38 results match your criteria mbn oral


A novel nutritional mixture, MBN, prevents memory impairment via inhibiting NLRP3 inflammasome formation in 5xFAD transgenic mice.

Nutr Neurosci 2021 Apr 20:1-8. Epub 2021 Apr 20.

Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea.

Objectives: Amyloid beta (Aβ)-induced abnormal neuroinflammation is recognized as a major pathological factor of Alzheimer's disease (AD), which results in memory impairment. Inhibition of excessive neuroinflammation mediated by Aβ is considered a promising strategy to ameliorate AD symptoms. To regulate the inflammatory response, nutritional and dietary supplements have been used for centuries. Read More

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Development and Optimization of Mirabegron Solid Lipid Nanoparticles as an Oral Drug Delivery for Overactive Bladder.

Pharm Nanotechnol 2021 ;9(2):120-129

Department of Pharmaceutics, Sinhgad College of Pharmacy, Pune, India.

Background: Mirabegron (MBN), a β-3 adrenergic agent, is used in the treatment of overactive bladder. MBN has alow water solubility, high first-pass metabolism, and low bioavailability, consequently having poor absorption in the gastrointestinal tract.

Objective: The present study is intended to formulate Mirabegron-loaded solid lipid nanoparticles (MBN-SLN) coated with PEG-400 to bypass hepatic first-pass metabolism and to improve its oral bioavailability. Read More

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January 2021

Peculiarities of the mouth and colum in the youth of annous age with arterial hypertension and metabolic disorders.

Klin Lab Diagn 2020 Dec;65(11):712-716

Tver´ State Medical University.

The purpose of the work is to determine the species, quantitative composition and frequency of occurrence of microorganisms in the oral fluid and large intestine in healthy young men and having arterial hypertension, and metabolic disorders. A survey was conducted of 51 young students studying at Tver State Medical University. It was found that more than 70% of students with AH (arterial hypertension) and MBN (metabolic disorders) showed pronounced dysbiotic disorders of the intestinal microbiota of II and III degree with a decrease in the number of Lactobacillus spp. Read More

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December 2020

Effects of Zn-Doped Mesoporous Bioactive Glass Nanoparticles in Etch-and-Rinse Adhesive on the Microtensile Bond Strength.

Nanomaterials (Basel) 2020 Sep 29;10(10). Epub 2020 Sep 29.

Department of Orthodontics, Dental Research Institute, Pusan National University, Yangsan 50612, Korea.

The purpose of this study was to assess the effects in the dentin bond strength of dental adhesives (DAs) and biological effects using zinc (Zn)-doped mesoporous bioactive glass nanoparticles (MBN-Zn). Synthesized MBN and MBN-Zn were characterized by scanning electron microscopy (SEM), X-ray diffraction and the Brunauer, Emmett and Teller (BET) method. The matrix metalloproteinases (MMP) inhibition effects of DA-MBN and DA-MBN-Zn were analyzed. Read More

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September 2020

The Effect of Mesoporous Bioactive Glass Nanoparticles/Graphene Oxide Composites on the Differentiation and Mineralization of Human Dental Pulp Stem Cells.

Nanomaterials (Basel) 2020 Mar 27;10(4). Epub 2020 Mar 27.

Department of Orthodontics, Dental Research Institute, Pusan National University, Yangsan 50612, Korea.

The purpose of this study was to investigate the effects of mesoporous bioactive glass nanoparticle (MBN)/graphene oxide (GO) composites on the mineralization ability and differentiation potential of human dental pulp stem cells (hDPSCs). MBN/GO composites were synthesized using the sol-gel method and colloidal processing to enhance the bioactivity and mechanical properties of MBN. Characterization using FESEM, XRD, FTIR, and Raman spectrometry showed that the composites were successfully synthesized. Read More

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Cyclo-oxygenase-2 Expression Is Associated With Lymph Node Metastasis in Oropharyngeal Squamous Cell Carcinoma Under the New TNM Classification.

Anticancer Res 2019 Oct;39(10):5623-5630

Department of Otorhinolaryngology, Head and Neck Surgery, Keio University, School of Medicine, Tokyo, Japan.

Background: This study aimed to investigate p16 and COX2 expression in oropharyngeal squamous cell carcinoma (OPSCC), and evaluate the prognostic role of COX2 expression under the new TNM classification.

Materials And Methods: Biopsy specimens obtained from 75 patients with OPSCC were stained for p16 and COX2 expression immunohistochemically. The results and clinical records were analyzed retrospectively. Read More

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October 2019

Striking Differences in Platelet Distribution between Advanced-Platelet-Rich Fibrin and Concentrated Growth Factors: Effects of Silica-Containing Plastic Tubes.

J Funct Biomater 2019 Sep 17;10(3). Epub 2019 Sep 17.

Division of Oral Bioengineering, Institute of Medicine and Dentistry, Niigata University, Niigata 951-8514, Japan.

Compared with platelet-rich plasma, the preparation of platelet-rich fibrin (PRF) is simple and has not been overly modified. However, it was recently demonstrated that centrifugation conditions influence the composition of PRF and that silica microparticles from silica-coated plastic tubes can enter the PRF matrix. These factors may also modify platelet distribution. Read More

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September 2019

Evidence for Contamination of Silica Microparticles in Advanced Platelet-Rich Fibrin Matrices Prepared Using Silica-Coated Plastic Tubes.

Biomedicines 2019 Jun 19;7(2). Epub 2019 Jun 19.

Division of Oral Bioengineering, Institute of Medicine and Dentistry, Niigata University, Niigata 951-8514, Japan.

Platelet-rich fibrin (PRF) therapy has been widely applied in regenerative dentistry, and PRF preparation has been optimized to efficiently form fibrin clots using plain glass tubes. Currently, a shortage of commercially available glass tubes has forced PRF users to utilize silica-coated plastic tubes. However, most plastic tubes are approved by regulatory authorities only for diagnostic use and remain to be approved for PRF therapy. Read More

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Spectrophotometric Determination of the Aggregation Activity of Platelets in Platelet-Rich Plasma for Better Quality Control.

Dent J (Basel) 2019 Jun 3;7(2). Epub 2019 Jun 3.

Division of Oral Bioengineering, Institute of Medicine and Dentistry, Niigata University, Niigata 951-8514, Japan.

Although platelet-rich plasma (PRP) is now widely used in regenerative medicine and dentistry, contradictory clinical outcomes have often been obtained. To minimize such differences and to obtain high quality evidence from clinical studies, the PRP preparation protocol needs to be standardized. In addition, emphasis must be placed on quality control. Read More

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Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization.

Nanomaterials (Basel) 2019 Apr 10;9(4). Epub 2019 Apr 10.

Department of Orthodontics, Dental Research Institute, Pusan National University Dental Hospital, Yangsan 50612, Korea.

Dentin hypersensitivity (DH) is one of the most common clinical conditions usually associated with exposed dentinal surfaces. In this study, we identified the effectiveness of poly(amidoamine) (PAMAM) dendrimer-coated mesoporous bioactive glass nanoparticles (MBN) ([email protected]) on DH treatment, examining the ion-releasing effect, dentin remineralization, and the occluding effect of dentinal tubules. We synthesized MBN and [email protected] Read More

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Acid-Responsive H -Releasing 2D MgB Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy.

Adv Healthc Mater 2019 07 10;8(13):e1900157. Epub 2019 Apr 10.

Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 1066 Xueyuan Road, Nanshan District, Shenzhen, 518060, Guangdong, China.

The hydrogen molecule is recognized as a high potential to attenuate toxic side effects of chemotherapy and also enhance chemotherapeutic efficacy, and the development of a novel hydrogen-generating prodrug for facile, safe, and efficient hydrogen delivery is vitally important for combined hydrogenochemotherapy but is still challenging. Here, targeting gastric cancer, a 2D magnesium boride nanosheet (MBN) is synthesized as a new type of acid-responsive hydrogen-releasing prodrug by an ultrasound-assisted chemical etching route, which is used to realize hydrogenochemotherapy by combination of facile oral administration of polyvinylpyrrolidone (PVP)-encapsulating MBN ([email protected]) pills with routine intravenous injection of doxorubicin (DOX). The [email protected] pill has high stability in normal tissues/blood environments as well as high gastric acid-responsiveness with sustained release behavior, which matches well with its metabolism rate in the stomach in great favor of continuous and long-term hydrogen administration. Read More

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Ultrasound-guided mandibular nerve block with local anesthetic and low-molecular weight dextran helps reduce anesthetic requirements for parotidectomy.

Minerva Anestesiol 2019 02 10;85(2):202-203. Epub 2018 Sep 10.

Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Kochi, Japan.

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February 2019

Quality Assessment of Platelet-Rich Fibrin-Like Matrix Prepared from Whole Blood Samples after Extended Storage.

Biomedicines 2017 Sep 18;5(3). Epub 2017 Sep 18.

Division of Oral Bioengineering, Institute of Medicine and Dentistry, Niigata University, Niigata 9518514, Japan.

The platelet-rich fibrin-like matrix (PRFM) is usually prepared onsite and immediately used for regenerative therapy. Nonetheless, to meet the clinical necessity of preserving the PRFM without quality deterioration, we developed a method for preparation of PRFMs from short-term-stored whole blood (WB) samples. In this study, to evaluate the practical expiration date of storage, we extended the storage time of WB samples from 2 to 7 days and assessed the quality of the resulting PRFMs. Read More

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September 2017

Optimal age classification of young individuals based on dental evidence in civil and criminal proceedings.

Int J Legal Med 2013 Nov 1;127(6):1157-64. Epub 2013 Oct 1.

Department of Statistics and Computer Science, University of Florence, Viale Morgagni 59, 50134, Florence, Italy.

Background: Criminal cases involving young people, irregular immigration and the many issues related to asylum seekers has increased the judicial demand of age estimation. Calcification of teeth and specifically of third molar has demonstrated to be reliable evidence to estimate age respect to 18 years threshold of age.

Aims: As prosecution of research of Pinchi et al. Read More

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November 2013

Dexmedetomidine decreases the oral mucosal blood flow.

Br J Oral Maxillofac Surg 2013 Dec 17;51(8):928-31. Epub 2013 Aug 17.

Department of Dental Anesthesiology, Ohu University, School of Dentistry, Fukushima, Japan. Electronic address:

There is an abundance of blood vessels in the oral cavity, and intraoperative bleeding can disrupt operations. There have been some interesting reports about constriction of vessels in the oral cavity, one of which reported that gingival blood flow in cats is controlled by sympathetic α-adrenergic fibres that are involved with vasoconstriction. Dexmedetomidine is a sedative and analgesic agent that acts through the α-2 adrenoceptor, and is expected to have a vasoconstrictive action in the oral cavity. Read More

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December 2013

Cellular blue nevus (CBN) lymph node metastases of the neck with no primary skin lesion: a case report and review of literature.

J Craniomaxillofac Surg 2010 Dec 12;38(8):601-4. Epub 2010 Mar 12.

Department of Oral and Maxillofacial Surgery, Martin-Luther-University Halle-Wittenberg, Germany.

A case of cervical lymph node infiltration by a benign cellular blue nevus (CBN) and a 27-year disease history is presented. Dermal dendritic melanocytes and pigmented spindle cells presented no histological evidence of malignancy (CD34-, desmin-, PanCy-, HMB-45+, anti-S-100+, Bcl-2+, MART-1+, focally expression of melan A, 1% Ki-67+ of the tumour cell nucleoli). The differentiation of the benign blue nevus (BN) from a malignant blue nevus (MBN) and a malignant melanoma (MM) is still a challenge. Read More

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December 2010

Steroid hormone control of cell death and cell survival: molecular insights using RNAi.

PLoS Genet 2009 Feb 13;5(2):e1000379. Epub 2009 Feb 13.

The Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.

The insect steroid hormone ecdysone triggers programmed cell death of obsolete larval tissues during metamorphosis and provides a model system for understanding steroid hormone control of cell death and cell survival. Previous genome-wide expression studies of Drosophila larval salivary glands resulted in the identification of many genes associated with ecdysone-induced cell death and cell survival, but functional verification was lacking. In this study, we test functionally 460 of these genes using RNA interference in ecdysone-treated Drosophila l(2)mbn cells. Read More

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February 2009

Salivary gland scintigraphy in gastro-esophageal reflux disease.

Inflammopharmacology 2007 Aug;15(4):141-5

Department of General Medicine and Emergency Care, Toho University School of Medicine, 6-11-1, Omori-Nishi, Ota-Ku, Tokyo 143-8541, Japan.

Unlabelled: Gastro-esophageal reflux disease (GERD) is associated with a decreased salivary flow as well as gastric acid production. This study therefore aimed to investigate functional disorders of salivary glands in patients with GERD.

Methods: Thirty-one consecutive patients with GERD underwent salivary gland scintigraphy. Read More

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Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head and neck cancer.

Anticancer Res 2007 Jul-Aug;27(4B):2189-95

National Institute of Sensory Organs, National Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan.

Background: The relation of connexins and carcinogenesis has been studied in various organs and cell lines, with connexins currently being considered tumor suppressors.

Materials And Methods: The expression of connexin-26 (Cx26) and connexin-30 (Cx30) in human head and neck carcinomas, as well as in adjacent normal mucosa, was evaluated by immunohistochemistry. Furthermore, the expression of these connexins with regard to apoptosis and cell differentiation was investigated. Read More

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September 2007

Seventy-five gram glucose tolerance test to assess carbohydrate malabsorption and small bowel bacterial overgrowth.

World J Gastroenterol 2006 May;12(19):3092-5

Department of General Medicine and Emergency Care, Toho University School of Medicine, Omori Hospital, Ota-Ku, Tokyo 143-8541, Japan.

Aim: To investigate non-invasively the incidence of absorption of carbohydrates in diabetic patients during an oral glucose tolerance test (OGTT) and to determine whether malabsorption may be associated with insulin secretion and insulin resistance.

Methods: A standard 75-g OGTT was performed in 82 diabetic patients. The patients received 75 g of anhydrous glucose in 225 mL of water after an overnight fasting and breath samples were collected at baseline and up to 120 min after ingestion. Read More

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The repressive effect of green tea ingredients on amyloid precursor protein (APP) expression in oral carcinoma cells in vitro and in vivo.

Cancer Lett 2007 Jan 3;245(1-2):81-9. Epub 2006 Feb 3.

Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan, ROC.

In a hamster model of N-methyl-N-benzylnitrosamine (MBN)-induced oral carcinogenesis, the incidence of buccal pouch (HBP) carcinomas in MBN-treated hamsters (17.8+/-7.5) was significantly higher than MBN-treated hamsters given tea (10. Read More

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January 2007

Breath sample collection through the nostril reduces false-positive results of 13C-urea breath test for the diagnosis of helicobacter pylori infection.

Dig Liver Dis 2004 Oct;36(10):661-5

Division of Gastroenterology and Hepatology, Toho University School of Medicine, Tokyo, Japan.

Background: One of the disadvantages of '3C-urea breath test is possible interference by urease activity not related to Helicobacterpylori.

Aims: We design the simple and non-invasive modification to avoid the contamination of 13CO(2) produced in the mouth.

Patients And Methods: One hundred and twenty-nine patients who underwent diagnostic upper endoscopy were enrolled. Read More

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October 2004

Successfully treated case of cervical abscess and mediastinitis due to esophageal perforation after gastrointestinal endoscopy.

Dis Esophagus 2002 ;15(3):250-2

First Department of Surgery, Juntendo University School of Medicine, Ouji Hospital, Tokyo, Japan.

Perforations of the esophagus are uncommon complications of flexible gastrointestinal endoscopy. Perforations after endoscopy are likely to occur in the cervical esophagus, where fiber insertion is difficult anatomically. The diagnosis should be made as soon as possible, because mediastinitis and sepsis frequently develop following esophageal perforations. Read More

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Pharmacoepidemiologic detection of calcium channel blocker-induced change on digoxin clearance using multiple trough screen analysis.

Biopharm Drug Dispos 2002 Jul;23(5):173-81

Department of Hospital Pharmacy, Kyushu Kosei-Nenkin Hospital, 2-1-1 Kishinoura, Yahatanishi-Ku, Kitakyushu 806-8501, Japan.

Nonlinear mixed effects modeling was used to estimate the effects of digoxin-calcium channel blockers (verapamil, diltiazem, nifedipine) in 336 serum levels gathered from 172 patients (104 male and 68 female) receiving oral digoxin as hospital in-patients. The final model describing digoxin clearance (CL) was CL (l/day)=(87.9+2. Read More

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A phase I study of combination chemotherapy with gemcitabine and oral UFT for advanced non-small cell lung cancer.

Br J Cancer 2002 Jun;86(11):1701-4

Division of Respiratory Diseases, Kumamoto Regional Medical Center, 5 Cho-me 16-10 Honjou, Kumamoto City 860 0811, Japan.

A phase I study was carried out to determine the optimal dose and administration schedule for combined UFT plus gemcitabine therapy in patients with non-small cell lung cancer. Twenty-four patients (including 11 patients previously treated with cisplatin as the key drug) received oral UFT 400 mg x m(-2) on days 1 to 14 with intravenous infusions of gemcitabine (800 mg x m(-2) on days 8 and 15, or 900 mg x m(-2) on days 8 and 15, or 900 mg x m(-2) on days 1, 8 and 15). The most appropriate dosing option appeared to be 400 mg x m(-2) per day of oral UFT for 14 consecutive days with 900 mg x m(-2) gemcitabine on days 8 and 15. Read More

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Rapid in vivo assay for topical oral cancer chemopreventive agents.

Int J Oncol 2002 Jul;21(1):159-64

Department of Pathology, Northwestern University Medical School, Chicago, IL 60611, USA.

The cancer chemopreventive effect of topically applied phenethyl isothiocyanate (PEIT) was examined in a hamster buccal pouch model, in which squamous cell carcinomas (SCC) are induced at high frequency, by topical application of N-methyl-N-benzylnitrosamine (MBN). The buccal pouches of eleven hamsters were pretreated thrice-weekly for two weeks with corn oil (CO) containing 50 mM PEIT, followed by 22 weeks of twice-weekly application of CO containing MBN and PEIT, both at 50 mM. Under similar conditions, twelve hamsters were pretreated with CO for 2 weeks, followed by MBN in CO. Read More

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Population-based investigation of relative clearance of digoxin in Japanese neonates and infants by multiple-trough screen analysis.

Eur J Clin Pharmacol 2001 Apr;57(1):19-24

Department of Hospital Pharmacy, Kyushu Kosei-Nenkin Hospital, 2-1-1 Kishinoura, Yahatanishi-Ku, Kitakyushu 806-8501, Japan.

Objective: The steady-state concentrations of digoxin at trough levels were studied to establish the role of patient characteristics in estimating doses for digoxin using routine therapeutic drug monitoring data.

Method: The data (n = 448) showing steady state after repetitive oral administration in 172 hospitalized neonates and infants were analyzed using Nonlinear Mixed Effect Model (NONMEM), a computer program designed to analyze pharmacokinetics in study populations by allowing pooling of data. Analysis of the pharmacokinetics of digoxin was accomplished using a simple steady-state pharmacokinetic model. Read More

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[Combined laparoscopic-endoscopic procedure in stomach carcinoma].

Chirurg 2000 Oct;71(10):1193-201

Abteilung für Chirurgie, East-Hospital, Kitasato Universität, Tokyo, Japan.

The purpose of this review is to outline the laparoscopic-endoscopic procedures that we perform for early gastric cancer. These procedures were applied to 29 patients. Preoperative work-up included gastric endoscopy, barium X-ray examination, endoscopic ultrasonography, and histological examination, and surgery was performed in patients diagnosed as having mucosal gastric cancer for which endoscopic mucosal resection (EMR) was difficult. Read More

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October 2000

P53 expression, p53 and Ha-ras mutation and telomerase activation during nitrosamine-mediated hamster pouch carcinogenesis.

Carcinogenesis 2000 Jul;21(7):1441-51

Faculty of Dentistry and Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan, ROC.

Squamous cell carcinomas (SCC) induced in hamster buccal pouch (HBP) by 22 weeks of topical N-methyl-N-benzylnitrosamine (MBN) treatment (twice-weekly, 10 mg MBN/ml propylene glycol) were evaluated for: (i) altered expression of p53 using immunohistochemistry (IHC); (ii) mutations in Ha-ras and p53 using PCR/single strand conformation polymorphism (SSCP); (iii) telomerase activity using the telomerase repeat amplification protocol (TRAP). Precancerous lesions were also evaluated using p53 IHC. Hamsters were killed for lesion analysis at either 3 days (group A, eight hamsters, 89 carcinomas) or 7 weeks (group B, six hamsters, 105 carcinomas) following the final MBN application. Read More

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Corticosteroid-induced pancreatitis in patients with autoimmune bullous disease: case report and prospective study.

Dermatology 1999 ;198(3):304-6

Department of Dermatology, Saitama Medical Center, Saitama Medical School, Saitama, Japan.

Corticosteroid pulse therapy using very high doses may produce corticosteroid-induced pancreatitis (CIP) that is unexpected during conventional oral corticosteroid therapy and may sometimes be fatal. Our goal was to evaluate the relation between pulse corticosteroid administration and pancreatitis. A case of CIP is reported, and a prospective study was performed. Read More

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