200,530 results match your criteria mechanism development


Effects of Long Noncoding RNA H19 on Isoflurane-Induced Cognitive Dysregulation by Promoting Neuroinflammation.

Neuroimmunomodulation 2021 Dec 2:1-11. Epub 2021 Dec 2.

Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University-Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.

Introduction: Isoflurane (ISO) may cause neuronal apoptosis and synaptic disorder during development, and damage long-term learning and memory function. This observation aimed to study the function of H19 in vitro and in vivo tests and the further mechanism was identified.

Methods: ISO cell models and rat models were established and reactive oxygen species (ROS) identified. Read More

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December 2021

Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3β/Fyn pathway.

Bioorg Chem 2021 Nov 25;119:105516. Epub 2021 Nov 25.

Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, School of Pharmacy, Guangdong Medical University, Zhanjiang 524023, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang, Guangdong 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, Guangdong 524023, China. Electronic address:

Both ruthenium (Ru) and isoquinoline (IQ) compounds are regarded as potential anticancer drug candidates. Here, we report the synthesis and characterization of three novel cyclometalated Ru(II)-isoquinoline complexes: RuIQ-3, RuIQ-4, and RuIQ-5, and evaluation of their in vitro cytotoxicities against a panel of cell lines including A549/DDP, a cisplatin-resistant human lung cancer cell line. A549/DDP 3D multicellular tumor spheroids (MCTSs) were also used to detect the drug resistance reversal effect of Ru(II)-IQ complexes. Read More

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November 2021

Preparation, in vitro and in vivo evaluation of Chitosan-Sodium alginate-Ethyl cellulose polyelectrolyte film as a novel buccal mucosal delivery vehicle.

Eur J Pharm Sci 2021 Nov 29:106085. Epub 2021 Nov 29.

Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002, Jilin Province, China; Yanbian Medical and Health Industry Pilot Base, College of Pharmacy, Yanbian University, Yanji, 133002, Jilin Province, China. Electronic address:

This paper describes the development of a film comprising chitosan (CS), sodium alginate (SA), and ethyl cellulose (EC) for buccal mucosal administration. A film of CS-SA unidirectional release drug-containing water-repellent layer EC was produced by interfacial reaction solvent-drying technique using self-made equipment. The CS-SA-EC film had superior mechanical properties compared to CS-EC and SA-EC films. Read More

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November 2021

Recent developments in the removal of metal-based engineered nanoparticles from the aquatic environments by adsorption.

Chemosphere 2021 Nov 29:133089. Epub 2021 Nov 29.

Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Nowadays, metal-based engineered nanoparticles (m-ENPs) are ubiquitous in aquatic environments for their wide applications in all walks of life. m-ENPs have been demonstrated to exert ecotoxicity, cytotoxicity and genotoxicity towards organisms and even humans. Therefore, the removal of m-ENPs from water has recently become a hot global concerned issue. Read More

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November 2021

Integrative investigation of the TF-miRNA coregulatory network involved in the inhibition of breast cancer cell proliferation by resveratrol.

FEBS Open Bio 2021 Dec 2. Epub 2021 Dec 2.

Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital, Jilin University, Changchun, 130021.

Resveratrol is a polyphenol with antiaging and anticancer effects. Most previous studies used a single analysis to determine the key functions of resveratrol in inhibiting cancer progression. However, most of the signal transmission pathways in biological processes are multilevel. Read More

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December 2021

Assessing BRCA1 activity in DNA damage repair using human induced pluripotent stem cells as an approach to assist classification of BRCA1 variants of uncertain significance.

PLoS One 2021 2;16(12):e0260852. Epub 2021 Dec 2.

Department of Medical & Molecular Genetics, King's College London, Faculty of Life Sciences & Medicine, London, United Kingdom.

Establishing a universally applicable protocol to assess the impact of BRCA1 variants of uncertain significance (VUS) expression is a problem which has yet to be resolved despite major progresses have been made. The numerous difficulties which must be overcome include the choices of cellular models and functional assays. We hypothesised that the use of induced pluripotent stem (iPS) cells might facilitate the standardisation of protocols for classification, and could better model the disease process. Read More

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December 2021

Relationships between ICT competencies related to work, self-esteem, and self-regulated learning with engineering competencies.

PLoS One 2021 2;16(12):e0260659. Epub 2021 Dec 2.

Institute of Social Technology, Suranaree University of Technology, Nakhon Ratchasima, Thailand.

The rapid development of advanced technology worldwide has promoted an increase in the need for highly skilled engineers who are adept at applying job-related technologies and have engineering competency (ENcom) to gain knowledge and introduce creative solutions. However, little is known about the underlying mechanism of the associations between ICT competencies related to work (ICT-Work) and the ENcom of engineering students. This study sought to examine the role of ICT-Work on ENcom. Read More

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December 2021

Primary school staff perspectives of school closures due to COVID-19, experiences of schools reopening and recommendations for the future: A qualitative survey in Wales.

PLoS One 2021 2;16(12):e0260396. Epub 2021 Dec 2.

Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Swansea, United Kingdom.

School closures due to the COVID-19 global pandemic are likely to have a range of negative consequences spanning the domains of child development, education and health, in addition to the widening of inequalities and inequities. Research is required to improve understanding of the impact of school closures on the education, health and wellbeing of pupils and school staff, the challenges posed during face-to-face reopening and importantly to identify how the impacts of these challenges can be addressed going forward to inform emerging policy and practice. This qualitative study aimed to reflect on the perspectives and experiences of primary school staff (pupils aged 3-11) in Wales regarding school closures and the initial face-to-face reopening of schools and to identify recommendations for the future. Read More

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December 2021

The bioinformatics analysis of RIOX2 gene in lung adenocarcinoma and squamous cell carcinoma.

PLoS One 2021 2;16(12):e0259447. Epub 2021 Dec 2.

Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Lung cancer is characterized by high morbidity and mortality rates, and it has become an important public health issue worldwide. The occurrence and development of tumors is a multi-gene and multi-stage complex process. As an oncogene, ribosomal oxygenase 2 (RIOX2) has been associated with a variety of cancers. Read More

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December 2021

Reversible Cerebral Vasoconstriction Syndrome in the Setting of COVID-19 and Pleomorphic Sarcoma: A Case Report.

Neurologist 2021 Nov 30. Epub 2021 Nov 30.

Departments of Neurology Internal medicine Radiology, Mayo Clinic College of Medicine and Science, Scottsdale, AZ.

Introduction: Reversible cerebral vasonstriction syndrome (RCVS) is an increasingly recognized clinical and radiologic syndrome. However, it has been rarely reported in the setting of the novel coronavirus disease-2019 (COVID-19) infection or sarcomatous tumors. RCVS might be the initial manifestations of COVID-19 infection or noncatecholamine producing masses including sarcoma. Read More

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November 2021

Room-Temperature Mixed-Potential Type ppb-Level NO Sensors Based on KFeO Electrolyte and Ni/Fe-MOF Sensing Electrodes.

ACS Sens 2021 Dec 2. Epub 2021 Dec 2.

State Key Laboratory of Integrated Optoelectronics, Key Laboratory of Advanced Gas Sensors, Jilin Province, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China.

Portable and sensitive mixed-potential type solid-state electrolyte (MPSE) gas sensors can detect exhaled biomarkers in a noninvasive and inexpensive way, which is significant for convenient disease diagnosis and saving medical resources. However, high working temperature is still one of the main bottlenecks for hindering MPSE gas sensors' applications in disease diagnosis. Here, we, for the first time, developed and fabricated new room-temperature MPSE gas sensors utilizing KFeO electrolyte and Ni/Fe-MOF (Ni/Fe clusters are coordinated with 1,4-HBDC) sensing electrodes (SEs) for the detection of ppb-level NO. Read More

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December 2021

The current status of anti-citrullinated protein antibodies and citrullinated protein-reactive B cells in the pathogenesis of rheumatoid arthritis.

Mol Biol Rep 2021 Dec 2. Epub 2021 Dec 2.

Department of Rheumatology and Immunology, Affiliated Hospital of Weifang Medical University, Weifang, China.

Anti-citrullinated protein antibodies are a hallmark of rheumatoid arthritis. It is widely acknowledged that the presence of ACPAs is the result of the interaction of genes, the environment and epigenetic modifications. The mechanism by which the factors, especially citrullination and ACPA glycosylation, affect ACPAs is still unclear. Read More

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December 2021

Transcriptome and DNA methylome analyses provide insight into the heterosis in flag leaf of inter-subspecific hybrid rice.

Plant Mol Biol 2021 Dec 2. Epub 2021 Dec 2.

State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan, 430072, China.

Key Message: Flag leaf heterosis of inter-subspecific hybrid rice is suggested to be related to leaf area, gene expression pattern and allele-specific expression, putatively related to DNA methylation differences between the hybrid and its parents. Inter-subspecific hybrid rice combinations of indica × japonica have great potential to broaden genetic diversity and enhance the heterosis. The genetic and epigenetic molecular mechanism of its heterosis is not completely understood. Read More

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December 2021

H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion.

Inflamm Res 2021 Dec 2. Epub 2021 Dec 2.

Key Laboratory of Endemic and Ethnic Diseases (Guizhou Medical University), Ministry of Education, Guiyang, China.

Objective: The CagA (cytotoxin-related gene A, CagA) protein is an important factor for the pathogenicity of Helicobacter pylori (H. pylori). Although H. Read More

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December 2021

The influence of social pain experience on empathic neural responses: the moderating role of gender.

Exp Brain Res 2021 Dec 2. Epub 2021 Dec 2.

Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, South China Normal University, Guangzhou, China.

Empathy for pain, the ability to share and understand the pain of others, plays an important role in the survival and development of individuals. Previous studies have found that social pain experience affects empathy for pain, but potential gender differences have not been considered. The stage of information processing during which gender is most likely to play a moderating role has yet to be clarified. Read More

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December 2021

Role of Rho GTPases in stem cell regulation.

Biochem Soc Trans 2021 Dec 2. Epub 2021 Dec 2.

Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, U.S.A.

The future of regenerative medicine relies on our understanding of stem cells which are essential for tissue/organ generation and regeneration to maintain and/or restore tissue homeostasis. Rho family GTPases are known regulators of a wide variety of cellular processes related to cytoskeletal dynamics, polarity and gene transcription. In the last decade, major new advances have been made in understanding the regulatory role and mechanism of Rho GTPases in self-renewal, differentiation, migration, and lineage specification in tissue-specific signaling mechanisms in various stem cell types to regulate embryonic development, adult tissue homeostasis, and tissue regeneration upon stress or damage. Read More

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December 2021

Sex-Inducing Activities of the Land Planarian Extract Fractions, Obtained Using Bioassay-Guided Fractionation, in the Freshwater Planarian .

Zoolog Sci 2021 Dec;38(6):544-557

Department of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Aomori 036-8561, Japan,

Sexually mature planarians produce sex-inducing substances that induce postembryonic development of hermaphroditic reproductive organs in asexual freshwater planarians. Although the sex-inducing substances may be useful for elucidating the mechanism underlying this reproductive switch, the available information is limited. The potency of sex-inducing activity is conserved, at least at the order level. Read More

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December 2021

Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice.

J Cell Mol Med 2021 Dec 2. Epub 2021 Dec 2.

Laboratory Animal Center, Guangxi Medical University, Nanning, Guangxi, China.

Vasorin (VASN) is an important transmembrane protein associated with development and disease. However, it is not clear whether the death of mice with VASN deficiency (VASN ) is related to cardiac dysfunction. The aim of this research was to ascertain whether VASN induces pathological cardiac hypertrophy by targeting myosin light chain 7 (MYL7). Read More

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December 2021

Isoforms of autophagy-related proteins: role in glioma progression and therapy resistance.

Mol Cell Biochem 2021 Dec 1. Epub 2021 Dec 1.

Tumor Immunology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, UP, 221005, India.

Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. During autophagy induction the healthy and tumor cells adapt themselves to harsh conditions such as cellular stress or insufficient supply of nutrients in the cell environment to maintain their homeostasis. Autophagy is currently seen as a form of programmed cell death along with apoptosis and necroptosis. Read More

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December 2021

High IKZF2 Expression in Malignant T cells Promotes Disease Progression in Cutaneous T cell Lymphoma.

Acta Derm Venereol 2021 Dec 2. Epub 2021 Dec 2.

Department of Dermatology and Venereology, Peking University First Hospital, No.8 Xishiku Street, Xi Cheng District, Beijing 100034, China.

Cutaneous T cell lymphoma is a generally indolent disease derived from skin-homing mature T cells. However, in advanced stages, CTCL may manifest as aggressive clinical behavior and lead to a poor prognosis. The mechanism of disease progression in CTCL remains unknown. Read More

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December 2021

Elucidating the charge storage mechanism of carbonaceous and organic electrode materials for sodium ion batteries.

Chem Commun (Camb) 2021 Dec 1. Epub 2021 Dec 1.

Department of Materials Science and Engineering, Korea University, Seoul 02841, Republic of Korea.

Sodium ion batteries (SIB) have received much research attention in the past decades as they are considered to be one alternative to the currently prevalent lithium ion batteries, and carbonaceous and organic compounds present two promising classes of SIB electrode materials advantaged by abundance of their constituent elements and reduced environmental footprints. To accelerate the development of these materials for SIB applications, future research directions must be guided by a thorough understanding of the charge storage mechanism. This review presents recent efforts in mechanism elucidation for these two classes of SIB electrode materials since, compared to their inorganic counterparts, they have unique challenges in material analysis. Read More

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December 2021

Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications.

Mol Ther Nucleic Acids 2021 Dec 10;26:1291-1302. Epub 2021 Nov 10.

Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, 603 203 Tamil Nadu, India.

The majority of the non-protein-coding RNAs are being identified with diversified functions that participate in cellular homeostasis. The circular RNAs (circRNAs) are emerging as noncoding transcripts with a key role in the initiation and development of many physiological and pathological conditions. The advancements in high-throughput RNA sequencing and bioinformatics tools help us to identify several circRNA regulatory pathways, one of which is microRNA (miRNA)-mediated regulation. Read More

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December 2021

Effects of dietary zinc deficiency on esophageal squamous cell proliferation and the mechanisms involved.

World J Gastrointest Oncol 2021 Nov;13(11):1755-1765

Department of Gastroenterology, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing 100038, China.

Background: Dietary zinc deficiency has been shown to be associated with the development of esophageal cancer in humans, but the exact mechanism of action is not known.

Aim: To observe the effects of dietary zinc deficiency on esophageal squamous cell proliferation.

Methods: Thirty C57BL/6 mice were randomly divided into three groups: A zinc-sufficient (ZS) group, zinc-deficient (ZD) group, and zinc-replenished (ZR) group. Read More

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November 2021

Preventive and inhibitive effects of Yiwei Xiaoyu granules on the development and progression of spasmolytic polypeptide-expressing metaplasia lesions.

World J Gastrointest Oncol 2021 Nov;13(11):1741-1754

Department of Gastroenterology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400000, China.

Background: Spasmolytic polypeptide-expressing metaplasia (SPEM) is a potential preneoplastic lesion.

Aim: To elucidate the microRNA (miR)-7-mediated preventive and inhibitive effects of Yiwei Xiaoyu granules (YWXY) in SPEM lesions.

Methods: Gastric mucosa biopsies were collected from chronic atrophic gastritis patients and healthy people with signed informed consent. Read More

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November 2021

Shuyu pills inhibit immune escape and enhance chemosensitization in hepatocellular carcinoma.

World J Gastrointest Oncol 2021 Nov;13(11):1725-1740

College of Integrated Chinese and Western Medicine, Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China.

Background: Hepatocellular carcinoma (HCC) is characterized by dysregulation of the immune microenvironment and the development of chemoresistance. Specifically, expression of the programmed cell death protein 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) axis, an immune checkpoint, may lead to tumour immune escape, resulting in disease progression. The latest research shows that tumour immune escape may be caused by the upregulation of PD-L1 mediated by hypoxia-inducible factor-1 alpha (HIF-1α), and simultaneous inhibition of HIF-1α and PD-L1 has the potential to enhance the host's antitumour immunity. Read More

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November 2021

Novel perspective in pancreatic cancer therapy: Targeting ferroptosis pathway.

World J Gastrointest Oncol 2021 Nov;13(11):1668-1679

Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.

Pancreatic cancer is a highly lethal malignancy with low resection and survival rates and is not sensitive to radiotherapy and chemotherapy. Ferroptosis is a novel form of nonapoptotic regulated cell death characterized by the accumulation of lipid peroxides and reactive oxygen species involved in iron metabolism. Ferroptosis has a significant role in the occurrence and development of various tumors. Read More

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November 2021

Temporomandibular disorders: a review of current concepts in aetiology, diagnosis and management.

Oral Surg 2020 Nov 25;13(4):321-334. Epub 2020 Jan 25.

Centre for Oral Health Research & Institute of Health and Society, Newcastle University, Newcastle, United Kingdom.

Temporomandibular disorders (TMD) is a collective term for a group of musculoskeletal conditions involving pain and/or dysfunction in the masticatory muscles, temporomandibular joints (TMJ) and associated structures. It is the most common type of non-odontogenic orofacial pain and patients can present with pain affecting the face/head, TMJ and or teeth, limitations in jaw movement, and sounds in the TMJ during jaw movements. Comorbid painful and non-painful conditions are also common among individuals with TMD. Read More

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November 2020

Local circuit amplification of spatial selectivity in the hippocampus.

Nature 2021 Dec 1. Epub 2021 Dec 1.

Department of Neuroscience, Columbia University, New York, NY, USA.

Local circuit architecture facilitates the emergence of feature selectivity in the cerebral cortex. In the hippocampus, it remains unknown whether local computations supported by specific connectivity motifs regulate the spatial receptive fields of pyramidal cells. Here we developed an in vivo electroporation method for monosynaptic retrograde tracing and optogenetics manipulation at single-cell resolution to interrogate the dynamic interaction of place cells with their microcircuitry during navigation. Read More

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December 2021

Emergence of mTOR mutation as an acquired resistance mechanism to AKT inhibition, and subsequent response to mTORC1/2 inhibition.

NPJ Precis Oncol 2021 Dec 1;5(1):99. Epub 2021 Dec 1.

Department of Investigational Cancer Therapeutics (Phase I Program), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

Acquired resistance to molecular targeted therapy is a significant challenge of the precision medicine era. The ability to understand these mechanisms of resistance may improve patient selection and allow for the development of rationally designed next-line or combination treatment strategies and improved patient outcomes. AKT is a critical effector of the phosphoinositide 3-kinase signaling cascade, one of the most commonly activated pathways in human cancer. Read More

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December 2021

Cancer-associated fibroblast-derived exosomal miR-18b promotes breast cancer invasion and metastasis by regulating TCEAL7.

Cell Death Dis 2021 Dec 1;12(12):1120. Epub 2021 Dec 1.

Department of Pathology, Weifang Medical University, Weifang, Shandong, China.

Studies have shown that cancer-associated fibroblasts (CAFs) play an irreplaceable role in the occurrence and development of tumors. Therefore, exploring the action and mechanism of CAFs on tumor cells is particularly important. In this study, we compared the effects of CAFs-derived exosomes and normal fibroblasts (NFs)-derived exosomes on breast cancer cells migration and invasion. Read More

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December 2021