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Linear Model Identification for Personalized Prediction and Control in Diabetes.

IEEE Trans Biomed Eng 2021 Aug 4;PP. Epub 2021 Aug 4.

Objective: Type-1 diabetes (T1D) is a metabolic disease, characterized by impaired blood glucose (BG) regulation, which forces patients to multiple daily therapeutic actions, the most critical of which is exogenous insulin administration. T1D management can considerably benefit of mathematical models enabling accurate BG predictions and effective/safe automated insulin delivery. In building these models, dealing with large inter- and intra-patient variability in glucose-insulin dynamics represents a major challenge. Read More

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The Swedish RAND-36: psychometric characteristics and reference data from the Mid-Swed Health Survey.

J Patient Rep Outcomes 2021 Aug 4;5(1):66. Epub 2021 Aug 4.

University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Background: This study aims to evaluate data quality, scaling properties, and reliability of the Swedish RAND-36 in a general population sample and to present reference data for the Swedish population.

Methods: Testing of data quality, scaling assumptions and reliability followed methods recommended for the International Quality of Life Assessment Project, previously used for psychometric testing of SF-36 and RAND-36. Data were collected via regular mail for a random stratified sample of the general population in a Swedish county. Read More

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Evaluation of a new online cognitive assessment tool in breast cancer survivors with cognitive impairment: a prospective cohort study.

Support Care Cancer 2021 Aug 4. Epub 2021 Aug 4.

Multidisciplinary Oncologic Center Antwerp (MOCA), Antwerp University Hospital, B2650, Edegem, Belgium.

Introduction: Currently cancer-related cognitive impairment (CRCI) is mainly assessed by means of questionnaires, which is very laborious for the patients and the supervising physician. We evaluated a new online cognitive assessment tool, the MyCognition Quotient (MyCQ, Cambridge) in breast cancer survivors with CRCI, and compared the results with a psychometric test measuring cognitive complaints, depression, and anxiety.

Materials And Methods: In this prospective study, 46 adult patients between 18 and 70 years old with a diagnosis of BC were studied, all complaining of disturbing cognitive impairment. Read More

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A higher reliability with a computed tomography scan-based three dimensional technique than with a two dimensional measurement for lower limb discrepancy in total hip arthroplasty planning.

Int Orthop 2021 Aug 4. Epub 2021 Aug 4.

ELSAN, 58bis Rue de la Boétie, 75008, Paris, France.

Purpose: The goal was to compare the reliability of a novel 3D method with the standard 2D technique for lower limb discrepancy (LLD) measurement during pre-operative THA planning.

Methods: This prospective study included 100 consecutive patients who underwent THA using 3D planning based on a low-dose CT scan. The LLD was subdivided into three parameters: the intra-articular LLD (IA-LLD), the segmental extra-articular LLD (EA-LLD), and the total LLD (T-LLD). Read More

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Quality of Hospital Electronic Health Record (EHR) Data Based on the International Consortium for Health Outcomes Measurement (ICHOM) in Heart Failure: Pilot Data Quality Assessment Study.

JMIR Med Inform 2021 Aug 4;9(8):e27842. Epub 2021 Aug 4.

Medical Informatics and Statistics Unit, Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Background: There is increasing recognition that health care providers need to focus attention, and be judged against, the impact they have on the health outcomes experienced by patients. The measurement of health outcomes as a routine part of clinical documentation is probably the only scalable way of collecting outcomes evidence, since secondary data collection is expensive and error-prone. However, there is uncertainty about whether routinely collected clinical data within electronic health record (EHR) systems includes the data most relevant to measuring and comparing outcomes and if those items are collected to a good enough data quality to be relied upon for outcomes assessment, since several studies have pointed out significant issues regarding EHR data availability and quality. Read More

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Influence of sample preparation optimization on the accuracy of dose assessment of an automatic non-fluorescent MN scoring system.

Int J Radiat Biol 2021 Aug 4:1-45. Epub 2021 Aug 4.

Institute of Nuclear Techniques, Budapest University of Technology and Economics, Budapest, Hungary.

Automatizing the scoring of the cytokinesis-blocked micronucleus assay spares a lot of valuable time. The dose-effect relationship can be applied reliably for dose estimation, if the quality of the slides is the same from the perspective of the used image processing algorithm. This aspect brings in additional requirements against the quality of the slides compared to the conventional visual scoring. Read More

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[Pulse oximetry: principles, limitations and practical applications].

Ned Tijdschr Geneeskd 2021 May 11;165. Epub 2021 May 11.

Amsterdam UMC, locatie VUmc, afd. Interne Geneeskunde, Amsterdam.

Pulse oximetry detects hypoxemia non-invasively by measuring light absorption at different wave lengths, depending on the oxygenation of hemoglobin. The plethysmographic signal is caused by volume changes in the arterial blood during systole. In this pulsatile flow, oxygen saturation is calculated using an algorithm. Read More

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Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice.

CNS Neurosci Ther 2021 Aug 4. Epub 2021 Aug 4.

Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University, Chongqing, China.

Aims: Secondary bleeding and further hematoma expansion (HE) aggravate brain injury after intracerebral hemorrhage (ICH). The majority of HE results from hypertensive ICH. Previous study reported higher iron content in the brains of hypertensive patients. Read More

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Latent Factor Analysis of the PROMIS and Single Assessment Numeric Evaluation in Patients Undergoing Shoulder Surgery.

Mil Med 2021 Aug 4. Epub 2021 Aug 4.

Department of Surgery Division of Orthopaedics, USU-Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.

Introduction: Patient-reported outcomes (PROs) are reporting tools that quantify patients' perceptions of their mental and physical health. Many PROs may inadvertently measure the same or overlapping theoretical constructs (e.g. Read More

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Using the Self-Management Assessment Scale for Screening Support Needs in Type 2 Diabetes: Qualitative Study.

JMIR Nurs 2020 Jan-Dec;3(1):e16318. Epub 2020 Sep 15.

Department of Nursing Umeå University Umeå Sweden.

Background: Globally, most countries face a common challenge by moving toward a population-based structure with an increasing number of older people living with chronic conditions such as type 2 diabetes. This creates a considerable burden on health care services. The use of digital tools to tackle health care challenges established views on traditional nursing, based on face-to-face meetings. Read More

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September 2020

Nursing Unit Communication During a US Public Health Emergency: Natural Experiment.

JMIR Nurs 2018 Jan-Dec;1(1):e11425. Epub 2018 Dec 6.

Institute for Software Research School of Computer Science Carnegie Mellon University Pittsburgh, PA United States.

Background: In the second half of 2014, the first case of Ebola virus disease (EVD) was diagnosed in the United States. During this time period, we were collecting data for the Measuring Network Stability and Fit (NetFIT) longitudinal study, which used social network analysis (SNA) to study relationships between nursing staff communication patterns and patient outcomes. One of the data collection sites was a few blocks away from where the initial EVD diagnosis was made. Read More

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December 2018

Assessment of kidney function: clinical indications for measured GFR.

Clin Kidney J 2021 Aug 22;14(8):1861-1870. Epub 2021 Feb 22.

Institute of Public Health, Charité Universitätsmedizin Berlin, Berlin, Germany.

In the vast majority of cases, glomerular filtration rate (GFR) is estimated using serum creatinine, which is highly influenced by age, sex, muscle mass, body composition, severe chronic illness and many other factors. This often leads to misclassification of patients or potentially puts patients at risk for inappropriate clinical decisions. Possible solutions are the use of cystatin C as an alternative endogenous marker or performing direct measurement of GFR using an exogenous marker such as iohexol. Read More

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Inter and Intra-Rater Reliability of Measuring Photometric Craniovertebral Angle Using a Cloud-Based Video Communication Platform.

Int J Telerehabil 2021 22;13(1):e6346. Epub 2021 Jun 22.

Department of Physical Therapy, College of Natural, Behavioral, and Health Sciences, Simmons University, Boston, Massachusetts, Usa.

Objective: Due to social distancing guidelines during the Coronavirus (COVID-19) pandemic, most providers and patients have wanted to avoid close contact. This makes physical therapy (PT) assessments difficult because of the lack of empirical evidence about the reliability of various clinical measurements performed in a virtual environment. One such procedure is the photometric measurement of craniovertebral (CV) angle. Read More

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Fuzzy Guided Autonomous Nursing Robot through Wireless Beacon Network.

Multimed Tools Appl 2021 Jul 29:1-29. Epub 2021 Jul 29.

Department of Digital Systems, Faculty of Technology, University of Thessaly, Geopolis, Larissa, Greece.

Robotics is one of the most emerging technologies today, and are used in a variety of applications, ranging from complex rocket technology to monitoring of crops in agriculture. Robots can be exceptionally useful in a smart hospital environment provided that they are equipped with improved vision capabilities for detection and avoidance of obstacles present in their path, thus allowing robots to perform their tasks without any disturbance. In the particular case of Autonomous Nursing Robots, major essential issues are effective robot path planning for the delivery of medicines to patients, measuring the patient body parameters through sensors, interacting with and informing the patient, by means of voice-based modules, about the doctors visiting schedule, his/her body parameter details, etc. Read More

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Establishment of HLA class I and MICA/B null HEK-293T panel expressing single MICA alleles to detect anti-MICA antibodies.

Sci Rep 2021 Aug 3;11(1):15716. Epub 2021 Aug 3.

Department of Microbiology, College of Medicine, The Catholic University of Korea, 505, Banpo-Dong, Seocho-Gu, Seoul, 137-040, Korea.

Pre- and post-transplantation anti-MICA antibody detection development are associated with an increased rejection risk and low graft survival. We previously generated HLA class I null HEK-293T using CRISPR/Cas9, while MICA and MICB genes were removed in this study. A panel of 11 cell lines expressing single MICA alleles was established. Read More

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Measuring oxygen access: lessons from health facility assessments in Lagos, Nigeria.

BMJ Glob Health 2021 08;6(8)

Department of Paediatrics, University College Hospital Ibadan, Ibadan, Oyo, Nigeria.

The COVID-19 pandemic has highlighted global oxygen system deficiencies and revealed gaps in how we understand and measure 'oxygen access'. We present a case study on oxygen access from 58 health facilities in Lagos state, Nigeria. We found large differences in oxygen access between facilities (primary vs secondary, government vs private) and describe three key domains to consider when measuring oxygen access: availability, cost, use. Read More

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Medial Prefrontal Cortex Glutamate Is Reduced in Schizophrenia and Moderated by Measurement Quality: A Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies.

Biol Psychiatry 2021 Jun 12. Epub 2021 Jun 12.

Department of Psychiatry and Behavioral Sciences, University of California Davis, Davis, California. Electronic address:

Background: Magnetic resonance spectroscopy studies measuring brain glutamate separately from glutamine are helping elucidate schizophrenia pathophysiology. An expanded literature and improved methodologies motivate an updated meta-analysis examining effects of measurement quality and other moderating factors in characterizing abnormal glutamate levels in schizophrenia.

Methods: Searching previous meta-analyses and the MEDLINE database identified 83 proton magnetic resonance spectroscopy datasets published through March 25, 2020. Read More

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Hemoperfusion with CytoSorb to Manage Multiorgan Dysfunction in the Spectrum of Hemophagocytic Lymphohistiocytosis Syndrome in Critically Ill Children.

Blood Purif 2021 Aug 3:1-8. Epub 2021 Aug 3.

Pediatric Emergency Department Pediatric Intensive Care Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition characterized by a state of hyperinflammation. Blood purification techniques can blunt the inflammatory process with a rapidly relevant nonselective effect on the cytokine storm, thus potentially translating into survival benefit for these patients. In this cohort, we evaluated the impact of hemoadsorption with CytoSorb combined with continuous kidney replacement therapy used as adjunctive therapy in 6 critically ill children with multiple organ dysfunction due to HLH. Read More

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Feasibility of assessment of skeletal muscle mass on a single cross-sectional image at the level of the fourth thoracic vertebra.

Eur J Radiol 2021 Jul 26;142:109879. Epub 2021 Jul 26.

Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht and Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.

Background: Skeletal muscle mass (SMM) determined on computed tomography (CT) is emerging as a novel imaging biomarker. Cross-sectional area (CSA) of SMM at the level of the third lumbar vertebra (L3) on abdominal imaging is considered the clinical reference standard for measuring SMM. In certain patient groups, such as those with oncological or non-oncological lung disease like COVID-19, a chest CT may be available while an abdominal CT is not. Read More

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Performance of Knee Image Digital Analysis of radiographs of patients with end-stage knee osteoarthritis.

Osteoarthritis Cartilage 2021 Jul 31. Epub 2021 Jul 31.

Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address:

Objective: Knee Image Digital Analysis (KIDA) is standardized radiographic analysis software for measuring osteoarthritis (OA) characteristics. It was validated in mild OA, but used for severe OA as well. The current goal was to evaluate the performance of KIDA in severe OA. Read More

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Examining the Mental Workload Associated With Digital Health Technologies in Health Care: Protocol for a Systematic Review Focusing on Assessment Methods.

JMIR Res Protoc 2021 Aug 3;10(8):e29126. Epub 2021 Aug 3.

Faculty of Health Care, Niederrhein University of Applied Sciences, Krefeld, Germany.

Background: The workload in health care is high; physicians and nurses report high stress levels due to a demanding environment where they often have to perform multiple tasks simultaneously. As a result, mental health issues among health care professionals (HCPs) are on the rise and the prevalence of errors in their daily tasks could increase. Processes of demographic change are partly responsible for even higher stress levels among HCPs. Read More

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Dynamic SOFA score assessments to predict outcomes after acute admission of octogenarians to the intensive care unit.

PLoS One 2021 2;16(8):e0253077. Epub 2021 Aug 2.

Department of Anesthesia and Critical Care, CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France.

Background: Identifying which octogenarians could benefit most from continuing critical care is challenging. We aimed to see if responses to therapies using the sequential organ failure assessment (SOFA) score on day 4 after unplanned admission to the intensive care unit (ICU) could be associated with short-term mortality.

Methods: In this prospective observational cohort study, data from 4 ICUs in a University Hospital included SOFA scores on admission and day 4, along with preadmission measurements of frailty, comorbidities, nutritional status and number of medications. Read More

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Iodized oil computed tomography versus ultrasound-guided radiofrequency ablation for early hepatocellular carcinoma.

Hepatol Int 2021 Aug 2. Epub 2021 Aug 2.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background And Purpose: Radiofrequency ablation (RFA) is the standard of care for early stage hepatocellular carcinoma (HCC). However, the clinical outcomes of iodized oil computed tomography (IoCT) versus ultrasound (US)-guided RFA for HCC remain unclear.

Methods: We retrospectively analyzed consecutive treatment-naïve patients who received curative RFA for HCC within Milan criteria from January 2016 to December 2018. Read More

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Effect of calcium dobesilate on retrobulbar blood flow and choroidal thickness in patients with non-proliferative diabetic retinopathy.

Int Ophthalmol 2021 Aug 2. Epub 2021 Aug 2.

Poostchi Ophthalmology Research Center, Department of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Diabetic retinopathy is one of the most common causes of blindness in work-aging adults and develops in one third of diabetic patients. Calcium dobesilate (CaD) treatment have protective effects on blood retinal barrier (BRB) and anti-oxidant as well as anti-inflammatory properties.

Objectives: To assess effects of CaD administration on retrobulbar blood flow and choroidal thickness in patients with diabetic retinopathy. Read More

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Models for measuring metabolic chemical changes in the metastasis of high grade serous ovarian cancer: fallopian tube, ovary, and omentum.

Mol Omics 2021 Aug 2. Epub 2021 Aug 2.

Department of Chemistry and Biochemistry, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.

Ovarian cancer (OC) is the most lethal gynecologic malignancy and high grade serous ovarian cancer (HGSOC) is the most common and deadly subtype, accounting for 70-80% of OC deaths. HGSOC has a distinct pattern of metastasis as many believe it originates in the fallopian tube and then it metastasizes first to the ovary, and later to the adipose-rich omentum. Metabolomics has been heavily utilized to investigate metabolite changes in HGSOC tumors and metastasis. Read More

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Sacubitril/valsartan in real-life European patients with heart failure and reduced ejection fraction: a systematic review and meta-analysis.

ESC Heart Fail 2021 Aug 2. Epub 2021 Aug 2.

Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, IRCCS Italian Cardiology Network, Genoa, Italy.

Aims: We systematically reviewed the European real-world evidence (RWE) about sacubitril-valsartan for heart failure with reduced ejection fraction.

Methods And Results: Twenty-one articles, including 16 952 subjects, were identified until 31 October 2020. Taking as reference the PARADIGM-HF cohort, few baseline characteristics were presented in >80% of these studies, most often with high heterogeneity. Read More

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Unexpected Outcomes of Measuring Decision Regret: Using a Breast Cancer Decision-Making Case Example.

Patient 2021 Aug 2. Epub 2021 Aug 2.

Division of Public Health Sciences, Department of Surgery, Washington University in St. Louis, Saint Louis, MO, USA.

Shared decision making can help patients feel supported and empowered when deciding between healthcare options. Decision regret can be a meaningful measure of the quality of that encounter. However, in a patient-engaged research study examining shared decision making for breast cancer surgery, decision regret was a difficult construct to assess, and asking questions about decision regret caused the patient to experience that emotion upon reflection. Read More

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Fear of Recurrence in Prostate Cancer Patients: A Cross-sectional Study After Radical Prostatectomy or Active Surveillance.

Eur Urol Open Sci 2021 Mar 3;25:44-51. Epub 2021 Feb 3.

Department of Urology, Vestfold Hospital Trust, Tønsberg, Norway.

Background: Fear of recurrence (FoR) is a distressing consequence of cancer. Little is known about the prevalence of FoR in different treatment groups and factors associated with FoR among prostate cancer (PCa) survivors.

Objective: To investigate the prevalence of high FoR among PCa survivors after radical prostatectomy (RP) or under active surveillance (AS) and to explore clinical and psychological factors potentially associated with FoR. Read More

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Towards data-driven stroke rehabilitation via wearable sensors and deep learning.

Proc Mach Learn Res 2020 Aug;126:143-171

Center for Data Science, Courant Institute of Mathematical Sciences, New York University.

Recovery after stroke is often incomplete, but rehabilitation training may potentiate recovery by engaging endogenous neuroplasticity. In preclinical models of stroke, high doses of rehabilitation training are required to restore functional movement to the affected limbs of animals. In humans, however, the necessary dose of training to potentiate recovery is not known. Read More

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Treatment of intrahepatic recurrence after hepatectomy for hepatocellular carcinoma.

Ann Gastroenterol Surg 2021 Jul 24;5(4):538-552. Epub 2021 Feb 24.

Department of Surgery The Jikei University School of Medicine Tokyo Japan.

Background: Prognostic factors after treatment for intrahepatic recurrent hepatocellular carcinoma (RHCC) after hepatic resection (Hx) are controversial. The current study aimed to examine the impact of treatment modality on the prognosis of intrahepatic RHCC following Hx.

Methods: For control of variables, the subjects were 56 patients who underwent treatment for intrahepatic RHCC, three or fewer tumors, each measuring ≤3 cm in diameter without macroscopic vascular invasion (MVI), between 2000 and 2011. Read More

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