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Unicompartmental knee arthroplasty: the Italian version of the Forgotten Joint Score-12 is valid and reliable to assess prosthesis awareness.

Knee Surg Sports Traumatol Arthrosc 2021 Apr 10. Epub 2021 Apr 10.

Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo, 200, Trigoria, 00128, Rome, Italy.

Purpose: Unicompartmental Knee Arthroplasty (UKA) recorded an increased incidence of around 30% per year in the United States. Patient's experience and satisfaction after surgery were traditionally assessed by pre, and post-surgical scores and Patient-Reported Outcome Measures (PROMs) scales. Traditional scales as Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and Oxford Knee Score (OKS) reported high ceiling effect. Read More

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The patient enablement instrument for back pain: reliability, content validity, construct validity and responsiveness.

Health Qual Life Outcomes 2021 Apr 9;19(1):116. Epub 2021 Apr 9.

Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.

Background: Currently, there are no outcome measures assessing the ability of people with non-specific low back pain to self-manage their illness. Inspired by the 'Patient Enablement Instrument', we developed the Patient Enablement Instrument for Back Pain (PEI-BP). The aim of this study was to describe the development of the Patient Enablement Instrument for Back Pain (PEI-BP) and investigate content validity, construct validity, internal consistency, test-retest reliability, measurement error, responsiveness and floor and ceiling effects. Read More

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Older adults in skilled nursing facilities demonstrate low physical activity during and after discharge.

Disabil Rehabil 2021 Apr 9:1-6. Epub 2021 Apr 9.

Physical Therapy Program, Department of Physical Medicine and Rehabilitation, University of Colorado, Aurora, CO, USA.

Purpose: This study sought to quantify physical activity and sedentary time among older adults during a skilled nursing facility (SNF) stay and after the transition home, a critical period when patients are at high risk for adverse events.

Materials And Methods: We performed an observational cohort study of physical activity and sedentary behavior during the last 3-5 days before discharge from SNF and the initial 3-5 days at home using accelerometers. Participants answered questions about perceived physical activity in the SNF and at home. Read More

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Characterization of Antibody-Drug Conjugate Pharmacokinetics and in Vivo Biotransformation Using Quantitative Intact LC-HRMS and Surrogate Analyte LC-MRM.

Anal Chem 2021 Apr 9. Epub 2021 Apr 9.

Integrated Bioanalysis, Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, 121 Oyster Point Boulevard, South San Francisco, California 94080, United States.

Antibody-drug conjugates (ADCs) pose challenges to bioanalysis because of their inherently intricate structures and potential for very complex catabolism. Common bioanalysis strategy is to measure the concentration of ADCs and Total Antibody (Ab) as well as deconjugated warhead in circulation. The ADCs and the Total Ab can be quantified with ligand binding assays (LBA) or with hybrid immunocapture-liquid chromatography coupled with multiple reaction monitoring mass spectrometry (LBA-LC-MRM). Read More

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LC-MS/MS measurement of 26 steroid hormones in human serum and plasma samples.

J Sep Sci 2021 Apr 9. Epub 2021 Apr 9.

Beijing AB Sciex Analytical Instrument Trading Co., Ltd., Beijing, 100011, China.

The measurement of steroid hormones provided critical information in the clinical evaluation of endocrine disorders. In this study, we developed a high throughput solid-phase extraction method for the analysis of 26 steroids in human serum and plasma samples by liquid chromatography-tandem mass spectrometry. Chromatographic condition and sample preparation were optimized to achieve good separation and maximum sensitivity for these analytes. Read More

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New Ag PO comparison material for stable oxygen isotope analysis.

Rapid Commun Mass Spectrom 2021 Apr 9:e9101. Epub 2021 Apr 9.

West Australian Biogeochemistry Centre, School of Biological Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.

Rationale: A silver phosphate reference material (Ag PO ) for the measurement of the stable oxygen isotope compositions is much needed; however, it is not available from the authorities distributing reference materials. This study aims to fill this gap by calibrating a new Ag PO stable isotope comparison material produced by the University of Natural Resources and Life Sciences (BOKU).

Methods: Aliquots of Ag PO were distributed to four laboratories frequently measuring the δ O value in Ag PO ; the University of Natural Resources and Life Sciences (BOKU), The University of Western Australia (UWA), the University of Helsinki (UH) and the Helmholtz Centre for Environmental Research (UFZ). Read More

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Toxicological Response of Chironomus dilutus in Single Chemical and Binary Mixture Exposure Experiments with Six Perfluoralkyl Substances.

Environ Toxicol Chem 2021 Apr 9. Epub 2021 Apr 9.

Towson University, Towson, Maryland, USA.

Few studies have determined the toxicity of perfluoralkyl substances to aquatic invertebrates. Here, we exposed Chironomus dilutus to six different perfluoroalkyl substances (PFAS) to assess single chemical toxicity and relative or proportional toxicity among substances. A 10 d range finding test was conducted to inform 20 d assays for the following PFAS: (perfluorooctane sulfonate [PFOS], perfluorooctanoic acid [PFOA], perfluorononanoic acid [PFNA], perfluorobutanesulfonic acid [PFBS], perfluorohexanesulfonic acid [PFHxS], and perfluoroheptanoic acid [PFHpA]). Read More

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Psychometric evaluation of a patient-reported item bank for healthcare engagement.

Qual Life Res 2021 Apr 9. Epub 2021 Apr 9.

National Center for PTSD, VA Palo Alto Health Care System, Menlo Park, USA.

Purpose: Healthcare engagement is a core measurement target for efforts to improve healthcare systems. This construct is broadly defined as the extent to which healthcare services represent collaborative partnerships with patients. Previous qualitative work operationalized healthcare engagement as generalized self-efficacy in four related subdomains: self-management, collaborative communication, health information use, and healthcare navigation. Read More

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Multicomponent transport model-based scaling up of long-term fixed bed adsorption of reactive dyes from textile effluent using aminated PAN beads.

Environ Sci Pollut Res Int 2021 Apr 9. Epub 2021 Apr 9.

Department of Chemical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India.

Novel functionalized polymeric beads have been prepared by a simple phase inversion technique and its potential as an effective sorbent for reactive dyes is studied. Polyacrylonitrile was used as the base polymer for the beads that were further functionalized using diethylenetriamine. Scanning electron microscopy, FTIR spectroscopy, BET technique, TGA analysis, and zeta potential measurement were used for characterization of the functionalized beads. Read More

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Universal neonatal foot orthotics-a novel treatment of infantile metatarsus adductus.

Eur J Pediatr 2021 Apr 9. Epub 2021 Apr 9.

Assuta Ashdod Hospital, Ashdod, Israel.

Approximately one in 100 babies has metatarsus adductus) MTA(. Although most deformities may resolve spontaneously, moderate and severe deformities might cause future discomfort and are therefore often treated. Common treatment alternatives include stretching, serial casting, and orthoses. Read More

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Entanglement Entropy Scaling Transition under Competing Monitoring Protocols.

Phys Rev Lett 2021 Mar;126(12):123604

Joint Quantum Institute, College Park, 20742 Maryland, USA and The Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, 20742 Maryland, USA.

Dissipation generally leads to the decoherence of a quantum state. In contrast, numerous recent proposals have illustrated that dissipation can also be tailored to stabilize many-body entangled quantum states. While the focus of these works has been primarily on engineering the nonequilibrium steady state, we investigate the buildup of entanglement in the quantum trajectories. Read More

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Doppler Flow Response Following Running Exercise Differs Between Healthy and Tendinopathic Achilles Tendons.

Front Physiol 2021 23;12:650507. Epub 2021 Mar 23.

University Outpatient Clinic, Sports Medicine and Orthopedics, University of Potsdam, Potsdam, Germany.

Background: The relationship between exercise-induced intratendinous blood flow (IBF) and tendon pathology or training exposure is unclear.

Objective: This study investigates the acute effect of running exercise on sonographic detectable IBF in healthy and tendinopathic Achilles tendons (ATs) of runners and recreational participants.

Methods: 48 participants (43 ± 13 years, 176 ± 9 cm, 75 ± 11 kg) performed a standardized submaximal 30-min constant load treadmill run with Doppler ultrasound "Advanced dynamic flow" examinations before (U) and 5, 30, 60, and 120 min (U-U) afterward. Read More

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Low-loss metasurface optics down to the deep ultraviolet region.

Light Sci Appl 2020 Apr 9;9(1):55. Epub 2020 Apr 9.

Physical Measurement Laboratory, National Institute of Standards and Technology, 20899, Gaithersburg, MD, USA.

Shrinking conventional optical systems to chip-scale dimensions will benefit custom applications in imaging, displaying, sensing, spectroscopy, and metrology. Towards this goal, metasurfaces-planar arrays of subwavelength electromagnetic structures that collectively mimic the functionality of thicker conventional optical elements-have been exploited at frequencies ranging from the microwave range up to the visible range. Here, we demonstrate high-performance metasurface optical components that operate at ultraviolet wavelengths, including wavelengths down to the record-short deep ultraviolet range, and perform representative wavefront shaping functions, namely, high-numerical-aperture lensing, accelerating beam generation, and hologram projection. Read More

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Risk Factors for Failed Nonsurgical Treatment Resulting in Surgery on Thumb Carpometacarpal Arthritis.

J Hand Surg Am 2021 Apr 5. Epub 2021 Apr 5.

Department of Orthopedics, University of Rochester, Rochester, NY; Department of Orthopedics, Washington University, St Louis, MO. Electronic address:

Purpose: The thumb carpometacarpal (CMC) joint is the second most common site of osteoarthritis in the hand, yet reported symptoms and ultimate treatment decisions are not simply a function of radiographic appearance. This study aimed to determine the patient- and/or disease-related factors associated with patients undergoing surgical treatment of thumb CMC arthritis.

Methods: This retrospective cohort study analyzed 1,994 patients with thumb CMC arthritis treated at 2 institutions between February 2015 and November 2018. Read More

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Adolescent alcohol consumption: protocol for a scoping review of screening and assessment tools used in Africa.

Syst Rev 2021 Apr 8;10(1):100. Epub 2021 Apr 8.

Department of International Public Health, The Liverpool School of Tropical Medicine, Liverpool, UK.

Background: Alcohol consumption is a key public health challenge in sub-Saharan Africa, which has the highest burden of alcohol attributable injury and disease of any region. Excess alcohol use is particularly harmful for adolescents and has been associated with neurocognitive defects and social and emotional problems. Effective screening and assessment tools are necessary to implement, evaluate and monitor interventions to prevent and decrease adolescent alcohol use. Read More

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Maximal kinetic energy and angular distribution analysis of spatial map imaging: Application to photoelectrons from a single quantum state of HO.

J Chem Phys 2021 Apr;154(13):134201

Department of Physics, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Dynamical or spatial properties of charged species can be obtained using electrostatic lenses by velocity map imaging (VMI) or spatial map imaging (SMI), respectively. Here, we report an approach for extracting dynamical and spatial information from patterns in SMI images that map the initial coordinates, velocity vectors, and angular distributions of charged particles onto the detector, using the same apparatus as in VMI. Deciphering these patterns required analysis and modeling, involving both their predictions from convolved spatial and velocity distributions and fitting observed images to kinetic energies (KEs) and anisotropy parameters (βs). Read More

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Improved experimental evaluation and model validation of a Cf irradiator for delayed gamma-ray spectrometry applications.

Appl Radiat Isot 2021 Apr 2;173:109694. Epub 2021 Apr 2.

Japan Atomic Energy Agency, Integrated Support Center for Nuclear Nonproliferation and Nuclear Security, Shirakata Shirane 2-4, Tokai, Naka, Ibaraki, Japan.

We present experimental and MCNP modeled results of neutron flux monitoring in an irradiator, which consists of aCf sealed source housed in the center of a cubic block of high-density polyethylene. This work is contributing to our development in the delayed gamma-ray spectroscopy non-destructive assay technique for nuclear safeguards and security applications. We evaluated the thermal and resonance flux values using the Westcott foil activation method for two measurement position count rates of Au and In. Read More

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Establishment of an analytical method for simultaneous quantitation of CDK4/6 inhibitors, aromatase inhibitors, and an estrogen receptor antagonist in human plasma using LC-ESI-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Mar 22;1173:122655. Epub 2021 Mar 22.

Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan; Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. Electronic address:

Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors (palbociclib, abemaciclib, and ribociclib) are used to treat human epithelial growth factor receptor (HER)-2 negative and hormone receptor (HR) positive advanced breast cancer in combination with aromatase inhibitors (letrozole, anastrozole) or an estrogen receptor antagonist (fulvestrant). Administration of these drugs frequently causes severe side effects, such as neutropenia and diarrhea. Therefore, therapeutic drug monitoring (TDM) of CDK4/6 inhibitors, aromatase inhibitors, and the estrogen receptor antagonist is considered important for ensuring the efficacy and safety of these drugs. Read More

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Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis.

Atherosclerosis 2021 Mar 25;324:58-68. Epub 2021 Mar 25.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551. Electronic address:

Background And Aims: Aging is the primary risk factor for cardiovascular disease (CVD), but the mechanisms underlying age-linked atherosclerosis remain unclear. We previously observed that long-lived vascular matrix proteins can acquire 'gain-of-function' isoDGR motifs that might play a role in atherosclerotic pathology.

Methods: IsoDGR-specific mAb were generated and used for ELISA-based measurement of motif levels in plasma samples from patients with coronary artery diseases (CAD) and non-CAD controls. Read More

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Bedside hyperspectral imaging indicates a microcirculatory sepsis pattern - an observational study.

Microvasc Res 2021 Apr 5:104164. Epub 2021 Apr 5.

Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany; Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany. Electronic address:

Introduction: Microcirculatory alterations are key mechanisms in sepsis pathophysiology leading to tissue hypoxia, edema formation, and organ dysfunction. Hyperspectral imaging (HSI) is an emerging imaging technology that uses tissue-light interactions to evaluate biochemical tissue characteristics including tissue oxygenation, hemoglobin content and water content. Currently, clinical data for HSI technologies in critical ill patients are still limited. Read More

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Development and Application of Multi-Color Burst Analysis Spectroscopy.

Biophys J 2021 Apr 5. Epub 2021 Apr 5.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX. Electronic address:

The formation and disassembly of macromolecular particles is a ubiquitous and essential feature of virtually all living organisms. Additionally, diseases are often associated with the accumulation and propagation of biologically active nanoparticles, like the formation of toxic protein aggregates in protein misfolding diseases and the growth of infectious viral particles. The heterogeneous and dynamic nature of biologically active particles can make them exceedingly challenging to study. Read More

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CaBagE: A Cas9-based Background Elimination strategy for targeted, long-read DNA sequencing.

PLoS One 2021 8;16(4):e0241253. Epub 2021 Apr 8.

Department of Human Genetics, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America.

A substantial fraction of the human genome is difficult to interrogate with short-read DNA sequencing technologies due to paralogy, complex haplotype structures, or tandem repeats. Long-read sequencing technologies, such as Oxford Nanopore's MinION, enable direct measurement of complex loci without introducing many of the biases inherent to short-read methods, though they suffer from relatively lower throughput. This limitation has motivated recent efforts to develop amplification-free strategies to target and enrich loci of interest for subsequent sequencing with long reads. Read More

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Psychometric properties of FACIT-Fatigue in systemic lupus erythematosus: a pooled analysis of three phase 3 randomised, double-blind, parallel-group controlled studies (BLISS-SC, BLISS-52, BLISS-76).

J Patient Rep Outcomes 2021 Apr 8;5(1):33. Epub 2021 Apr 8.

Optum, Johnston, RI, USA.

Background: Fatigue is a key symptom in patients with systemic lupus erythematosus (SLE), and regulatory bodies recommend its assessment in clinical trials of SLE therapies.

Methods: This post hoc pooled analysis of the three BeLimumab In Subjects with Systemic lupus erythematosus (BLISS) Phase 3 randomised, double-blind, parallel-group controlled trials evaluated the measurement properties of the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue. Patients (N = 2520) completed the FACIT-Fatigue every 4 weeks from baseline until the end of each study period. Read More

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Preoperative Analysis of CA-I25 and its Relation with Histopathological Study in Ovarian Tumours.

Mymensingh Med J 2021 Apr;30(2):402-409

Dr Towhida Nazneen, Junior Consultant, Department of Obs & Gynae, General Hospital Munshigong, Dhaka, Bangladesh; Email: towhida

Ovarian cancer (OC) is the seventh most common cancer among women in the world. Epithelial OC is the most predominant pathological subtype, with five major histotype. All five subtypes that differ in origination, pathogenesis, molecular alterations, risk factors and prognosis. Read More

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Monte Carlo simulations using extant data to mimic populations: Applications to the modified linear probability model and logistic regression.

Psychol Methods 2021 Apr 8. Epub 2021 Apr 8.

Department of Human Development and Family Studies.

Monte Carlo simulations are widely used in the social sciences to explore the viability of analytic methods in the face of assumption violations. Simulation results, however, may not be applicable to substantive research applications because they often are conducted under idealized rather than realistic conditions. Shortcomings of simulation design are discussed using linear equations as a case study, focusing on (a) variable distributions, (b) population level specification error, (c) population level measurement precision, and (d) predictor variable relationships. Read More

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Biological and behavioural responses of European honey bee (Apis mellifera) colonies to perfluorooctane sulfonate (PFOS) exposure.

Integr Environ Assess Manag 2021 Apr 7. Epub 2021 Apr 7.

School of Environmental and Rural Science, University of New England, Armidale, NSW, 2351, Australia.

Bees provide pollination services to managed and wild ecosystems but are threatened globally due to multiple stressors, including exposure to contaminants. Perfluorooctane sulfonate (PFOS) is a widely detected and persistent contaminant that accumulates and biomagnifies in foodchains. In this exposure effect study, small whole colonies of Apis mellifera (1000 bees) were exposed to PFOS using a purpose-built cage system over a four-week period. Read More

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The role of EBV in hematolymphoid proliferations: Emerging concepts relevant to diagnosis and treatment.

Histopathology 2021 Apr 7. Epub 2021 Apr 7.

Robert J. Tomsich Pathology and Laboratory Medicine Institute, Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.

Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus with >90% of the adult population worldwide harboring latent infection. A small subset of those infected develop EBV-associated neoplasms including a range of lymphoproliferative disorders (LPD). The diagnostic distinction of these entities appears increasingly relevant as our understanding of EBV-host interactions and mechanisms of EBV-driven lymphomagenesis improves. Read More

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Dosimetric Effect of Biozorb Markers for Accelerated Partial Breast Irradiation in Proton Therapy.

Int J Part Ther 2021 8;7(4):19-28. Epub 2021 Mar 8.

Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Purpose: To investigate dosimetric implications of biodegradable Biozorb (BZ) markers for proton accelerated partial breast irradiation (APBI) plans.

Materials And Methods: Six different BZs were placed within in-house breast phantoms to acquire computed tomography (CT) images. A contour correction method with proper mass density overriding for BZ titanium clip and surrounding tissue was applied to minimize inaccuracies found in the CT images in the RayStation planning system. Read More

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Determining Trap Compliances, Microsphere Size Variations, and Response Linearities in Single DNA Molecule Elasticity Measurements with Optical Tweezers.

Front Mol Biosci 2021 22;8:605102. Epub 2021 Mar 22.

Department of Physics, University of California San Diego, La Jolla, CA, United States.

We previously introduced the use of DNA molecules for calibration of biophysical force and displacement measurements with optical tweezers. Force and length scale factors can be determined from measurements of DNA stretching. Trap compliance can be determined by fitting the data to a nonlinear DNA elasticity model, however, noise/drift/offsets in the measurement can affect the reliability of this determination. Read More

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Microsaccades: Empirical Research and Methodological Advances - Introduction to Part 1 of the Thematic Special Issue.

J Eye Mov Res 2020 Jun 19;12(6). Epub 2020 Jun 19.

University of Bern and SciAns GmbH, Iffwil, Switzerland.

Recent technical developments and increased affordability of high-speed eye tracking devices have brought microsaccades to the forefront of research in many areas of sensory, perceptual, and cognitive processes. The present thematic issue on "Microsaccades: Empirical Research and Methodological Advances" invited authors to submit original research and reviews encompassing measurements and data analyses in fundamental, translational, and applied studies. We present the first volume of this special issue, comprising 14 articles by research teams around the world. Read More

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