684 results match your criteria mcs play

Mast Cells Modulate Antigen-Specific CD8 T Cell Activation During LCMV Infection.

Front Immunol 2021 14;12:688347. Epub 2021 Jun 14.

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Mast cells (MCs), strategically localized at mucosal surfaces, provide first-line defense against pathogens and shape innate and adaptive immune responses. Recent studies have shown that MCs are involved in pathogenic responses to several viruses including herpes simplex viruses, dengue virus, vaccinia virus and influenza virus. However, the underlying mechanisms of MCs in the activation of CD8 T cells during viral infections are not fully understood. Read More

View Article and Full-Text PDF

Forsythiasides-Rich Extract From Forsythiae Fructus Inhibits Mast Cell Degranulation by Enhancing Mitochondrial Ca Uptake.

Front Pharmacol 2021 14;12:696729. Epub 2021 Jun 14.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Mast cells (MCs) activated via IgE/FcεRI or MAS-related G protein coupled receptor (Mrgpr)-mediated pathway can release granules that play prominent roles in hypersensitivity reactions. Forsythiae Fructus, a well-known traditional Chinese medicine, has been clinically used for allergic diseases. Although previous studies indicated that Forsythiae Fructus extract inhibited compound 48/80-induced histamine release from MCs, its effect on IgE-dependent MC degranulation and possible underlying mechanisms remain to be explored. Read More

View Article and Full-Text PDF

Generation and characterisation of a cell-type specific, inducible Cre-driver line to study olfactory processing.

J Neurosci 2021 Jun 7. Epub 2021 Jun 7.

Sensory and Behavioural Neuroscience Unit, Okinawa Institute of Science and Technology Graduate University

In sensory systems of the brain, mechanisms exist to extract distinct features from stimuli to generate a variety of behavioural repertoires. These often correspond to different cell types at various stages in sensory processing. In the mammalian olfactory system, complex information processing starts in the olfactory bulb, whose output is conveyed by mitral and tufted cells (MCs and TCs). Read More

View Article and Full-Text PDF

Direct effects of mast cell proteases, tryptase and chymase, on bronchial epithelial integrity proteins and anti-viral responses.

BMC Immunol 2021 Jun 2;22(1):35. Epub 2021 Jun 2.

Department of Experimental Medical Science, Lund University, Lund, Sweden.

Background: Mast cells (MCs) are known to contribute to both acute and chronic inflammation. Bronchial epithelial cells are the first line of defence against pathogens and a deficient anti-viral response has been suggested to play a role in the pathogenesis of asthma exacerbations. However, effects of MC mediators on bronchial epithelial immune response have been less studied. Read More

View Article and Full-Text PDF

IL-10 in Mast Cell-Mediated Immune Responses: Anti-Inflammatory and Proinflammatory Roles.

Int J Mol Sci 2021 May 7;22(9). Epub 2021 May 7.

Department of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan.

Mast cells (MCs) play critical roles in Th2 immune responses, including the defense against parasitic infections and the initiation of type I allergic reactions. In addition, MCs are involved in several immune-related responses, including those in bacterial infections, autoimmune diseases, inflammatory bowel diseases, cancers, allograft rejections, and lifestyle diseases. Whereas antigen-specific IgE is a well-known activator of MCs, which express FcεRI on the cell surface, other receptors for cytokines, growth factors, pathogen-associated molecular patterns, and damage-associated molecular patterns also function as triggers of MC stimulation, resulting in the release of chemical mediators, eicosanoids, and various cytokines. Read More

View Article and Full-Text PDF

Mast Cell Proteases Tryptase and Chymase Induce Migratory and Morphological Alterations in Bronchial Epithelial Cells.

Int J Mol Sci 2021 May 16;22(10). Epub 2021 May 16.

Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden.

Chronic respiratory diseases are often characterized by impaired epithelial function and remodeling. Mast cells (MCs) are known to home into the epithelium in respiratory diseases, but the MC-epithelial interactions remain less understood. Therefore, this study aimed to investigate the effect of MC proteases on bronchial epithelial morphology and function. Read More

View Article and Full-Text PDF

Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers.

Stem Cell Res Ther 2021 05 29;12(1):312. Epub 2021 May 29.

Department of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo, 060-8556, Japan.

Background: Small hepatocyte-like progenitor cells (SHPCs) appear to form transient clusters in rat livers treated with retrorsine (Ret) and 70% partial hepatectomy (PH). We previously reported that the expansion of SHPCs was amplified in Ret/PH-treated rat livers transplanted with Thy1 cells derived from D-galactosamine-treated injured livers. Extracellular vesicles (EVs) produced by hepatic Thy1 donor cells activated SHPCs via interleukin (IL)-17 receptor B signaling. Read More

View Article and Full-Text PDF

MicroRNA-30c delivered by bone marrow-mesenchymal stem cells induced apoptosis and diminished cell invasion in U-251 glioblastoma cell line.

Life Sci 2021 Aug 25;279:119643. Epub 2021 May 25.

Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Glioblastoma multiform (GBM) is the most belligerent and prevalent brain malignancy among adults. Due to the blood-brain barrier (BBB), drug administration is confronted by massive challenges, making resectional surgery the only treatment pipeline. MicroRNAs have recently absorbed the attention of studies for correlating with the progression of various malignancies. Read More

View Article and Full-Text PDF

Substance P-induced lung inflammation in mice is mast cell dependent.

Clin Exp Allergy 2021 May 17. Epub 2021 May 17.

School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, China.

Background: Allergic asthma is a common inflammatory lung disease and a major health problem worldwide. Mast cells (MCs) play a key role in the early-stage pathophysiology of allergic asthma. Substance P (SP) functions in neurogenic inflammation by activating MCs, and therefore, it may to participate in the occurrence and development of asthma. Read More

View Article and Full-Text PDF

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Int J Mol Sci 2021 Apr 27;22(9). Epub 2021 Apr 27.

Medical Faculty, Institute for Molecular and Clinical Immunology, Otto-Von-Guericke-University Magdeburg, 39120 Magdeburg, Germany.

Mast cells (MCs) are best-known as key effector cells of immediate-type allergic reactions that may even culminate in life-threatening anaphylactic shock syndromes. However, strategically positioned at the host-environment interfaces and equipped with a plethora of receptors, MCs also play an important role in the first-line defense against pathogens. Their main characteristic, the huge amount of preformed proinflammatory mediators embedded in secretory granules, allows for a rapid response and initiation of further immune effector cell recruitment. Read More

View Article and Full-Text PDF

The Play of Citrate Infusion with Calcium in Plateletpheresis Donors.

Indian J Hematol Blood Transfus 2021 Apr 1;37(2):295-301. Epub 2020 Sep 1.

Department of Transfusion Medicine, Institute of Liver and Biliary Sciences, New Delhi, 110 070 India.

Citrate is the anticoagulant of choice for plateletpheresis. Citrate toxicity is common during plateletpheresis as citrate chelates calcium and causes hypocalcemia in donors. We have conducted this study to analyze the effects of routine citrate infusion during plateletpheresis on laboratory and clinical parameters. Read More

View Article and Full-Text PDF

New Paradigm in NKT Cell Antigens: MCS-0208 (2-(Hydroxymethyl)phenylthio-phytoceramide) - an Aryl-Phytoceramide Compound with a Single Hydroxyl Group Stimulates NKT Cells.

ChemMedChem 2021 Apr 6. Epub 2021 Apr 6.

Medicinal Chemistry and Synthesis (MCS) Laboratory, Institut de Química Avançada de Catalunya (IQAC) Consejo Superior de Investigaciones Científicas (CSIC), C/ Jordi Girona 18-26, 08034, Barcelona, Spain.

Natural Killer T (NKT) cells play an important role in the immune response and can be activated by glycolipids presented by CD1d protein. We present MCS-0208, an unprecedented arylthioether-phytoceramide able to induce potent invariant NKT (iNKT) cell activation, notably when tested in human iNKT cells. This arylsphingolipid analog has a simple phenyl group containing a single hydroxyl substituent as a surrogate of the sugar ring. Read More

View Article and Full-Text PDF

Increased Presence of Complement Factors and Mast Cells in Alveolar Bone and Tooth Resorption.

Int J Mol Sci 2021 Mar 9;22(5). Epub 2021 Mar 9.

Center for Trauma Research Ulm (ZTF), University of Ulm, 89081 Ulm, Germany.

Periodontitis is the inflammatory destruction of the tooth-surrounding and -supporting tissue, resulting at worst in tooth loss. Another locally aggressive disease of the oral cavity is tooth resorption (TR). This is associated with the destruction of the dental mineralized tissue. Read More

View Article and Full-Text PDF

Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody.

Front Immunol 2021;12:650331. Epub 2021 Mar 10.

Allakos Inc., Redwood City, CA, United States.

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a global health crisis. Immune cell activation via pattern recognition receptors has been implicated as a driver of the hyperinflammatory response seen in COVID-19. However, our understanding of the specific immune responses to SARS-CoV-2 remains limited. Read More

View Article and Full-Text PDF

Proton path reconstruction for pCT using neural networks.

Phys Med Biol 2021 Mar 18. Epub 2021 Mar 18.

FBK, Trento, 38100, ITALY.

The Most Likely Path formalism (MLP) is widely established as the most statistically precise method for proton path reconstruction in proton computed tomography (pCT). However, while this method accounts for small-angle Multiple Coulomb Scattering (MCS) and energy loss, inelastic nuclear interactions play an influential role in a significant number of proton paths. By applying cuts based on energy and direction, tracks influenced by nuclear interactions are largely discarded from the MLP analysis. Read More

View Article and Full-Text PDF

Hepatoprotective effect of Qushihuayu formula on non-alcoholic steatohepatitis induced by MCD diet in rat.

Chin Med 2021 Mar 16;16(1):27. Epub 2021 Mar 16.

State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, China.

Background: Non-alcoholic steatohepatitis (NASH) is an advanced form of non-alcoholic fatty liver disease (NAFLD) for which there is yet any standard pharmacotherapy. Traditional Chinese medicine formula such as Qushihuayu (QSHY) composing of multiple bioactive compounds has been used to treat NAFLD and NASH and shows beneficial effects over single compound treatment. This study aimed to investigate the mechanism of hepatoprotective effect of QSHY formula using a rat model. Read More

View Article and Full-Text PDF

Native and IgE-primed rat peritoneal mast cells exert pro-inflammatory activity and migrate in response to yeast zymosan upon Dectin-1 engagement.

Immunol Res 2021 Apr 11;69(2):176-188. Epub 2021 Mar 11.

Department of Experimental Immunology, Faculty of Health Sciences, Medical University of Lodz, Pomorska 251, 92-213, Lodz, Poland.

Mast cells (MCs) play an essential role in host defense, primarily because of their location, their ability to pathogen destruction via several mechanisms, and the pattern recognition receptors they express. Even though most data is available regarding MC activation by various bacteria- or virus-derived molecules, those cells' activity in response to constituents associated with fungi is not recognized enough. Our research aimed to address whether Saccharomyces cerevisiae-derived zymosan, i. Read More

View Article and Full-Text PDF

Divergent Mast Cell Responses Modulate Antiviral Immunity During Influenza Virus Infection.

Front Cell Infect Microbiol 2021 19;11:580679. Epub 2021 Feb 19.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States.

Influenza A virus (IAV) is a respiratory pathogen that infects millions of people each year. Both seasonal and pandemic strains of IAV are capable of causing severe respiratory disease with a high risk of respiratory failure and opportunistic secondary infection. A strong inflammatory cytokine response is a hallmark of severe IAV infection. Read More

View Article and Full-Text PDF

Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer's Disease, ALS, and Harmful Stress Conditions.

Int J Mol Sci 2021 Feb 15;22(4). Epub 2021 Feb 15.

Institute of Biomedical Sciences (ICB), Faculty of Medicine & Faculty of Life Sciences, Universidad Andres Bello, Santiago 8370186, Chile.

Considered relevant during allergy responses, numerous observations have also identified mast cells (MCs) as critical effectors during the progression and modulation of several neuroinflammatory conditions, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). MC granules contain a plethora of constituents, including growth factors, cytokines, chemokines, and mitogen factors. The release of these bioactive substances from MCs occurs through distinct pathways that are initiated by the activation of specific plasma membrane receptors/channels. Read More

View Article and Full-Text PDF
February 2021

Mast cells contribute to alveolar bone loss in Spontaneously Hypertensive Rats with periodontal disease regulating cytokines production.

PLoS One 2021 4;16(3):e0247372. Epub 2021 Mar 4.

Programa Multicêntrico de Pós-graduação em Ciências Fisiológicas, SBFis, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.

Mast cells (MCs) play a pivotal role in inflammatory responses and had been studied in inflammatory bone disorders, however, their role in alveolar bone loss induced by periodontal disease (PD) is not yet fully understood. We, therefore, aimed to evaluate the effects of MCs depletion in the PD-induced alveolar bone loss in Wistar (W) and Spontaneously Hypertensive Rats (SHRs). PD was induced by ligating the lower first molars with silk thread one day after the MCs depletion, by the pre-treatment with compound 48/80 for 4 days. Read More

View Article and Full-Text PDF

Peripheral blood cultured mast cells: Phenotypic and functional outcomes of different culture protocols.

J Immunol Methods 2021 May 26;492:113003. Epub 2021 Feb 26.

University of Antwerp, Faculty of Medicine and Health Sciences, Department of Immunology, Allergology, Rheumatology and the Infla-Med Centre of Excellence, Antwerp (Belgium) and Immunology, Allergology, Rheumatology, Antwerp University Hospital, Antwerp, Belgium; Department of Immunology and Allergology, AZ Jan Palfijn Gent, Ghent, Belgium. Electronic address:

Background: Mast cells (MCs) play a pivotal role in innate and adaptive immune responses. However, MCs are also involved in different pathologic conditions. Studies on the mechanisms that govern human MC functions are impeded by their limited and difficult recovery. Read More

View Article and Full-Text PDF

Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation.

Sci Immunol 2021 Feb;6(56)

Jeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.

Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway, including asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP). Distinct MC subsets infiltrate the airway mucosa in T2 disease, including subepithelial MCs expressing the proteases tryptase and chymase (MC) and epithelial MCs expressing tryptase without chymase (MC). However, mechanisms underlying MC expansion and the transcriptional programs underlying their heterogeneity are poorly understood. Read More

View Article and Full-Text PDF
February 2021

Update on the adverse effects of microcystins on the liver.

Environ Res 2021 04 19;195:110890. Epub 2021 Feb 19.

College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. Electronic address:

Microcystins (MCs) are the most common cyanobacteria toxins in eutrophic water, which have strong hepatotoxicity. In the past decade, epidemiological and toxicological studies on liver damage caused by MCs have proliferated, and new mechanisms of hepatotoxicity induced by MCs have also been discovered and confirmed. However, there has not been a comprehensive and systematic review of these new findings. Read More

View Article and Full-Text PDF

Spinophilin modulates pain through suppressing dendritic spine morphogenesis via negative control of Rac1-ERK signaling in rat spinal dorsal horn.

Neurobiol Dis 2021 May 17;152:105302. Epub 2021 Feb 17.

Institute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, Shaanxi Province, PR China; Key Laboratory of Brain Stress and Behavior, People's Liberation Army, Xi'an 710038, PR China. Electronic address:

Both spinophilin (SPN, also known as neurabin 2) and Rac1 (a member of Rho GTPase family) are believed to play key roles in dendritic spine (DS) remodeling and spinal nociception. However, how SPN interacts with Rac1 in the above process is unknown. Here, we first demonstrated natural existence of SPN-protein phosphatase 1-Rac1 complex in the spinal dorsal horn (DH) neurons by both double immunofluorescent labeling and co-immunoprecipitation, then the effects of SPN over-expression and down-regulation on mechanical and thermal pain sensitivity, GTP-bound Rac1-ERK signaling activity, and spinal DS density were studied. Read More

View Article and Full-Text PDF

Impella versus extracorporal life support in cardiogenic shock: a propensity score adjusted analysis.

ESC Heart Fail 2021 04 9;8(2):953-961. Epub 2021 Feb 9.

Department of Medicine, Division of Cardiology, Pulmonary Diseases and Vascular Medicine, University Hospital Düsseldorf, Düsseldorf, Germany.

Aims: The mortality in cardiogenic shock (CS) is high. The role of specific mechanical circulatory support (MCS) systems is unclear. We aimed to compare patients receiving Impella versus ECLS (extracorporal life support) with regard to baseline characteristics, feasibility, and outcomes in CS. Read More

View Article and Full-Text PDF

Comparative analysis of the role of mast cells in murine asthma models using Kit-sufficient mast cell-deficient animals.

Allergy 2021 Jul 9;76(7):2030-2043. Epub 2021 Mar 9.

Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.

Background: Asthma is a frequent chronic disease that can potentially severely affect the respiratory capacity and well-being of patients. Mast cells (MCs) are regarded as major players in human asthma due to their capacity to release crucial inflammatory mediators following allergen exposure. However, unambiguous characterization of their role in animal models has long been hindered by the unavailability of specific MC-deficient models lacking confounding MC-unrelated effects. Read More

View Article and Full-Text PDF

Resveratrol inhibits MRGPRX2-mediated mast cell activation via Nrf2 pathway.

Int Immunopharmacol 2021 Apr 4;93:107426. Epub 2021 Feb 4.

College of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:

Mast cells (MCs) are crucial effectors in inflammation and allergic reactions. The Mas-related G-protein-coupled receptor X2 (MRGPRX2) was the MC-specific receptor and play a key role in IgE-independent allergic reactions. The activation of the Nuclear factor erythroid derived 2-related factor 2 (Nrf2) is involved in IgE-mediated MC degranulation. Read More

View Article and Full-Text PDF

The role of intestinal mast cell infiltration in irritable bowel syndrome.

J Dig Dis 2021 Mar 7;22(3):143-151. Epub 2021 Mar 7.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.

As an essential part of the immune system, mast cells (MCs) play an important role in the pathogenesis of irritable bowel syndrome (IBS). Accumulating evidence has identified altered MC count and density in intestinal mucosa of patients with IBS; however, conflicting findings yield inconsistent conclusions. Currently, most studies have suggested intestinal MC infiltration in IBS patients. Read More

View Article and Full-Text PDF

Use of Cocultures for the Study of Cellular Interactions Influencing B-Cell Regulatory Functions.

Methods Mol Biol 2021 ;2270:263-282

Department of Medicine (DAME), University of Udine, Udine, Italy.

Although IL-10-producing B cells have been shown to play key roles in regulating immune responses involved in autoimmunity, inflammation, and cancer, the mechanisms at the base of the generation and maintenance of the pool of regulatory B cells are still poorly characterized. Several evidences show that the cross talk between B cells and other immune cell types promotes IL-10 production by B lymphocytes. Soluble mediators released into the microenvironment, together with direct cell-cell contact, are key signals in the process of regulatory B-cell development and differentiation. Read More

View Article and Full-Text PDF

Activated mesangial cells acquire the function of antigen presentation.

Cell Immunol 2021 03 31;361:104279. Epub 2020 Dec 31.

Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, China; Department of Nephrology, The First Medical Center, Chinese PLA General Hospital, Beijing, China. Electronic address:

Mesangial cells (MCs), as resident cells of the kidneys, play an important role in maintaining glomerular function. MCs are located between the capillary loops of the glomeruli and mainly support the capillary plexus, constrict blood vessels, extracellular matrix components, produce cytokines, and perform phagocytosis and clearance of macromolecular substances. When the glomerular environment changes, MCs are often affected, which can lead to functional transformation. Read More

View Article and Full-Text PDF