7,472,739 results match your criteria mcemammalian cell


The Evidence for Antimicrobial and Hard to Infect Regenerative Matrices.

Surg Technol Int 2021 Dec 6;39. Epub 2021 Dec 6.

Department of Surgery, Mount Sinai Healthcare System, Icahn School of Medicine, New York, NY.

Preparation of the wound bed is a key step in the use of cell- and tissue-based therapy (CTP). In particular, good pre-application debridement is an essential component of CTP. However, there are many situations in which the wound bed is not adequately debrided, including trauma, burn, and in cases of chronic wounds with significant biofilm. Read More

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December 2021

First Baby Born in Brazil after Simultaneous Diagnosis through Non-Invasive and Conventional PGT-A.

Rev Bras Ginecol Obstet 2021 Nov 6;43(11):878-882. Epub 2021 Dec 6.

Nilo Frantz Medicina Reprodutiva, Porto Alegre, RS, Brazil.

Non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) aiming to assess cell-free embryonic DNA in spent culture media is promising, especially because it might overcome the diminished rates of implantation caused by the inadequate performance of trophectoderm (TE) biopsy. Our center is part of the largest study to date assessing the concordance between conventional PGT-A and niPGT-A, and we report here the delivery of the first baby born in Brazil using niPGT-A. The parents of the baby were admitted to our center in 2018. Read More

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November 2021

Can Prenatal and Postnatal Cell Phone Exposure Increase Adverse Maternal, Infant and Child Outcomes?

Rev Bras Ginecol Obstet 2021 Nov 6;43(11):870-877. Epub 2021 Dec 6.

Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Objective:  To determine the association between maternal mobile phone use and adverse outcomes in infants, children, and mothers.

Method:  In March 202, we conducted a search on the MEDLINE, Embase, and Scopus databases. Data extraction and an assessment of the quality of the studies were performed by two authors. Read More

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November 2021

Teleoncology Orientation of Low-Income Breast Cancer Patients during the COVID-19 Pandemic: Feasibility and Patient Satisfaction.

Rev Bras Ginecol Obstet 2021 Nov 6;43(11):840-846. Epub 2021 Dec 6.

Breast Surgery Department, Hospital Vila Santa Catarina, São Paulo, SP, Brazil.

Objective:  The present study aims to assess the feasibility and patient satisfaction of teleoncology orientation in a vulnerable population of breast cancer patients assessed in a government health system during the coronavirus pandemic in 2020.

Methods:  Eligible patients received an invitation to receive remote care to minimize exposure to an environment in which the risk of respiratory infection was present. The means of communication was telephone through an application that allows free conversation with no charge. Read More

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November 2021

Neutrophil transit time and localization within the megakaryocyte define morphologically distinct forms of emperipolesis.

Blood Adv 2021 Dec 6. Epub 2021 Dec 6.

Brigham and Women's Hospital, United States.

Neutrophils transit through megakaryocytes in a process termed emperipolesis, but it is unknown whether this interaction is a single type of cell-in-cell interaction or a set of distinct processes. Using a murine in vitro model, we characterized emperipolesis by live-cell spinning disk microscopy and electron microscopy. Approximately half of neutrophils exited the megakaryocyte rapidly, typically in 10 minutes or less, displaying ameboid morphology as they passed through the host cell (fast emperipolesis). Read More

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December 2021

Targeting CD70 in cutaneous T-cell lymphoma using an antibody-drug conjugate in patient-derived xenograft models.

Blood Adv 2021 Dec 6. Epub 2021 Dec 6.

University of California, San Francisco, San Francisco, California, United States.

CD70 is a member of the tumor necrosis factor (TNF) receptor superfamily. Emerging data indicate that CD70 may be a suitable target for various malignancies. We investigated the expression of CD70 in cutaneous and systemic T cell lymphomas; and conducted pre-clinical studies of SGN-CD70A, a CD70-directed antibody-drug conjugate, using patient-derived cutaneous T cell lymphoma (CTCL PDX) models. Read More

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December 2021

Unrelated donor α/β T-cell and B-cell-depleted HSCT for the treatment of pediatric acute leukemia.

Blood Adv 2021 Dec 6. Epub 2021 Dec 6.

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.

Unrelated donor (URD) hematopoietic stem cell transplant (HSCT) is associated with an increased risk of severe GVHD. TCRαβ/CD19 depletion may reduce this risk, while maintaining graft-versus-leukemia. Outcome data with TCRαβ/CD19 depletion generally describes haploidentical donors, with relatively few URDs. Read More

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December 2021

A Clinical Laboratory-Developed LSC17 Stemness Score Assay for Rapid Risk Assessment of Acute Myeloid Leukemia Patients.

Blood Adv 2021 Dec 6. Epub 2021 Dec 6.

Department of Medicine, University of Toronto, Canada.

Leukemia stem cells (LSC) are linked to relapse in acute myeloid leukemia (AML). The LSC17 gene expression score robustly captures LSC stemness properties in AML and can be used to predict survival outcomes and response to therapy, enabling risk-adapted upfront treatment approaches. The LSC17 score was developed and validated in a research setting. Read More

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December 2021

Efficacy of the BNT162b2 mRNA COVID-19 Vaccine in Patients with Chronic Lymphocytic Leukemia: A Serologic and Cellular Study.

Chemotherapy 2021 Dec 6. Epub 2021 Dec 6.

Background: Antibody response following SARS-CoV2 vaccination is somewhat defective in chronic lymphocytic leukemia (CLL). Moreover, the correlation between serologic response and status of cellular immunity has been poorly studied.

Objective: This study was undertaken to assess humoral immune and cellular responses to the BNT162b2 messenger RNA (mRNA) COVID-19 vaccination in CLL. Read More

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December 2021

Emodin Promotes Autophagy and Prevents Apoptosis in Sepsis-Associated Encephalopathy through Activating BDNF/TrkB Signaling.

Pathobiology 2021 Dec 6:1-11. Epub 2021 Dec 6.

Department of Emergency ICU, The First Hospital of Jilin University, Changchun, China.

Objective: Sepsis-associated encephalopathy (SAE) is a severe and common complication of sepsis and can induce cognitive dysfunction and apoptosis of neurons and neuroinflammation. Emodin has been confirmed to have anti-inflammatory effects. Thus, we sought to investigate the role of Emodin in SAE. Read More

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December 2021

SIGNIFICANCE OF LOW MATERNAL SERUM Β-HCG LEVELS IN THE ASSESSMENT OF THE RISK OF ATYPICAL CHROMOSOMAL ABNORMALITIES.

Fetal Diagn Ther 2021 Dec 6. Epub 2021 Dec 6.

Introduction: The introduction of prenatal cell-free DNA as a screening test has surpassed traditional combined first-trimester screening (cFTS) in the detection of common trisomies. However, its current limitation in detecting only common trisomies is affecting the diagnostic yield for other clinically significant chromosomal abnormalities.

Methods: In efforts to optimize the detection of fetuses with genetic abnormalities, we have analyzed the relationship between the cFTS risk score and biomarkers with atypical chromosomal abnormalities. Read More

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December 2021

Skeletal muscle radiodensity and visceral adipose tissue index are associated with survival in renal cell cancer - A multicenter population-based cohort study.

Clin Nutr 2021 Nov 19;41(1):131-143. Epub 2021 Nov 19.

Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

Introduction: Body composition has been associated with disease outcome in several cancer types. Results for localized and metastatic renal cell cancer (RCC) are limited and inconsistent. Our aim was to examine the association between body composition and survival in RCC. Read More

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November 2021

Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins.

Redox Biol 2021 Nov 25;48:102196. Epub 2021 Nov 25.

Department of Biochemistry & Molecular Biology, University of Iowa, Iowa City, IA, USA. Electronic address:

Mutations in the human LMNA gene cause a collection of diseases called laminopathies, which includes muscular dystrophy and dilated cardiomyopathy. The LMNA gene encodes lamins, filamentous proteins that form a meshwork on the inner side of the nuclear envelope. How mutant lamins cause muscle disease is not well understood, and treatment options are currently limited. Read More

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November 2021

1,25-Dihydroxyvitamin D attenuates IL-1β secretion by suppressing NLRP1 inflammasome activation by upregulating the NRF2-HO-1 pathway in epidermal keratinocytes.

Redox Biol 2021 Dec 1;48:102203. Epub 2021 Dec 1.

DHC Corporation Laboratories, Division 2, 2-42 Hamada, Mihama-ku, Chiba, 261-0025, Japan. Electronic address:

The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein (NLRP) inflammasome is a key inflammatory signaling pathway activated via a two-step signaling process consisting of priming and activation steps. Several studies have shown that 1,25-dihydroxyvitamin D3 (1,25(OH)VD) inhibits the priming step required for NLRP3 inflammasome activation in immune cells. However, as activating the NLRP1 inflammasome in keratinocytes does not necessarily require a priming step, whether 1,25(OH)VD inhibits NLRP1 activation in unprimed keratinocytes is currently unknown. Read More

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December 2021

Reactive oxygen species formation driven by acidophiles mediated pyrite oxidation and its potential role on 2,4-dichlorophenol transformation.

J Hazard Mater 2021 Nov 23;425:127833. Epub 2021 Nov 23.

School of Minerals Processing and Bioengineering, Key Laboratory of Biometallurgy of Ministry of Education, Central South University, Changsha 410083, China. Electronic address:

Researches of reactive oxygen species (ROS) generation from pyrite oxidation and its impact on contaminants transformation has been constrained to abiotic conditions. However, pyrite oxidation by acidophiles is widespread in acidic environments. The potential role of these microorganisms on pyrite-induced ROS formation and pollutants processing is not understood well. Read More

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November 2021

When good turns bad: how viruses exploit innate immunity factors.

Curr Opin Virol 2021 Dec 3;52:60-67. Epub 2021 Dec 3.

Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081 Ulm, Germany. Electronic address:

Humans evolved numerous cell-intrinsic restriction factors as a first line of defense against viral pathogens. Typically, they inhibit efficient viral replication and thus prevent viral zoonoses and pandemics. However, viruses show enormous adaptability and are well known for their ability to counteract antiviral mechanisms. Read More

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December 2021

MicroRNAs and exosomes: Cardiac stem cells in heart diseases.

Pathol Res Pract 2021 Nov 20;229:153701. Epub 2021 Nov 20.

Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Treating cardiovascular diseases with cardiac stem cells (CSCs) is a valid treatment among various stem cell-based therapies. With supplying the physiological need for cardiovascular cells as their main function, under pathological circumstances, CSCs can also reproduce the myocardial cells. Although studies have identified many of CSCs' functions, our knowledge of molecular pathways that regulate these functions is not complete enough. Read More

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November 2021

Deubiquitinase USP13 promotes the epithelial-mesenchymal transition and metastasis in gastric cancer by maintaining Snail protein.

Pathol Res Pract 2021 Nov 24;229:153705. Epub 2021 Nov 24.

Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:

The dynamic balance between ubiquitination and deubiquitination is a key mechanism that regulates protein degradation and maintains cell protein homeostasis. Ubiquitin-specific peptidase 13 (USP13), a deubiquitinase (DUB), regulates various physiological and pathological processes, including cancer. A previous study reported that high USP13 mRNA expression confers poor prognosis in gastric cancer (GC). Read More

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November 2021

Renal histopathology in critically ill patients with Septic Acute Kidney Injury(S-AKI).

J Crit Care 2021 Dec 3;68:38-41. Epub 2021 Dec 3.

Laboratorio Anatomía Patológica Hospital Maciel, ASSE, Montevideo, Uruguay.

Purpose: To describe the kidney histopathology of patients with S-AKI and correlate the histological findings with AKI severity, presence of septic shock, and the degree of multiple organic dysfunction (MOD) using the SOFA score.

Materials And Methods: This was a prospective, observational, and analytical study of a cohort of critically ill patients with S-AKI who died from sepsis at the "Hospital Español" intensive care unit (ICU). Kidney necropsies were performed within 2 h after death. Read More

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December 2021

Pig farm vaccination against classical swine fever reduces the risk of transmission from wild boar.

Prev Vet Med 2021 Dec 1;198:105554. Epub 2021 Dec 1.

Division of Transboundary Animal Disease Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan.

In 2018, classical swine fever (CSF) re-emerged in the Gifu Prefecture, central Japan, causing an on-going outbreak among wild boars and domestic pigs in the country. Consequently, oral vaccination for wild boar and compulsory vaccination for pig farms started in 2019. We have previously shown that, before vaccination in the Gifu Prefecture, the presence of CSF-infected wild boar near pig farms increased the risk of CSF transmission. Read More

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December 2021

Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation.

Biochem Biophys Res Commun 2021 Dec 1;587:99-106. Epub 2021 Dec 1.

Department of General Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China. Electronic address:

Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive system, and Chinese herbal medicine plays an important role in tumor treatment. The in-depth study of auriculasin isolated from Flemingia philippinensis showed that auriculasin promoted reactive oxygen species (ROS) generation in a concentration-dependent manner; when ROS scavenger NAC was added, the effects of auriculasin in promoting ROS generation and inhibiting cell viability were blocked. Auriculasin induced CRC cell apoptosis, led to mitochondrial shrinkage, and increased the intracellular accumulation of Fe and MDA. Read More

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December 2021

Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling-independent manner.

Biochem Biophys Res Commun 2021 Nov 27;587:78-84. Epub 2021 Nov 27.

Department of Biochemistry, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.

An interaction between acute myeloid leukemia (AML) cells and endothelial cells in the bone marrow seems to play a critical role in chemosensitivity on leukemia treatment. The endothelial niche reportedly enhances the paracrine action of the soluble secretory proteins responsible for chemoresistance in a vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 (VEGFR-2) signaling pathway-dependent manner. To further investigate the contribution of VEGF-A/VEGFR-2 signaling to the chemoresistance of AML cells, a biochemical assay system in which the AML cells were cocultured with human endothelial EA. Read More

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November 2021

SOX9-mediated UGT8 expression promotes glycolysis and maintains the malignancy of non-small cell lung cancer.

Biochem Biophys Res Commun 2021 Nov 30;587:139-145. Epub 2021 Nov 30.

Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address:

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to small lipophilic chemicals and are associated with a wide range of diseases including cancer. The human genome contains 22 UGT genes which could be classified into four families: UGT1, UGT2, UGT3, and UGT8. The UGT8 family contains only one member which utilizes UDP galactose to galactosidate ceramide. Read More

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November 2021

Changes in the properties of membrane tethers in response to HP1α depletion in MCF7 cells.

Biochem Biophys Res Commun 2021 Nov 27;587:126-130. Epub 2021 Nov 27.

School of Fundamental Sciences, Massey University, Palmerston North, 4442, New Zealand. Electronic address:

Plasma membrane tension is known to regulate many cell functions, such as motility and membrane trafficking. Membrane tether pulling is an effective method for measuring the apparent membrane tension of cells and exploring membrane-cytoskeleton interactions. In this article, the mechanical properties of HP1α-depleted MCF7 breast cancer cells are explored in comparison to controls, by pulling membrane tethers using optical tweezers. Read More

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November 2021

Solitary manifestations of primary B-lymphoblastic lymphoma of the spine: Systematic literature review with case illustration.

Clin Neurol Neurosurg 2021 Nov 24;212:107064. Epub 2021 Nov 24.

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, 175N Medical Drive East, Salt Lake City, UT 84132, USA.

Background: Given the locally destructive osteolytic nature of primary B-cell lymphoblastic lymphoma (B-LBL) of the spine, careful attention is needed to identify clinical signs and symptoms as well as radiological findings of spinal instability because these lesions may warrant resection, decompression, and instrumentation with posterolateral fusion. Our objective was to summarize the presenting symptoms, clinical features, potential treatment modalities, and clinical outcome of cases described in the literature.

Methods: We undertook a systematic literature review to identify all relevant cases and case series describing primary manifestations B-LBL of the spine using Pubmed/Medline. Read More

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November 2021

Phytochemical control of poultry coccidiosis: a review.

Poult Sci 2021 Oct 14;101(1):101542. Epub 2021 Oct 14.

Poultry and Fish Diseases Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt.

Avian coccidiosis is a major parasitic disorder in chickens resulting from the intracellular apicomplexan protozoa Eimeria that target the intestinal tract leading to a devastating disease. Eimeria life cycle is complex and consists of intra- and extracellular stages inducing a potent inflammatory response that results in tissue damage associated with oxidative stress and lipid peroxidation, diarrheal hemorrhage, poor growth, increased susceptibility to other disease agents, and in severe cases, mortality. Various anticoccidial drugs and vaccines have been used to prevent and control this disorder; however, many drawbacks have been reported. Read More

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October 2021

Reprogramming of one human induced pluripotent stem cell line from healthy donor.

Stem Cell Res 2021 Dec 1;57:102613. Epub 2021 Dec 1.

The Second Hospital of Hebei Medical University, Hebei Province 050017, China; Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China. Electronic address:

In this study, skin biopsy was, and the fibroblasts were isolated from the dermal explant cultures. Human induced pluripotent stem cell (iPSC) line was generated from the skin fibroblasts collected from a healthy 50-year old male donor with informed consent. The reprogramming of fibroblasts was performed with four Yamanaka factors containing Oct3/4, Sox2, Klf4 and c-Myc. Read More

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December 2021

L-Methionine prevents β-cell damage by modulating the expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats.

Acta Histochem 2021 Dec 3;124(1):151820. Epub 2021 Dec 3.

Laboratory of Epigenetics and Diseases, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar (Mohali), Punjab 160062, India. Electronic address:

L-Methionine (L-Met) is an essential sulphur-containing amino acid having a vital role in various key cellular processes. Here we investigated the effect of L-Met on streptozotocin-induced β-cell damage model of diabetes mellitus in Sprague Dawley rats. At the end of study biochemical parameters, immunoblotting, qRT-PCR and ChIP-qPCR are performed. Read More

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December 2021

ZnT1 is a neuronal Zn/Ca exchanger.

Cell Calcium 2021 Nov 23;101:102505. Epub 2021 Nov 23.

Department of Physiology and Cell Biology, and the Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Faculty of Health Sciences, POB 653, Beer-Sheva 84108, Israel. Electronic address:

Zinc transporter 1 (ZnT1; SLC30A1) is present in the neuronal plasma membrane, critically modulating NMDA receptor function and Zn neurotoxicity. The mechanism mediating Zn transport by ZnT1, however, has remained elusive. Here, we investigated ZnT1-dependent Zn transport by measuring intracellular changes of this ion using the fluorescent indicator FluoZin-3. Read More

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November 2021

The ameliorative effect of melatonin on LPS-induced Sertoli cells inflammatory and tight junctions damage via suppression of the TLR4/MyD88/NF-κB signaling pathway in newborn calf.

Theriogenology 2021 Nov 27;179:103-116. Epub 2021 Nov 27.

Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, Heilongjiang, China. Electronic address:

The blood-testicular barrier (BTB) is involved in spermatogenesis, protects sperm development, and plays a crucial role in the reproductive process. Tight junctions (TJs) between Sertoli cells (SCs) are the key structure of (BTB), and if its structure is damaged, BTB function is affected. The cellular inflammation caused by Gram-negative bacteria affects the structural integrity of TJs. Read More

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November 2021