5,672 results match your criteria measured binary

Association between the inclination angle of the proximal tibiofibular joint surface and medial compartment knee osteoarthritis.

Ann Palliat Med 2021 Jul 27. Epub 2021 Jul 27.

PLA Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Background: Fibular support for the lateral tibial plateau through the proximal tibiofibular joint (PTFJ) results in nonuniform settlement of the tibial plateau in middle-aged and elderly persons and may lead to medial compartment knee osteoarthritis. However, the inclination angle of the PTFJ surface varies widely and may affect nonuniform settlement. The purpose of this case-control study was to assess the association between the inclination angle of the PTFJ surface and medial compartment knee osteoarthritis. Read More

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Drug Metab Dispos 2021 Jul 29. Epub 2021 Jul 29.

Groton Laboratories, Pfizer Global Research and Development, United States

Cytochrome P450 3A (CYP3A) is a frequent target for time-dependent inhibition (TDI) that can give rise to drug-drug interactions (DDI). Yet many drugs that exhibit in vitro TDI for CYP3A, do not result in DDI. Twenty-three drugs with published clinical DDI were evaluated for CYP3A TDI in human liver microsomes (HLM) and hepatocytes (HHEP), and these data were utilized in static and dynamic models for projecting DDI caused by inactivation of CYP3A in both liver and intestine. Read More

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COVID-19 pandemic related long-term chronic stress on the prevalence of depression and anxiety in the general population.

BMC Psychiatry 2021 Jul 28;21(1):380. Epub 2021 Jul 28.

Department of Stress Medicine, Faculty of Psychology, Navy Medical University, 800 Xiangyin Road, Shanghai, China.

Background: The COVID-19 pandemic has lasted for more than 1 year, causing far-reaching and unprecedented changes in almost all aspects of society. This study aimed to evaluate the long-term consequences of the COVID-19 pandemic on depression and anxiety, and explore the factors associated with it.

Methods: A cross-sectional study using an online survey was conducted to assess mental health problems from February 2 to February 9, 2021 by using patient health questionnaire-9 (PHQ-9) and generalized anxiety disorder-7 (GAD-7). Read More

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Epidemiology and Prognostic Utility of Cellular Components of Hematological System in Sepsis.

Indian J Crit Care Med 2021 Jun;25(6):660-667

Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.

Background: Data are lacking on the role of cellular components of hematological system as biomarkers for prognosis of sepsis. We planned to identify if these parameters measured at admission to ICU and at 72 hours can be useful as prognostic marker in septic critically ill patients.

Materials And Methods: In this prospective observational study, 130 adult patients with sepsis were recruited. Read More

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Predictors of coronary artery calcification and its association with cardiovascular events in patients with chronic kidney disease.

Ren Fail 2021 Dec;43(1):1172-1179

Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, PR China.

Objective: To investigate the predictors of coronary artery calcification (CAC) and its association with cardiovascular events (CVE) in patients with stage 3-5 chronic kidney disease (CKD).

Method: Two hundred ninety CKD patients in our nephrology department were enrolled from 2018 to May 2019. The levels of matrix Gla protein (MGP) and interleukin 6 (IL-6) were measured enzyme-linked immunosorbent assay (ELISA) method in 131 CKD patients of all. Read More

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December 2021

Systematic thermodynamic analysis of apremilast polymorphs via solubility measurement with modeling: Mechanism evaluation through molecular simulation.

Eur J Pharm Sci 2021 Jul 25;165:105958. Epub 2021 Jul 25.

State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.

The polymorphism of apremilast has been investigated. Two polymorphs have been identified and characterized by differential scanning calorimeter, fourier transform infrared spectroscopy, and powder X-ray diffractometer. Solubilities of apremilast forms B and E in three binary solvents of methanol-water, acetonitrile-water, and acetonitrile-methanol have been measured using the static method at a temperature ranging from 288. Read More

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Use of Ecological Momentary Assessment Through a Passive Smartphone-Based App (eB2) by Patients With Schizophrenia: Acceptability Study.

J Med Internet Res 2021 Jul 26;23(7):e26548. Epub 2021 Jul 26.

Departamento de Psiquiatria, IIS-Fundación Jiménez Díaz, Madrid, Spain.

Background: Ecological momentary assessment (EMA) tools appear to be useful interventions for collecting real-time data on patients' behavior and functioning. However, concerns have been voiced regarding the acceptability of EMA among patients with schizophrenia and the factors influencing EMA acceptability.

Objective: The aim of this study was to investigate the acceptability of a passive smartphone-based EMA app, evidence-based behavior (eB2), among patients with schizophrenia spectrum disorders and the putative variables underlying their acceptance. Read More

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Recovery of Infectious Human Norovirus GII.4 Sydney From Fomites Replication in Human Intestinal Enteroids.

Front Cell Infect Microbiol 2021 7;11:693090. Epub 2021 Jul 7.

Department of Environmental Health and Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States.

Contamination of fomites by human norovirus (HuNoV) can initiate and prolong outbreaks. Fomite swabbing is necessary to predict HuNoV exposure and target interventions. Historically, swab recovered HuNoV has been measured by molecular methods that detect viral RNA but not infectious HuNoV. Read More

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In Situ Observation of the Chemical Bonding State of Si in the Molten State of Eutectic Au-Si alloy of Au81Si19 by Using a Soft X-ray Emission Spectroscopy Electron Microscope.

Microscopy (Oxf) 2021 Jul 25. Epub 2021 Jul 25.

Institute of Multidisciplinary Research for Advanced Materials, Tohoku, University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.

Phase diagram of Au-Si binary alloy system shows a large drop of melting temperature of about 1000 K compared with that of Si at a composition of Au:Si=81:19, where the melting temperature is about 636 K. Mixing of Au and Si below the melting temperature was observed by transmission electron microscopy experiment and found the mixed region show a diffraction pattern of a diffuse ring intensity indicating an amorphous structure of the mixed area. Si L-emission spectra, which reflects the energy state of bonding electrons of Si atom, of molten Au81Si19 alloy was measured for the first time to investigate the energy state of valence electrons of Si. Read More

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Predictors of poor function in RA based on two prospective UK inception cohorts. Do comorbidities matter?

Rheumatology (Oxford) 2021 Jul 24. Epub 2021 Jul 24.

Centre for Rheumatic Diseases, King's College London, London, UK.

Objectives: Evidence suggests that factors beyond disease activity associate with functional disability in Rheumatoid Arthritis (RA). The primary study objective was to explore associations between comorbidities, sociodemographic factors and functional outcomes at five and 10 years.

Methods: RA patients from two UK prospective cohorts were grouped into low (<1. Read More

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Suggestive evidence of genetic association of -572G > C polymorphism with primary open angle glaucoma in a North Indian Punjabi population.

Hum Immunol 2021 Jul 20. Epub 2021 Jul 20.

Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India. Electronic address:

Background: IL6 is an important candidate gene implicated in the pathogenesis of glaucoma. The present study assessed the genetic association of -174G > C and -572G > C polymorphisms in the IL6 promoter region with primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG) in a north Indian Punjabi cohort.

Methods: 910 subjects (313 POAG, 148 PACG cases and 449 controls) were recruited. Read More

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Ultrasound Evaluation of the Rectus Femoris for Sarcopenia in Patients with Early Subacute Stroke.

J Clin Med 2021 Jul 6;10(14). Epub 2021 Jul 6.

Department of Rehabilitation Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 14647, Korea.

We investigated the ultrasound characteristics of the rectus femoris for sarcopenia detected by dual-energy X-ray absorptiometry (DEXA) in the early subacute stroke phase. Physical features (age, sex, body mass index, and circumference of thigh) and performances (modified Barthel index in Korean, functional ambulation categories, and mini-mental state examination in Korean) were measured. The thickness of the fat layer, the thickness of the rectus femoris (TRF), echo intensity (EI), EI to TRF ratio, and strain ratio of elastography (SRE) were measured by ultrasound in 30 patients with first-ever stroke (male: = 20). Read More

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"My Life during the Lockdown": Emotional Experiences of European Adolescents during the COVID-19 Crisis.

Int J Environ Res Public Health 2021 Jul 18;18(14). Epub 2021 Jul 18.

Department of Human Neurosciences, Sapienza University, 00185 Rome, Italy.

This study investigates, using an online self-report questionnaire, adolescents' emotional reactions during the lockdown in a sample of 2105 secondary school students (aged 14-19) in Italy, Romania, and Croatia. We used a self-reported online questionnaire (answers on a 5-point scale or binary), composed of 73 questions investigating the opinions, feelings, and emotions of teenagers, along with sociodemographic information and measures of the exposure to lockdown. The survey was conducted online through a web platform in Italy (between 27 April and 15 June 2020), Romania, and Croatia (3 June and 2 July 2020). Read More

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Thermodynamics and Intermolecular Interactions of Nicotinamide in Neat and Binary Solutions: Experimental Measurements and COSMO-RS Concentration Dependent Reactions Investigations.

Int J Mol Sci 2021 Jul 8;22(14). Epub 2021 Jul 8.

Department of Physical Chemistry, Pharmacy Faculty, Collegium Medicum of Bydgoszcz, Nicolaus Copernicus University in Toruń, Kurpińskiego 5, 85-950 Bydgoszcz, Poland.

In this study, the temperature-dependent solubility of nicotinamide (niacin) was measured in six neat solvents and five aqueous-organic binary mixtures (methanol, 1,4-dioxane, acetonitrile, DMSO and DMF). It was discovered that the selected set of organic solvents offer all sorts of solvent effects, including co-solvent, synergistic, and anti-solvent features, enabling flexible tuning of niacin solubility. In addition, differential scanning calorimetry was used to characterize the fusion thermodynamics of nicotinamide. Read More

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Solvent Screening for Solubility Enhancement of Theophylline in Neat, Binary and Ternary NADES Solvents: New Measurements and Ensemble Machine Learning.

Int J Mol Sci 2021 Jul 8;22(14). Epub 2021 Jul 8.

Department of Physical Chemistry, Faculty of Pharmacy, Collegium Medicum of Bydgoszcz, Nicolaus Copernicus University in Toruń, Kurpińskiego 5, 85-950 Bydgoszcz, Poland.

Theophylline, a typical representative of active pharmaceutical ingredients, was selected to study the characteristics of experimental and theoretical solubility measured at 25 °C in a broad range of solvents, including neat, binary mixtures and ternary natural deep eutectics (NADES) prepared with choline chloride, polyols and water. There was a strong synergistic effect of organic solvents mixed with water, and among the experimentally studied binary systems, the one containing DMSO with water in unimolar proportions was found to be the most effective in theophylline dissolution. Likewise, for NADES, the addition of water (0. Read More

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Lab-scale and pore-scale study of low-permeability soil diffusional tortuosity.

J Contam Hydrol 2021 Jul 8;242:103858. Epub 2021 Jul 8.

Faculty of Mechatronics, Informatics and Interdisciplinary Studies, Technical University of Liberec, Studentská 2, Liberec, Czechia.

Diffusion coefficients for Na was measured in low-permeability samples (diameter of 3 cm and average length of 7 cm) from the deep disposal site of the Siberian Chemical Combine (SCC) using the end-diffusion technique. The direction of diffusion was perpendicular to the direction of bedding. Special equipment was designed and constructed for the experiment. Read More

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Excessive anterior tibial translation in the contralateral uninjured limb is significantly associated with ramp lesion in anterior cruciate ligament injury.

J Exp Orthop 2021 Jul 23;8(1):54. Epub 2021 Jul 23.

Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.

Purpose: This study aimed to evaluate the excessive anterior tibial translation (ATT) and muscle strength of patients with ramp lesions. We hypothesised that the higher ATT, lower hamstring-to-quadriceps (HQ) ratio, and higher flexion peak torque influenced by semimembranosus would be associated with ramp lesions.

Methods: One hundred and twenty-one patients who underwent anterior cruciate ligament (ACL) reconstruction were retrospectively evaluated. Read More

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Prophylactic nimodipine treatment for hearing preservation after vestibular schwannoma surgery: study protocol of a randomized multi-center phase III trial-AkniPro 2.

Trials 2021 Jul 22;22(1):475. Epub 2021 Jul 22.

Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

Background: A previously performed phase III trial on 112 subjects investigating prophylactic nimodipine treatment in vestibular schwannoma (VS) surgery showed no clear beneficial effects on preservation of facial and cochlear nerve functions, though it should be considered that protection of facial nerve function was the primary outcome. However, the risk for postoperative hearing loss was halved in the nimodipine group compared to the control group (OR 0.49; 95% CI 0. Read More

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How is everyone doing? Baseline psychological distress and adaptive functioning among transgender, nonbinary, and CIS youth presenting for intensive outpatient psychiatric services.

Psychol Serv 2021 Jul 22. Epub 2021 Jul 22.

Department of Psychiatry.

Psychological and psychosocial functioning of binary transgender and nonbinary youth has been understudied in settings treating individuals at risk for psychiatric hospitalization. Further, little is currently known about potential differences in baseline levels of psychiatric distress and adaptive functioning across gender-diverse youth and their psychiatrically distressed cisgender counterparts. Key differences may elucidate avenues for adapted treatment and protocols among youth presenting for psychiatric care. Read More

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Cognition and transcranial sonography in Parkinson's disease patients with or without orthostatic hypotension.

Brain Behav 2021 Jul 21. Epub 2021 Jul 21.

Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: Orthostatic hypotension (OH) is a common nonmotor symptom in patients with Parkinson's disease (PD), with an incidence ranging from 14% to 54%.

Aims: This study explored changes in cognition and transcranial sonography (TCS) findings in patients with PD and OH.

Methods: We enrolled PD patients who visited the outpatient or inpatient department from 2017 to 2020. Read More

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Cross-shift change of acute kidney injury biomarkers in sugarcane farmers and cutters.

Hum Ecol Risk Assess 2021 2;27(5):1170-1187. Epub 2020 Sep 2.

Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Department of Public Health, Lowell, USA.

Sugarcane farmers and cutters have been reported to be at high risk of acute kidney injury. This cross-sectional study aimed to assess acute kidney injury biomarkers, and cross-shift change among 150 sugarcane cutters and 98 sugarcane farmers in Thailand. Physical health examination, environmental measurements, and measured urinary neutrophil gelatinase-associated lipocalin (NGAL) were assessed. Read More

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September 2020

Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease.

Neurobiol Aging 2021 Jun 21;106:119-129. Epub 2021 Jun 21.

Department of Nuclear Medicine, Multimodal Neuroimaging Group, University of Cologne, University Hospital of Cologne, Cologne, Germany.

Although beta-amyloid (Aβ) positivity has shown to be associated with higher risk of progression to Alzheimer's disease (AD) in mild cognitive impairment (MCI), information on the time to conversion to manifest dementia cannot be readily deduced from this binary classification. Here, we assessed if regional patterns of Aβ deposition measured with F-florbetapir may serve as biomarker for progression risk in Aβ-positive cognitively normal (CN) and MCI patients, including clinical follow-up data and cerebrospinal fluid (CSF) biomarkers. Voxel-wise group comparisons between age and sex-matched Aβ-positive groups (i. Read More

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Thermodynamic Characteristics of Phenacetin in Solid State and Saturated Solutions in Several Neat and Binary Solvents.

Molecules 2021 Jul 3;26(13). Epub 2021 Jul 3.

Department of Physical Chemistry, Pharmacy Faculty, Collegium Medicum of Bydgoszcz, Nicolaus Copernicus University in Toruń, Kurpińskiego 5, 85-950 Bydgoszcz, Poland.

The thermodynamic properties of phenacetin in solid state and in saturated conditions in neat and binary solvents were characterized based on differential scanning calorimetry and spectroscopic solubility measurements. The temperature-related heat capacity values measured for both the solid and melt states were provided and used for precise determination of the values for ideal solubility, fusion thermodynamic functions, and activity coefficients in the studied solutions. Factors affecting the accuracy of these values were discussed in terms of various models of specific heat capacity difference for phenacetin in crystal and super-cooled liquid states. Read More

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The Relationships of Dehydroepiandrosterone Sulfate, Erectile Function and General Psychological Health.

Sex Med 2021 Jul 14;9(4):100386. Epub 2021 Jul 14.

Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:

Introduction: Dehydroepiandrosterone sulfate (DHEAS) has been reported to be associated with sexual function and general psychological health respectively, however, no one has ever examined their mutual relationships in a single study.

Aim: The aim of the present study was to find out whether DHEAS, general psychological health, and erectile function were all associated with each other.

Methods: A cross-sectional study was conducted on 34 patients with erectile dysfunction (ED) and 32 healthy controls (HC). Read More

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Capped L-norm metric based robust least squares twin support vector machine for pattern classification.

Neural Netw 2021 Jul 4;142:457-478. Epub 2021 Jul 4.

College of Science, China Agricultural University, Beijing, Haidian, 100083, China. Electronic address:

Least squares twin support vector machine (LSTSVM) is an effective and efficient learning algorithm for pattern classification. However, the distance in LSTSVM is measured by squared L-norm metric that may magnify the influence of outliers. In this paper, a novel robust least squares twin support vector machine framework is proposed for binary classification, termed as CL-LSTSVM, which utilizes capped L-norm distance metric to reduce the influence of noise and outliers. Read More

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Thermodynamic and structural features of chlorodifluoromethane (a sI-sII dual hydrate former) + external guest (N or CH) hydrates and their significance for greenhouse gas separation.

Phys Chem Chem Phys 2021 Jul;23(29):15693-15701

Department of Urban and Environmental Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.

In this study, a new sI-sII dual hydrate former [chlorodifluoromethane (CHClF2); an important greenhouse gas with a global warming potential of 1810], which forms sI hydrate by itself and forms sII hydrate in the presence of external help guests such as CH4 and N2, was introduced and closely investigated for its potential significance in gas hydrate-based gas separation. The phase equilibria of CHClF2 hydrate, binary CHClF2 (5%) + N2 (95%) hydrate, and binary CHClF2 (5%) + CH4 (95%) hydrate were measured to examine the formation conditions and thermodynamic stability regions of CHClF2 + external guest hydrates. Nuclear magnetic resonance and in situ Raman spectroscopic results confirmed the formation of sII hydrates for CHClF2 + external guest (N2 or CH4) mixtures. Read More

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The diagnostic value of metabolic, morphological and heterogeneous parameters of 18F-FDG PET/CT in mediastinal lymph node metastasis of non-small cell lung cancer.

Nucl Med Commun 2021 Jul 15. Epub 2021 Jul 15.

Department of Nuclear Medicine Department of Radiology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, P.R. China.

Objectives: To investigate the value of PET/CT metabolic, morphological and heterogeneous parameters in the diagnosis of 18F-FDG positive mediastinal lymph node metastasis in non-small cell lung cancer (NSCLC).

Patients And Methods: A total of 156 patients with pathologically diagnosed NSCLC and underwent 18F-FDG PET/CT scans were enrolled in this study. Mediastinal lymph nodes with 18F-FDG uptake greater than the mediastinum were analyzed. Read More

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Geographic distribution modeling and taxonomy of (Cothouny Gould, 1846) (Charopidae) reveal potential distributional areas of the species along the Patagonian Forests.

PeerJ 2021 5;9:e11614. Epub 2021 Jul 5.

Instituto de Biodiversidad Neotropical, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Universidad Nacional de Tucuman (UNT), Yerba Buena, Horco Molle, Tucumán, Argentina.

Background: (Couthouy Gould, 1846), an endemic Charopidae from southern South America, was described from few dry shells. The distribution of this species is known on scattering occurrences, mainly from material deposited in museum collections. We provide here new information on anatomy, habitat, and microhabitat preferences and estimate the potential geographic distribution of the species to test if it is exclusively endemic to the Subpolar Magellanic Forest. Read More

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