1,202 results match your criteria mca addition

Perfusion image guided mechanical thrombectomy combined with tirofiban successfully revascularize systemic lupus erythematosus related acute large vessel occlusion: A case report.

Medicine (Baltimore) 2021 May;100(18):e25779

Department of Neurological Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Rationale: Systemic lupus erythematosus (SLE) is an important cause of stroke, more than a half the cases present as acute ischemic stroke. Thrombolysis is an effective choice in most cases, but for large vessel occlusion, mechanical thrombectomy is more effective. Here we reported a case of SLE-related stroke with left middle cerebral artery (MCA) occlusion, who was successfully treated by MT and tirofiban. Read More

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Extracranial vertebral artery to middle cerebral artery bypass in therapeutic internal carotid artery occlusion for epipharyngeal carcinoma: A technical case report.

Surg Neurol Int 2021 8;12:149. Epub 2021 Apr 8.

Department of Neurosurgery, Sapporo Teishinkai Hospital, Higashi-ku, Sapporo, Japan.

Background: Vertebral artery (VA) to middle cerebral artery (MCA) bypass is a rarely selected technique because a complex expanded dissection is required, and often, a better donor artery than VA exists. A good indication for VA-MCA bypass is the treatment of head-and-neck malignancies with the sacrifice of the internal carotid artery (ICA) or for carotid artery rupture.

Methods: A 23-year-old man with epipharyngeal carcinoma, treated by ligating the carotid artery with a VAMCA bypass before chemoradiotherapy, was reported. Read More

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A Synergistic Platform for Continuous Co-removal of 1,1,1-Trichloroethane, Trichloroethene, and 1,4-Dioxane via Catalytic Dechlorination Followed by Biodegradation.

Environ Sci Technol 2021 05 21;55(9):6363-6372. Epub 2021 Apr 21.

Biodesign Swette Center for Environmental Biotechnology, Arizona State University, Tempe, Arizona 85287 United States.

Groundwater co-contaminated with 1,4-dioxane, 1,1,1-trichloroethane (TCA), and trichloroethene (TCE) is among the most urgent environmental concerns of the U.S. Department of Defense (DoD), U. Read More

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Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke.

IBRO Neurosci Rep 2021 Jun 5;10:18-30. Epub 2021 Jan 5.

Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, United States.

Background: The absolute number of new stroke patients is annually increasing and there still remains only a few Food and Drug Administration (FDA) approved treatments with significant limitations available to patients. Tanshinone IIA (Tan IIA) is a promising potential therapeutic for ischemic stroke that has shown success in pre-clinical rodent studies but lead to inconsistent efficacy results in human patients. The physical properties of Tan-IIA, including short half-life and low solubility, suggests that Poly (lactic-co-glycolic acid) (PLGA) nanoparticle-assisted delivery may lead to improve bioavailability and therapeutic efficacy. Read More

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Aril Ameliorates Diet-Induced Metabolic Dysfunction and Non-Alcoholic Fatty Liver by Modulating Gut Microbiota.

Int J Mol Sci 2021 Mar 5;22(5). Epub 2021 Mar 5.

Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei City 112, Taiwan.

Obesity and its associated conditions, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), are a particular worldwide health problem at present. (MC) is consumed widely in Southeast Asia. However, whether it has functional effects on fat-induced metabolic syndrome remains unclear. Read More

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Two-stage 3-methylcholanthrene and butylated hydroxytoluene-induced lung carcinogenesis in mice.

Methods Cell Biol 2021 24;163:153-173. Epub 2020 Aug 24.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Lung cancer is one of the deadliest types of cancer and as such requires disease models that are useful for identification of novel pathways for biomarkers as well as to test therapeutic agents. Adenocarcinoma (ADC), the most prevalent type of lung cancer, is a subtype of non-small cell lung carcinoma (NSCLC) and a disease driven mainly by smoking. However, it is also the most common subtype of lung cancer found in non-smokers with environmental exposures. Read More

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Eltrombopag for the treatment of refractory thrombocytopenia associated with connective tissue disease.

Sci Rep 2021 Mar 9;11(1):5459. Epub 2021 Mar 9.

Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

To assess the efficacy and safety of eltrombopag in connective tissue disease (CTD)-immune thrombocytopenia (ITP), we conducted this single-center retrospective observational study, including patients with refractory CTD-ITP who were treated with eltrombopag between January 2018 and August 2019. The characteristics of patients at baseline, and the efficacy and safety of the drug were analyzed. The predictors for a response were analyzed using a univariate analysis such as Chi-square or nonparametric test and a multiple correspondence analysis (MCA) method. Read More

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Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model.

Radiat Oncol 2021 Mar 4;16(1):48. Epub 2021 Mar 4.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA.

Background: Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases. Thus, new approaches for improving the treatment of HER2/neu + BC to prevent metastatic dissemination are urgently needed. Our previous studies have shown that losartan, an angiotensin receptor blocker, increases tumor perfusion and decreases hypoxia in a number of tumor models. Read More

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Validation of an artificial intelligence-driven large vessel occlusion detection algorithm for acute ischemic stroke patients.

Neuroradiol J 2021 Mar 3:1971400921998952. Epub 2021 Mar 3.

Department of Biomedical Engineering, University at Buffalo, USA.

Rapid and accurate diagnosis of large vessel occlusions (LVOs) in acute ischemic stroke (AIS) patients using automated software could improve clinical workflow in determining thrombectomy in eligible patients. Artificial intelligence-based methods could accomplish this; however, their performance in various clinical scenarios, relative to clinical experts, must be thoroughly investigated. We aimed to assess the ability of Canon's Stroke Solution LVO application in properly detecting and locating LVOs in AIS patients. Read More

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Adaptive Transition Probability Matrix Learning for Multiview Spectral Clustering.

IEEE Trans Neural Netw Learn Syst 2021 Mar 2;PP. Epub 2021 Mar 2.

Multiview clustering as an important unsupervised method has been gathering a great deal of attention. However, most multiview clustering methods exploit the self-representation property to capture the relationship among data, resulting in high computation cost in calculating the self-representation coefficients. In addition, they usually employ different regularizers to learn the representation tensor or matrix from which a transition probability matrix is constructed in a separate step, such as the one proposed by Wu et al. Read More

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Doppler assessment of the fetus in pregnant women recovered from COVID-19.

J Obstet Gynaecol Res 2021 May 1;47(5):1757-1762. Epub 2021 Mar 1.

University of Health Sciences, Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.

Objective: The aim of this study was to evaluate the maternal-fetal Doppler patterns in pregnant women recovered from COVID-19.

Methods: This prospective case-control study was conducted in Ankara City Hospital between July 1, 2020 and August 30, 2020. Thirty pregnant women who were diagnosed with COVID-19 and completed the quarantine process were compared with 40 healthy pregnant women in terms of the fetal Doppler parameters. Read More

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[2,3,5,4'-Tetrahydroxystibane-2-O-β-D-glucoside induces liver injury by disrupting bile acid homeostasis and phospholipids efflux].

Zhongguo Zhong Yao Za Zhi 2021 Jan;46(1):139-145

Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University Nanjing 210009, China Center for Drug Research and Development, Guangdong Pharmaceutical University Guangzhou 510006, China.

Polygonum multiflorum is a traditional Chinese herbal medicine and has many biological activities such as hair-blacking, anti-atherosclerosis, anti-inflammatory and anti-aging. However, the liver injury induced by P. multiflorum has aroused wide attention in recent years. Read More

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January 2021

Oropharyngeal 3-dimensional changes after maxillary expansion with 2 different orthodontic approaches.

Am J Orthod Dentofacial Orthop 2021 Mar;159(3):352-359

Faculty of Medicine and Dentistry, School of Dentistry, University of Alberta, Alberta, Canada, University of Texas Health Science at San Antonio, San Antonio, Tex.

Introduction: The objective of this research was to compare the oropharyngeal volume and minimal cross-sectional area (MCA) changes after maxillary expansion using either the Damon system or Hyrax appliances as assessed through cone-beam computed tomography (CBCT) imaging.

Methods: Patients aged between 11 and 17 years with skeletal maxillary transverse discrepancy in need of maxillary expansion were included and allocated randomly into 1 of the 2 treatment groups, Damon or Hyrax. Patients underwent CBCT imaging at 2 time points: T1, after initial clinical evaluation before treatment, and T2, after completion of full orthodontic treatment. Read More

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Peak systolic velocity of fetal middle cerebral artery to predict anemia in Red Cell Alloimmunization in un-transfused and transfused fetuses.

Eur J Obstet Gynecol Reprod Biol 2021 Mar 29;258:437-442. Epub 2021 Jan 29.

Fetal Medicine Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt; Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address:

Objective: To assess the accuracy of middle cerebral artery peak systolic velocity (MCA-PSV) in prediction of severe fetal anemia resulting from Red Cell Alloimmunization (Anti-D) in un-transfused and transfused fetuses. In addition to comparing the accuracy of MCA-PSV and the estimation of the daily decline of fetal hemoglobin (Hb), to determine the appropriate time of subsequent transfusions.

Study Design: This was a retrospective study of a series of 84 anaemic fetuses due to Red Cell alloimmunization. Read More

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The effect of diabetes on corneal endothelium: a meta-analysis.

BMC Ophthalmol 2021 Feb 10;21(1):78. Epub 2021 Feb 10.

Department of Ophthalmology, The Second Affiliated Hospital of Jilin University, Changchun, 13000, China.

Background: This research was conducted with the aim to determine the effect of diabetes mellitus on corneal endothelial cells.

Methods: The terms: ("diabetes mellitus" or "diabetes" or "diabetic") and ("corneal endothelium" or "cornea" or "Corneas") searched in Pubmed, Embase, Cochrane, and Web of science until August 2019. The included types of studies contained observational studies. Read More

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February 2021

Determinants of cerebral blood flow velocity change during squat-stand maneuvers.

Am J Physiol Regul Integr Comp Physiol 2021 04 3;320(4):R452-R466. Epub 2021 Feb 3.

Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.

The large changes in mean arterial blood pressure (MABP) and cerebral blood flow velocity (CBFV) induced by squat-stand maneuvers (SSM) make this approach particularly suited for studying dynamic cerebral autoregulation (CA). However, the role of other systemic determinants of CBFV has not been described and could provide alternative physiological interpretations of SSM results. In 32 healthy subjects (16 female), continuous recordings of MABP (Finometer), bilateral CBFV (transcranial Doppler, MCA), end-tidal CO (EtCO; capnography), and heart rate (HR; electrocardiogram) were performed for 5 min standing at rest, and during 15 SSM at the frequency of 0. Read More

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Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth.

Cancer Immunol Res 2021 Jan 26. Epub 2021 Jan 26.

Aeglea BioTherapeutics, Inc., Austin, Texas.

Metabolic dysregulation is a hallmark of cancer. Many tumors exhibit auxotrophy for various amino acids, such as arginine, because they are unable to meet the demand for these amino acids through endogenous production. This vulnerability can be exploited by employing therapeutic strategies that deplete systemic arginine in order to limit the growth and survival of arginine auxotrophic tumors. Read More

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January 2021

Support for 5G Mission-Critical Applications in Software-Defined IEEE 802.11 Networks.

Sensors (Basel) 2021 Jan 20;21(3). Epub 2021 Jan 20.

School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ 85281, USA.

With the emergence of 5G networks and the stringent Quality of Service (QoS) requirements of Mission-Critical Applications (MCAs), co-existing networks are expected to deliver higher-speed connections, enhanced reliability, and lower latency. IEEE 802.11 networks, which co-exist with 5G, continue to be the access choice for indoor networks. Read More

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January 2021

Flame-retardant ethylene vinyl acetate composite materials by combining additions of aluminum hydroxide and melamine cyanurate: Preparation and characteristic evaluations.

J Colloid Interface Sci 2021 May 18;589:525-531. Epub 2021 Jan 18.

College of Geography and Environmental Sciences, Zhejiang Normal University, Jinhua 321004, PR China. Electronic address:

There is a great interest to develop efficient fire-resistant materials. While ethylene vinyl acetate (EVA) is a widely used material, it suffers from the problem of relatively high inflammability which seriously hinders its usage as the product material with a high flame-retardant requirement. In this study, a strategy to combine aluminum hydroxide (ATH) and melamine cyanurate (MCA) with EVA was proposed to prepare the EVA composite materials with high flame resistance. Read More

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Impact of eloquent motor cortex-tissue reperfusion beyond the traditional thrombolysis in cerebral infarction (TICI) scoring after thrombectomy.

J Neurointerv Surg 2020 Dec 18. Epub 2020 Dec 18.

Neurology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.

Background: Targeted eloquence-based tissue reperfusion within the primary motor cortex may have a differential effect on disability as compared with traditional volume-based (thrombolysis in cerebral infarction, TICI) reperfusion after endovascular thrombectomy (EVT) in the setting of acute ischemic stroke (AIS).

Methods: We explored the impact of eloquent reperfusion (ER) within primary motor cortex (PMC) on clinical outcome (modified Rankin Scale, mRS) in AIS patients undergoing EVT. ER-PMC was defined as presence of flow on final digital subtraction angiography (DSA) within four main cortical branches, supplying the PMC (middle cerebral artery (MCA) - precentral, central, postcentral; anterior cerebral artery (ACA) - medial frontal branch arising from callosomarginal or pericallosal arteries) and graded as absent (0), partial (1), and complete (2). Read More

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December 2020

Fetal Outcomes Associated with the Sequence of Doppler Deterioration in Severely Growth-Restricted Fetuses.

J Ultrasound Med 2021 Jan 13. Epub 2021 Jan 13.

Osaka Women's and Children's Hospital, Department of Maternal-Fetal Medicine, Osaka, Japan.

Objectives: Various patterns of Doppler deterioration exist in fetal growth restriction (FGR). However, the factors that differentiate these patterns are still unknown. The purpose of this study was to clarify the perinatal outcomes and factors to determine the pattern of Doppler deterioration in severe FGR. Read More

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January 2021

Does inferior turbinate outfracture provide additional benefit when combined with inferior turbinate radiofrequency ablation?

Eur Arch Otorhinolaryngol 2021 Jan 3. Epub 2021 Jan 3.

Department of Otorhinolaryngology, Ankara Numune Training and Research Hospital, ENT&HNS Clinic, Talatpaşa Boulevard No:44, Altındağ, 06230, Ankara, Turkey.

Purpose: To evaluate, both subjectively and objectively, whether turbinate outfracture provides any additional benefit in the treatment of inferior turbinate hypertrophy when combined with radiofrequency ablation.

Methods: The study was conducted on 58 patients diagnosed with inferior turbinate hypertrophy. The patients were randomly divided into two groups according to the treatment they receive. Read More

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January 2021

Synthesis, Characterization, and Application of Carboxymethyl Cellulose from Asparagus Stalk End.

Polymers (Basel) 2020 Dec 28;13(1). Epub 2020 Dec 28.

School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.

Cellulose from stalk end was extracted and synthesized to carboxymethyl cellulose (CMC) using monochloroacetic acid (MCA) via carboxymethylation reaction with various sodium hydroxide (NaOH) concentrations starting from 20% to 60%. The cellulose and CMC were characterized by the physical properties, Fourier Transform Infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), Scanning electron microscopy (SEM) and X-ray diffraction (XRD). In addition, mechanical properties of CMC films were also investigated. Read More

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December 2020

QiDiTangShen granules modulated the gut microbiome composition and improved bile acid profiles in a mouse model of diabetic nephropathy.

Biomed Pharmacother 2021 Jan 28;133:111061. Epub 2020 Nov 28.

Department of Endocrinology and Nephrology, Renal Research Institute of Beijing University of Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Haiyuncang Road No. 5, Beijing, 100700, China; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Haiyuncang Road No. 5, Beijing, 100700, China. Electronic address:

QiDiTangShen granules (QDTS), a traditional Chinese herbal medicine, have been used in clinical practice for treating diabetic kidney disease for several years. In our previous study, we have demonstrated that QDTS displayed good efficacy on reducing proteinuria in mice with diabetic nephropathy (DN). However, the exact mechanism by which QDTS exerts its reno-protection remains largely unknown. Read More

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January 2021

Effects of artery input function on dynamic contrast-enhanced MRI for determining grades of gliomas.

Br J Radiol 2021 Mar 17;94(1119):20200699. Epub 2020 Dec 17.

Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Objective: To evaluate the effect of artery input function (AIF) derived from different arteries for pharmacokinetic modeling on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters in the grading of gliomas.

Methods: 49 patients with pathologically confirmed gliomas were recruited and underwent DCE-MRI. A modified Tofts model with different AIFs derived from anterior cerebral artery (ACA), ipsilateral and contralateral middle cerebral artery (MCA) and posterior cerebral artery (PCA) was used to estimate quantitative parameters such as K (volume transfer constant) and V (fractional extracellular-extravascular space volume) for distinguishing the low grade glioma from high grade glioma. Read More

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Comparison Between Blood-Brain Barrier Water Exchange Rate and Permeability to Gadolinium-Based Contrast Agent in an Elderly Cohort.

Front Neurosci 2020 30;14:571480. Epub 2020 Nov 30.

Laboratory of FMRI Technology (LOFT), USC Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.

Dynamic contrast-enhanced (DCE) MRI using intravenous injection of gadolinium-based contrast agents (GBCAs) is commonly used for imaging blood-brain barrier (BBB) permeability. Water is an alternative endogenous tracer with limited exchange rate across the BBB. A direct comparison between BBB water exchange rate and BBB permeability to GBCA is missing. Read More

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November 2020

Magnetic compression anastomosis for rectal atresia following necrotizing enterocolitis: A case report.

Medicine (Baltimore) 2020 Dec;99(50):e23613

Department of Neonatal Intensive Care Unit, The Northwest Women's and Children's Hospital, Xi'an, Shanxi, China.

Rationale: Rectal atresia caused by necrotizing enterocolitis (NEC) is a serious and rare complication in children. Magnetic compression anastomosis (MCA) has been effectively applied in children with congenital oesophageal atresia and biliary atresia. Herein, we reported a case of successfully application of MCA in an infant with rectal atresia following NEC. Read More

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December 2020

Perpendicular magnetic anisotropy in half-metallic thin-film CoCrAl.

J Phys Condens Matter 2021 Mar;33(10):105801

Department of Physics, University of Northern Iowa, Cedar Falls, IA 50614, United States of America.

Magnetocrystalline anisotropy (MCA) is one of the key parameters investigated in spin-based electronics (spintronics), e.g. for memory applications. Read More

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Diagnosis, Classification and Management of Mast Cell Activation Syndromes (MCAS) in the Era of Personalized Medicine.

Int J Mol Sci 2020 Nov 27;21(23). Epub 2020 Nov 27.

Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD 20852, USA.

Mast cell activation (MCA) is seen in a variety of clinical contexts and pathologies, including IgE-dependent allergic inflammation, other immunologic and inflammatory reactions, primary mast cell (MC) disorders, and hereditary alpha tryptasemia (HAT). MCA-related symptoms range from mild to severe to life-threatening. The severity of MCA-related symptoms depends on a number of factors, including genetic predisposition, the number and releasability of MCs, organs affected, and the type and consequences of comorbid conditions. Read More

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November 2020

Extracardiac Doppler indices predict perinatal mortality in fetuses with Ebstein anomaly and tricuspid valve dysplasia.

Prenat Diagn 2021 Feb 9;41(3):332-340. Epub 2021 Jan 9.

Department of Pediatrics, Division of Cardiology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

Objectives: Ebstein anomaly and tricuspid valve dysplasia (EA/TVD) carry high perinatal mortality. Past studies have focused on cardiac predictors of mortality; we sought to describe the fetal echo (FE) extracardiac Dopplers in this cohort and determine their association with perinatal mortality.

Method: Fetuses with EA/TVD at 23 centers from 2005-2011 were included for retrospective study. Read More

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February 2021