;34:43-63. Epub 2021 Jul 6.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611130, PR China.

Introduction: Recently, Nrf2/HO-1 has received extensive attention as the main regulatory pathway of intracellular defense against oxidative stress and is considered an ideal target for alleviating endothelial cell (EC) injury.

Objectives: This paper aimed to summarized the natural monomers/extracts that potentially exert protective effects against oxidative stress in ECs.

Methods: A literature search was carried out regarding our topic with the keywords of "atherosclerosis" or "Nrf2/HO-1" or "vascular endothelial cells" or "oxidative stress" or "Herbal medicine" or "natural products" or "natural extracts" or "natural compounds" or "traditional Chinese medicines" based on classic books of herbal medicine and scientific databases including Pubmed, SciFinder, Scopus, the Web of Science, GoogleScholar, BaiduScholar, and others. Read More

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December 2021

A Network Pharmacology-Based Study on Antidepressant Effect of Salicornia europaea L. Extract with Experimental Support in Chronic Unpredictable Mild Stress Model Mice.

Chin J Integr Med 2022 Jan 13. Epub 2022 Jan 13.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.

Objective: To investigate the pharmacodynamic material basis, mechanism of actions and targeted diseases of Salicornia europaea L. (SE) based on the network pharmacology method, and to verify the antidepressant-like effect of the SE extract by pharmacological experiments.

Methods: Retrieval tools including Chinese medicine (CM), PubMed, PharmMapper, MAS 3. Read More

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January 2022

Role and significance of water and acid washing on biochar for regulating methane production from waste activated sludge.

Sci Total Environ 2022 Jan 8;817:152950. Epub 2022 Jan 8.

State Key Laboratory of Urban Water Resource and Environment, School of Civil and Environmental Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.

Methane recovered from anaerobic digestion of waste activated sludge (WAS) can be used as the energy supplement of the wastewater treatment plant, benefiting to its carbon-neutral operation. In order to enhance methane production, biochar (BC) has been widely selected as conductive material to build direct interspecies electron transfer (DIET) in anaerobic digestion of WAS. However, the role and significance of washing strategies, including water and acid washing, on BCs for regulating methane production have not been reported. Read More

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January 2022

Thermal Hydrolysis Pretreatment-Anaerobic Digestion Promotes Plant-Growth Biostimulants Production from Sewage Sludge by Upregulating Aromatic Amino Acids Transformation and Quinones Supply.

Environ Sci Technol 2022 Jan 10. Epub 2022 Jan 10.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

Micromolecular plant-growth biostimulants (micro-PBs) production from sewage sludge is attracting increasing interest, as it is expected to enhance the fertilizing effect of sludge for land application. This study attempted to promote effective micro-PBs production from sewage sludge through thermal hydrolysis pretreatment-anaerobic digestion (THP-AD) and explore the underpinning regulation mechanisms. Results showed that the highest effective micro-PB production in digested sludge was achieved in THP(160 °C)-AD by day 12, with 80. Read More

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January 2022

Pyrroloquinoline quinone ameliorates diabetic cardiomyopathy by inhibiting the pyroptosis signaling pathway in C57BL/6 mice and AC16 cells.

Eur J Nutr 2022 Jan 8. Epub 2022 Jan 8.

Institute of Food Science and Engineering, Hangzhou Medical College, Tianmushan Road 182th, Hangzhou, 310013, Zhejiang, People's Republic of China.

Purpose: Diabetic cardiomyopathy (DCM), a common complication of diabetes mellitus and is characterized by myocardial hypertrophy and myocardial fibrosis. Pyrroloquinoline quinone (PQQ), a natural nutrient, exerts strong protection against various myocardial diseases. Pyroptosis, a type of inflammation-related programmed cell death, is vital to the development of DCM. Read More

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January 2022

Redox properties and regulatory mechanism of the iron-quinone electron acceptor in photosystem II as revealed by FTIR spectroelectrochemistry.

Photosynth Res 2022 Jan 5. Epub 2022 Jan 5.

Division of Material Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8602, Japan.

Photosystem II (PSII) performs oxidation of water and reduction of plastoquinone through light-induced electron transfer. Electron transfer reactions at individual redox cofactors are controlled by their redox potentials, and the forward and backward electron flows in PSII are regulated by tuning them. It is, thus, crucial to accurately estimate the redox potentials of the cofactors and their shifts by environmental changes to understand the regulatory mechanisms in PSII. Read More

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January 2022

Identification of adducts between oxidized rosmarinic acid and glutathione compounds by electrochemistry, liquid chromatography and mass spectrometry.

Anal Methods 2022 Jan 5. Epub 2022 Jan 5.

SPO, INRA, Montpellier Supagro, Montpellier University, UMR 1083, F-34060, Montpellier, France.

Natural polyphenols are omnipresent and are an integral part of the human diet as well as quinones. Glutathione (GSH) is present in a significant amount inside cells and consequently, GSH conjugates of polyphenols will be encountered in the body. In the current work, voltammetry and liquid chromatography-mass spectrometry were carried out to characterize the reaction mechanism of the electrochemical oxidation of polyphenolic rosmarinic acid (RA) with GSH nucleophiles in aqueous solution. Read More

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January 2022

Synthesis and biological evaluation of celastrol derivatives as potential anti-glioma agents by activating RIP1/RIP3/MLKL pathway to induce necroptosis.

Eur J Med Chem 2021 Dec 23;229:114070. Epub 2021 Dec 23.

Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang, 110016, China. Electronic address:

Celastrol, a quinone methide triterpenoid, possesses potential anti-glioma activity. However, its relatively low activity limit its application as an effective agent for glioma treatment. In search for effective anti-glioma agents, this work designed and synthesized two series of celastrol C-3 OH and C-20 COOH derivatives 4a-4o and 6a-6o containing 1, 2, 3-triazole moiety. Read More

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December 2021

Metabolomics-driven of relationships among kidney, bone marrow and bone of rats with postmenopausal osteoporosis.

Bone 2021 Dec 25;156:116306. Epub 2021 Dec 25.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

As a global public health problem, postmenopausal osteoporosis (PMOP) poses a great threat to old women's health. Bone is the target organ of PMOP, and the dynamic changes of bone marrow could affect the bone status. Kidney is the main organ regulating calcium and phosphorus homeostasis. Read More

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December 2021

Metamitron, a Photosynthetic Electron Transport Chain Inhibitor, Modulates the Photoprotective Mechanism of Apple Trees.

Plants (Basel) 2021 Dec 17;10(12). Epub 2021 Dec 17.

Group of Agrophysics Studies, MIGAL-Galilee Research Institute, Kiryat Shemona, Upper Galilee 11016, Israel.

Chemical thinning of apple fruitlets is an important practice as it reduces the natural fruit load and, therefore, increases the size of the final fruit for commercial markets. In apples, one chemical thinner used is Metamitron, which is sold as the commercial product Brevis (Adama, Ashdod, Israel). This thinner inhibits the electron transfer between Photosystem II and Quinone-b within light reactions of photosynthesis. Read More

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December 2021

Iron-mediated epigenetic activation of NRF2 targets.

J Nutr Biochem 2021 Dec 23;101:108929. Epub 2021 Dec 23.

School of Biomedical Science, Institute of Clinical Science, University of Birmingham, Edgbaston, Birmingham, UK.

The toxic effects of excess dietary iron within the colonic lumen are well documented, particularly in the context of Inflammatory Bowel Disease (IBD) and Colorectal Cancer (CRC). Proposed mechanisms that underpin iron-associated intestinal disease include: (1) the pro-inflammatory and ROS-promoting nature of iron, (2) gene-expression alterations, and (3) intestinal microbial dysbiosis. However, to date no studies have examined the effect of iron on the colonic epigenome. Read More

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December 2021

[Rhein inhibits hydrogen peroxide-induced apoptosis of human umbilical vein endothelial cells and its mechanism].

Zhongguo Zhong Yao Za Zhi 2021 Dec;46(23):6204-6215

Department of Pharmacy, Affiliated Hospital of Southwest Medical University Luzhou 646000, China.

This study investigated the effect of rhein(RH) on the apoptosis and autophagy of human umbilical vein endothelial cells(HUVECs) induced by hydrogen peroxide(H_2O_2) and its underlying mechanism. The oxidative damage model in HUVECs was established and the cells were divided into different treatment groups. Cell survival rate was detected by MTT assay, apoptosis by Annexin V-FITC/PI double staining and Hoechst 33258 fluorescence staining, autophagy by Ad-mCherry-GFP-LC3 B adenovirus transfection, and protein expression by Western blot. Read More

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December 2021

Response of Cytoprotective and Detoxifying Proteins to Vanadate and/or Magnesium in the Rat Liver: The Nrf2-Keap1 System.

Oxid Med Cell Longev 2021 13;2021:8447456. Epub 2021 Dec 13.

Department of General, Oncological, and Minimally Invasive Surgery, 1 Military Clinical Hospital with The Outpatient Clinic in Lublin, Poland.

Oxidative stress (OS) is a mechanism underlying metal-induced toxicity. As a redox-active element, vanadium (V) can act as a strong prooxidant and generate OS at certain levels. It can also attenuate the antioxidant barrier and intensify lipid peroxidation (LPO). Read More

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December 2021

Anti-fatigue effect of phlorizin on exhaustive exercise-induced oxidative injury mediated by Nrf2/ARE signaling pathway in mice.

Eur J Pharmacol 2021 Dec 20:174563. Epub 2021 Dec 20.

Department of Clinical Pharmacotherapeutics, School of Pharmacy, Zunyi Medical University, Zunyi, China; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China. Electronic address:

Oxidative stress plays a crucial role in fatigue, thus it is of significance to develop safe and efficient antioxidant to prevent fatigue. Phlorizin (PHZ) is a major active ingredient of dihydrochalcone from Lithocarpus polystachyus Rehd., which has already been approved as a new food material in China since 2017. Read More

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December 2021

Suppression mechanism of model humic constituents on laccase-enabled 17β-estradiol oxidation and oligomerization.

Authors:
Shunyao Li Kai Sun

Chemosphere 2021 Dec 17;290:133356. Epub 2021 Dec 17.

School of Resources and Environment, Anhui Agricultural University, 130 Changjiang West Road, Hefei, 230036, Anhui, China. Electronic address:

Humic constituents (HCs) are ubiquitous in the aquatic ecosystems, and contain various functional groups that seriously impact the conversion of 17β-estradiol (17β-E2) by fungal laccase. The purpose of this study was to explore the influencing mechanism of HCs on Trametes versicolor laccase-enabled 17β-E2 oxidation and oligomerization. Herein, T. Read More

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December 2021

Bipolar Organic Polymer for High Performance Symmetric Aqueous Proton Battery.

Small Methods 2021 Aug 26;5(8):e2100367. Epub 2021 Jun 26.

Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.

Bipolar electroactive organic molecules receive an increasing research attention as electrode materials for rechargeable batteries due to their flexibility, controllability, and environmental friendliness. While its application for symmetric aqueous proton batteries is still in its infancy. Herein, a symmetric aqueous proton battery (APB) based on a bipolar poly(aminoanthraquinone) (PNAQ) is developed. Read More

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Use of Ore-Derived Humic Acids With Diverse Chemistries to Elucidate Structure-Activity Relationships (SAR) of Humic Acids in Plant Phenotypic Expression.

Front Plant Sci 2021 1;12:758424. Epub 2021 Dec 1.

FBSciences, Inc., R&D, Norfolk, VA, United States.

We report the results of a structure-activity relationship study that was undertaken to identify humic substance chemistries that drive the plant biostimulant response. The effects of seven extensively chemically characterized, ore-derived humic acids (HA) on corn seedling biomass and root and shoot morphological parameters were investigated. Chemometric analyses were then conducted to identify correlations between HA chemical features and plant biomass and morphological characteristics. Read More

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December 2021

Anthraquinone (AQS)/polyaniline (PANI) modified carbon felt (CF) cathode for selective HO generation and efficient pollutant removal in electro-Fenton.

J Environ Manage 2022 Feb 20;304:114315. Epub 2021 Dec 20.

Key Laboratory of Northwest Water Resources, Environment and Ecology, Ministry of Education, Xi'an University of Architecture and Technology, Xi'an, 710055, China; Shaanxi Key Laboratory of Environmental Engineering, Xi'an University of Architecture and Technology, Xi'an, 710055, China.

A novel binder-free anthraquinone (AQS)/polyaniline (PANI) modified carbon felt (CF) cathode for selective HO generation and efficient pollutant removal in electro-Fenton was fabricated by CV electro-deposition method. AQS, the oxygen reduction reaction (ORR) catalyst, was immobilized by the PANI film, which contributed to the obtained high stability of the AQS/[email protected] cathode. The concentration of the electro-generated HO on AQS/[email protected] cathode (83. Read More

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February 2022

[Aloin inhibits lactate-induced proliferation and migration of gastric cancer cells by downregulating HMGB1 expression].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Nov;41(11):1700-1706

Department of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu 241002, China.

Objective: To assess the inhibitory effects of aloin on lactate-induced gastric proliferation and migration of cancer cells and explore the underlying molecular mechanism.

Methods: Gastric cancer BGC-823 cells were treated with aloin, lactate or the combination of lactate and different doses of aloin. EdU assay was used to detect the proliferation of BGC-823 cells, and colony formation ability of the cells was evaluated with colony forming assay; wound healing and Transwell assays were used to detect the changes in migration ability of the treated cells. Read More

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November 2021

Genomic analysis of Elsinoë arachidis reveals its potential pathogenic mechanism and the biosynthesis pathway of elsinochrome toxin.

PLoS One 2021 16;16(12):e0261487. Epub 2021 Dec 16.

Department of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning, China.

Elsinochromes (ESCs) are virulence factors produced by Elsinoë arachidis which is the cause of peanut scab. However, the biosynthesis pathway of ESCs in E. arachidis has not been elucidated and the potential pathogenic mechanism of E. Read More

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January 2022

A dynamic substrate pool revealed by cryo-EM of a lipid-preserved respiratory supercomplex.

Antioxid Redox Signal 2021 Dec 16. Epub 2021 Dec 16.

Hanyang University, 26716, Department of Bioengineering, Seongdong-gu, Korea (the Republic of);

Aims: Mitochondrial respiratory supercomplexes mediate redox electron transfer, generating a proton gradient for ATP synthesis. To provide structural information on the function of supercomplexes in physiologically relevant conditions, we conducted cryo-electron microscopy studies with supercomplexes in a lipid-preserving state.

Results: Here, we present cryo-electron microscopy structures of bovine respiratory supercomplex I1III2IV1 by using a lipid-preserving sample preparation. Read More

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December 2021

Assessing the source of the photochemical formation of hydroxylating species from dissolved organic matter using model sensitizers.

Environ Sci Process Impacts 2021 Dec 15. Epub 2021 Dec 15.

Department of Civil, Environmental, and Architectural Engineering, Environmental Engineering Program, University of Colorado Boulder, 607 UCB, CO 80309, USA.

Dissolved organic matter (DOM) is ubiquitous in natural waters and can facilitate the chemical transformation of many contaminants through the photochemical production of reactive intermediates, such as singlet oxygen (O), excited triplet state DOM (DOM*), and hydroxylating species (˙OH and other intermediates of similar reaction chemistry). The formation mechanism of most reactive intermediates is well understood, but this is not the case for the formation of hydroxylating species from DOM. To investigate this chemistry, DOM model sensitizers were irradiated with two different probe compounds (benzene and benzoic acid) at two irradiation wavelengths (254 and 320 nm). Read More

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December 2021

Expanding the Reactive Sulfur Metabolome: Intracellular and Efflux Measurements of Small Oxoacids of Sulfur (SOS) and HS in Human Primary Vascular Cell Culture.

Molecules 2021 Nov 26;26(23). Epub 2021 Nov 26.

Department of Chemistry and Biochemistry, Baylor University, Waco, TX 76798, USA.

Hydrogen sulfide (HS) is an endogenous signaling molecule which is important for cardiovascular health, but its mechanism of action remains poorly understood. Here, we report measurements of HS as well as its oxidized metabolites, termed small oxoacids of sulfur (SOS = HSOH and HOSOH), in four human primary vascular cell lines: smooth muscle and endothelial cells derived from both human arterial and coronary tissues. We use a methodology that targets small molecular weight sulfur species; mass spectrometric analysis allows for species quantification to report cellular concentrations based on an HS calibration curve. Read More

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November 2021

Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression.

Int J Mol Sci 2021 Nov 30;22(23). Epub 2021 Nov 30.

Pharmaceutical Research and Technology Institute, Kindai University, Higashi-Osaka, Osaka 577-8502, Japan.

Royal jelly (RJ) is secreted by honeybees and has been used as an apitherapy to obtain healthy skin since ancient times. However, the mechanism of the protective effects of RJ against skin aging and skin diseases caused by skin stress and its components have not been clarified. In this study, we attempted to understand the effect of RJ on epidermal function and observed that NAD(P)H quinone dehydrogenase 1 (NQO1) is significantly induced by RJ in keratinocytes. Read More

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November 2021

3D imaging of single bacterial cells using surface-enhanced Raman spectroscopy with a multivariate curve resolution model.

Analyst 2021 Dec 8. Epub 2021 Dec 8.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Imaging biomolecules within a single bacterial cell is crucial for understanding cellular genetic mechanisms. Herein, we exploited a surface-enhanced Raman spectroscopy (SERS) imaging strategy for single cell analysis. Cellular biosynthesized Ag nanoparticles (NPs) provided the necessary enhancement for SERS imaging. Read More

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December 2021

Inhibition of CYP3A4 enhances aloe-emodin induced hepatocyte injury.

Toxicol In Vitro 2022 Mar 4;79:105276. Epub 2021 Dec 4.

School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address:

Aloe-emodin (AE) is a natural hydroxyanthraquinone derivative that was found in many medicinal plants and ethnic medicines. AE showed a wide array of pharmacological activities including anticancer, antifungal, laxative, antiviral, and antibacterial effects. However, increasing number of published studies have shown that AE may have some hepatotoxicity effects but the mechanism is not fully understood. Read More

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Expanding the spectrum of polydopamine antioxidant activity by nitroxide conjugation.

J Mater Chem B 2021 12 15;9(48):9980-9988. Epub 2021 Dec 15.

Department of Chemistry "G. Ciamician", University of Bologna, Via S. Giacomo 11, 40126, Bologna, Italy.

Polydopamine (PDA) materials are important due to their unique physicochemical properties and their potential as chemopreventive agents for diseases connected with oxidative stress. Although PDA has been suggested to display antioxidant activity, its efficacy is controversial and its mechanism of action is still unclear. Herein, we report that accurately purified PDA nanoparticles in water at pH 7. Read More

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December 2021

Thermal stress induces a positive phenotypic and molecular feedback loop in zebrafish embryos.

J Therm Biol 2021 Dec 23;102:103114. Epub 2021 Oct 23.

Department of Biological and Marine Sciences, University of Hull, Cottingham Road, Kingston Upon Hull, HU6 7RX, United Kingdom. Electronic address:

Aquatic organisms must cope with both rising and rapidly changing temperatures. These thermal changes can affect numerous traits, from molecular to ecological scales. Biotic stressors are already known to induce the release of chemical cues which trigger behavioural responses in other individuals. Read More

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December 2021