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FREQUENT LEPTOSPIRA SPP. DETECTION BUT ABSENCE OF TULA ORTHOHANTAVIRUS IN MICROTUS SPP. VOLES, NORTHWESTERN SPAIN.

J Wildl Dis 2021 Jul 28. Epub 2021 Jul 28.

Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493 Greifswald-Insel Riems, Germany.

The common vole (Microtus arvalis) is a major agricultural pest in Europe and is a reservoir for several zoonotic agents, such as Leptospira spp. and Tula orthohantavirus (TULV). However, little is known about the occurrence of those pathogens in voles from Spain, where the species has largely expanded its distribution range in the past decades, causing agricultural pests and zoonotic diseases. Read More

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Allele Mining in Diverse Accessions of Tropical Grasses to Improve Forage Quality and Reduce Environmental Impact.

Ann Bot 2021 Jul 28. Epub 2021 Jul 28.

Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.

Background And Aims: The C4 Urochloa spp (syn. Brachiaria) and Megathyrsus maximus (syn. Panicum maximum) are used as pasture for cattle across vast areas in tropical agriculture systems in Africa and South America. Read More

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Use of Artificial Intelligence for Optimizing Biosorption of Textile Wastewater using Agricultural waste.

Environ Technol 2021 Jul 28:1-35. Epub 2021 Jul 28.

Department of Hydrology, Indian Institute of Technology Roorkee, India - 247667, Email:

Most of the dyes are toxic and non-biodegradable in textile industry wastewaters. Therefore, removal of textile dye using agriculture waste becomes crucial for the environment. This can be accomplished by the biosorption process which is passive uptake of pollutants by agricultural waste. Read More

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Absence of QTc Prolongation with Sodium N-(8-[2-Hydroxybenzoyl] Amino) Caprylate (SNAC), an Absorption Enhancer Co-Formulated with the GLP-1 Analogue Semaglutide for Oral Administration.

Diabetes Ther 2021 Jul 28. Epub 2021 Jul 28.

Novo Nordisk A/S, Søborg, Denmark.

Introduction: Oral delivery of proteins, including glucagon-like peptide 1 (GLP-1) receptor agonists, is impeded by low gastrointestinal permeation. Oral semaglutide has been developed for once-daily oral administration by co-formulation of the GLP-1 analogue semaglutide with an absorption enhancer, sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC, 300 mg). A randomised, partially double-blind, placebo-controlled thorough QT/corrected QT (QTc) trial was conducted to confirm the absence of unacceptable QTc interval prolongation with SNAC. Read More

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Extracellular volume-guided late gadolinium enhancement analysis for non-ischemic cardiomyopathy: The Women's Interagency HIV Study.

BMC Med Imaging 2021 Jul 27;21(1):116. Epub 2021 Jul 27.

Division of Radiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street MR 110, Baltimore, MD, 21287, USA.

Background: Quantification of non-ischemic myocardial scar remains a challenge due to the patchy diffuse nature of fibrosis. Extracellular volume (ECV) to guide late gadolinium enhancement (LGE) analysis may achieve a robust scar assessment.

Methods: Three cohorts of 80 non-ischemic-training, 20 non-ischemic-validation, and 10 ischemic-validation were prospectively enrolled and underwent 3. Read More

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Recent Achievements about Targeted Alpha Therapy-Based Targeting Vectors and Chelating Agents.

Anticancer Agents Med Chem 2021 Jul 27. Epub 2021 Jul 27.

Department of Nuclear Medicine and Molecular Imaging, Clinical Development Research Unit of Farshchian Heart Center, Hamadan University of Medical Sciences, Hamadan, Iran.

One of the most rapidly growing options in the management of cancer therapy is Targeted Alpha Therapy (TAT) through which lethal α-emitting radionuclides conjugated to tumor-targeting vectors selectively deliver high amount of radiation to cancer cells.Ac, Bi, At, Bi, and Ra have been investigated by plenty of clinical trials and preclinical researches for the treatment of smaller tumor burdens, micro-metastatic disease, and post-surgery residual disease. In order to send maximum radiation to tumor cells while minimizing toxicity in normal cells, a high affinity of targeting vectors to cancer tissue is essential. Read More

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Tendons exhibit greater resistance to tissue and molecular-level damage with increasing strain rate during cyclic fatigue.

Acta Biomater 2021 Jul 24. Epub 2021 Jul 24.

Department of Biomedical Engineering; Scientific Computing and Imaging Institute; Department of Orthopaedics; School of Computing, University of Utah, Salt Lake City, Utah, USA. Electronic address:

Musculoskeletal soft connective tissues are commonly injured due to repetitive use, but the evolution of mechanical damage to the tissue structure during repeated loading is poorly understood. We investigated the strain rate dependence of mechanical denaturation of collagen as a form of structural microdamage accumulation during creep fatigue loading of rat tail tendon fascicles. We cycled tendons at three strain rates to the same maximum stress relative to their rate-dependent tensile strength. Read More

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Preparation and characterization of chitosan/polyvinyl porous alcohol aerogel microspheres with stable physicochemical properties.

Int J Biol Macromol 2021 Jul 24. Epub 2021 Jul 24.

Key Laboratory of Bionic Engineering (Ministry of Education), College of Biological and Agricultural Engineering, Jilin University, Changchun 130022, China. Electronic address:

Chitosan/polyvinyl alcohol (CS/PVA) porous aerogel microspheres with stable physicochemical properties were obtained by gelation and freeze-drying process, and modified by adding different content of polyvinyl alcohol (PVA) into the microspheres. The physicochemical properties of porous aerogel microspheres, including porosity, swelling degree, acid-base resistance and compression performance were compared with chitosan (CS) microspheres. The microspheres were characterized by scanning electronic microscopy, Fourier transform infrared spectra, X-ray diffraction and compression test. Read More

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Surface oxidation-induced restructuring of liquid Pd-Ga SCALMS model catalysts.

Phys Chem Chem Phys 2021 Jul 27. Epub 2021 Jul 27.

Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Lehrstuhl für Physikalische Chemie II, Egerlandstr. 3, 91058 Erlangen, Germany.

We have examined model systems for the recently reported Pd-Ga Supported Catalytically Active Liquid Metal Solutions (SCALMS) catalysts using near-ambient pressure X-ray photoelectron spectroscopy (NAP-XPS) under oxidizing conditions. Gallium is known to be highly prone to oxidation and in practical applications, handling of the catalyst material in air or the presence of traces of oxygen in the reactor are unavoidable. Therefore, we expect our results to be of high relevance for the application of Ga-based SCALMS catalysts. Read More

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Effects of light-felling intensity on hydrological effects of litter in Korean pine forests by 'planting conifer and preserving broadleaved tree' in Xiaoxing'an Mountains of China.

Ying Yong Sheng Tai Xue Bao 2021 Jul;32(7):2335-2346

Center for Ecological Research, Northeast Forestry University, Harbin 150040, China.

To understand the effects of 'planting conifer and preserving broadleaved tree' and light-felling on the hydrological effects of litter layer during the restoration of the climax vegetation broad-leaved Korean pine forest in temperate zone of Northeast China, we measured litter accumulation, water holding process of litter, and maximum holding water, maximum blocking and effective blocking amount of litter layers using sample survey method and indoor immersion method in three forests (aspen-Korean pine forests, white birch-Korean pine forest, and Mongolian oak-Korean pine forest) under different light-felling intensity (control, C; low light-felling, L; moderate light-felling, M; heavy light-felling, H) in Xiaoxing'an Mountains. The results showed that the intensity of light-felling had different effects on litter accumulation (7.32 to 15. Read More

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Influence of Insulin Application Time and High-Intensity Intermittent Exercise on Hypoglycemic Risk in Adolescents With Type 1 Diabetes.

Pediatr Exerc Sci 2021 Jul 26:1-7. Epub 2021 Jul 26.

Federal University of Paraná.

Purpose: The study analyzed the influence of exercise on hypoglycemia episodes postexercise and in the subsequent 24 hours in children and adolescents with type 1 diabetes.

Methods: Thirty young people performed the same protocol of physical exercises for 1 hour (Ex1h) and 2 hours (Ex2h) after the administration of insulin. They performed 30 minutes of exercise on a cycle ergometer with a load of 60% of maximal oxygen uptake, interspersed with maximum intensity sprints lasting 10 seconds every 5 minutes. Read More

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[Emission Characteristics and Atmospheric Chemical Reactivity of Volatile Organic Compounds(VOCs) in Automobile Repair Industry].

Huan Jing Ke Xue 2021 Aug;42(8):3604-3614

Beijing Municipal Research Institute of Environmental Protection, Beijing 100037, China.

Volatile organic compounds (VOCs) emitted by the automobile repair industry are an important source of ozone precursors. However, the current reduction policy generally focuses on the emissions of VOCs, without considering their chemical reactivity. Based on an investigation of the development status of China's automobile repair industry, this study analyzes VOCs emission nodes in different sections of automobile repair enterprises. Read More

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Green Synthesis of Gold Nano-bioconjugates from Onion Peel Extract and Evaluation of Their Antioxidant, Anti-inflammatory, and Cytotoxic Studies.

ACS Omega 2021 Jul 8;6(28):17811-17823. Epub 2021 Jul 8.

Material Nanochemistry Laboratory, Physical Sciences Division, Institute of Advanced Study in Science and Technology, Paschim Boragaon, Garchuk, Guwahati 781035, India.

Plant secondary metabolites such as flavonoids demonstrate high degrees of antioxidant, anti-inflammatory, and anticancer activities. Among flavonoids, quercetin plays an important role in inflammation by downregulating the level of various cytokines. Thereby, in this work, onion () peel was successfully utilized for the synthesis of gold nano-bioconjugates acting as a natural therapeutic drug. Read More

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Performance evaluation of FAO Penman-Monteith and best alternative models for estimating reference evapotranspiration in Bangladesh.

Heliyon 2021 Jul 7;7(7):e07487. Epub 2021 Jul 7.

Department of Environmental Sciences, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.

Proper assessment of reference evapotranspiration ( ) is necessary for pastoral activity and water management. The Penman-Monteith FAO56 ( ) method has been recommended as the identical estimation model; nonetheless, it belongs to a vast climatic data requirement. There is an urgent need to discover an ideal alternate model for evaluating in particular places where all climatic data is insufficient. Read More

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A Lytic Bacteriophage Obtained From the Bone Marrow of in a Plague-Focus Area in China.

Front Cell Infect Microbiol 2021 8;11:700322. Epub 2021 Jul 8.

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

A lytic phage vB_YpPYepMm (also named YepMm for briefly) was first isolated from the bone marrow of a who died of natural causes on the Qinghai-Tibet plateau in China. Based on its morphologic (isometric hexagonal head and short non-contractile conical tail) and genomic features, we classified it as belonging to the family. At the MOI of 10, YepMm reached maximum titers; and the one-step growth curve showed that the incubation period of the phage was about 10 min, the rise phase was about 80 min, and the lysis amount of the phage during the lysis period of 80 min was about 187 PFU/cell. Read More

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Biomechanics of Different Types of PEEK as Implant Materials for Implant-Retained Mandibular Overdentures.

Eur J Prosthodont Restor Dent 2021 Jul 5. Epub 2021 Jul 5.

Associate Professor, Prosthodontics Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Purpose: To evaluate the biomechanical behavior of different types of PEEK as implant materials for mandibular implant-retained overdentures.

Materials & Methods: Virtual models of mandibular overdentures retained by two interforaminal implants were simulated. In each model, one implant material was assumed resulting in four models; titanium, carbon-reinforced PEEK, ceramic-filled PEEK and unfilled PEEK models. Read More

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Evaluation of essential and non-essential elemental composition of commonly used medicinal plants from district Peshawar, Khyber Pakhtunkhwa, Pakistan.

Environ Sci Pollut Res Int 2021 Jul 24. Epub 2021 Jul 24.

Centralized Resource Laboratory, University of Peshawar, Peshawar, 25120, Pakistan.

This study illustrates a profile of some essential and non-essential elements (Na, K, Mg, Ca, Cu, Zn, Mn, Fe, Pb, Cr, Cd, Co, Al, and Sn) in the aerial parts of six medicinal plants, i.e. Coriandrum sativum L. Read More

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Application of tunable resistive pulse sensing for the quantification of submicron particles in pharmaceutical monoclonal antibody preparations.

J Pharm Sci 2021 Jul 22. Epub 2021 Jul 22.

Ludwig-Maximilians Universität München, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Butenandtstraße 5-13, 81377 Munich, Germany.

Tunable resistive pulse sensing (TRPS, qNano Gold, IZON Ltd.) was investigated as a method to quantify submicron particles (SMPs) between 0.1 and 1 µm in solutions of biopharmaceuticals. Read More

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Simultaneous monitoring assay for T-cell receptor stimulation-dependent activation of CD4 and CD8 T cells using inducible markers on the cell surface.

Biochem Biophys Res Commun 2021 Jul 21;571:53-59. Epub 2021 Jul 21.

Laboratory of Immunosenescence, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan. Electronic address:

Isolation of antigen (Ag)-specific T cells is an important step in the investigation of T-cell immunity. Activation-induced markers (AIMs), such as CD154/tumor necrosis factor (TNF)/CD107A/CD134/CD137 enable the sorting of Ag-specific T cells without using human leukocyte antigen (HLA)-multimers. However, optimal conditions suitable for simultaneous detection of both Ag-specific CD4 and CD8 T cells have not been investigated. Read More

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Effect of KHPO-modified biochar on immobilization of Cr, Cu, Pb, Zn and as during anaerobic digestion of swine manure.

Bioresour Technol 2021 Jul 15;339:125570. Epub 2021 Jul 15.

State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology (SKLUWRE, HIT), Harbin 150090, PR China; School of Environment, Harbin Institute of Technology, Harbin 150090, PR China. Electronic address:

In this study, the immobilization performance and mechanisms of heavy metals (HMs) in swine manure (SM) during anaerobic digestion (AD) with biochar (BC) and KHPO-modified biochar (BP) were investigated. BC and BP addition decreased DTPA-extractable Cr, Cu, Pb and Zn amount, transformed these HMs to more stable state, and decreased the ecological risks of these HMs by 2 grades accordingly. BP exhibited a higher passivation efficiency for Cr, Cu and Pb and 5% -10% biochar dosage showed the maximum passivation effects. Read More

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Methotrexate-Loaded Gelatin and Polyvinyl Alcohol (Gel/PVA) Hydrogel as a pH-Sensitive Matrix.

Polymers (Basel) 2021 Jul 14;13(14). Epub 2021 Jul 14.

Innovation Cell Sarojaayudh Vastram Bharath Pvt. Ltd., Bengaluru 560039, India.

The aim was to formulate and evaluate Gel/PVA hydrogels as a pH-sensitive matrix to deliver methotrexate (MTX) to colon. The primed Gel/PVA hydrogels were subjected to evaluation for swelling behavior, diffusion coefficient, sol-gel characteristic and porosity using an acidic (pH 1.2) and phosphate buffer (PBS) (pH 6. Read More

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Hydrogels Based on Poly([2-(acryloxy)ethyl] Trimethylammonium Chloride) and Nanocellulose Applied to Remove Methyl Orange Dye from Water.

Polymers (Basel) 2021 Jul 10;13(14). Epub 2021 Jul 10.

Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile (USACH), Santiago 9160000, Chile.

Bio-based hydrogels that adsorb contaminant dyes, such as methyl orange (MO), were synthesized and characterized in this study. The synthesis of poly([2-(acryloyloxy)ethyl] trimethylammonium chloride) and poly(ClAETA) hydrogels containing cellulose nanofibrillated (CNF) was carried out by free-radical polymerization based on a factorial experimental design. The hydrogels were characterized by Fourier transformed infrared spectroscopy, scanning electron microscopy, and thermogravimetry. Read More

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Mechanical and Durability Properties of Latex-Modified Hybrid Fiber-Reinforced Roller-Compacted Rapid-Set Cement Concrete for Pavement Repair.

Materials (Basel) 2021 Jul 16;14(14). Epub 2021 Jul 16.

Department of Regional Construction Engineering, Kongju National University, Yesan 32439, Korea.

This study evaluated the mechanical properties and durability performance of latex-modified hybrid fiber-reinforced roller-compacted rapid-set cement concrete (LMHFRCRSC) for emergency repair of concrete pavement. Experimental parameters included the blend ratio of the hybrid fiber, which comprised natural jute fiber (0-0.2 vol. Read More

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The Effect of Various Si/Al, Na/Al Molar Ratios and Free Water on Micromorphology and Macro-Strength of Metakaolin-Based Geopolymer.

Materials (Basel) 2021 Jul 9;14(14). Epub 2021 Jul 9.

School of Civil Engineering, Northeast Forestry University, Harbin 150040, China.

The current work aimed to explore the effect of Na/Al ratios of 0.43, 0.53, 0. Read More

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Antioxidant and anti-aging carbon quantum dots using tannic acid.

Nanotechnology 2021 Jul 23;32(41). Epub 2021 Jul 23.

Department of Nanoscience and Engineering, Inje University, Gimhae, 50834, Republic of Korea.

Overexpression of collagenase, elastase, and tyrosinase is caused by external factors such as ultraviolet (UV) radiation and stress, resulting in wrinkle formation and freckles through the loss of skin elasticity and skin pigmentation. In this study, we developed novel carbon quantum dots (CQDs) with antioxidant and anti-aging properties using tannic acid as a carbon source through a simple microwave-assisted pyrolysis method. The synthesized tannic acid-derived CQDs (T-CQDs) showed bright blue fluorescence (QY = 28. Read More

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Efficient biosynthesis of D-allulose in Bacillus subtilis through D-psicose 3-epimerase translation modification.

Int J Biol Macromol 2021 Jul 20;187:1-8. Epub 2021 Jul 20.

College of Light Industry and Food Engineering, Guangxi University, 100 Daxue Road, Nanning 530004, Guangxi, China; Sugar Industry Collaborative Innovation Center, Guangxi University, 100 Daxue Road, Nanning 530004, Guangxi, China. Electronic address:

The combined catalysis of glucose isomerase (GI) and D-psicose 3-epimerase (DPEase) provided a convenient route for the direct synthesis of D-allulose from d-glucose, whose cost is lower than d-fructose. In the present research, the weak activity of DPEase was the key rate-limiting step and resulted in the accumulation of d-fructose in engineered Bacillus subtilis. Then, the 5'-untranslated region (5'-UTR) structure of the mRNA translational initiation region was optimized for the precise control of DPEase expression. Read More

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Optical absorbance of the tympanic membrane in rat and human samples.

PLoS One 2021 22;16(7):e0254902. Epub 2021 Jul 22.

Department of Otorhinolaryngology, Hannover Medical School, Hannover, Germany.

Chronic infections are often connected to biofilm formation. In presence of implants, this can lead to loss of the implant. Systemic or local application of drugs is relatively ineffective in case of biofilm formation. Read More

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Investigation of the usage potential of calcium alginate beads functionalized with sodium dodecyl sulphate (SDS) for wastewater treatment contaminated with waste motor oil.

Water Environ Res 2021 Jul 20. Epub 2021 Jul 20.

Department of Environmental Engineering, Mersin University, Mersin, Turkey.

In this study, calcium alginate (Ca-Alg) beads, an inexpensive, easily available, biodegradable material, were activated with anionic surfactant and used for the treatment of wastewater contaminated with waste motor oil. First, polyethyleneimine (PEI) was used to bind sodium dodecyl sulfate (SDS) onto the Ca-Alg beads' surface. Three different SDS concentrations (25, 50, 100 mg/L) were prepared and treated with Ca-Alg beads for 1, 2, 4, 6, 24 h. Read More

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Mild Acquired Factor XIII Deficiency and Clinical Relevance at the ICU-A Retrospective Analysis.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211024741

Institute of IMD Blood Coagulation Centre, Frankfurt/Bad Homburg, Germany.

Acquired FXIII deficiency is a relevant complication in the perioperative setting; however, we still have little evidence about the incidence and management of this rarely isolated coagulopathy. This study aims to help find the right value for the substitution of patients with an acquired mild FXIII deficiency. In this retrospective single-center cohort study, we enrolled critically ill patients with mild acquired FXIII deficiency (>5% and ≤70%) and compared clinical and laboratory parameters, as well as pro-coagulatory treatments. Read More

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Enhanced adsorption of phosphorus in soil by lanthanum-modified biochar: improving phosphorus retention and storage capacity.

Environ Sci Pollut Res Int 2021 Jul 20. Epub 2021 Jul 20.

Ministry of Agriculture and Rural Affairs, Agro-Environmental Protection Institute, Tianjin, 300191, China.

Use of soil adsorbent is an effective method for the promotion of phosphorus adsorption capacity of soil, though most of the soil adsorbents have weak phosphorus retention ability. Herein, we compared the traditional gypsum (GP) and zeolite (ZP) adsorbents to explore the phosphorus retention ability of lanthanum modified walnut shell biochar (La-BC) in soil. The results showed that with the increase of exogenous phosphorus concentration, the adsorption amount of phosphorus by adsorbents in soil increased at first and then tended to be stable. Read More

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