29,961 results match your criteria measles

A recombinant Chinese measles virus vaccine strain rMV-Hu191 inhibits human colorectal cancer growth through inducing autophagy and apoptosis regulating by PI3K/AKT pathway.

Transl Oncol 2021 Apr 10;14(7):101091. Epub 2021 Apr 10.

Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, Zhejiang. China; Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang. China. Electronic address:

The potential therapeutic effects of oncolytic measles virotherapy have been verified against plenty of malignancies. However, the oncolytic effects and underlying mechanisms of the recombinant Chinese measles virus vaccine strain Hu191 (rMV-Hu191) against human colorectal cancer (CRC) remain elusive. In this study, the antitumor effects of rMV-Hu191 were evaluated in CRC both in vitro and in vivo. Read More

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Evaluation of measles vaccination coverage in Lincang City, Yunnan Province, China.

Hum Vaccin Immunother 2021 Apr 13:1-8. Epub 2021 Apr 13.

Epidemiology and Biostatistics Unit, Faculty of Public Health, Dali University, Dali, China.

Lincang City in Yunnan Province on the China-Myanmar border, has reached the World Health Organization recommended coverage (95%) for measles-containing vaccine (MCV), but measles outbreaks still occur. We conducted a survey in Lincang City to determine the measles vaccination status of children on the China-Myanmar border. We used multistage sampling among children aged 8-83 months. Read More

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Anaphylactic reactions to mRNA COVID-19 vaccines: A call for further study.

Vaccine 2021 Apr 6. Epub 2021 Apr 6.

Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:

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Outbreak response operations during the US measles epidemic, 2017-19.

BMC Public Health 2021 Apr 13;21(1):620. Epub 2021 Apr 13.

Johns Hopkins Center for Health Security and Department of Environmental Health and Engineering, Johns Hopkins University Bloomberg School of Public Health, 621 East Pratt Street, Suite, Baltimore, 210, USA.

Background: To understand operational challenges involved with responding to US measles outbreaks in 2017-19 and identify applicable lessons in order to inform preparedness and response operations for future outbreaks, particularly with respect to specific operational barriers and recommendations for outbreak responses among insular communities.

Methods: From August 2019 to January 2020, we conducted 11 telephone interviews with 18 participants representing state and local health departments and community health centers that responded to US measles outbreaks in 2017-19, with a focus on outbreaks among insular communities. We conducted qualitative, thematic coding to identify and characterize key operational challenges and lessons identified by the interviewees. Read More

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[Aseptic meningitis due to mumps vaccine. Case report and review of the literature].

Rev Chilena Infectol 2020 Dec;37(6):769-774

Hospital Clínico San Borja Arriarán, Santiago, Chile.

We report the case of an older infant with no prior morbidity that approximately 3 weeks after receiving MMR vaccination (measles, mumps, rubella) was hospitalized for feverish symptoms, increased parotid volume and compromised consciousness. Aseptic meningitis was diagnosed, detecting pleocytosis in the CSF, predominantly mononuclear, and confirming by molecular biology, presence of parotid virus in CSF. A study was carried out by the Institute of Public Health of Chile, where serology (IgM and IgG) was positive. Read More

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December 2020

Immunity to Varicella, Measles, and Mumps in Patients Evaluated for Lung Transplantation.

Am J Transplant 2021 Apr 11. Epub 2021 Apr 11.

Duke University, Medical Center Division of Pulmonary, Allergy, and Critical Care Medicine, Durham, NC, USA.

Vaccine-preventable viral infections are associated with increased risk of morbidity and mortality in post-transplant patients on immunosuppression regimens. Therefore, we studied rates of immunity against vaccine-preventable viruses in lung transplantation (LTx) candidates and their associations with underlying lung disease and clinical characteristics. We retrospectively studied 1025 consecutive adult patients who underwent first-time evaluation for LTx at a single center between January 2016 and October 2018. Read More

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An Immune Recovery-Based Revaccination Protocol for Pediatric Hematopoietic Stem Cell Transplant Recipients: Revaccination Outcomes Following Pediatric HSCT.

Transplant Cell Ther 2021 Apr 28;27(4):317-326. Epub 2021 Jan 28.

Division of Pediatric Infectious Diseases, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado.

Following hematopoietic stem cell transplant (HSCT), patients are at increased risk of vaccine-preventable diseases (VPDs) and experience worse outcomes of VPDs compared to immunocompetent patients. Therefore, patients are routinely vaccinated post-HSCT to restore VPD immunity. Published guidelines recommend revaccination based on time post-HSCT, although optimal revaccination timing and the value of using other clinical and laboratory variables to guide revaccination remain unclear. Read More

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Primary differentiated respiratory epithelial cells respond to apical measles virus infection by shedding multinucleated giant cells.

Proc Natl Acad Sci U S A 2021 Mar;118(11)

The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205

Measles virus (MeV) is highly infectious by the respiratory route and remains an important cause of childhood mortality. However, the process by which MeV infection is efficiently established in the respiratory tract is controversial with suggestions that respiratory epithelial cells are not susceptible to infection from the apical mucosal surface. Therefore, it has been hypothesized that infection is initiated in lung macrophages or dendritic cells and that epithelial infection is subsequently established through the basolateral surface by infected lymphocytes. Read More

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Are patients with rheumatic diseases on immunosuppressive therapies protected against preventable infections? A cross-sectional cohort study.

RMD Open 2021 Apr;7(1)

Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany.

Objective: To evaluate the prevalence of infections, prevalence of hospitalisation due to infections, the vaccination status and perceived screening of infections prior to the start of biologic disease modifying antirheumatic drugs (bDMARDs) of a patient cohort with chronic inflammatory rheumatic diseases (CIRD).

Methods: Consecutive CIRD patients reporting to our specialised centre were prospectively included (n=975) in this cross-sectional study. Data on comorbidities including infections, treatment, vaccination status, screening for latent tuberculosis infection (LTBI) and hepatitis B (HepB) were collected. Read More

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Public health practitioner perspectives on dealing with measles outbreaks if high anti-vaccination sentiment is present.

BMC Public Health 2021 04 9;21(1):578. Epub 2021 Apr 9.

Australian Centre for Health Engagement, Evidence & Values (ACHEEV), School of Health and Society, Faculty of the Arts, Social Sciences & Humanities, University of Wollongong, Northfields Ave, Wollongong, NSW, Australia.

Background: Communities with low vaccination rates are at greater risk during outbreaks of vaccine preventable diseases. Most Australian parents support vaccines, but some refuse and are often judged harshly by their community, especially during an outbreak. We sought the perspectives of Australian public health experts on the key issues faced when managing a measles outbreak in an area with high anti-vaccination sentiment. Read More

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Rubella and tick-borne encephalitis vaccination rates among staff and students at Austrian University of Applied Sciences.

Cent Eur J Public Health 2021 Mar;29(1):18-22

University of Applied Sciences Wiener Neustadt, Wiener Neustadt, Austria.

Objectives: Rubella and tick-borne encephalitis (TBE) are infectious diseases caused by viruses. Rubella is an air-borne infection. TBE, on the other hand, is transmitted by virus-infected ticks. Read More

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Cross-sectional Retrospective Study on Paracetamol Post Infants' Vaccination in Malaysia.

J Pharm Bioallied Sci 2020 Nov 5;12(Suppl 2):S696-S702. Epub 2020 Nov 5.

Department of Family Medicine, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Kuantan, Malaysia.

Introduction: Practice of dispensing paracetamol (PCM) in post infants' vaccination remains debatable in Malaysia as the administration of PCM postvaccination in infants was found to cause the vaccine to be less effective, thus requiring appropriate regulation measures.

Objective: This research aimed to investigate the prevalence of adverse events following immunization (AEFI) with/without PCM to be prescribed post infants' vaccination in Malaysia (possible associated factors: age, types and stages of vaccination, concomitant vaccines and drugs, and/vitamins).

Materials And Methods: A retrospective cross-sectional study was conducted from 2011 to 2017. Read More

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November 2020

Measles vaccine coverage among children born to Somali immigrants in Norway.

BMC Public Health 2021 Apr 7;21(1):668. Epub 2021 Apr 7.

Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.

Background: Despite overall good vaccination coverage in many countries, vaccine hesitancy has hindered full coverage and exposed groups to the risk of outbreaks. Somali immigrant groups have been known to have low measles vaccination coverage, leading to outbreaks in their communities. Current research indicates a general lack of trust in the healthcare system, the use of alternative information sources and inadequate health literacy can be contributing factors. Read More

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Modeling and presentation of vaccination coverage estimates using data from household surveys.

Vaccine 2021 Apr 3. Epub 2021 Apr 3.

Department of Biostatistics, University of Washington, Health Sciences Building, NE Pacific St, Seattle, WA 98195, USA; Department of Statistics, University of Washington, Padelford Hall, NE Stevens Way, Seattle, WA 98195, USA.

It is becoming increasingly popular to produce high-resolution maps of vaccination coverage by fitting Bayesian geostatistical models to data from household surveys. Usually, the surveys adopt a stratified cluster sampling design. We discuss a number of crucial choices with respect to two key aspects of the map production process: the acknowledgement of the survey design in modeling, and the appropriate presentation of estimates and their uncertainties. Read More

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Immunisation Coverage Annual Report 2019.

Commun Dis Intell (2018) 2021 03 31;45. Epub 2021 Mar 31.

National Centre for Immunisation Research and Surveillance.

Abstract: Australian Immunisation Register data have been analysed for children aged < 5 years, focusing on changes in vaccination coverage at standard age milestones (12, 24 and 60 months) between 2018 and 2019. 'Fully vaccinated' coverage in 2019 increased by 0.1-0. Read More

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Immunisation Coverage Annual Report 2018.

Commun Dis Intell (2018) 2021 03 31;45. Epub 2021 Mar 31.

National Centre for Immunisation Research and Surveillance.

Abstract: Australian Immunisation Register data have been analysed for children aged < 5 years, focusing on changes in coverage at key milestone ages (12, 24 and 60 months) between 2017 and 2018, while also documenting longer term trends. Fully vaccinated coverage increased at the 12- and 60-months milestones to 93.9% and 94. Read More

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["If there is a risk, I should have a choice:" Risk management and risk perception in Italian vaccine hesitancy movements].

Salud Colect 2021 Feb 10;17:e3231. Epub 2021 Feb 10.

Licenciada en Antropología Médica y Salud Global. Magíster en Antropología Médica y Salud Global, Universitat Rovira i Virgili, Tarragona, Cataluña, España.

In Italy, the passing of mandatory pediatric vaccinations in 2017 was a consequence of increasing vaccine hesitancy in the country, a phenomenon that has largely spread on social networks. This article examines risk management and risk perception regarding pediatric vaccinations through an analysis of online content shared by Italian vaccine hesitancy movements between December of 2019 and April of 2020. Results show that these movements carry out a reinterpretation of risk, scientific evidence, and parental responsibility, especially with regard to the alleged correlation between the measles vaccine and autism. Read More

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February 2021