77,939 results match your criteria measured quantitative

The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats.

Drug Des Devel Ther 2021 8;15:3845-3862. Epub 2021 Sep 8.

Department of Hepatology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People's Republic of China.

Background: Acute-on-chronic liver failure (ACLF) is a severe, complicated human disease. E2F1-mediated apoptosis plays an important role in ACLF development. Jieduan-Niwan (JDNW) formula, a traditional Chinese medicine (TCM), has shown remarkable clinical efficacy in ACLF treatment. Read More

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September 2021

Comparative proteome analysis of form-deprivation myopia in sclera with iTRAQ-based quantitative proteomics.

Mol Vis 2021 1;27:494-505. Epub 2021 Sep 1.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai, China.

Objective: Scleral remodeling plays a key role in axial elongation in myopia. The aim of the present study was to identify the proteomics changes and specific signaling networks to gain insight into the molecular basis of scleral remodeling in myopic eyes.

Methods: Guinea pig form-deprivation myopia was induced with a translucent diffuser on a random eye for 4 weeks, while the other eye served as the contralateral control group. Read More

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September 2021

HGF/MET in osteogenic differentiation of primary human palatal periosteum-derived mesenchymal stem cells.

J Oral Sci 2021 Sep 15. Epub 2021 Sep 15.

Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago.

Purpose: This study aimed to determine expressions of hepatocyte growth factor (HGF) and MET proto-oncogene receptor tyrosine kinase (MET) in palatal periosteum (PP) and to examine the effect of HGF/MET on osteogenic differentiation of human palatal periosteum-derived mesenchymal stem cells (PD-MSCs).

Methods: HGF/MET proteins in human palatal periosteum (n = 3) were localized using immunohistochemistry. PD-MSCs (n = 3) were cultured in serum-free Essential 8 (E8) medium or osteogenic medium with and without Capmatinib, a selective ATP-inhibitor of MET. Read More

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September 2021

Assessing the usability of wearable devices to measure gait and physical activity in chronic conditions: a systematic review.

J Neuroeng Rehabil 2021 Sep 15;18(1):138. Epub 2021 Sep 15.

UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.

Background: The World Health Organisation's global strategy for digital health emphasises the importance of patient involvement. Understanding the usability and acceptability of wearable devices is a core component of this. However, usability assessments to date have focused predominantly on healthy adults. Read More

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September 2021

A youth empowerment intervention to prevent childhood obesity: design and methods for a cluster randomized trial of the HGO! program.

BMC Public Health 2021 Sep 15;21(1):1675. Epub 2021 Sep 15.

Division of Preventive and Behavioral Medicine, Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA, 01655, USA.

Background: Reducing sugar-sweetened beverage (SSB) consumption is a promising dietary target for childhood obesity prevention. This paper describes the design and methods of a cluster randomized trial of HGO!, a youth empowerment intervention to prevent childhood obesity through reducing SSB consumption among a low-income, ethnically diverse sample of youth.

Methods: This cluster randomized controlled trial is an academic-community partnership with the Massachusetts Alliance of Boys and Girls Clubs (BGC). Read More

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September 2021

Effect of epigallocatechin gallate on dental biofilm of Streptococcus mutans: An in vitro study.

BMC Oral Health 2021 Sep 15;21(1):447. Epub 2021 Sep 15.

Department of Orthodontics, Hadassah Medical Center, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Background: Streptococcus mutans (S. mutans) plays a major role in the formation of dental caries. The aim of this study was to examine the effect of the green tea polyphenol, epigallocatechin gallate (EGCG), on biofilm formation of S. Read More

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September 2021

Hand hygiene monitoring technology: A descriptive study of ethics and acceptance in nursing.

Nurs Ethics 2021 Sep 15:9697330211015351. Epub 2021 Sep 15.

Albert-Ludwigs-University Freiburg, Germany.

Background: Nosocomial infections represent a serious challenge for healthcare systems worldwide. Adherence to hand hygiene plays a major role in infection prevention and control. These adherence rates can be improved through behaviour tracking innovations. Read More

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September 2021

Modeling transport of soft particles in porous media.

Phys Rev E 2021 Aug;104(2-2):025112

Department of Mechanical Engineering, The City College of New York, New York, New York 10031, USA.

Flow-driven transport of soft particles in porous media is ubiquitous in many natural and engineering processes, such as the gel treatment for enhanced oil recovery. In many of these processes, injected deformable particles block the pores and thus increase the overall pressure drop and reduce the permeability of the particle-resided region. The change of macroscopic properties (e. Read More

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Nondestructive Microanalysis of Thin-Film Coatings on Historic Metal Threads.

Anal Chem 2021 Sep 15. Epub 2021 Sep 15.

Museum Conservation Institute, Smithsonian Institution, 4210 Silver Hill Road, Suitland, Maryland 20746, United States.

A new standards-based scanning electron microscopy with the energy-dispersive X-ray spectrometry (SEM-EDS) quantification method was used to analyze the thin-film coating of an 18th century French textile decorated with metal threads in variable pressure conditions. This analytical technique can allow for nondestructive quantitative characterization of the near surface of cultural heritage objects small enough to be placed in an SEM chamber that may contain corrosion products, without applying a conductive coating. A multivoltage analysis consisting of measurements taken at a series of electron beam energies was obtained and input into a film thickness and composition (FTC) computational model to characterize a layered Au on Ag reference material, in addition to a historic metal thread. Read More

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September 2021

Evaluation of the correlation between the Access SARS-CoV-2 IgM and IgG II antibody tests with the SARS-CoV-2 surrogate virus neutralization test.

J Med Virol 2021 Sep 15. Epub 2021 Sep 15.

Department of Clinical Laboratory, Saitama Medical University Hospital, Saitama, Japan.

Fully automated immunoassays for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies that are strongly correlated with neutralization antibodies (nAbs) are clinically important because they enable assessment of humoral immunity after infection and vaccination. Access SARS-CoV-2 IgM and IgG II antibody tests are semi-quantitative, fully automated immunoassays that detect anti-receptor-binding domain (RBD) antibodies and might reflect nAb levels in coronavirus disease 2019 (COVID-19). However, no studies have investigated the clinical utility of these tests in association with nAbs to date. Read More

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September 2021

Diagnostic evaluation of qRT-PCR-based kit and dPCR-based kit for COVID-19.

Genes Genomics 2021 Sep 15. Epub 2021 Sep 15.

Department of Bio-Convergence Engineering, Dankook University, Jukjeon, 16890, Republic of Korea.

Background: Coronavirus disease of 2019 (COVID-19) is well known as a fatal disease, first discovered at Wuhan in China, ranging from mild to death, such as shortness of breath and fever. Early diagnosis of COVID-19 is a crucial point in preventing global prevalence.

Objective: We aimed to evaluate the diagnostic competency and efficiency with the Allplex™ 2019-nCoV Assay kit and the Dr. Read More

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September 2021

Quantitative characterization of Tetraspanin 8 homointeractions in the plasma membrane.

Biochem J 2021 Sep 15. Epub 2021 Sep 15.

Johns Hopkins University, Baltimore, Maryland, United States.

The spatial distribution of proteins in cell membranes is crucial for signal transduction, cell communication and membrane trafficking. Members of the Tetraspanin family organize functional protein clusters within the plasma membrane into so-called Tetraspanin-enriched microdomains (TEMs). Direct interactions between Tetraspanins are believed to be important for this organization. Read More

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September 2021

Psychological Effects of Heart Rate and Physical Vibration on the Operation of Construction Machines: Experimental Study.

JMIR Mhealth Uhealth 2021 Sep 15;9(9):e31637. Epub 2021 Sep 15.

Graduate School of Technology Management, Ritsumeikan University, Ibaraki, Japan.

Background: A construction method has emerged in which a camera is installed around a construction machine, and the operator remotely controls the machine while synchronizing the vibration of the machine with the images seen from the operator's seat using virtual reality (VR) technology. Indices related to changes in heart rate (HR) and physical vibration, such as heart rate variability (HRV) and multiscale entropy (MSE), can then be measured among the operators. As these indices are quantitative measures of autonomic regulation in the cardiovascular system, they can provide a useful means of assessing operational stress. Read More

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September 2021

Quantitative physical examination indicators to detect patients with stenosis at a high risk of thrombosis at hemodialysis vascular access sites: A retrospective case-control study.

J Vasc Access 2021 Sep 15:11297298211045505. Epub 2021 Sep 15.

Department of Nephrology, Yuan's General Hospital, Kaohsiung.

Background: Quantitative physical examination (PE) indicators, including palpable pulsatility length and outflow scores, can be used to quantify stenosis severity at hemodialysis vascular access sites. It is known that the risk of high-shear-related thrombosis is increased when the minimal luminal diameter (MLD) of stenosis decreases. At present, MLD is measured using sonography or angiography. Read More

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September 2021

Conductive hearing loss in the Hyp mouse model of X-linked hypophosphatemia is accompanied by hypomineralization of the auditory ossicles.

J Bone Miner Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Trauma and Orthopaedic Surgery, Division of Orthopaedics, University Medical Center Hamburg-Eppendorf; Hamburg, Germany.

X-linked hypophosphatemia (XLH) is a hereditary musculoskeletal disorder caused by loss-of-function mutations in the PHEX gene. In XLH, increased circulating fibroblast growth factor 23 (FGF23) levels cause renal phosphate wasting and low concentrations of 1,25-dihydroxyvitamin D, leading to an early clinical manifestation of rickets. Importantly, hearing loss is commonly observed in XLH patients. Read More

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September 2021

All-optical dynamic analysis of the photothermal and photoacoustic response of a microcantilever by laser Doppler vibrometry.

Photoacoustics 2021 Dec 31;24:100299. Epub 2021 Aug 31.

Laboratory for Soft Matter and Biophysics, Department of Physics and Astronomy, KU Leuven, Leuven, B-3001, Belgium.

Light absorption induced thermoelastic and photoacoustic excitation, combined with laser Doppler vibrometry, was utilized to analyze the dynamic mechanical behavior of a microcantilever. The measured frequency response, modal shapes, and acoustic coupling effects were interpreted in the framework of a simple Bernouilli-Euler model and quantitative 3D finite element method (FEM) analysis. Three opto-mechanical generation mechanisms, each initiated by modulated optical absorption and heating, were identified both by an analytical and finite element model. Read More

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December 2021

MiR-374b-5p inhibits KDM5B-induced epithelial-mesenchymal transition in pancreatic cancer.

Am J Cancer Res 2021 15;11(8):3907-3920. Epub 2021 Aug 15.

Department of Hepatobiliary Surgery, Beijing Chao-Yang Hospital, Affiliated to Capital Medical University Beijing, China.

Micro(mi)RNAs play a critical regulatory role in the progression and metastasis of pancreatic cancer (PC). In this study, we aimed to reveal the mechanisms of miR-374b-5p in regulating epithelial-mesenchymal transition (EMT) in PC. Gene Expression Omnibus datasets (GSE24279 and GSE71533) and the pancreatic ductal adenocarcinoma (PDAC) cohort of The Cancer Genome Atlas were employed to screen for potential prognostic miRNAs. Read More

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Mitofusin-2 Promotes the Epithelial-Mesenchymal Transition-Induced Cervical Cancer Progression.

Immune Netw 2021 Aug 23;21(4):e30. Epub 2021 Jul 23.

Department of Anatomy, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Korea.

High expression of mitofusin-2 (MFN2), a mitochondrial fusion protein, has been frequently associated with poor prognosis of patients with cervical cancer. Here, we aimed to identify the function of MFN2 in cervical cancer to understand its influence on disease prognosis. To this end, from cervical adenocarcinoma, we performed an MTT assay and quantitative RT-PCR (qRT-PCR) analysis to assess the effects of MFN2 on the proliferation and of HeLa cells. Read More

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Erythroferrone Expression in Anemic Rheumatoid Arthritis Patients: Is It Disordered Iron Trafficking or Disease Activity?

J Inflamm Res 2021 7;14:4445-4455. Epub 2021 Sep 7.

Clinical Pathology Department, Ain Shams University, Cairo, Egypt.

Purpose: Erythroferrone (ERFE) is well acknowledged for its inhibitory function on hepcidin synthesis in the liver during stress erythropoiesis, thereby ensuring sufficient iron supply to bone marrow erythroblasts. Hepcidin plays an indispensable role in the pathogenesis of anemia of chronic disease (ACD). Thus, ERFE was suggested to protect against ACD in various diseases. Read More

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September 2021

The use of multi-criteria method in the process of threat assessment to the environment.

Sci Rep 2021 Sep 14;11(1):18296. Epub 2021 Sep 14.

Department of Safety Engineering, Faculty of Mining, Safety Engineering and Industrial Automation, Silesian University of Technology, 2 Akademicka St., 44-100, Gliwice, Poland.

Measurements of the content of trace elements, including toxic and carcinogenic metals, in various fractions of particulate matter PM are an important element of environmental monitoring and research involving their impact on human health. The article presents the measurement results of atmospheric composition of suspended dust (PM), respirable fraction (PM) and submicron particulate matter (PM) collected with the Dekati PM cascade impactor. Samples were collected in the vicinity of four working power plants (from 28 May to 23 September 2014) and four coking plants (from 4 May to 28 August 2015) in Upper Silesia, Poland. Read More

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September 2021

The role of XBP-1-mediated unfolded protein response in colorectal cancer progression-a regulatory mechanism associated with lncRNA-miRNA-mRNA network.

Cancer Cell Int 2021 Sep 14;21(1):488. Epub 2021 Sep 14.

Department of General Surgery, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital, No. 218, Hengjie Road, Huangyan District, Taizhou City, 318020, Zhejiang Province, China.

Background: We aim to identify the expression and analyze the molecular action of dysregulated lncRNA-miRNA mediated by XBP-1 in colorectal cancer (CRC).

Methods: Here, we identified XBP-1-mediated dysregulated lncRNAs and miRNAs in CRC by bioinformatics analysis. The expression level of lncRNAs and miRNA was measured using quantitative real time PCR, and the expression of XBP-1, as well as apoptosis-related proteins, were detected by western blot. Read More

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September 2021

Adhesion pathway proteins and risk of atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis.

BMC Cardiovasc Disord 2021 Sep 14;21(1):436. Epub 2021 Sep 14.

Department of Quantitative Health Sciences, Mayo Clinic, 200 First Street Southwest, Rochester, MN, USA.

Background: The cellular adhesion pathway has been suggested as playing an important role in the pathogenesis of atrial fibrillation (AF). However, prior studies that have investigated the role of adhesion pathway proteins in risk of AF have been limited in the number of proteins that were studied and in the ethnic and racial diversity of the study population. Therefore we aimed to study the associations of fifteen adhesion pathway proteins with incident AF in a large, diverse population. Read More

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September 2021

Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway.

Cytokine 2021 Sep 11;148:155686. Epub 2021 Sep 11.

Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, PR China. Electronic address:

Background: Osteoarthritis (OA) is the most common joint disease in the elderly and is characterized by the progressive degeneration of articular cartilage. It is necessary to study the molecular pathology of OA. This study aimed to explore the role and mechanism of BLNK in regulating interleukin-1β (IL-1β)-induced chondrocyte injury and OA progression. Read More

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September 2021

Outer Retinal Folds Following Pars Plana Vitrectomy vs Pneumatic Retinopexy for Retinal Detachment Repair: Post Hoc Analysis from PIVOT.

Ophthalmol Retina 2021 Sep 11. Epub 2021 Sep 11.

Department of Ophthalmology and Vision Sciences, University of Toronto, CANADA; Department of Ophthalmology, St. Michael's Hospital, Unity Health Toronto, CANADA; Kensington Vision and Research Centre, University of Toronto, CANADA; Keenan Research Centre for Biomedical Science/ Li Ka Shing Knowledge Institute, Toronto, Canada. Electronic address:

Purpose: To assess the incidence of post-operative outer retinal folds (ORFs) in pars plana vitrectomy (PPV) vs pneumatic retinopexy (PnR) following rhegmatogenous retinal detachment (RRD) repair and to determine the association of ORFs with functional outcomes at 1 year.

Design: Randomized controlled trial PARTICIPANTS: Patients with primary macula-off RRD meeting PIVOT trial criteria randomly assigned to PPV vs PnR.

Methods: Post-hoc analysis of the PIVOT trial. Read More

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September 2021

EIF3D promotes the progression of preeclampsia by inhibiting of MAPK/ERK1/2 pathway.

Reprod Toxicol 2021 Sep 11;105:166-174. Epub 2021 Sep 11.

Department of Obstetrics and Gynecology, Binzhou Medical University Hospital, Binzhou, 256603, Shandong, P.R. China. Electronic address:

Preeclampsia (PE) has been recognized as one of the main reasons for neonatal and maternal mortality and morbidity. This study intended to identify certain genes that correlated with the pathogenesis of PE, and disclose the underlying mechanisms. The GSE14776 and GSE65271 datasets were obtained from the Gene Expression Omnibus database. Read More

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September 2021

Midbrain area and the hummingbird sign from brain MRI in progressive supranuclear palsy and idiopathic normal pressure hydrocephalus.

J Neuroimaging 2021 Sep 14. Epub 2021 Sep 14.

Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.

Background And Purpose: The main radiological finding in progressive supranuclear palsy (PSP) is reduced midbrain volume. Both qualitative (e.g. Read More

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September 2021

Premature Triadic Music Therapy (PT-MT) for babies and their parents: a pilot study.

J Reprod Infant Psychol 2021 Sep 14:1-20. Epub 2021 Sep 14.

Department of Health Sciences, School of Psychology, University of Florence, Florence, Italy.

Objective: We aim to test the feasibility and effectiveness of Premature Triadic Music Therapy (PT-MT) in the premature baby unit.

Methods: The design was a clinical pre-test-post-test trial with a convenience sample. Inclusion criteria were a gestational age higher than 28 weeks for preterm infants and the absence of shock or extreme distress for parents. Read More

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September 2021

Luminal enhancement in intracranial aneurysms: fact or feature?-A quantitative multimodal flow analysis.

Int J Comput Assist Radiol Surg 2021 Sep 14. Epub 2021 Sep 14.

Laboratory of Fluid Dynamics and Technical Flows, Otto-von-Guericke University, University of Magdeburg, Forschungscampus STIMULATE, Universitätsplatz 3, 39106, Magdeburg, Germany.

Purpose: Intracranial aneurysm (IA) wall enhancement on post-contrast vessel wall magnetic resonance imaging (VW-MRI) is assumed to be a biomarker for vessel wall inflammation and aneurysm instability. However, the exact factors contributing to enhancement are not yet clarified. This study investigates the relationship between luminal enhancement and intra-aneurysmal flow behaviour to assess the suitability of VW-MRI as a surrogate method for determining quantitative and qualitative flow behaviour in the aneurysm sac. Read More

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September 2021

Space Use and the Physical Attributes of Acute Care Units: A Quantitative Study.

HERD 2021 Sep 14:19375867211043848. Epub 2021 Sep 14.

Turner Construction Company, Nashville, TN, USA.

This article shares the results of a quantitative analysis of the space use and physical attributes of 140 acute care units (ACU) completed since 2007.

Objective: To fill a gap in the literature with respect to the state of practice for ACU design over the study period by investigating relationships among the physical characteristics and density of completed ACUs.

Background: Robust industry interest about the topic-further agitated by the dearth of large-scale quantitative research regarding ACU space use-motivated completion of the study. Read More

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September 2021

mir-221, mir-190b, mir-363-3p, mir-200c are involved in rat liver ischaemia-reperfusion injury through oxidative stress, apoptosis and endoplasmic reticulum stress.

Int J Clin Pract 2021 Sep 14:e14848. Epub 2021 Sep 14.

Department of Anesthesia and Reanimation, University of Health Sciences Turkey, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.

Aim: In this study, it was aimed to investigate the relationship between expression levels of micro-RNAs, endoplasmic reticulum (ER) stress, apoptosis and oxidative stress markers in hepatic ischaemia-reperfusion (IR) injury.

Methods: Sixteen rats were randomised into two groups: Sham and IR groups. In the IR group, portal vein and hepatic artery were totally clamped with an atraumatic microvascular clamp and 60 minutes later unclamped and finally IR model was accomplished (60 minutes ischaemia and 60 minutes reperfusion). Read More

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September 2021