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An Integrated Mental Health and Acute Care Clinical Rotation on a Dedicated Education Unit.

Nurse Educ 2021 Mar 30. Epub 2021 Mar 30.

Author Affiliations: Clinical Instructor (Ms Walsh and Ms Pfeifer), Research Professor (Dr Higgins), and Associate Clinical Professor (Dr Robertson), Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia; and Unit Manger (Ms Goodson), Emory Decatur Hospital, Decatur, Georgia.

Background: Traditional mental health clinical experiences expose students to an environment that may not prepare them to address mental health needs in hospital settings.

Purpose: The purpose is of this project was to evaluate the implementation of an integrated mental health and acute care clinical model on a dedicated education unit (DEU).

Methods: In this pilot project, students provided dually focused medical and mental health care on assigned patients. Read More

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Accuracy of buffers and self-drawn neighbourhoods in representing adolescent GPS measured activity spaces: An exploratory study.

Health Place 2021 Apr 18;69:102569. Epub 2021 Apr 18.

School of Sport, Carnegie, Leeds Beckett University, Leeds, LS6 3QT, UK.

Background: There continues to be a lack of understanding as to the geographical area at which the environment exerts influence on behaviour and health. This exploratory study compares different potential methods of both researcher- and participant-defined definitions of neighbourhood reflect an adolescent's activity space.

Methods: Seven consecutive days of global positioning system (GPS) tracking data were collected at 15 s intervals using a small exploratory adolescent sample of 14-18 year olds (n = 69) in West Yorkshire, England. Read More

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Analgesic Activity of Jin Ling Zi Powder () and Its Single Herbs: A Serum Metabonomics Study.

Chin J Integr Med 2021 Apr 21. Epub 2021 Apr 21.

Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing, 100850, China.

Objective: To compare the analgesic effect of Jin Ling Zi Powder (, JLZ) and its two single herbs.

Methods: The hot plate method was used to induce pain. Totally 36 mice were randomly divided into 6 groups by a complete random design, including control, model, aspirin (ASP, 0. Read More

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Triptolide reduces salivary gland damage in a non-obese diabetic mice model of Sjögren's syndrome via JAK/STAT and NF-κB signaling pathways.

J Clin Biochem Nutr 2021 Mar 19;68(2):131-138. Epub 2020 Dec 19.

Department of Rheumatism, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 138, Xianlin Avenue, Qixia District, Nanjing 210000, China.

Triptolide (TP) has anti-inflammatory and immunosuppressive effects. However, the effect of triptolide on Sjögren's syndrome (SS) is rarely reported. In this paper, we studied the effects of triptolide on non-obese diabetes mice model of SS. Read More

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[Evaluation of fracture strength of two kinds of zirconia all-ceramic crowns with different edge compensation angles].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Mar;53(2):402-405

Center for Digital Dentistry, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To evaluate the effects of different edge compensation angles on the fracture strength of multilayer zirconia all-ceramic crowns and traditional uniform zirconia all-ceramic crowns.

Methods: The resin tooth preparation specimen of the mandibular first molar with a knife-edge was fabricated. A 3D digital model of the specimen was obtained by scanning it with a 3D dental model scanner. Read More

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Tumor attenuation and quantitative analysis of perfusion parameters derived from tri-phasic CT scans in hepatocellular carcinoma: Relationship with histological grade.

Medicine (Baltimore) 2021 Apr;100(16):e25627

Department of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, PR China.

Abstract: The aim of the current study was to explore the value of tumor attenuation and quantitative analysis of perfusion parameters obtained from traditional tri-phasic CT scans in grading hepatocellular carcinoma (HCC).Totally 39 patients (42 lesion samples) with pathologically confirmed HCC who underwent tri-phasic CT scans were enrolled. HCC lesions were divided into non-poorly differentiated HCC (NP-HCC; n = 31) and poorly differentiated HCC (pHCC; n = 11). Read More

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Histopathological analysis of incompetent great saphenous veins after mechanochemical ablation treatment - An ex-vivo experiment.

Vascular 2021 Apr 20:17085381211007613. Epub 2021 Apr 20.

Department of Cardiovascular, China-Japan Friendship Hospital, Beijing, China.

Background: The endovascular technique of mechanochemical ablation (MOCA) has become popular in treating patients with saphenous reflux. We reported the histopathological findings in human ex-vivo incompetent great saphenous veins following treatment with saline, polidocanol, mechanical ablation and MOCA using ClariVein device.

Methods: Twenty-four vein GSV specimens were obtained via traditional surgery and treated with four methods: Group A: 0. Read More

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Curculigoside attenuates oxidative stress and osteoclastogenesis via modulating Nrf2/NF-κB signaling pathway in RAW264.7 cells.

J Ethnopharmacol 2021 Apr 17:114129. Epub 2021 Apr 17.

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China; School of Pharmacy, Second Military Medical University, Shanghai, 200433, China. Electronic address:

Ethnopharmacological Relevance: Curculigo orchioides Gaertn is used for the treatment of impotence, atrophic debility of bones (osteoporosis), limb limpness, and arthritis of the lumbar and knee joints in traditional Chinese medicine and Ayurvedic medical system. Curculigoside (Cur) from Curculigo orchioides Gaertn has been shown to have regulatory effects on bone metabolism via anti-oxidative activities in rats and osteoblasts. However, little is known about the molecular pharmacological activity of Cur in osteoclastic bone resorption. Read More

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Interaction between miRNA-155 targeting neuronal pacemaker ion channels and release of amino acid transmitters during cerebral ischemia.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):3007-3014

Department of Neurology, Qingdao Hospital of Traditional Chinese Medicine (Qingdao Hiser Hospital), Qingdao, Shandong, China.

Objective: Cerebral hemorrhage can cause hemorrhagic stroke, leading to severe brain damage. MiRNA-155 is closely related to the development of stroke. However, the regulatory mechanism of miRNA-155 during cerebral ischemia has not yet been elucidated. Read More

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Assessing the cone of economy in patients with spinal disease using only a force plate: an observational retrospective cohort study.

Eur Spine J 2021 Apr 20. Epub 2021 Apr 20.

Texas Back Institute, 6020 West Parker Road, Plano, TX, 75093, USA.

Study Design: This is a retrospective cohort with multiple regression modeling.

Objective: The aim is to develop a new method for estimating cone of economy (CoE) using a force plate rather than traditional motion capture.

Background: Currently, most spinal deformity surgeons rely on static radiographic parameters for alignment, balance, and outcomes data alongside patient-reported outcome measures. Read More

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Are Cramér-Rao lower bounds an accurate estimate for standard deviations in in vivo magnetic resonance spectroscopy?

NMR Biomed 2021 Apr 19:e4521. Epub 2021 Apr 19.

Department of Biomedical Engineering, Columbia University Fu Foundation School of Engineering and Applied Science, New York, New York, USA.

Due to inherent time constraints for in vivo experiments, it is infeasible to repeat multiple MRS scans to estimate standard deviations on the desired measured parameters. As such, the Cramér-Rao lower bounds (CRLBs) have become the routine method to approximate standard deviations for in vivo experiments. Cramér-Rao lower bounds, however, as the name suggests, are theoretically a lower bound on the standard deviation and it is not clear if and under what circumstances this approximation is valid. Read More

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Immunogenicity and efficacy of mRNA COVID-19 vaccine MRT5500 in preclinical animal models.

NPJ Vaccines 2021 Apr 19;6(1):61. Epub 2021 Apr 19.

Sanofi Pasteur, Marcy l'Etoile, France.

Emergency use authorization of COVID vaccines has brought hope to mitigate pandemic of coronavirus disease 2019 (COVID-19). However, there remains a need for additional effective vaccines to meet the global demand and address the potential new viral variants. mRNA technologies offer an expeditious path alternative to traditional vaccine approaches. Read More

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The Effects of the Traditional Scaling Technique Versus a Modified Scaling Technique on Muscle Activity and Pinch Force Generation: A pilot study.

J Dent Hyg 2021 Apr;95(2):6-13

Department of Exercise and Sport Science at the University of North Carolina, Chapel Hill, NC, USA.

Dental hygienists perform precision instrumentation tasks repetitively throughout the workday, placing them at increased risk for developing a musculoskeletal disorder. The purpose of this pilot study was to determine differences in muscle activity and pinch force generation between the traditional scaling technique and a modified scaling technique. A convenience sample of dental hygienists (n=12) acted as their own controls in this counterbalance-designed pilot study. Read More

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The Cost of Hip and Knee Revision Arthroplasty by Diagnosis-Related Groups: Comparing Time-Driven Activity-Based Costing and Traditional Accounting.

J Arthroplasty 2021 Mar 20. Epub 2021 Mar 20.

Department of Orthopedic Surgery, New England Baptist Hospital, Boston, MA.

Background: Traditional hospital cost accounting (TA) has innate disadvantages that limit the ability to meaningfully measure care pathways and quality improvement. Time-driven activity-based costing (TDABC) allows a meticulous account of costs in primary total joint arthroplasty (TJA). However, differences between TA and TDABC have not been examined in revision hip and knee TJA (rTJA). Read More

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Anti-seizure medication correlated changes of cortical morphology in childhood epilepsy with centrotemporal spikes.

Epilepsy Res 2021 Mar 23;173:106621. Epub 2021 Mar 23.

Department of Medical Imaging, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, China; Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China; State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, 210093, China; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Suite 2301, Charlestown, MA, 02129, USA. Electronic address:

To investigate the morphological changes of cerebral cortex correlating with anti-seizure medication in Childhood Epilepsy with Centrotemporal Spikes (CECTS), and their relationships with seizure control. This study included a total of 188 children, including 62 patients with CECTS taking anti-seizure drugs, 56 patients with drug-naive, and 70 healthy controls. A portion of cases were also followed-up for longitudinal analysis. Read More

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Effects of Triangle Grass Decoction on Bone Metabolism in Rats with Chronic Kidney Disease Complicated with Mineral and Bone Abnormalities.

J Ethnopharmacol 2021 Apr 16:114126. Epub 2021 Apr 16.

Department of Nephrology, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan 528400, China. Electronic address:

Ethnopharmacological Relevance: Triangle grass is a liliaceous Chlorophytum perennial herb of ChlorophytumlaxumR.Br. It is distributed mainly in Guangdong and Guangxi Provinces of China. Read More

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Qigong exercise enhances cognitive functions in the elderly via an interleukin-6-hippocampus pathway: a randomized active-controlled trial.

Brain Behav Immun 2021 Apr 16. Epub 2021 Apr 16.

State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong; Laboratory of Neuropsychology and Human Neuroscience, The University of Hong Kong, Hong Kong; Institute of Clinical Neuropsychology, The University of Hong Kong, Hong Kong. Electronic address:

Background: Evidence has suggested that exercise protects against cognitive decline in aging, but the recent lockdown measures associated with the COVID-19 pandemic have limited the opportunity for outdoor exercise. Herein we tested the effects of an indoor exercise, Qigong, on neurocognitive functioning as well as its potential neuro-immune pathway.

Methods: We conducted a 12-week randomized active-controlled trial with two study arms in cognitively healthy older people. Read More

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A pilot study on ex vivo expanded autologous adipose-derived stem cells of improving fat retention in localized scleroderma patients.

Stem Cells Transl Med 2021 Apr 19. Epub 2021 Apr 19.

Department of Plastic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

In patients with localized scleroderma (LoS), facial deformity induced by subcutaneous atrophy greatly reduces life quality. Autologous fat grafting (AFG) is used for volume restoration but with low-fat retention due to various reasons. Adipose-derived stem cells (ADSCs) have shown potential effects in improving fat retention. Read More

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Longitudinal Studies 3: Data Modeling Using Standard Regression Models and Extensions.

Methods Mol Biol 2021 ;2249:125-165

Department of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.

In longitudinal studies, the relationship between exposure and disease can be measured once or multiple times while participants are monitored over time. Traditional regression techniques are used to model outcome data when each epidemiological unit is observed once. These models include generalized linear models for quantitative continuous, discrete, or qualitative outcome responses, and models for time-to-event data. Read More

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January 2021

Circulating TNFrII levels predict incidence of ischemic heart disease and total mortality, independently of intima media thickness and pulse wave velocity in male with type 2 diabetes.

Heart Vessels 2021 Apr 19. Epub 2021 Apr 19.

Department of Health, Medicine and Caring Sciences, Linköping University, SE 581 85, Linköping, Sweden.

New and clinically useful markers of cardiovascular risk are of great importance in patients with type 2 diabetes since cardiovascular disease is a major cause of death in these patients. We analyzed inflammatory markers and other risk factors for heart disease in 761 patients who participated in the CARDIPP-study, Cardiovascular Risk factors in Patients with Diabetes-a Prospective study in Primary care. All participants had type 2 diabetes and were 55-66 years old at recruitment during the years 2005-2008. Read More

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Hepatic Macrophage activation and the LPS pathway in patients with different degrees of severity and histopathological patterns of drug induced liver injury.

Histol Histopathol 2021 Apr 15:18340. Epub 2021 Apr 15.

Department of Pathology and Hepatology Institution, The Fifth Medical Center, General Hospital of PLA, Beijing, China.

Background: Inflammatory activation of hepatic macrophages plays a primary role in drug-induced liver injury (DILI). However, the exact mechanism underlying DILI remains unclear.

Methods: A total of 328 DILI patients and 80 healthy individuals were prospectively enrolled in this study. Read More

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The Costs of Austerity: Labor Emigration and the Rise of Radical Right Politics in Central and Eastern Europe.

Front Sociol 2019 11;4:69. Epub 2019 Oct 11.

Department of Sociology, University of Toronto, Toronto, ON, Canada.

The right to free movement, to move and work freely within the European Union (EU), is a cornerstone right held by EU and European Free Trade Area (EFTA) citizens. Labor flows across the EU are, however, not uniform but are characterized by significant geographic disparities. In particular, since the 2008 global financial crisis, labor emigration, measured by the rate of EU citizens living and working in other EU countries, has increased exclusively among certain Central and Eastern European nations. Read More

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October 2019

Sub-chronic toxicity of ethanol leaf extract of on the biochemical parameters and histopathology of liver and kidney in the rats.

Toxicol Rep 2021 3;8:822-828. Epub 2021 Apr 3.

Department of Anatomy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Wall. leaf is being used as a traditional medicine against hypertension and diabetes mellitus. Unlike its efficacy, the safety profile of this plant upon long-term administration has not been investigated yet. Read More

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Inhibitory Effects of Extract on Oxidation and Inflammatory Responses.

Evid Based Complement Alternat Med 2021 1;2021:6650037. Epub 2021 Apr 1.

Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.

(laver) has long been a popular and traditional seaweed food in Korea, Japan, and China. Historically, it was known as a marine medicinal herb to treat hemorrhoids and cholera morbus in . We investigated the effects of extract (PTE) for its antioxidant and anti-inflammatory activities. Read More

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Study of the Mechanism of Action of Guanxin Shutong Capsules in the Treatment of Coronary Heart Disease Based on Metabolomics.

Front Pharmacol 2021 25;12:650438. Epub 2021 Mar 25.

College of Pharmacy, Tianjin Medical University, Tianjin, China.

: Guan-Xin-Shu-Tong capsule (GXSTC) is a traditional Chinese medicine (TCM) that has been used to treat coronary heart disease (CHD) for many years in China. However, the holistic mechanism of GXSTC against CHD is still unclear. Therefore, the purpose of this paper was to systematically explore the mechanism of action GXSTC in the treatment of CHD rats using a metabolomics strategy. Read More

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Intra- and inter-observer reliability of implant positioning evaluation on a CT-based three-dimensional postoperative matching system for total knee arthroplasty.

BMC Musculoskelet Disord 2021 Apr 17;22(1):363. Epub 2021 Apr 17.

Department of Orthopaedic Surgery, Graduate School of Medicine, Development of Orthopaedic Surgery, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.

Background: The evaluation of postoperative total knee arthroplasty (TKA) alignment mainly relies on measurement data obtained from plain radiographs. The aim of this retrospective observational study was to document the intra- and inter-observer reliability in assessment of TKA component positioning after surgery using a three-dimensional (3D) computed tomography (CT) image matching system.

Methods: Fourteen knees from 14 patients who received primary TKA were included, and images were analyzed by blinded readers not associated with the surgeries. Read More

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Intra-chain interaction topology can identify functionally similar Intrinsically Disordered Proteins.

Authors:
J Huihui K Ghosh

Biophys J 2021 Apr 15. Epub 2021 Apr 15.

Functionally similar IDPs (Intrinsically Disordered Proteins) often have little sequence similarity. This is in stark contrast to folded proteins and poses a challenge for the inverse problem: functional classification of IDPs using sequence alignment. The problem is further compounded due to the lack of structure in IDPs, preventing structural alignment as an alternate tool for classification. Read More

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Soluble alpha klotho in acromegaly: Comparison to traditional markers of disease activity.

J Clin Endocrinol Metab 2021 Apr 17. Epub 2021 Apr 17.

Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, LMU Klinikum, Munich, Germany.

Context: Soluble alpha klotho (sαKL) has been linked to growth hormone (GH) action, but systematic evaluation and comparison to traditional biomarkers in acromegaly are lacking.

Objective: To evaluate the potential of sαKL to aid classification of disease activity.

Design And Setting: Retrospective study at two academic centers. Read More

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Measuring sleep regularity: Theoretical properties and practical usage of existing metrics.

Sleep 2021 Apr 17. Epub 2021 Apr 17.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia.

Study Objectives: Sleep regularity predicts many health-related outcomes. Currently, however, there is no systematic approach to measuring sleep regularity. Traditionally, metrics have assessed deviations in sleep patterns from an individual's average. Read More

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