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Anti-seizure medication correlated changes of cortical morphology in childhood epilepsy with centrotemporal spikes.

Epilepsy Res 2021 Mar 23;173:106621. Epub 2021 Mar 23.

Department of Medical Imaging, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, China; Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China; State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, 210093, China; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Suite 2301, Charlestown, MA, 02129, USA. Electronic address:

To investigate the morphological changes of cerebral cortex correlating with anti-seizure medication in Childhood Epilepsy with Centrotemporal Spikes (CECTS), and their relationships with seizure control. This study included a total of 188 children, including 62 patients with CECTS taking anti-seizure drugs, 56 patients with drug-naive, and 70 healthy controls. A portion of cases were also followed-up for longitudinal analysis. Read More

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Analysis of factors that could affect symptomatic outcome in patients having laparoscopic excision of deep rectovaginal endometriosis in BSGE endometriosis centres.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 16;261:17-24. Epub 2021 Apr 16.

Birmingham Women's and Children's Hospital, Edgbaston, Birmingham, B15 2TG, United Kingdom. Electronic address:

Objective: Investigate factors that influence quality of life after laparoscopic excision of deep rectovaginal endometriosis.

Study Design: A multicentre prospective cohort study involving 63 hospitals accredited as British Society for Gynaecological Endoscopy specialist endometriosis centres was conducted. The study population comprised of 8368 women who had undergone laparoscopic surgical excision of deep rectovaginal endometriosis requiring dissection of the pararectal space. Read More

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Full length RAG2 expression enhances the DNA damage response in pre-B cells.

Immunobiology 2021 Apr 6;226(3):152089. Epub 2021 Apr 6.

Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, United States. Electronic address:

V(D)J recombination by the RAG1 and RAG2 protein complex in developing lymphocytes includes DNA double strand break (DSB) intermediates. RAG2 undergoes export from the nucleus and enrichment at the centrosome minutes following production of DSBs by genotoxic stress, suggesting that RAG2 participates in cellular responses to DSBs such as those generated during V(D)J recombination. To determine the effect of RAG2 expression on cell viability following DSB generation, we measured pre-B cells that expressed either full length (FL) wild-type RAG2, or a T490A mutant of RAG2 that has increased stability and fails to undergo nuclear export following generation of DSBs. Read More

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Dynamic curve analysis of indicators related to lumbar cistern drainage for postoperative meningitis.

World Neurosurg 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, 110022, China. Electronic address:

Objective: The purpose of this work was two-fold: to analyze the dynamic curve of cerebrospinal fluid (CSF) related indices in cases of postoperative meningitis after selective craniotomy and to provide reference data for the clinical treatment with lumbar cisterna drainage (LCD).

Methods: We conducted a retrospective study of LCD placement in 51 patients. Primary outcomes measured included pre-intervention and post-intervention dynamic changes of body temperature, and CSF biochemical parameters over the course of 13 days of catheter placement. Read More

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Does anterior arthroscopic acromioplasty modify critical shoulder angle?

Orthop Traumatol Surg Res 2021 Apr 16:102936. Epub 2021 Apr 16.

Centre Hospitalier Universitaire d'Angers, Département de Chirurgie Osseuse, 4 Rue Larrey, 49100 Angers, France.

Introduction: Critical shoulder angle (CSA) is measured on AP view in neutral rotation as the angle subtended by the tangent to the glenoid and the lateral edge of the acromion. CSA >35° is a risk factor for primary rotator cuff tear and iterative tear after cuff repair. The aim of the present study was to assess change in CSA following arthroscopic anterior acromioplasty. Read More

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Effects of Triangle Grass Decoction on Bone Metabolism in Rats with Chronic Kidney Disease Complicated with Mineral and Bone Abnormalities.

J Ethnopharmacol 2021 Apr 16:114126. Epub 2021 Apr 16.

Department of Nephrology, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan 528400, China. Electronic address:

Ethnopharmacological Relevance: Triangle grass is a liliaceous Chlorophytum perennial herb of ChlorophytumlaxumR.Br. It is distributed mainly in Guangdong and Guangxi Provinces of China. Read More

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Endogenous β-endorphin Plays a Pivotal Role in Angiotensin II-mediated Central Neurochemical Changes and Pressor Response.

Chem Biol Interact 2021 Apr 16:109475. Epub 2021 Apr 16.

Pharmacology and Toxicology Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

Endorphins are endogenous opioid neuropeptides that are mainly produced from pituitary gland in response to pain and different triggers including interleukin 1 beta (IL-1β) and corticotropin-releasing factor (CRF). Angiotensin II (Ang II) can stimulate β-endorphin production, but the exact molecular mechanisms involved in this effect, and the role of the released endorphin in Ang II-mediated pressor response remain elusive. Male rats were injected with IL-1β receptor antagonist (IL-1Ra, 100 μg/kg), the CRF receptor blocker, astressin (20 μg/rat) or a combination of both, prior to Ang II injection (200 μg/kg). Read More

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Improving hypertension knowledge, medication adherence, and blood pressure control: A feasibility study.

J Clin Nurs 2021 Apr 19. Epub 2021 Apr 19.

Department of Nursing, Johns Hopkins University School of Nursing, Baltimore, MD, USA.

Aims And Objectives: To examine the feasibility of a culturally tailored education programme for Haitian immigrants diagnosed with hypertension.

Background: Hypertension is a major public health problem, impacting more than 26% of the global population. The overall prevalence of hypertension is 45. Read More

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Influence of amount and frequency of protein supplementation to ruminants consuming low-quality cool-season forages: Efficiency of nitrogen utilization in lambs and performance of gestating beef cows.

J Anim Sci 2021 Apr 19. Epub 2021 Apr 19.

Department of Animal Science, Texas A&M University, College Station, TX, USA.

We evaluated the influence of amount and crude protein (CP) supplementation frequency (SF) on nitrogen (N) use by wethers and performance of late-gestation beef cows. In Exp. 1, 7 Western whiteface wethers (31. Read More

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Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial.

Am J Clin Nutr 2021 Apr 19. Epub 2021 Apr 19.

School of Public Health, Physiotherapy and Sport Science, University College Dublin, Dublin, Ireland.

Background: Leucine-enriched protein (LEU-PRO) and long-chain (LC) n-3 (ω-3) PUFAs have each been proposed to improve muscle mass and function in older adults, whereas their combination may be more effective than either alone.

Objective: The impact of LEU-PRO supplementation alone and combined with LC n-3 PUFAs on appendicular lean mass, strength, physical performance and myofibrillar protein synthesis (MyoPS) was investigated in older adults at risk of sarcopenia.

Methods: This 24-wk, 3-arm parallel, randomized, double-blind, placebo-controlled trial was conducted in 107 men and women aged ≥65 y with low muscle mass and/or strength. Read More

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Presleep Arousal and Sleep in Early Childhood.

J Genet Psychol 2021 Apr 19:1-16. Epub 2021 Apr 19.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Research suggests that arousal during the transition to sleep-presleep arousal-is associated with sleep disturbances. Although a robust literature has examined the role of presleep arousal in conferring risk for sleep disturbances in adults, substantially less research has examined the developmental origins of presleep arousal in early childhood. The authors examined presleep arousal using parent report and psychophysiological measures in a sample of preschoolers to explore the association between different measures of presleep arousal, and to examine how nightly presleep arousal is associated with sleep. Read More

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Substance use and mental health in pregnant women during the COVID-19 pandemic.

J Reprod Infant Psychol 2021 Apr 17:1-14. Epub 2021 Apr 17.

Analytics and PsychoPharmacology Laboratory (APPL), Washington State University, Spokane, WA, U.S.A.

: We examined the prevalence of substance use as a coping mechanism and identified relationships between maternal mental health over time and use of substances to cope during the Coronavirus Disease 2019 (COVID-19) pandemic among pregnant women in the U.S.A. Read More

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The Association Between Weight Gain, Sex and Immune Activation Following the Initiation of Antiretroviral Therapy.

J Infect Dis 2021 Apr 19. Epub 2021 Apr 19.

University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH, U.S.

Background: Immune activation persists despite suppressive antiretroviral therapy (ART) and may be affected by sex or body composition. We explored these relationships in a subset of participants who initiated ART in two large randomized trials.

Methods: Purposeful sampling selected participants who achieved virologic suppression on ART and either maintained weight within +/- 0. Read More

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Sleep onset (mis)perception in relation to sleep fragmentation, time estimation and pre-sleep arousal.

Sleep Med X 2020 Dec 28;2:100014. Epub 2020 Mar 28.

Department of Electrical Engineering, Eindhoven University of Technology, De Zaale, Eindhoven, the Netherlands.

Study Objective: To elucidate the contribution of time estimation and pre sleep arousal to the component of sleep onset misperception not explained by sleep fragmentation.

Methods: At-home ambulatory polysomnograms (PSGs) of 31 people with insomnia were recorded. Participants performed a time estimation task and completed the Pre Sleep Arousal Scale (PSAS). Read More

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December 2020

Exposure to household air pollutants and endothelial dysfunction in rural Bangladesh: A cross-sectional study.

Environ Epidemiol 2021 Apr 19;5(2):e132. Epub 2021 Feb 19.

icddr,b, Dhaka, Bangladesh.

More than one third of world's population use biomass fuel for cooking that has been linked to an array of adverse health hazards including cardiovascular mortality and morbidity. As part of Bangladesh Global Environmental and Occupational Health (GEO Health) project, we assessed whether household air pollution (HAP) was associated with dysfunction in microvascular circulation (measured by reactive hyperemia index [RHI]).

Methods: We measured exposure to HAP (particulate matter [PM2. Read More

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Implementation of a Rapid Post-Code Debrief Quality Improvement Project in a Community Emergency Department Setting.

Spartan Med Res J 2021 Apr 13;6(1):21376. Epub 2021 Apr 13.

Michigan State University College of Osteopathic Medicine.

Context: Regular debriefing has been associated with improved resource utilization and measurable improvements in team performance in crisis situations. While Emergency Department (ED) staff have often stated that they would like to be provided a formal debriefing model after "code blue" and similar events, few EDs have such protocols in place.

Methods: The study consisted of two data collection processes: (1) completion of a 7-item survey distributed pre-intervention, 6-months post-intervention, and 1-year post-intervention, and (2) completion of a Rapid Post-Code Debriefing form. Read More

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The impact of early social support on subsequent health recovery after a major disaster: A longitudinal analysis.

SSM Popul Health 2021 Jun 26;14:100779. Epub 2021 Mar 26.

Tulane University School of Public Health and Tropical Medicine, USA.

Social support may facilitate disaster recovery. Prior analyses are hampered by the limits of cross-sectional approaches. We use longitudinal data from the KATIVA-NOLA survey to explore whether social support soon after Hurricane Katrina facilitated recovery of health status for a representative sample of 82 Vietnamese New Orleanians. Read More

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iTRAQ-Based proteomic dataset for bovine pre-ovulatory plasma and follicular fluid containing high and low Estradiol.

Data Brief 2021 Jun 26;36:106998. Epub 2021 Mar 26.

Department of Animal Science, South Dakota State University, Brookings, South Dakota, USA.

This is isobaric tags for a relative and absolute quantification (iTRAQ)-Based Proteomic Data on bovine plasma (PL) and follicular fluid (FF) containing high and low pre-ovulatory circulating concentration of estradiol (E2). The PL and FF were collected from nine beef cows that were identified to initiate a new follicular wave on day -4 during synchronization. Follicular dynamics and ovulatory response were monitored using transrectal ultrasonography. Read More

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Bilirubin Induces Pain Desensitization in Cholestasis by Activating 5-Hydroxytryptamine 3A Receptor in Spinal Cord.

Front Cell Dev Biol 2021 1;9:605855. Epub 2021 Apr 1.

Department of Critical Care Medicine, Shanghai Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.

Background: Cholestasis patients often suffer from pain desensitization, resulting in serious complications in perioperative period. This study was aim to investigate the mechanism of bilirubin in cholestasis mediating pain desensitization through 5-hydroxytryptamine 3A (5-HT ) receptor activation in spinal dorsal horn (SDH).

Methods: A cholestasis model was established by bile duct ligation (BDL) in rats. Read More

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SARS-CoV-2 Antigens Expressed in Plants Detect Antibody Responses in COVID-19 Patients.

Front Plant Sci 2021 31;12:589940. Epub 2021 Mar 31.

Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has swept the world and poses a significant global threat to lives and livelihoods, with 115 million confirmed cases and at least 2.5 million deaths from Coronavirus disease 2019 (COVID-19) in the first year of the pandemic. Developing tools to measure seroprevalence and understand protective immunity to SARS-CoV-2 is a priority. Read More

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High Circulating Follicle-Stimulating Hormone Level Is a Potential Risk Factor for Renal Dysfunction in Post-Menopausal Women.

Front Endocrinol (Lausanne) 2021 1;12:627903. Epub 2021 Apr 1.

Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Objective: Menopause contributes to renal dysfunction in women, which is generally attributed to estrogen withdrawal. In addition to decreased estrogen level, serum follicle-stimulating hormone (FSH) level increases after menopause. This study investigated the association between high circulating FSH level and renal function in post-menopausal women. Read More

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Changes in Walking Speed After High-Intensity Treadmill Training Are Independent of Changes in Spatiotemporal Symmetry After Stroke.

Front Neurol 2021 1;12:647338. Epub 2021 Apr 1.

Brain Plasticity Lab, Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, United States.

Decreased walking speeds and spatiotemporal asymmetry both occur after stroke, but it is unclear whether and how they are related. It is also unclear whether rehabilitation-induced improvements in walking speed are associated with improvements in symmetry or greater asymmetry. High-intensity speed-based treadmill training (HISTT) is a recent rehabilitative strategy whose effects on symmetry are unclear. Read More

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Seismic and Aseismic Fault Slip During the Initiation Phase of the 2017 = 6.9 Valparaíso Earthquake.

Geophys Res Lett 2021 Mar 22;48(6):e2020GL091916. Epub 2021 Mar 22.

Laboratoire de Géologie, Département de Géosciences CNRS UMR 8538 École Normale Supérieure PSL University Paris France France.

Transient deformation associated with foreshocks activity has been observed before large earthquakes, suggesting the occurrence of a detectable preseismic slow slip during the initiation phase. A critical issue consists in discriminating the relative contributions from seismic and aseismic fault slip during the preparation phase of large earthquakes. We focus on the April-May 2017 Valparaíso earthquake sequence, which involved a  = 6. Read More

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Utilizing electronic health record data to understand comorbidity burden among people living with HIV: a machine learning approach.

AIDS 2021 May;35(Suppl 1):S39-S51

South Carolina SmartState Center for Healthcare Quality.

Objectives: An understanding of the predictors of comorbidity among people living with HIV (PLWH) is critical for effective HIV care management. In this study, we identified predictors of comorbidity burden among PLWH based on machine learning models with electronic health record (EHR) data.

Methods: The study population are individuals with a HIV diagnosis between January 2005 and December 2016 in South Carolina (SC). Read More

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Establishing the role of the pharmacist in mental health: Implementing Mental Health First Aid into the doctor of pharmacy core curriculum.

Curr Pharm Teach Learn 2021 Jun 12;13(6):608-615. Epub 2021 Feb 12.

Practice Advancement and Clinical Education Division, University of North Carolina Eshelman School of Pharmacy, 1310 Kerr Hall, CB# 7574, 301 Pharmacy Lane, Chapel Hill, NC 27599, United States. Electronic address:

Introduction: The objective of this study was to assess the impact of implementing Mental Health First Aid (MHFA) training in a doctor of pharmacy (PharmD) curriculum on student pharmacists' knowledge, attitudes, self-efficacy, and empathy towards people with mental health conditions and/or crises.

Methods: Participants were third-year PharmD students enrolled in Patient Care Experience, a required communication and ethics course. A survey was administered pre- and post-intervention (i. Read More

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Preoperative cephalhematoma size measured with computed tomography predicts intraoperative bleeding in pediatric patients undergoing cranioplasty.

Anesth Pain Med (Seoul) 2021 Apr 15. Epub 2021 Apr 15.

Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Cranioplasty for the treatment of cephalhematomas in small infants with limited blood volume is challenging because of massive bleeding. This study aimed to elucidate the correlation between cephalhematoma size and intraoperative blood loss and identify criteria that can predict large intraoperative blood loss.

Methods: We reviewed the medical records of 120 pediatric patients aged less than 24 months who underwent cranioplasty for treatment of a cephalhematoma. Read More

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Minimally Invasive Parathyroidectomy: Are Auxiliary Methods Necessary?

J Coll Physicians Surg Pak 2021 Apr;30(4):440-444

Department of General Surgery, University of Health Sciences, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.

Objective: To determine the success rate of minimally invasive parathyroidectomies (MIPs) with preoperative scintigraphy and ultrasonography, and to assess whether these imaging modalities are sufficient.

Study Design:  Observational study.

Place And Duration Of Study:   Department of General Surgery, University of Health Sciences, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey between March 2017 and December 2019. Read More

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Role of Ga-PSMA PET/CT parameters in treatment evaluation and survival prediction in prostate cancer patients compared with biochemical response assessment.

Hell J Nucl Med 2021 Apr 20. Epub 2021 Apr 20.

Department of Nuclear Medicine, Saglik Bilimleri University, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.

Objective: In this study, we aimed to evaluate the concordance of biochemical treatment response with gallium-68-prostate specific membrane antigen (Ga-PSMA) positron emission tomography/computed tomography (PET/CT) treatment response in prostate cancer (PCa) and investigate their prognostic effects on survival.

Materials And Methods: One hundred and fifty-onepatients with PCa, who underwent Ga-PSMA PET/CT imaging in our clinic between May 2016 and December 2019, were on treatment, and had pre-treatment and post-treatment imaging studies were included in our study. The treatment patients received and prostate-specific antigen (PSA) levels at the time of PET/CT imaging were recorded. Read More

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The prognostic impact of circulating miRNAs in patients with advanced esophagogastric cancer during palliative chemotherapy.

Cancer Treat Res Commun 2021 Apr 9;27:100371. Epub 2021 Apr 9.

Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Department of Medical Oncology, Amsterdam, Netherlands,; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, Netherlands,. Electronic address:

The prognosis of patients with advanced oesophageal cancer (EC) and gastric cancer (GC) is poor. Circulating microRNAs (ci-miRNAs) may have prognostic and predictive value to improve patient selection for palliative treatment. The purpose of this study is to assess the prognostic and predictive value of specific ci-miRNAs in plasma of patients with EC and GC treated with first-line palliative gemcitabine and cisplatin. Read More

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