48,304 results match your criteria measured provided

The influence of the trunk muscle activation on occlusion pressure and respiratory muscle strength in healthy participants: randomized controlled trial.

Respir Physiol Neurobiol 2021 May 9:103682. Epub 2021 May 9.

Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, Poland. Electronic address:

Objectives: The purpose of the study was to check if the trunk muscle activation done in accordance with rules of the Bobath concept affects the occlusion pressure and respiratory muscle efficacy in forced breathing manoeuvres in healthy participants.

Design: Randomized controlled trial. Between-subjects design. Read More

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The Immunity Clock.

J Gerontol A Biol Sci Med Sci 2021 May 12. Epub 2021 May 12.

Department of Genetics, Physiology and Microbiology (Unity of Animal Physiology), Faculty of Biology, Complutense University of Madrid (UCM), Madrid, Spain.

The immune system has been for long considered a marker of health. The age-related decline in its function results in a greater incidence of infections, autoimmune diseases and cancer. Nevertheless, it is still not known if immune function can be used to accurately estimate the rate of aging of an individual. Read More

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Opioid Treatment Deserts: Concept development and application in a US Midwestern urban county.

PLoS One 2021 12;16(5):e0250324. Epub 2021 May 12.

Center for Urban Regional Analysis, The Ohio State University, Columbus, OH, United States of America.

Objectives: An Opioid Treatment Desert is an area with limited accessibility to medication-assisted treatment and recovery facilities for Opioid Use Disorder. We explored the concept of Opioid Treatment Deserts including racial differences in potential spatial accessibility and applied it to one Midwestern urban county using high resolution spatiotemporal data.

Methods: We obtained individual-level data from one Emergency Medical Services (EMS) agency (Columbus Fire Department) in Franklin County, Ohio. Read More

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Confounding and regression adjustment in difference-in-differences studies.

Health Serv Res 2021 May 12. Epub 2021 May 12.

Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.

Objective: To define confounding bias in difference-in-difference studies and compare regression- and matching-based estimators designed to correct bias due to observed confounders.

Data Sources: We simulated data from linear models that incorporated different confounding relationships: time-invariant covariates with a time-varying effect on the outcome, time-varying covariates with a constant effect on the outcome, and time-varying covariates with a time-varying effect on the outcome. We considered a simple setting that is common in the applied literature: treatment is introduced at a single time point and there is no unobserved treatment effect heterogeneity. Read More

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Identifying Return to Work Self-Efficacy Trajectories in Employees with Mental Health Problems.

J Occup Rehabil 2021 May 12. Epub 2021 May 12.

Tranzo Scientific Center for Care and Wellbeing, Tilburg School of Social and Behavioral Sciences, Tilburg University, Professor Cobbenhagenlaan 125, 5037 DB, Tilburg, The Netherlands.

Purpose Return to work self-efficacy (RTW-SE) is a strong predictor of return to work (RTW) in employees with mental health problems (MHPs). However, little is known about the development of RTW-SE during the RTW process. In this study, we aimed to identify RTW-SE trajectories in the year following sick leave in employees with MHPs and provided a description of the trajectories in terms of personal and work characteristics, and RTW status. Read More

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Psychological recovery in a step 4 service: a qualitative study exploring the views of service users and clinicians.

J Ment Health 2021 May 12:1-7. Epub 2021 May 12.

School of Psychology, Newcastle University, Newcastle Upon Tyne, UK.

Background: Psychological recovery is typically measured in improving access to psychological therapies (IAPT) services as the reduction of symptoms on routine outcome measures (ROMs). However, conceptualisations of psychological recovery vary, and there are concerns that ROMs may not be suitable for measuring recovery from complex mental health difficulties.

Aim: To gain insight into psychological recovery and measurement in clinical practice. Read More

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Pharmaceutical contaminants in shallow groundwater and their implication to poor sanitation facilities in low-income countries.

Environ Toxicol Chem 2021 May 12. Epub 2021 May 12.

Faculty of Engineering, University of Ruhuna, Hapugala, Galle, Sri Lanka.

Rudimentary onsite sanitation systems (OSSs) are extensively used in low-income countries despite the risk of groundwater contamination. The present study investigated the potential impact of community soak pits on sandy shallow aquifers in a rural area in Sri Lanka. Thirty-two groundwater samples were collected and measured for traditional indicators, i. Read More

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Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model.

Clinics (Sao Paulo) 2021 5;76:e2513. Epub 2021 May 5.

Departamento de Cirurgia, Disciplina de Anestesiologia, Dor e Medicina Intensiva, Universidade Federal de Sao Paulo, Sao Paulo, SP, BR.

Objectives: The current study compared the impact of pretreatment with melatonin and N-acetylcysteine (NAC) on the prevention of rat lung damage following intestinal ischemia-reperfusion (iIR).

Methods: Twenty-eight Wistar rats were subjected to intestinal ischemia induced by a 60 min occlusion of the superior mesenteric artery, followed by reperfusion for 120 min. Animals were divided into the following groups (n=7 per group): sham, only abdominal incision; SS+iIR, pretreated with saline solution and iIR; NAC+iIR, pretreated with NAC (20 mg/kg) and iIR; MEL+iIR, pretreated with melatonin (20 mg/kg) and iIR. Read More

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Inhibition of CTCF-regulated miRNA-185-5p mitigates renal interstitial fibrosis of chronic kidney disease.

Epigenomics 2021 May 12. Epub 2021 May 12.

Clinical Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu 241001, PR China.

The present study aimed to elucidate the effect of CTCF on renal interstitial fibrosis in chronic kidney disease (CKD) and underlying mechanisms. We measured NPHS2 expression and investigated its function in a unilateral ureteral obstruction-induced mouse model of CKD. NPHS2 was poorly expressed in CKD mice. Read More

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Three-dimensional assessment of brain arterial compliance: Technical development, comparison with aortic pulse wave velocity, and age effect.

Magn Reson Med 2021 May 12. Epub 2021 May 12.

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Purpose: The ability to measure cerebral vascular compliance (VC) is important in the evaluation of vascular diseases. Additionally, quantification of arterial wall pulsation in the brain may be useful for understanding the driving force of the recently discovered glymphatic system. Our goal is to develop an MRI technique to measure VC and arterial wall pulsation in major intracranial vessels. Read More

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Mathematical Modeling to Study KRAS Mutant-Specific Responses to Pathway Inhibition.

Edward C Stites

Methods Mol Biol 2021 ;2262:311-321

Integrative Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.

This chapter will describe how mathematical modeling allows the RAS pathway to be studied with computational experiments. The mathematical model utilized simulates the biochemical reactions that regulate RAS signaling. This type of model incorporates knowledge of reaction mechanisms, including measured quantitative parameters that characterize these reactions for both wild-type and mutant RAS proteins. Read More

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January 2021

Protocol for a randomised controlled trial of a primary care intervention to Reverse Frailty and Enhance Resilience through Exercise and dietary protein Education (REFEREE) in community-dwelling adults aged 65 and over.

HRB Open Res 2020 21;3:91. Epub 2020 Dec 21.

School of Medicine, University College Dublin, Dublin, Ireland.

Resistance exercises and dietary protein have been shown to reverse frailty, yet they are not commonly offered in clinical practice. We aim to measure changes in health outcomes, including physical frailty status (SHARE-FI), clinical frailty status (CFS) and muscle mass, as a result of an optimised exercise and dietary intervention versus usual care in a primary care (PC) setting. The intervention has been derived from our systematic review and meta-analysis findings and optimised through patient and public involvement and multidisciplinary team input. Read More

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December 2020

Using fractal self-similarity to increase precision of shrub biomass estimates.

Ecol Evol 2021 May 18;11(9):4866-4873. Epub 2021 Mar 18.

USDA Forest Service Pacific Northwest Research Station University of Washington Seattle WA USA.

We show that aerial tips are self-similar fractals of whole shrubs and present a field method that applies this fact to improves accuracy and precision of biomass estimates of tall-shrubs, defined here as those with diameter at root collar (DRC) ≥ 2.5 cm. Power function allometry of biomass to stem diameter generates a disproportionate prediction error that increases rapidly with diameter. Read More

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Multidimensional Pain Characteristics in Older Adults with Chronic Venous Leg Ulcers.

Adv Wound Care (New Rochelle) 2021 May 11. Epub 2021 May 11.

University of Florida, Geriatric Medicine, HPNP box 100187, Gainesville, Florida, United States, 32610;

Objective: Pain affects wound healing, treatment, and quality of life because it has significant impacts on physical, psychological, and social wellbeing. Despite the fact that more than half of chronic venous leg ulcer (CVLU) patients experience mild to moderate pain, the multidimensional characteristics of CVLU pain are not well documented. The objective of this study was to describe the multidimensional pain characteristics including the sensory, affective, cognitive, and behavioral dimensions of CVLU prior to debridement. Read More

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Hsa Circ 001839 Promoted Inflammation in Renal Ischemia-Reperfusion Injury Through NLRP3 by miR-432-3p.

Nephron 2021 May 11:1-13. Epub 2021 May 11.

College of Sports, Southwest Medical University, Luzhou, China.

Background: In recent years, increasing discovery of the extremely important regulatory effects of circular RNAs on biological development, angiogenesis, tumor genesis, and development, as well as stem cell proliferation and differentiation has provided new opportunities for investigating regulation mechanism in angiogenesis.

Objectives: This study explored the expression of circ 001839 in renal ischemia-reperfusion injury (RI-RI) rats and whether its upstream microRNA-432-3p (miR-432-3p) affects inflammation in both RI-RI rats and NRK52E cells.

Methods: Rat model of RI-RI was made, and circ 001839 was identified by the gene-chip analysis in RI-RI rats. Read More

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Occurrence of parabens, triclosan and triclocarban in paired human urine and indoor dust from two typical cities in China and its implications for human exposure.

Sci Total Environ 2021 May 3;786:147485. Epub 2021 May 3.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Institute of Environment and Health, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, Zhejiang 310000, China; Institute of Environment and Health, Jianghan University, Wuhan, Hubei 430056, China; College of Resources and Environment, University of Chinese Academy Sciences, Beijing 100049, China. Electronic address:

Parabens, triclosan (TCS) and triclocarban (TCC) are emerging endocrine disrupting chemicals, which are commonly used in personal care products and household applications in daily life. Due to their adverse health effects, human exposure to these chemicals has been a public concern. Despite evidence showing different exposure pathways of these chemicals, few studies have examined contribution of certain exposure to total human exposure. Read More

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Mothers' voices and white noise on premature infants' physiological reactions in a neonatal intensive care unit: A multi-arm randomized controlled trial.

Int J Nurs Stud 2021 Mar 26;119:103934. Epub 2021 Mar 26.

Associate Professor, Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore. Electronic address:

Background: A few positive effects of mothers' voice on physiological outcomes have been studied and limited studies have focused on the level of cortisol. In addition, white noise has recently been found to be beneficial for human sleep, but studies in premature infants were limited and no study has compared the effects of mothers' voice and white noise on premature infants.

Objective: To examine the effects of mothers' voice and white noise on sleep-wake patterns, salivary cortisol levels, weight gain, heart rate, and oxygen saturation of premature infants in a neonatal intensive care unit (NICU). Read More

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Structural Heterogeneity of Human Histone H2A.1.

J Phys Chem B 2021 May 11. Epub 2021 May 11.

Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.

Histones are highly basic chromatin proteins that tightly package and order eukaryotic DNA into nucleosomes. While the atomic structure of the nucleosomes has been determined, the three-dimensional structure of DNA-free histones remains unresolved. Here, we combine tandem nonlinear and linear ion mobility spectrometry (FAIMS-TIMS) coupled to mass spectrometry in parallel with molecular modeling to study the conformational space of a DNA-free histone H2A type 1 (H2A. Read More

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Determination of Respiratory Parameters by means of Hurst Exponents of the Respiratory Sounds and Stochastic Processing Methods.

IEEE Trans Biomed Eng 2021 May 11;PP. Epub 2021 May 11.

Objectives: System approach to the human respiratory system and input/output signals which characterize the system properties were not explored in detail in the literature. The aim of this study is to propose a combination of methods to investigate the indirect relationship between the fractal properties of Respiratory Signals (RS) and Respiratory Sound Signals (RSS) and the clinically measured respiratory parameters.

Methods: We used Hurst exponent to reveal the fractal properties of RS and RSS and to estimate the pressures in the respiratory system. Read More

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[Carrier screening model for Duchenne muscular dystrophy for women of reproductive age based on a pre-pregnancy birth defect control platform].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 May;38(5):485-487

Hangzhou Health Service Center for Children and Women, Hangzhou, Zhejiang 310006, China.

Objective: To establish a screening model for females of reproductive age carrying Duchenne muscular dystrophy (DMD) variants based on a current community health examination platform.

Methods: A total of 61 870 participants were recruited between October 2017 and October 2019. Serum creatine kinase (CK) was measured with a Roche Cobasc 701/702 using an enzymatic rate method. Read More

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New insights into large tropical tree mass and structure from direct harvest and terrestrial lidar.

R Soc Open Sci 2021 Feb 10;8(2):201458. Epub 2021 Feb 10.

Department of Geography, University College London, London, UK.

A large portion of the terrestrial vegetation carbon stock is stored in the above-ground biomass (AGB) of tropical forests, but the exact amount remains uncertain, partly owing to the lack of measurements. To date, accessible peer-reviewed data are available for just 10 large tropical trees in the Amazon that have been harvested and directly measured entirely via weighing. Here, we harvested four large tropical rainforest trees (stem diameter: 0. Read More

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February 2021

Associations between body mass index and body composition measures in a birth cohort.

Pediatr Res 2021 May 10. Epub 2021 May 10.

University of Iowa, Iowa City, IA, USA.

Background: Associations among body composition measures have been limited to cross-sectional analyses of different subjects. We identified cross-sectional relationships between body mass index (BMI) and other body composition measures and predicted body composition measures from BMI throughout childhood and adolescence.

Methods: BMI was calculated and % body fat (%BF), fat mass index (FMI), and fat-free mass index (FFMI) were measured using dual-energy x-ray absorptiometry at ages 5, 9, 11, 13, 15, and 17 years in a birth cohort (n = 629). Read More

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Blood-Based Cardiac Biomarkers and the Risk of Cognitive Decline, Cerebrovascular Disease, and Clinical Events.

Stroke 2021 May 11:STROKEAHA120032571. Epub 2021 May 11.

Department of Pharmacology, National University of Singapore. (M.K.P.L., C.C., S.H.).

Background And Purpose: Cardiac biomarkers, NT-proBNP (N-terminal probrain natriuretic peptide), hs-cTnT (high-sensitivity-cardiac troponin T), and GDF-15 (growth differentiation factor-15) have been proposed as important biomarkers of early vascular pathology. However, little is known of the longitudinal associations of these cardiac biomarkers with cerebrovascular disease and clinical events. We examine the association of blood-based cardiac biomarkers (NT-proBNP, hs-cTnT, and GDF-15) with cognitive decline, incident cerebrovascular disease, vascular events, and mortality. Read More

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Effect of a sodium hypochlorite mouthwash on plaque and clinical parameters of periodontal disease.

Int J Dent Hyg 2021 May 10. Epub 2021 May 10.

Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands.

Objective: The present study aimed to establish the efficacy of sodium hypochlorite mouthwash (NaOCl-MW) compared with a control mouthwash on plaque and clinical parameters of periodontal disease.

Methods: MEDLINE-PubMed, Embase, and Cochrane-CENTRAL databases were searched for clinical trials on patients with gingivitis or periodontitis that assessed the effect of NaOCl-MW in comparison with a negative or positive control on plaque index (PI), gingival index (GI), and bleeding index (BI) scores and probing pocket depth (PPD). Data were extracted from the eligible studies. Read More

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Detection of Emotional Sensitivity Using fNIRS based Dynamic Functional Connectivity.

IEEE Trans Neural Syst Rehabil Eng 2021 May 10;PP. Epub 2021 May 10.

In this study, we proposed an analytical framework to identify dynamic task-based functional connectivity (FC) features as new biomarkers of emotional sensitivity in nursing students, by using a combination of unsupervised and supervised machine learning techniques. The dynamic FC was measured by functional Near-Infrared Spectroscopy (fNIRS), and computed using a sliding window correlation (SWC) analysis. A k-means clustering technique was applied to derive four recurring connectivity states. Read More

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Longitudinal Relationship between Idylla Plasma ctBRAF V600 Mutation Detection and Tumor Burden in Patients with Metastatic Melanoma.

Mol Diagn Ther 2021 May 10. Epub 2021 May 10.

James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA.

Background: Circulating tumor DNA (ctDNA) may complement radiography for interim assessment of patients with cancer.

Objective: Our objective was to explore the relationship between changes in plasma ctDNA versus radiographic imaging among patients with metastatic melanoma.

Methods: Using the Idylla system, we measured B-Raf proto-oncogene (BRAF) V600 ctDNA in plasma from 15 patients with BRAF V600E/K-positive primary tumors undergoing standard-of-care monitoring, including cross-sectional computed tomography (CT) imaging. Read More

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Lives on track? Long-term earnings returns to selective school placement in England and Denmark.

Br J Sociol 2021 May 10. Epub 2021 May 10.

Department of Sociology, University of Copenhagen, Copenhagen K, Denmark.

We explore the influence of between-school ability placement at lower secondary education on earnings across the life course in England and Denmark. We go beyond the mid-career snapshot provided by previous studies by exploiting the availability of four decades worth of earnings data for individuals born in the mid-1950s. Members of this cohort who were judged to be among the most academically able attended grammar schools in England (19%) and advanced secondary schools (Realskole) in Denmark (51%) prior to the start of comprehensivization. Read More

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Relationship between financial well-being, life satisfaction, and cognitive function among low-income community-dwelling older adults: the moderating role of sex.

Psychogeriatrics 2021 May 9. Epub 2021 May 9.

Malaysian Research Institute on Ageing (MyAgeing™), Universiti Putra Malaysia, Serdang, Malaysia.

Background: Low financial well-being is a common predicament among older adults living in poverty. The existing literature suggests a correlation between financial well-being and mental health in old age. Therefore, this study aimed to identify the relationships among financial well-being, life satisfaction, and cognitive function among low-income older adults and to examine the moderating effect of sex on these relationships. Read More

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Mutational landscape of thymic epithelial tumors in a Chinese population: insights into potential clinical implications.

Gland Surg 2021 Apr;10(4):1410-1417

Medical Oncology Session No.1, Cancer Hospital of Shantou University Medical College, Shantou, China.

Background: Thymic epithelial tumors (TETs) are a heterogeneous group of rare malignancies which may be devastating, difficult to treat, and for which treatment options are limited. Herein, we investigated the comprehensive genomic alterations of TETs in a Chinese population for providing clinical management, especially targeted therapy.

Methods: Comprehensive genomic profiling (CGP) was performed with DNA targeted sequencing of cancer-associated genes (CSYS) from a cohort of 40 Chinese TET patients. Read More

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The association between social support and posttraumatic stress symptoms among survivors of betrayal trauma: a meta-analysis.

Eur J Psychotraumatol 2021 Mar 30;12(1):1883925. Epub 2021 Mar 30.

Department of Psychiatry & Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.

: Betrayal traumas have a particularly deleterious effect on mental health. Although social support is a robust predictor of posttraumatic stress disorder (PTSD) symptom severity, it is not clear what factors may impact this relationship among betrayal trauma survivors. : This study sought to describe the association between social support and PTSD symptom severity among survivors of betrayal trauma and examine whether methodological, sample, trauma, and social support characteristics moderated this association. Read More

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