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Correlates of poor sleep based upon wrist actigraphy data in bipolar disorder.

J Psychiatr Res 2021 Jun 21;141:385-389. Epub 2021 Jun 21.

Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA, USA; Stein Institute for Research on Aging, University of California San Diego School of Medicine, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA.

Background: Wrist-worn actigraphy can objectively measure sleep, and has advantages over self-report, particularly for people with Bipolar Disorder (BD) for whom self-reports might be influenced by affect. Clinically useful data reduction approaches are needed to explore these complex data.

Methods: We created a composite score of sleep metrics in BD based on 51 BD and 80 healthy comparison (HC) participants. Read More

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Personal Characteristics Associated with Progression in Trauma and Orthopaedic Specialty Training: A Longitudinal Cohort Study.

J Surg Educ 2021 Jul 26. Epub 2021 Jul 26.

Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom.

Aim: To identify demographic factors, including protected characteristics, and training specific factors which predict a nonstandard Annual Review of Competency Progression (ARCP) outcome during Trauma and Orthopedic Specialty training in the United Kingdom (UK).

Method: A longitudinal cohort study using data from UKMED was performed. ARCP outcome was the primary outcome measure. Read More

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Evaluation of the effects of metformin as adenosine monophosphate-activated protein kinase activator on spatial learning and memory in a rat model of multiple sclerosis disease.

Biomed Pharmacother 2021 Jul 22;141:111932. Epub 2021 Jul 22.

Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Electronic address:

In patients with multiple sclerosis (MS) disease, cognitive deficits have been detected because of destruction of hippocampus. Cognitive impairment is one of the common signs in MS. Recent studies showed that metformin (Met) has wide-ranging effects in the treatment of diseases. Read More

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Telemedicine Improves the Short-Term Medical Care of Acute ST-Segment Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention.

Front Cardiovasc Med 2021 12;8:693731. Epub 2021 Jul 12.

Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Telemedicine appears to be a promising tool for healthcare professionals to deliver remote care to patients with cardiovascular diseases especially during the COVID-19 pandemic. We aimed in this study to evaluate the value of telemedicine added to the short-term medical care of acute ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI). Two hundred acute STEMI patients after primary PCI were randomly divided into two groups. Read More

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The Impact of Dental Pain due to Caries in the Oral Health-Related Quality of Life of Children.

J Dent Child (Chic) 2021 May;88(2):80-85

Dr. Granville-Garcia is an associate professor, both in the Department of Dentistry, State University of Para í ba, Campina Grande, Paraiba, Brazil;, Email:

To determine the extent to which history of dental pain explains the impact of dental caries on oral health-related quality of life (OHRQoL) among pre-schoolers.
A population-based study was conducted with a random sample of 769 five-year-old children. Preschoolers self-completed the Brazilian version of the Scale of Oral Health Outcomes for Five-Year-Old Children (SOHO-5), and caregivers completed a questionnaire addressing sociodemographic characteristics. Read More

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Using Consistently Low Performance to Identify Low-Quality Physician Groups.

JAMA Netw Open 2021 Jul 1;4(7):e2117954. Epub 2021 Jul 1.

Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts.

Importance: There has been a growth in the use of performance-based payment models in the past decade, but inherently noisy and stochastic quality measures complicate the assessment of the quality of physician groups. Examining consistently low performance across multiple measures or multiple years could potentially identify a subset of low-quality physician groups.

Objective: To identify low-performing physician groups based on consistently low performance after adjusting for patient characteristics across multiple measures or multiple years for 10 commonly used quality measures for diabetes and cardiovascular disease (CVD). Read More

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Health behaviours in 131,182 UK women planning pregnancy.

BMC Pregnancy Childbirth 2021 Jul 28;21(1):530. Epub 2021 Jul 28.

Department of Women and Children's Health, School of Life Course Sciences, King's College London, 10th Floor North Wing, St Thomas' Hospital, Westminster Bridge Road, SE1 7EH, London, UK.

Background: A woman's health at the time of conception lays the foundation for a healthy pregnancy and the lifelong health of her child. We investigated the health behaviours of UK women planning pregnancy.

Methods: We analysed survey data from the 'Planning for Pregnancy' online tool (Tommy's, UK). Read More

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Examining the influence of mental stress on balance perturbation responses in older adults.

Exp Gerontol 2021 Jul 24;153:111495. Epub 2021 Jul 24.

University of Maryland School of Medicine, Department of Physical Therapy and Rehabilitation Science, Baltimore, MD 21201, USA. Electronic address:

Background: Reach-to-grasp responses following balance perturbations are important to fall prevention but are often ineffective in older adults. The ability to shift attention from an ongoing cognitive task to balance related processes has been shown to influence reach-to-grasp effectiveness in older adults. However, the added influence of stress and anxiety - known to negatively affect attention shifting ability - has not yet been explored in relation to recovery from balance perturbations. Read More

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Behavioral, neurocognitive, polysomnographic and cardiometabolic profiles associated with obstructive sleep apnea in adolescents with ADHD.

J Child Psychol Psychiatry 2021 Jul 26. Epub 2021 Jul 26.

Sleep Research & Treatment Center, Penn State Milton S. Hershey Medical Center, College of Medicine, Pennsylvania State University, Hershey, PA, USA.

Background: A high comorbidity between attention-deficit/hyperactivity disorder (ADHD) and obstructive sleep apnea (OSA) as well as similar impairments across neurobehavioral outcomes has been described in children. However, there is a paucity of research examining the comorbidity of these two disorders in adolescents. This study examined the association of OSA with sleep, neurobehavioral, and cardiometabolic outcomes in adolescents with ADHD from the general population. Read More

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Retrospective Review of Perioperative Multimodal Analgesia for Orthopedic Patients in a Veterans Affairs Setting.

Sr Care Pharm 2021 Aug;36(8):397-408

Objectives: To determine adherence of perioperative knee/hip arthroplasties and hip fracture repairs to the American Pain Society (APS) guideline recommendations for perioperative pain control. One secondary objective was to perform an internal quality audit on the use of enhanced recovery after surgery (ERAS) protocols; another secondary objective was to design an evidence-based, multi-modal perioperative quick-order menu (if warranted).

Design/patients: A retrospective quality improvement (QI) review of uncomplicated knee/hip replacement and hip fracture repairs from January 2018 through March 2018. Read More

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Cochlear Implant Performance in Candidates With Moderate Hearing Loss Qualifying in Noise.

Otol Neurotol 2021 Jul 23. Epub 2021 Jul 23.

Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.

Objective: To determine postcochlear implantation performance for patients qualifying on preimplant testing in noise.

Study Design: Retrospective chart review of cochlear implant recipients.

Main Outcome Measure: Performance on word and sentence testing in the implanted ear and bimodal condition were compared between pre- and postimplantation time points. Read More

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Generalized Equations for Predicting Percent Body Fat from Anthropometric Measures Using a Criterion Five-Compartment Model.

Med Sci Sports Exerc 2021 Jul 23. Epub 2021 Jul 23.

Department of Exercise Science, Shenandoah University, Winchester, VA Department of Kinesiology, University of Alabama, Tuscaloosa, AL College of Nursing and Health Sciences, Texas A&M International University, Laredo, TX Department of Education, Ewha Womans University, Seoul, South Korea Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO.

Introduction: Anthropometric-based equations are used to estimate percent body fat (%BF) when laboratory methods are impractical or not available. However, because these equations are often derived from two-compartment models, they are prone to error due to assumptions regarding fat-free mass composition. The purpose of this study was to develop a new anthropometric-based equation for the prediction of %BF, using a five-compartment (5C) model as the criterion measure. Read More

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Sedentary Behavior in United States Adults: Fall 2019.

Med Sci Sports Exerc 2021 Jul 23. Epub 2021 Jul 23.

Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD Division of Population Health, Centers for Disease Control and Prevention, Atlanta, GA Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, Saint Louis, MO Risk Factor Assessment Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD Division of Nutrition, Physical Activity, and Obesity, Centers for Disease Control, Atlanta, GA Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD Department of Geography, University of Hong Kong, Hong Kong, China Department of Kinesiology, California Polytechnic State University, San Luis Obispo, CA Health Behaviors Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD.

Purpose: Higher levels of sedentary behavior are associated with early mortality, but the distribution of sedentary time by classes of behavior and demographic groups is poorly described in United States (US) adults. To quantify the amount and sources of sedentary time in US adults we conducted a nationwide survey using a novel validated self-administerd previous-day recall method and compare these values with a commonly used sitting time question.

Methods: Participants from the AmeriSpeak panel aged 20 to 75 years (N = 2,640) completed up to two Activities Completed over Time in 24 Hours (ACT24) previous day recalls. Read More

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Recovery of Infectious Human Norovirus GII.4 Sydney From Fomites Replication in Human Intestinal Enteroids.

Front Cell Infect Microbiol 2021 7;11:693090. Epub 2021 Jul 7.

Department of Environmental Health and Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States.

Contamination of fomites by human norovirus (HuNoV) can initiate and prolong outbreaks. Fomite swabbing is necessary to predict HuNoV exposure and target interventions. Historically, swab recovered HuNoV has been measured by molecular methods that detect viral RNA but not infectious HuNoV. Read More

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MRI-Based Morphometric Study Regarding Operative Windows of Oblique Lumbar Interbody Fusion in Indian Population.

Indian J Orthop 2021 Jul 7;55(Suppl 2):366-373. Epub 2021 Apr 7.

Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh India.

Background: The novel Oblique lumbar interbody fusion [OLIF] technique has been proposed as a solution to approach related complications of anterior lumbar interbody fusion [ALIF] and lateral lumbar interbody fusion [LLIF]. There exists no study concerning morphological evaluation of retroperitoneal oblique corridor for the Oblique lumbar interbody fusion (OLIF) technique in the Indian population. The aim of our study was (a) to measure magnetic resonance imaging (MRI) based anatomic parameters concerning OLIF operative windows from L2-L3 to L4-L5 level (b) to determine the feasibility of this technique following MRI-based morphometric evaluation in the Indian population. Read More

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Clustering of obesity-related characteristics: A latent class analysis from the Canadian Longitudinal Study on Aging.

Prev Med 2021 Jul 21;153:106739. Epub 2021 Jul 21.

Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main St. West, Hamilton, Ontario L8S 4L8, Canada; Centre for Health Economics and Policy Analysis, McMaster University, 1280 Main St. West, Hamilton, Ontario L8S 4K1, Canada. Electronic address:

Measures of obesity, including body mass index (BMI) and waist circumference (WC), do not fully capture the complexity of obesity-related health risks. This study identified distinct classes of obesity-related characteristics and evaluated their associations with BMI, WC, and percent body fat (%BF) using cross-sectional data from 30,096 participants aged 45-85 in the Canadian Longitudinal Study on Aging (2011-2015). Sixteen obesity-related variables, including behavioural, metabolic, physical health, and mental health/social factors, were included in a latent class analysis to identify distinct classes of participants. Read More

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Prediction of Patient Height and Weight With a 3-Dimensional Camera.

J Comput Assist Tomogr 2021 May-Jun 01;45(3):427-430

From the Department of Radiology, NYU Langone Health, New York, NY.

Objective: The aim of this study was to determine accuracy of height and weight prediction by a 3-dimensional (3D) camera.

Methods: A total of 453 patients whose computed tomography imaging used a 3D camera from December 19, 2018 to March 19, 2019 were retrospectively identified. An image of each patient was taken before the computed tomography by a 3D camera mounted to the ceiling. Read More

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Effect of opposing needling on motor cortex excitability in healthy participants and in patients with post-stroke hemiplegia: study protocol for a single-blind, randomised controlled trial.

Trials 2021 Jul 22;22(1):481. Epub 2021 Jul 22.

South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510000, China.

Background: Opposing needling has an obvious curative effect in the treatment of post-stroke hemiplegia; however, the mechanism of the opposing needling in the treatment of post-stroke hemiplegia is still not clear. The purpose of this study is to investigate the effect of opposing needling on the excitability of primary motor cortex (M1) of healthy participants and patients with post-stroke hemiplegia, which may provide insight into the mechanisms of opposing needling in treating post-stroke hemiplegia.

Methods: This will be a single-blind, randomised, sham-controlled trial in which 80 healthy participants and 40 patients with post-stroke hemiplegia will be recruited. Read More

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Retrospective study of glycemic variability, BMI, and blood pressure in diabetes patients in the Digital Twin Precision Treatment Program.

Sci Rep 2021 Jul 21;11(1):14892. Epub 2021 Jul 21.

Twin Health, Mountain View, CA, USA.

The objective of this retrospective observational cohort study was to measure glycemic variability and reductions in body mass index (BMI), blood pressure (BP), and use of antihypertensive medications in type 2 diabetes (T2D) patients participating in the digital twin-enabled Twin Precision Treatment (TPT) Program. Study participants included 19 females and 45 males with T2D who chose to participate in the TPT Program and adhered to program protocols. Nine additional enrollees were excluded due to major program non-adherence. Read More

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Hepatic fat in early childhood is independently associated with estimated insulin resistance: The Healthy Start Study.

J Clin Endocrinol Metab 2021 Jul 21. Epub 2021 Jul 21.

Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.

Background: Fatty liver disease is a common metabolic abnormality in adolescents with obesity, but remains under-studied in early childhood.

Objectives: To describe hepatic fat deposition in prepubertal children and examine associations with metabolic markers and body composition.

Methods: Data were from 286 children ages 4-8 years old in the Healthy Start Study, a longitudinal pre-birth cohort in Colorado. Read More

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Assessment and Impact of the Risk of Exposure of Portuguese Biomedical Scientists in the Context of COVID-19.

Int J Environ Res Public Health 2021 Jul 2;18(13). Epub 2021 Jul 2.

School of Applied Sciences, Abertay University, Dundee DD1 1HG, UK.

Currently, the main public health concern worldwide is the COVID-19 pandemic, caused by SARS-CoV-2, which was recently discovered and described. Due to its high pathogenicity and infectiousness, it is necessary to determine the risk healthcare professionals face every day while dealing with infected patients and contaminated biological samples. The purpose of this study was to assess Portuguese Biomedical Scientists' risk of COVID-19 exposure and related stress appraisals. Read More

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Age as an Independent Predictor of Adult Spinal Cord Stimulation Pain Outcomes.

Stereotact Funct Neurosurg 2021 Jul 19:1-7. Epub 2021 Jul 19.

Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York, USA.

Introduction: Spinal cord stimulation (SCS) is an efficacious chronic pain treatment most commonly used in middle-aged patients. Results from previous studies that investigated SCS' effects in older patient populations have been equivocal. We examine whether SCS outcomes correlate with age. Read More

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From cells to stems: the effects of primary vascular construction on drought-induced embolism in fern rhizomes.

New Phytol 2021 Jul 17. Epub 2021 Jul 17.

The Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA.

While considerable data exists on the link between xylem construction and hydraulic function, few studies have focused on resistance to drought-induced embolism of primary vasculature in herbaceous plants. Ferns rely entirely on primary xylem and display a remarkable diversity of vascular construction in their rhizomes, making them an ideal group in which to examine hydraulic structure-function relationships. New optical methods allowed us to measure vulnerability to embolism in rhizomes, which are notoriously difficult to work with. Read More

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Prevalence of Burnout Among Respiratory Therapists Amidst the COVID-19 Pandemic.

Respir Care 2021 Jul 16. Epub 2021 Jul 16.

Boston Children's Hospital, Boston, MA.

Burnout is a major challenge in health care, but its prevalence has not been evaluated in practicing respiratory therapist (RTs). The purpose of this study was to identify RT burnout prevalence and factors associated with RT burnout. An online survey was administered to 26 centers in the United States and between January and March 2021. Read More

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A method for measuring time spent in bradykinesia and dyskinesia in people with Parkinson's disease using an ambulatory monitor.

J Neuroeng Rehabil 2021 Jul 16;18(1):116. Epub 2021 Jul 16.

Florey Institute of Neuroscience and Mental Health, Victoria, Australia.

Background: Fluctuations in motor function in Parkinson's Disease (PD) are frequent and cause significant disability. Frequently device assisted therapies are required to treat them. Currently, fluctuations are self-reported through diaries and history yet frequently people with PD do not accurately identify and report fluctuations. Read More

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Disparities in receipt of medications for opioid use disorder among pregnant women.

Subst Abus 2021 Jul 16:1-6. Epub 2021 Jul 16.

Department of Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

: Medications for opioid use disorder (MOUD) improve outcomes for pregnant women and infants. Our primary aim was to examine disparities in maternal MOUD receipt by family sociodemographic characteristics. : This retrospective cohort study included mother-infant dyads with Medicaid-covered deliveries in Tennessee from 2009 to 2016. Read More

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Doppler ultrasound impacts response to intravenous tocilizumab in rheumatoid arthritis patients.

Clin Rheumatol 2021 Jul 16. Epub 2021 Jul 16.

Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, 1000 Veteran Avenue, Box 32-59, Los Angeles, CA, 90024, USA.

Objective: Within rheumatoid arthritis (RA) patients treated with intravenous tocilizumab (IV-TCZ), it is unclear if power Doppler ultrasonography (PDUS) can predict future clinical response. This study sought to determine if baseline PDUS or its early changes can predict 12-week and 24-week disease activity outcomes, and quantify the need for dose escalation (4 to 8 mg/kg).

Methods: Fifty-four RA patients starting IV-TCZ were evaluated at baseline, 4, 6, 12, 16, and 24 weeks using 34-joint PDUS (US34-PDUS), clinical disease activity index (CDAI), 28-joint disease activity score using erythrocyte sedimentation rate (DAS28-ESR), ACR 20/50/70, health assessment questionnaire-disability index (HAQ-DI), and PDUS 20/50/70, a novel measure. Read More

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Multi-institutional TSA-amplified Multiplexed Immunofluorescence Reproducibility Evaluation (MITRE) Study.

J Immunother Cancer 2021 Jul;9(7)

Akoya Biosciences, Marlborough, Massachusetts, USA.

Background: Emerging data suggest predictive biomarkers based on the spatial arrangement of cells or coexpression patterns in tissue sections will play an important role in precision immuno-oncology. Multiplexed immunofluorescence (mIF) is ideally suited to such assessments. Standardization and validation of an end-to-end workflow that supports multisite trials and clinical laboratory processes are vital. Read More

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Estuarine oiling increases a long-term decline in mussel growth.

Environ Pollut 2021 Sep 3;284:117506. Epub 2021 Jun 3.

Belle Baruch Marine Field Lab, North Inlet -Winyah Bay National Estuarine Research Reserve, PO Box1630, Georgetown, SC, 29442, USA. Electronic address:

The ribbed mussel, Geukensia granosissima, cycles nutrients, contributes to soil stability, and can be a major component of predator-prey communities in salt marshes. Mussels were exposed to the 2010 Deepwater Horizon oil spill in the Gulf of Mexico, and salt marshes remain contaminated eight years later. We hypothesized that the oiled mussels had reduced annual growth, altered population size frequency, and perhaps changed valve morphometrics. Read More

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September 2021

Are Health Literacy and Patient Activation Related to Health Outcomes in Breast Cancer Patients?

Health Lit Res Pract 2021 Jul 15;5(3):e171-e178. Epub 2021 Jul 15.

Background: Assessing health literacy and patient activation at the beginning of care could facilitate the provision of appropriate information to patients with breast cancer and increase the effectiveness of interventions geared toward improving patient involvement in self-managing their health and, consequently, their quality of life.

Objective: The aim of this study was to evaluate cancer health literacy and patient activation in patients with breast cancer as well as examine their relationships to health-related quality of life (HRQoL) and resource use.

Methods: Patients with breast cancer positive for human epidermal growth factor receptor 2 (HER2+) receiving care at 12 oncology clinics in Texas were offered participation in the study via convenience sampling. Read More

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