J Clin Epidemiol 2021 Apr 6. Epub 2021 Apr 6.
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands; Health Data Research UK and Institute of Health Informatics, University College London, Gibbs Building, 215 Euston Road, London, NW1 2BE, United Kingdom. Electronic address:
Objective: To illustrate how to evaluate the need of complex strategies for developing generalizable prediction models in large clustered datasets.
Study Design And Setting: We developed eight Cox regression models to estimate the risk of heart failure using a large population-level dataset. These models differed in the number of predictors, the functional form of the predictor effects (non-linear effects and interaction) and the estimation method (maximum likelihood and penalization). Read More