4,222 results match your criteria measurable change

Notes from the youth mental health field: Using movement towards goals as a potential indicator of service change and quality improvement.

J Clin Psychol 2021 Jun 11. Epub 2021 Jun 11.

Child Outcomes Research Consortium, Anna Freud Centre, London, UK.

The aim of this paper is to report our notes from the field on using movement toward goals at an aggregate level as an inference of service effectiveness. Analysis of routinely collected data from UK youth mental health services was conducted (N = 8,172, age M = 13.8, 67% female, 32% male) to explore the impact of including goal-based outcome data in combined calculations of standardized measures based on the principles of reliable change ("measurable change"). Read More

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Isotopic content in high mountain karst aquifers as a proxy for climate change impact in Mediterranean zones: The Port del Comte karst aquifer (SE Pyrenees, Catalonia, Spain).

Sci Total Environ 2021 May 29;790:148036. Epub 2021 May 29.

Groundwater Hydrology Group, Dept. Civil and Environmental Eng., Technical University of Catalonia (UPC). Royal Academy of Sciences, of Spain.

The objective of this work is to characterize the impact of climate change in the karst aquifer of the Port del Comte Massif (PCM). Six regional climate models (RCMs) from CLYM'PY Project are used to analyse the magnitude and trends of changes on precipitation and temperature (RCP4.5 and RCP8. Read More

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Sustaining Personal Activism: Behavior Analysts as Antiracist Accomplices.

Behav Anal Pract 2021 Jun 2:1-8. Epub 2021 Jun 2.

Special Education and Clinical Sciences, University of Oregon, 860 Willow Ave, Eugene, OR 97404 USA.

One pervasive social issue that has received little attention within the behavior-analytic community is racism and the systemic oppression of Black, Indigenous, and non-Black people of color. The present article offers guidance and examples of how each of us as behavior analysts might build individualized self-management behavior change plans that support initiating and sustaining socially significant antiracism work as we move from allies to accomplices within our own sphere of influence. This article introduces the concept of self-managed antiracism behavior change plans that (a) operationally define antiracist action using measurable outcomes and strategies for data collection on specific antiracist and support actions, (b) provide choices to improve engagement and reduce barriers to adherence, and (c) use effective behavioral interventions to alter the availability of discriminative stimuli or reduce their influence, and increase the availability of reinforcers that are compatible with the goal of the behavior change plan for increasing antiracism behavior and dismantling structures perpetuating racial inequities. Read More

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Lenvatinib versus sorafenib for first-line treatment of unresectable hepatocellular carcinoma: patient-reported outcomes from a randomised, open-label, non-inferiority, phase 3 trial.

Lancet Gastroenterol Hepatol 2021 Jun 1. Epub 2021 Jun 1.

FSBSI N N Blokhin Russian Cancer Research Center, Moscow, Russia.

Background: Hepatocellular carcinoma is the third-leading cause of cancer-related death worldwide. Preservation of health-related quality of life (HRQOL) during treatment is an important therapeutic goal. The aim of this study was to evaluate the effect of treatment with lenvatinib versus sorafenib on HRQOL. Read More

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Determining usefulness of machine learning in materials discovery using simulated research landscapes.

Phys Chem Chem Phys 2021 Jun 3. Epub 2021 Jun 3.

Department of Chemistry, University of Liverpool, Liverpool, L69 3BX, UK.

When existing experimental data are combined with machine learning (ML) to predict the performance of new materials, the data acquisition bias determines ML usefulness and the prediction accuracy. In this context, the following two conditions are highly common: (i) constructing new unbiased data sets is too expensive and the global knowledge effectively does not change by performing a limited number of novel measurements; (ii) the performance of the material depends on a limited number of physical parameters, much smaller than the range of variables that can be changed, albeit such parameters are unknown or not measurable. To determine the usefulness of ML under these conditions, we introduce the concept of simulated research landscapes, which describe how datasets of arbitrary complexity evolve over time. Read More

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Refinement of response assessment in neuro-oncology (RANO) using non-enhancing lesion type and contrast enhancement evolution pattern in IDH wild-type glioblastomas.

BMC Cancer 2021 Jun 1;21(1):654. Epub 2021 Jun 1.

Department of Neurosurgery, University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.

Background: Updated response assessment in neuro-oncology (RANO) does not consider peritumoral non-enhancing lesion (NEL) and baseline (residual) contrast enhancement (CE) volume. The objective of this study is to explore helpful imaging characteristics to refine RANO for assessing early treatment response (pseudoprogression and time-to-progression [TTP]) in patients with IDH wild-type glioblastoma.

Methods: This retrospective study enrolled 86 patients with IDH wild-type glioblastoma who underwent consecutive MRI examinations before and after concurrent chemoradiotherapy (CCRT). Read More

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Corneal endothelial cell density in patients receiving chemotherapy.

Cutan Ocul Toxicol 2021 Jun 16:1-5. Epub 2021 Jun 16.

Penn Medicine Lancaster General Health, Lancaster, PA, USA.

Purpose: This study aimed to determine if the corneal endothelium was affected by chemotherapy.

Methods: Chemotherapy patients were recruited to undergo specular microscopy before treatment and again at 1- and 2-year follow-up visits. One eye per patient, per follow-up, was selected for comparison to baseline. Read More

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Dual Mechanisms of Metabolism and Gene Expression of the CCRF-CEM Leukemia Cells under Glucocorticoid Treatment.

Int J Mol Sci 2021 May 31;22(11). Epub 2021 May 31.

Department of Life Sciences, School of Sciences, European University Cyprus, 1516 Nicosia, Cyprus.

Background: Glucocorticoids play an essential part in anti-leukemic therapies, but resistance is a crucial event for the prognosis of the disease. Glucocorticoids influence the metabolic properties of leukemic cells. The inherent plasticity of clinically evolving cancer cells justifies the characterization of drug-induced early oncogenic pathways, which represent a likely source of detrimental secondary effects. Read More

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Recent Advances in the Development of Smart and Active Biodegradable Packaging Materials.

Nanomaterials (Basel) 2021 May 18;11(5). Epub 2021 May 18.

Department of Food Science, University of Massachusetts Amherst, Amherst, MA 01003, USA.

Interest in the development of smart and active biodegradable packaging materials is increasing as food manufacturers try to improve the sustainability and environmental impact of their products, while still maintaining their quality and safety. Active packaging materials contain components that enhance their functionality, such as antimicrobials, antioxidants, light blockers, or oxygen barriers. Smart packaging materials contain sensing components that provide an indication of changes in food attributes, such as alterations in their quality, maturity, or safety. Read More

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Stress and the Gut-Brain Axis: Implications for Cancer, Inflammation and Sepsis.

J Surg Res 2021 May 29;266:336-344. Epub 2021 May 29.

Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

Background: The gut-brain axis has been discussed, directly or indirectly, for centuries, with the ideas of the gut affecting anything from moods to overall physiology being discussed across the centuries. With a recent explosion in research that looks to the microbiota as a mechanistic link between the gut and the brain, one sees that the gut-brain axis has various means of communication, such as through the vagus nerve and the enteric nervous system and can use the metabolites in the gut to communicate to the brain.

Methods: The purpose of this review is to view the gut-brain axis through the lens of stress and how stress, from the prenatal period all the way through adulthood can impact the physiology of a human being. Read More

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Residency Education Redesign: The Interplay of Innovation and Standardization.

Fam Med 2021 Jun 1. Epub 2021 Jun 1.

Oregon Health & Science University, Portland, OR.

Tensions have always existed between innovation and standardization in family medicine, due to the need for rapid responses to changing health issues while ensuring proficiency. For innovation in residency training to be successful, standardization of milestones and frameworks as well as outcomes of residency education are needed and must be clear and rely on measurable effectiveness standards. Standardization without innovation can cause educational stasis, failure to adapt to change, and/or lack of evidence-guided education. Read More

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Nurses and Midwives as Global Partners to Achieve the Sustainable Development Goals in the Anthropocene.

J Nurs Scholarsh 2021 May 31. Epub 2021 May 31.

Dean and Linda Koch Lorimer Professor of Nursing, Yale University School of Nursing, Orange, CT, USA.

Purpose: To highlight ongoing and emergent roles of nurses and midwives in advancing the United Nations 17 Sustainable Development Goals by 2030 at the intersection of social and economic inequity, the climate crisis, interprofessional partnership building, and the rising status and visibility of the professions worldwide.

Design: Discussion paper.

Methods: Literature review. Read More

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Simple periprocedural precautions to reduce Doppler microembolic signals during AF ablation.

J Interv Card Electrophysiol 2021 May 31. Epub 2021 May 31.

Technische Universität Dresden, Klinikum Pirna, Struppener Strasse 13, 01796, Pirna, Germany.

Background: Doppler microembolic signals (MES) occur during atrial fibrillation ablation despite of permanent flushed transseptal sheaths, frequent controls of periprocedural coagulation status and the use of irrigated ablation catheters PURPOSE: To investigate the number and type of MES depending on the procedure time, prespecified procedure steps, the activated clotting time (ACT) during the ablation procedure and the catheter contact force.

Methods: In a prospective trial, 53 consecutive atrial fibrillation patients underwent pulmonary vein isolation by super-irrigated "point-by-point" ablation. All patients underwent a periinterventional, continuous transcranial Doppler examination (TCD) of the bilateral middle cerebral arteries during the complete ablation procedure. Read More

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Record-breaking wildfires in the world's largest continuous tropical wetland: Integrative fire management is urgently needed for both biodiversity and humans.

J Environ Manage 2021 May 27;293:112870. Epub 2021 May 27.

Instituto de Biociências, Universidade Federal de Mato Grosso Do Sul, Campo Grande, MS, Brazil. Electronic address:

In the Brazilian Pantanal, wildfire occurrence has increased, reaching record highs of over 40,000 km in 2020. Smoke from wildfires worsened the situation of isolated, as well as urban communities, already under an increasing toll of COVID-19. Here we review the impacts and the possible causes of the 2020 mega-fires and recommend improvements for public policies and fire management in this wetland. Read More

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J Vasc Surg 2021 May 18. Epub 2021 May 18.

Faculty of Medicine and Health Technology, Tampere University, FI-33014 / Arvo Ylpön katu 34, 33520 Tampere, Finland; Finnish Cardiovascular Research Center, FI-33014 / Arvo Ylpön katu 34, 33520, Tampere, Finland; Department of Cardiology, Tampere University Hospital, Heart Hospital, PO BOX 2000 FI-33521 Tampere, Finland.

Objective: Statin therapy, associated with improved short-term survival after treatment of abdominal aortic aneurysms (AAAs), may also predispose to muscle side effects. Evidence on statin-related sarcopenia is limited mainly to muscle function and it is subject to several sources of bias. In the long-term, postoperative development of sarcopenia is linked to mortality after endovascular repair (EVAR). Read More

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Measuring tibial hemodynamics and metabolism at rest and after exercise using near-infrared spectroscopy.

Appl Physiol Nutr Metab 2021 May 21. Epub 2021 May 21.

University of Georgia College of Education, 166837, Department of Kinesiology, Athens, Georgia, United States;

The bone vascular system is important; yet, evaluation of bone hemodynamics is difficult and expensive. This study evaluated the utility and reliability of near-infrared spectroscopy (NIRS), a portable and relatively inexpensive device, in measuring tibial hemodynamics and metabolic rate. Eleven participants were tested twice using post-occlusive reactive hyperemia technique with the NIRS probes placed on the tibia and the medial gastrocnemius (MG) muscle. Read More

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F-Fluciclovine PET/CT performance in biochemical recurrence of prostate cancer: a systematic review.

Prostate Cancer Prostatic Dis 2021 May 19. Epub 2021 May 19.

Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Background: A systematic literature review of the performance of Fluorine-fluciclovine PET/CT for imaging of men with recurrent prostate cancer was performed.

Methods: Scientific literature databases (MEDLINE, ScienceDirect and Cochrane Libraries) were searched systematically during Oct 2020 using PRISMA criteria. No limit was put on the date of publication. Read More

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Androgen receptor modulates multimodal displays in the Bornean rock frog (Staurois parvus).

Integr Comp Biol 2021 May 1. Epub 2021 May 1.

Department of Biological Sciences, Smith College, Northampton, MA 01063.

Multimodal communication is common in the animal kingdom. It occurs when animals display by stimulating two or more receiver sensory systems, and often arises when selection favors multiple ways to send messages to conspecifics. Mechanisms of multimodal display behavior are poorly understood, particularly with respect to how animals coordinate the production of different signals. Read More

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Forensic isoscapes based on intra-individual temporal variation of O and Pb/Pb in human teeth.

Forensic Sci Res 2020 Aug 28;6(1):42-52. Epub 2020 Aug 28.

Information Technology Services, Colorado College, Colorado Springs, CO, USA.

Isotopic signatures used in the georeferencing of human remains are largely fixed by spatially distinct geologic and environmental processes. However, location-dependent temporal changes in these isotope ratios should also be considered when determining an individual's provenance and/or trajectory. Distributions of the relevant isotopes can be impacted by predictable external factors such as climate change, delocalisation of food and water sources and changes in sources and uses of metals. Read More

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Comparative Nasal Airflow with Loratadine-Pseudoephedrine and Fluticasone Nasal Spray for Allergic Rhinitis.

Ann Allergy Asthma Immunol 2021 May 14. Epub 2021 May 14.

Allergy Research Unit, Kingston Health Sciences Centre - KGH Site, Kingston, ON, Canada; Division of Allergy & Immunology, Department of Medicine, Queen's University, Kingston, ON, Canada; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON Canada. Electronic address:

Background: Although known that oral antihistamine/pseudoephedrine combination tablets have a faster onset than intranasal corticosteroid sprays in the treatment of allergic rhinitis after the first dose, the magnitude of change has not been measured in a comparative manner. Furthermore, the sensation of sprayed liquid in the nose may lead patients to mistakenly believe that intranasal steroid sprays work instantly.

Objective: This head-to-head study was conducted to assess, numerically, nasal airflow changes provided by a single dose of loratadine/pseudoephedrine tablet (LP) and fluticasone propionate nasal spray (FP) in participants experiencing allergic rhinitis symptoms including nasal congestion. Read More

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Design of an effective piezoelectric microcantilever biosensor for rapid detection of COVID-19.

J Med Eng Technol 2021 May 17:1-11. Epub 2021 May 17.

Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran.

Acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also called COVID-19, is one of the most contagious viruses resulting in a progressive pandemic. Since specific antiviral treatments have not been developed yet and its fatal rate is almost high, early and fast detection is critical for controlling the outbreak. In this study, a piezoelectric microcantilever biosensor has been designed for detecting COVID-19 samples directly without requiring preparation steps. Read More

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Quantitative analysis of vascular changes during photoimmunotherapy using speckle variance optical coherence tomography (SV-OCT).

Biomed Opt Express 2021 Apr 2;12(4):1804-1820. Epub 2021 Mar 2.

Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.

Near-infrared (NIR) photoimmunotherapy (NIR-PIT) is an emerging cancer therapy based on a monoclonal antibody and phthalocyanine dye conjugate. Direct tumor necrosis and immunogenic cell death occur during NIR irradiation. However, the alteration of tumor blood vessels and blood volume inside the blood vessels induced by the NIR-PIT process is still unknown. Read More

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Only time will tell: Acute stress response patterns with time series analysis.

Int J Psychophysiol 2021 May 12. Epub 2021 May 12.

Department of Psychology, Virginia Polytechnic Institute and State University, United States of America.

Stress has long attracted attention in psychophysiological research, due to its effects on physiology that are measurable and well documented. Acute stress is often conceptualized as a response pattern that activates the fight-or-flight response via the sympathetic nervous system (SNS). However, other stress response patterns can manifest as well, such as parasympathetic nervous system (PNS) shutdown, and SNS-PNS coactive hypervigilance. Read More

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Estimating the Effect of the New York State Nurse Practitioners Modernization Act on Care Received by Medicaid Patients.

Policy Polit Nurs Pract 2021 Aug 14;22(3):212-220. Epub 2021 May 14.

School of Nursing, Columbia University, New York, New York, United States.

The demand for primary care services may surpass the supply of primary care providers, exacerbating challenges with access, quality, and cost in the U.S. health care system. Read More

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Plasmonic Sensing: Connecting the Dots.

J Phys Chem Lett 2021 May 12;12(19):4697-4705. Epub 2021 May 12.

Department of Chemistry, Assam University, Silchar-788011, India.

Plasmonic sensitivity of noble metals has often been attributed to the morphology of the nanostructures and dielectric effects of both the materials and the surrounding medium. The measurable plasmonic shift with respect to the change in local dielectric as a function of analyte concentrations within nanoscale volume forms the basis of plasmonic sensing. However, the situation of the surrounding medium in the presence of multicomponent systems and, moreover, inhomogeneous adsorption around the anisotropic nanostructures become seemingly complicated as the precise description of several individual components becomes nearly impossible. Read More

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General Practitioners and Community Pharmacists' Collaboration in Primary Care: Small Steps for a Major Change.

Int J Integr Care 2021 Apr 23;21(2):10. Epub 2021 Apr 23.

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.

Background: Healthcare authorities worldwide search for ways to develop integrated care and interprofessional collaboration. In Belgium, Medical-Pharmaceutical Concertation (MPC) was introduced as a format to promote constructive dialogues between GPs and community pharmacists (CPs) with a focus on pharmacotherapy.

Objective: To evaluate the implementation of MPC from the perspective of healthcare authorities and GPs/CPs. Read More

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Effects of a robot-aided somatosensory training on proprioception and motor function in stroke survivors.

J Neuroeng Rehabil 2021 05 10;18(1):77. Epub 2021 May 10.

Human Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, Minneapolis, USA.

Background: Proprioceptive deficits after stroke are associated with poor upper limb function, slower motor recovery, and decreased self-care ability. Improving proprioception should enhance motor control in stroke survivors, but current evidence is inconclusive. Thus, this study examined whether a robot-aided somatosensory-based training requiring increasingly accurate active wrist movements improves proprioceptive acuity as well as motor performance in chronic stroke. Read More

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pH-Independent Heat Capacity Changes during Phosphorolysis Catalyzed by the Pyrimidine Nucleoside Phosphorylase from .

Biochemistry 2021 May 6;60(20):1573-1577. Epub 2021 May 6.

Te Aka Ma̅tuatua-School of Science, Te Whare Wa̅nanga o Waikato-University of Waikato, Hamilton 3240, New Zealand.

Enzyme-catalyzed reactions sometimes display curvature in their Eyring plots in the absence of denaturation, indicative of a change in activation heat capacity. However, the effects of pH and (de)protonation on this phenomenon have remained unexplored. Herein, we report a kinetic characterization of the thermophilic pyrimidine nucleoside phosphorylase from across a two-dimensional working space covering 35 °C and 3 pH units with two substrates displaying different p values. Read More

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Host and parasite traits predict cross-species parasite acquisition by introduced mammals.

Proc Biol Sci 2021 05 5;288(1950):20210341. Epub 2021 May 5.

Odum School of Ecology, University of Georgia, Athens, GA, USA.

Species invasions and range shifts can lead to novel host-parasite communities, but we lack general rules on which new associations are likely to form. While many studies examine parasite sharing among host species, the directionality of transmission is typically overlooked, impeding our ability to derive principles of parasite acquisition. Consequently, we analysed parasite records from the non-native ranges of 11 carnivore and ungulate species. Read More

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The ups and downs of lifestyle modification: An existential journey among persons with severe obesity.

Scand J Caring Sci 2021 May 4. Epub 2021 May 4.

Department of Physio and Occupational Therapy, Horsens Regional Hospital, Horsens, Denmark.

Background: Maintaining a healthy living after the end of a lifestyle intervention is a challenge for persons with severe obesity. Measurable outcomes are often emphasised, but there is a need for understanding the process of lifestyle change and the long-term perspectives among persons with severe obesity.

Aim And Objective: To describe and deepen the understanding of how persons with severe obesity experience making and maintaining lifestyle changes in everyday life three years after lifestyle intervention. Read More

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