19,577 results match your criteria mci

Cross-cohort generalizability of deep and conventional machine learning for MRI-based diagnosis and prediction of Alzheimer's disease.

Neuroimage Clin 2021 Jun 4;31:102712. Epub 2021 Jun 4.

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.

This work validates the generalizability of MRI-based classification of Alzheimer's disease (AD) patients and controls (CN) to an external data set and to the task of prediction of conversion to AD in individuals with mild cognitive impairment (MCI). We used a conventional support vector machine (SVM) and a deep convolutional neural network (CNN) approach based on structural MRI scans that underwent either minimal pre-processing or more extensive pre-processing into modulated gray matter (GM) maps. Classifiers were optimized and evaluated using cross-validation in the Alzheimer's Disease Neuroimaging Initiative (ADNI; 334 AD, 520 CN). Read More

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In-vitro and in-vivo study of the interference between Rift Valley fever virus (clone 13) and Sheeppox/Limpy Skin disease viruses.

Sci Rep 2021 Jun 11;11(1):12395. Epub 2021 Jun 11.

R&D Virology, MCI Santé Animale, Lot. 157, Z I, Sud-Ouest (ERAC), B.P. 278, 28810, Mohammedia, Morocco.

Viral interference is a common occurrence that has been reported in cell culture in many cases. In the present study, viral interference between two capripox viruses (sheeppox SPPV and lumpy skin disease virus LSDV in cattle) with Rift Valley fever virus (RVFV) was investigated in vitro and in their natural hosts, sheep and cattle. A combination of SPPV/RVFV and LSDV/RVFV was used to co-infect susceptible cells and animals to detect potential competition. Read More

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T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment.

Neuroimage 2021 Jun 9;238:118214. Epub 2021 Jun 9.

Bristol Medical School, University of Bristol, Institute of Clinical Neurosciences, Learning & Research Building at Southmead Hospital, Bristol BS10 5NB, UK; Clinical Neurosciences, North Bristol NHS Trust, Bristol, UK.

A better understanding of early brain changes that precede loss of independence in diseases like Alzheimer's disease (AD) is critical for development of disease-modifying therapies. Quantitative MRI, such as T2 relaxometry, can identify microstructural changes relevant to early stages of pathology. Recent evidence suggests heterogeneity of T2 may be a more informative MRI measure of early pathology than absolute T2. Read More

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Longitudinal trajectories of metabolic syndrome on different neurocognitive domains: a cohort study from the Taiwan biobank.

Aging (Albany NY) 2021 Jun 11;13. Epub 2021 Jun 11.

Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Metabolic syndrome (MetS) brings considerable effects on cognitive function, but trajectories within remain unclear. We investigated the interactions between distinct MetS components and cognitive domains. A total of 5693 participants from the Taiwan biobank during 2008-2018 were enrolled. Read More

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Assessing Hospital Adaptive Resource Allocation Strategies in Responding to Mass Casualty Incidents.

Disaster Med Public Health Prep 2021 Jun 11:1-9. Epub 2021 Jun 11.

Research Center in Emergency and Disaster Medicine, CRIMEDIM, Novara, Italy.

Background: Hospitals are expected to operate at a high performance level even under exceptional conditions of peak demand and resource disruptions. This understanding is not mature yet and there are wide areas of possible improvement. In particular, the fast mobilization and reconfiguration of resources frequently result into the severe disruption of elective activities, worsening the quality of care. Read More

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Prediction methods of maxillary canine impaction: a systematic review.

Acta Odontol Scand 2021 Jun 10:1-14. Epub 2021 Jun 10.

Faculty of Dentistry, Orthodontics and Orthopaedic Department, Andrés Bello University, Santiago, Chile.

Objective: To describe and assess the available evidence of prediction methods of maxillary canine impaction (MCI).

Material And Methods: A systematic search was conducted through PubMed, Cochrane Library, Embase, EBSCOhost, Scopus, ScienceDirect, Bireme and Scielo until December 2020. This systematic review was conducted according to the PRISMA statement. Read More

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Quantifying activities of daily living impairment in Parkinson's disease using the Functional Activities Questionnaire.

Neurol Sci 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Objective: Cognitive-driven activity of daily living (ADL) impairment in Parkinson's disease (PD) is increasingly discussed as prodromal marker for dementia. Diagnostic properties of assessments for this specific ADL impairment are sparsely investigated in PD. The ability of the Functional Activities Questionnaire (FAQ) for differentiating between PD patients with normal cognition and with mild cognitive impairment (PD-MCI), according to informant and self-reports, was examined. Read More

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Brain connectivity markers in advanced Parkinson's disease for predicting mild cognitive impairment.

Eur Radiol 2021 Jun 9. Epub 2021 Jun 9.

Department of Neurosurgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, 3002# Sungang West Road, Futian District, Shenzhen, 518035, China.

Objectives: Mild cognitive impairment (MCI) is a well-defined non-motor manifestation and a harbinger of dementia in Parkinson's disease. This study is to investigate brain connectivity markers of MCI using diffusion tensor imaging and resting-state functional MRI, and help MCI diagnosis in PD patients.

Methods: We evaluated 131 advanced PD patients (disease duration > 5 years; 59 patients with MCI) and 48 healthy control subjects who underwent a diffusion-weighted and resting-state functional MRI scanning. Read More

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Regulation of Th1 T Cell Differentiation by Iron Upregulation of T Cell Immunoglobulin and Mucin Containing Protein-3 (TIM-3).

Front Immunol 2021 24;12:637809. Epub 2021 May 24.

Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.

Iron plays an important role in host-pathogen interactions, in being an essential element for both pathogen and host metabolism, but also by impacting immune cell differentiation and anti-microbial effector pathways. Iron has been implicated to affect the differentiation of T lymphocytes during inflammation, however, so far the underlying mechanism remained elusive. In order to study the role of iron in T cell differentiation we here investigated how dietary iron supplementation affects T cell function and outcome in a model of chronic infection with the intracellular bacterium (). Read More

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Clinical and Objective Cognitive Measures for the Diagnosis of Cognitive Frailty Subtypes: A Comparative Study.

Front Psychol 2021 24;12:603974. Epub 2021 May 24.

Shanghai Institute of Geriatrics and Gerontology, Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, Research Center of Aging and Medicine, Shanghai Institute of Geriatrics and Gerontology, Shanghai Medical College, Fudan University, Shanghai, China.

Background: Cognitive frailty (CF) includes reversible and potentially reversible subtypes; the former is known as concurrent physical frailty (PF) and pre-mild cognitive impairment subjective cognitive decline (pre-MCI SCD), whereas the latter is known as concurrent PF and MCI. The diagnoses of pre-MCI SCD and MCI are based on clinical criteria and various subjective cognitive decline questionnaires. Heterogeneous assessment of cognitive impairment (CI) results in significant variability of CI, CF, and their subtype prevalence in various population-based studies. Read More

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The effect of biopsychosocial holistic care models on the cognitive function and quality of life of elderly patients with mild cognitive impairment: a randomized trial.

Ann Palliat Med 2021 May;10(5):5600-5609

Department of Nursing, Nantong Health College of Jiangsu Province, Nantong, China.

Background: Cognitive dysfunction is a functional disorder that occurs after brain tissue damage, which can be classified as mild, moderate, or severe according to the degree of illness, especially in the elderly. Mild cognitive impairment (MCI) has many causes and is difficult to treat. It has been reported that biopsychosocial holistic care models can achieve good results in treating MCI. Read More

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Altered brain network centrality in patients with mild cognitive impairment: an fMRI study using a voxel-wise degree centrality approach.

Aging (Albany NY) 2021 Jun 9;13. Epub 2021 Jun 9.

Department of Ophthalmology and Geriatric Medicine, The First Affiliated Hospital of Nanchang University, Jiangxi Center of Natural Ocular Disease Clinical Research Center, Nanchang 330006, Jiangxi, China.

Purpose: Previous studies in patients with Alzheimer's disease have shown amyloid beta accumulation in the brain and abnormal brain activity, with mild cognitive impairment (MCI) in early stages of the disease. The aim of the current study was to investigate functional connectivity in patients with MCI.

Methods: We recruited 24 subjects in total, including 12 patients with MCI (6 men and 6 women) and 12 healthy controls (HCs) (6 men and 6 women), matched for age, gender, and lifestyle factors. Read More

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Pathogenic Factors Identification of Brain Imaging and Gene in Late Mild Cognitive Impairment.

Interdiscip Sci 2021 Jun 9. Epub 2021 Jun 9.

Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing, Hunan Normal University, Changsha, People's Republic of China.

Mild cognitive impairment (MCI) is a dangerous signal of severe cognitive decline. It can be separated into two steps: early MCI (EMCI) and late MCI (LMCI). As the post-state of MCI and pre-state of Alzheimer's disease (AD), LMCI receives insufficient attention in the field of brain science, causing the internal mechanism of LMCI has not been well understood. Read More

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Association of regional white matter hyperintensity volumes with cognitive dysfunction and vascular risk factors in patients with amnestic mild cognitive impairment.

Geriatr Gerontol Int 2021 Jun 9. Epub 2021 Jun 9.

Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.

Aim: White matter hyperintensities (WMH) obtained by magnetic resonance imaging (MRI) have been reported to promote neurodegeneration and cognitive decline in patients with mild cognitive impairment (MCI). However, little is known about the association between regional WMH (rWMH) and cognitive dysfunction in MCI. We hence investigated the associations between rWMH volumes and cognitive dysfunction in MCI. Read More

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Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment.

Neural Plast 2021 19;2021:8812490. Epub 2021 May 19.

Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 10053, China.

Widespread structural and functional alterations have been reported in the two highly prevalent mild cognitive impairment (MCI) subtypes, amnestic MCI (aMCI) and vascular MCI (VaMCI). However, the changing pattern in functional connectivity strength (FCS) remains largely unclear. The aim of the present study is to detect the differences of FCS and to further explore the detailed resting-state functional connectivity (FC) alterations among VaMCI subjects, aMCI subjects, and healthy controls (HC). Read More

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Neural and Retinal Characteristics in Relation to Working Memory in Older Adults with Mild Cognitive Impairment.

Curr Alzheimer Res 2021 Jun 8. Epub 2021 Jun 8.

Department of Psychiatry, The University of Hong Kong, Hung Hom, Hong Kong.

Objective: This study investigated the relationship between neural activities and retinal structures associated with working memory (WM) in older adults with mild cognitive impairment (MCI).

Methods: Eleven older adults with MCI and 29 healthy controls (60 to 73 years old) were tested. All participants underwent an event-related potential (ERP) recording while performing the two-back memory task. Read More

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Risk Assessment During Longitudinal Progression of Cognition in Older Adults: A Community-based Bayesian Networks Model.

Curr Alzheimer Res 2021 Jun 8. Epub 2021 Jun 8.

Department of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan, China.

Background: Cognitive dysfunction, particularly in Alzheimer's disease (AD), serious- ly affects the health and quality of life of older adults. Early detection can prevent and slow cogni- tive decline.

Objective: This study aimed at evaluating the role of socio-demographic variables, lifestyle, and physical characteristics in cognitive decline during AD progression and analyzing the probable causes and predicting stages of the disease. Read More

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First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial.

Lancet 2021 Jun 4. Epub 2021 Jun 4.

Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: First-line chemotherapy for advanced or metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric or gastro-oesophageal junction adenocarcinoma has a median overall survival (OS) of less than 1 year. We aimed to evaluate first-line programmed cell death (PD)-1 inhibitor-based therapies in gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma. We report the first results for nivolumab plus chemotherapy versus chemotherapy alone. Read More

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Cycling: how can we activate care-dependent older adults with a mild cognitive impairment?

Disabil Rehabil Assist Technol 2021 Jun 8:1-8. Epub 2021 Jun 8.

REVAL - Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium.

Purpose: In residential care, 50% of older adults are sedentary in most of their time, regardless of the positive impact of physical exercise on health. This study analysed whether television images positively impact the motivation and exercise intensity of cycling exercises of older adults in residential care.

Methods: In this randomised controlled cross-over study, 10 residential older adults (mean age 85. Read More

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Determinants of Medical Direct Costs of Care among Patients of a Memory Center.

J Prev Alzheimers Dis 2021 ;8(3):351-361

Dr Virginie Dauphinot, Hôpital des Charpennes, 27 rue Gabriel Péri, 69100 Villeurbanne, France, Tel: +33 (0) 472433114. Fax: +33 (0) 472432054, E-mail address:

Background: Alzheimer's disease and related diseases (ADRD) are a major cause of health-related cost increase.

Objectives: This study aimed to estimate the real medical direct costs of care of patients followed at a memory center, and to investigate potential associations between patients' characteristics and costs.

Design: Cross-sectional analyses conducted on matched data between clinical data of a cohort of patients and the claims database of the French Primary Health Insurance Fund. Read More

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January 2021

Development, Validation and Field Evaluation of the Singapore Longitudinal Ageing Study (SLAS) Risk Index for Prediction of Mild Cognitive Impairment and Dementia.

J Prev Alzheimers Dis 2021 ;8(3):335-344

A/P Tze Pin Ng, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Level 9, NUHS Tower Block, 1E Kent Ridge Road, Singapore 119228, Fax: 65-67772191, Email:

Background: Mild cognitive impairment (MCI) is a critical pre-dementia target for preventive interventions. There are few brief screening tools based on self-reported personal lifestyle and health-related information for predicting MCI that have been validated for their generalizability and utility in primary care and community settings.

Objective: To develop and validate a MCI risk prediction index, and evaluate its field application in a pilot community intervention trial project. Read More

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January 2021

Mail and Telephone Outreach from Electronic Health Records for Research Participation on Cognitive Health and Aging.

J Prev Alzheimers Dis 2021 ;8(3):292-298

Carolyn W. Zhu, PhD, Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai and JJP VA Medical Center, 130 West Kingsbridge Road, Bronx NY 10468, USA. Email: Telephone: 718-584-9000 ext. 6146, Fax: 718-741-4211.

Objectives: This report describes the efficacy and utility of recruiting older individuals by mail to participate in research on cognitive health and aging using Electronic Health Records (EHR).

Methods: Individuals age 65 or older identified by EHR in the Mount Sinai Health System as likely to have Mild Cognitive Impairment (MCI) were sent a general recruitment letter (N=12,951). A comparison group of individuals with comparable age and matched for gender also received the letter (N=3,001). Read More

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January 2021

Current State of Self-Administered Brief Computerized Cognitive Assessments for Detection of Cognitive Disorders in Older Adults: A Systematic Review.

J Prev Alzheimers Dis 2021 ;8(3):267-276

Katherine L. Possin, PhD, Associate Professor in Residence, Department of Neurology, University of California San Francisco, Memory and Aging Center, Box 1207, 675 Nelson Rising Lane, Suite 190, San Francisco, CA 94158, Tel: 415-476-1889, E-mail:

Early diagnosis of cognitive disorders in older adults is a major healthcare priority with benefits to patients, families, and health systems. Rapid advances in digital technology offer potential for developing innovative diagnostic pathways to support early diagnosis. Brief self-administered computerized cognitive tools in particular hold promise for clinical implementation by minimizing demands on staff time. Read More

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January 2021

Longitudinal Network Changes and Conversion to Cognitive Impairment in Multiple Sclerosis.

Neurology 2021 Jun 7. Epub 2021 Jun 7.

Amsterdam UMC, Vrije Universiteit Amsterdam, Dept. of Anatomy and Neurosciences, MS center Amsterdam, Amsterdam Neuroscience, the Netherlands.

Objective: To characterize functional network changes related to conversion to cognitive impairment in a large sample of MS patients over a period of 5 years.

Methods: 227 MS patients and 59 healthy controls (HCs) of the Amsterdam MS cohort underwent neuropsychological testing and resting-state fMRI at two time points (time-interval 4.9±0. Read More

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Stimulus-induced gamma rhythms are weaker in human elderly with Mild Cognitive Impairment and Alzheimer's Disease.

Elife 2021 Jun 8;10. Epub 2021 Jun 8.

Centre for Neuroscience, Indian Institute of Science, Bengaluru, India.

Alzheimer's Disease (AD) in elderly adds substantially to socio-economic burden necessitating early diagnosis. While recent studies in rodent models of AD have suggested diagnostic and therapeutic value for gamma rhythms in brain, the same has not been rigorously tested in humans. In this case-control study, we recruited a large population (N=244; 106 females) of elderly (>49 years) subjects from the community, who viewed large gratings that induced strong gamma oscillations in their electroencephalogram (EEG). Read More

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Resting-state electroencephalographic biomarkers of Alzheimer's disease.

Neuroimage Clin 2021 May 29;31:102711. Epub 2021 May 29.

Neurology Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy; Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy; Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy; Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy. Electronic address:

Objective: We evaluated the value of resting-state EEG source biomarkers to characterize mild cognitive impairment (MCI) subjects with an Alzheimer's disease (AD)-like cerebrospinal fluid (CSF) profile and to track neurodegeneration throughout the AD continuum. We further applied a resting-state functional MRI (fMRI)-driven model of source reconstruction and tested its advantage in terms of AD diagnostic accuracy.

Methods: Thirty-nine consecutive patients with AD dementia (ADD), 86 amnestic MCI, and 33 healthy subjects enter the EEG study. Read More

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The Clock Drawing Test as a predictor of cognitive decline in non-demented stroke patients.

J Neurol 2021 Jun 6. Epub 2021 Jun 6.

Neurology Unit, Luigi Sacco University Hospital, Milan, Italy.

Background: The early detection of patients at risk of post-stroke cognitive impairment (PSCI) may help planning subacute and long-term care. We aimed to determine the predictivity of two screening cognitive tests on the occurrence of mild cognitive impairment or dementia in acute stroke patients.

Methods: A cognitive assessment within a few days of ischemic or hemorrhagic stroke was performed in patients consecutively admitted to a stroke unit over 14 months by means of the Clock Drawing Test (CDT) and the Montreal Cognitive Assessment-Basic (MoCA-B). Read More

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Associations of actigraphic sleep and circadian rest/activity rhythms with cognition in the early phase of Alzheimer's disease.

Sleep Adv 2021 27;2(1):zpab007. Epub 2021 Apr 27.

Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Study Objectives: To compare sleep and circadian rest/activity rhythms (RARs), quantified by standard and novel actigraphic metrics, between controls and participants with mild cognitive impairment (MCI), and to examine the cross-sectional relationships between these measures and cognition.

Methods: Actigraphy data were collected in 179 older individuals (mean age = 72.6 years) with normal cognition ( = 153) and MCI ( = 26). Read More

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Inter-Cohort Validation of SuStaIn Model for Alzheimer's Disease.

Front Big Data 2021 20;4:661110. Epub 2021 May 20.

Laboratory of Neuroinformatics, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Alzheimer's disease (AD) is a neurodegenerative disorder which spans several years from preclinical manifestations to dementia. In recent years, interest in the application of machine learning (ML) algorithms to personalized medicine has grown considerably, and a major challenge that such models face is the transferability from the research settings to clinical practice. The objective of this work was to demonstrate the transferability of the Subtype and Stage Inference (SuStaIn) model from well-characterized research data set, employed as training set, to independent less-structured and heterogeneous test sets representative of the clinical setting. Read More

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Well-Differentiated Thyroid Cancer Invading the Trachea in a Pediatric Patient.

AACE Clin Case Rep 2021 May-Jun;7(3):207-210. Epub 2021 Mar 23.

University of Michigan, Department of Otolaryngology-Head and Neck Surgery, Ann Arbor, Michigan.

Objectives: Pediatric thyroid cancer is rare. Most cases are well-differentiated thyroid cancers (WDTCs). However, gross laryngotracheal invasion of WDTCs is unusual. Read More

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