246,326 results match your criteria maximal

Lateral Wall Implant as an Adjunct to Lateral Wall Orbital Decompression in Severe Thyroid Eye Disease.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Division of Oculofacial Plastic and Reconstructive Surgery, UC San Diego Viterbi Family Department of Ophthalmology, La Jolla, California Division of Plastic and Reconstructive Surgery, UC San Diego Department of Surgery, La Jolla, California, U.S.A.

Purpose: To describe the use of a lateral wall implant as an adjunct in lateral orbital wall decompression in severe thyroid eye disease.

Methods: This study is a retrospective review of 6 patients who underwent prior orbital decompression but had persistent proptosis. These patients underwent lateral wall decompression with adjunct lateral wall implant placement with a manually vaulted 0. Read More

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Population Pharmacokinetic Analysis of Ulotaront in Subjects with Schizophrenia.

CPT Pharmacometrics Syst Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Sunovion Pharmaceuticals Inc, Marlborough, MA, USA.

Ulotaront (SEP-363856) is a trace amine-associated receptor 1 (TAAR1) agonist with 5-HT agonist activity in Phase 3 development for the treatment of schizophrenia. The efficacy of ulotaront is not mediated by blockade of D or 5-HT receptors. The aim of this study was to evaluate the population PK of ulotaront in adult subjects using pooled data from seven Phase 1 studies, one Phase 2 acute study, and one 6-month extension study. Read More

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Changes in neural drive to calf muscles during steady submaximal contractions after repeated static stretches.

J Physiol 2021 Jul 22. Epub 2021 Jul 22.

Department of Integrative Physiology, University of Colorado, Boulder, CO, United States.

Key Points: Repeated static-stretching interventions consistently increase the range of motion about a joint and decrease total joint stiffness, but findings on the changes in muscle and connective-tissue properties are mixed. The influence of these stretch-induced changes on muscle function at submaximal forces is unknown. To address this gap in knowledge, we estimated the changes in neural drive to the plantar flexor muscles after a static-stretch intervention. Read More

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Emergency teleradiological activity is an epidemiological estimator and predictor of the covid-19 pandemic in mainland France.

Insights Imaging 2021 Jul 22;12(1):103. Epub 2021 Jul 22.

Imadis Teleradiology, Lyon, Bordeaux, Marseille, France.

Background: COVID-19 pandemic highlighted the need for real-time monitoring of diseases evolution to rapidly adapt restrictive measures. This prospective multicentric study aimed at investigating radiological markers of COVID-19-related emergency activity as global estimators of pandemic evolution in France. We incorporated two sources of data from March to November 2020: an open-source epidemiological dataset, collecting daily hospitalisations, intensive care unit admissions, hospital deaths and discharges, and a teleradiology dataset corresponding to the weekly number of CT-scans performed in 65 emergency centres and interpreted remotely. Read More

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The quadrupedal walking gait of the olive baboon, Papio anubis: an exploratory study integrating kinematics and EMG.

J Exp Biol 2021 Jul 22;224(14). Epub 2021 Jul 22.

Histoire Naturelle de l'Homme Préhistorique, UMR 7194, CNRS-MNHN-UPVD, 75116 Paris, France.

Primates exhibit unusual quadrupedal features (e.g. diagonal gaits, compliant walk) compared with other quadrupedal mammals. Read More

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Effects of Exercise Structure and Modality on Physiological and Perceptual Responses to Exercise.

J Strength Cond Res 2021 Jul 20. Epub 2021 Jul 20.

School of Physical Education and Sports Science, National and Kapodistrian University of Athens, Athens, Greece; and Department of Kinesiology, California State University-San Marcos, San Marcos, California.

Abstract: Bogdanis, GC, Mallios, VJ, Katsikas, C, Fouseki, T, Holman, I, Smith, C, and Astorino, TA. Effects of exercise structure and modality on physiological and perceptual responses to exercise. J Strength Cond Res XX(X): 000-000, 2021-This study examined the effect of exercise mode and intensity on physiological and perceptual responses to exercise. Read More

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Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.

Integr Cancer Ther 2021 Jan-Dec;20:15347354211031646

Department of Dermatology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Cutaneous squamous cell carcinoma (CSCC) is a malignant tumor that originates from keratinocytes in the epidermis or appendage. Traditional Chinese medicine Huaier has anti-tumor activity in various malignancies. Little is known about the role of Huaier in CSCC. Read More

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Hypoxia and glucose metabolism assessed by FMISO and FDG PET for predicting IDH1 mutation and 1p/19q codeletion status in newly diagnosed malignant gliomas.

EJNMMI Res 2021 Jul 21;11(1):67. Epub 2021 Jul 21.

Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Miki-cho, Kagawa, Japan.

Background: Tumor hypoxia and glycolysis have been recognized as determinant factors characterizing tumor aggressiveness in malignant gliomas. To clarify in vivo hypoxia and glucose metabolism in relation to isocitrate dehydrogenase (IDH) mutation and chromosome 1p and 19q (1p/19q) codeletion status, we retrospectively analyzed hypoxia as assessed by positron emission tomography (PET) with [F]-fluoromisonidazole (FMISO) and glucose metabolism as assessed by PET with [F]-fluoro-2-deoxy-D-glucose (FDG) in newly diagnosed malignant gliomas.

Methods: In total, 87 patients with newly diagnosed supratentorial malignant (WHO grade III and IV) gliomas were enrolled in this study. Read More

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Proximity to the Promoter and Terminator Regions Regulates the Transcription Enhancement Potential of an Intron.

Front Mol Biosci 2021 5;8:712639. Epub 2021 Jul 5.

Department of Biological Science, Wayne State University, Detroit, MI, United States.

An evolutionarily conserved feature of introns is their ability to enhance expression of genes that harbor them. Introns have been shown to regulate gene expression at the transcription and post-transcription level. The general perception is that a promoter-proximal intron is most efficient in enhancing gene expression and the effect diminishes with the increase in distance from the promoter. Read More

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Biochemical and Phylogenetic Characterization of a Novel NADP-Specific Isocitrate Dehydrogenase From the Marine Microalga .

Front Mol Biosci 2021 5;8:702083. Epub 2021 Jul 5.

Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases, Key Laboratory of Biomedicine in Gene Diseases and Health of Anhui Higher Education Institutes, College of Life Sciences, Anhui Normal University, Wuhu, China.

Isocitrate dehydrogenase (IDH) family of proteins is classified into three subfamilies, namely, types I, II, and III. Although IDHs are widely distributed in bacteria, archaea, and eukaryotes, all type III IDHs reported to date are found only in prokaryotes. Herein, a novel type III IDH subfamily member from the marine microalga (PtIDH2) was overexpressed, purified, and characterized in detail for the first time. Read More

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Opportunistic diagnosis of osteoporosis, fragile bone strength and vertebral fractures from routine CT scans; a review of approved technology systems and pathways to implementation.

Ther Adv Musculoskelet Dis 2021 10;13:1759720X211024029. Epub 2021 Jul 10.

University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, NIHR Cambridge Biomedical Research Centre, Cambridge, CB2 0QQ, UK.

Osteoporosis causes bones to become weak, porous and fracture more easily. While a vertebral fracture is the archetypal fracture of osteoporosis, it is also the most difficult to diagnose clinically. Patients often suffer further spine or other fractures, deformity, height loss and pain before diagnosis. Read More

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Immune-Related Nine-MicroRNA Signature for Predicting the Prognosis of Gastric Cancer.

Front Genet 2021 5;12:690598. Epub 2021 Jul 5.

The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.

Recent findings have demonstrated the superiority and utility of microRNAs (miRNAs) as new biomarkers for cancer diagnosis, therapy, and prognosis. In this study, to explore the prognostic value of immune-related miRNAs in gastric cancer (GC), we analyzed the miRNA-expression profiles of 389 patients with GC, using data deposited in The Cancer Genome Atlas database. Using a forward- and backward-variable selection and multivariate Cox regression analyses model, we identified a nine-miRNA signature (the "ImmiRSig," consisting of , , , , , , , , and ) in the training cohort that enabled the division of patients into high- and low-risk groups with significantly different survival rates. Read More

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Minocycline Treatment Reduces Mass and Force Output From Fast-Twitch Mouse Muscles and Inhibits Myosin Production in C2C12 Myotubes.

Front Physiol 2021 5;12:696039. Epub 2021 Jul 5.

School of Medicine, Western Sydney University, Sydney, NSW, Australia.

Minocycline, a tetracycline-class of antibiotic, has been tested with mixed effectiveness on neuromuscular disorders such as amyotrophic lateral sclerosis, autoimmune neuritis and muscular dystrophy. The independent effect of minocycline on skeletal muscle force production and signalling remain poorly understood. Our aim here is to investigate the effects of minocycline on muscle mass, force production, myosin heavy chain abundance and protein synthesis. Read More

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Long-term respiratory and developmental outcomes in children with bronchopulmonary dysplasia and history of tracheostomy.

J Perinatol 2021 Jul 21. Epub 2021 Jul 21.

Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.

Objective: The long-term morbidity among children with severe bronchopulmonary dysplasia who require tracheostomy (tBPD) relative to those without tracheostomy (sBPD) is not well characterized. We compared childhood lung function and neurodevelopmental outcomes in tBPD and sBPD.

Study Design: Retrospective case-control study of N = 49 tBPD and N = 280 sBPD subjects in Boston Children's Hospital Preterm Lung Patient Registry and medical record. Read More

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Effects of inspiratory muscle training after lung transplantation in children.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

First Department of Internal Medicine, Shinshu University School of Medicin, Matsumoto, Nagano, Japan.

Pulmonary rehabilitation is a cornerstone of management for patients after lung transplantation (LT), but the benefits of inspiratory muscle training (IMT) after LT in children are unclear. Therefore, we examined whether IMT can improve respiratory function and dyspnoea in a paediatric patient after LT.The patient was a 13-year-old boy who underwent double LT. Read More

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Ventilatory efficiency in athletes, asthma and obesity.

Eur Respir Rev 2021 Sep 20;30(161). Epub 2021 Jul 20.

Division of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.

During submaximal exercise, minute ventilation ( ) increases in proportion to metabolic rate ( carbon dioxide production ( )) to maintain arterial blood gas homeostasis. The ratio / , commonly termed ventilatory efficiency, is a useful tool to evaluate exercise responses in healthy individuals and patients with chronic disease. Emerging research has shown abnormal ventilatory responses to exercise (either elevated or blunted / ) in some chronic respiratory and cardiovascular conditions. Read More

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September 2021

Diagnostic yield of bacteriological tests and predictors of severe outcome in adult patients with COVID-19 presenting to the emergency department.

Emerg Med J 2021 Jul 21. Epub 2021 Jul 21.

Internal Medicine, Haga Teaching Hospital, Den Haag, The Netherlands.

Background: Guidelines recommend maximal efforts to obtain blood and sputum cultures in patients with COVID-19, as bacterial coinfection is associated with worse outcomes. The aim of this study was to evaluate the yield of bacteriological tests, including blood and sputum cultures, and the association of multiple biomarkers and the Pneumonia Severity Index (PSI) with clinical and microbiological outcomes in patients with COVID-19 presenting to the emergency department (ED).

Methods: This is a substudy of a large observational cohort study (PredictED study). Read More

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The Relationship Between Visual Sensitivity and Eccentricity, Cone Density and Outer Segment Length in the Human Foveola.

Invest Ophthalmol Vis Sci 2021 Jul;62(9):31

Department of Ophthalmology, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

Purpose: The cellular topography of the human foveola, the central 1° diameter of the fovea, is strikingly non-uniform, with a steep increase of cone photoreceptor density and outer segment (OS) length toward its center. Here, we assessed to what extent the specific cellular organization of the foveola of an individual is reflected in visual sensitivity and if sensitivity peaks at the preferred retinal locus of fixation (PRL).

Methods: Increment sensitivity to small-spot, cone-targeted visual stimuli (1 × 1 arcmin, 543-nm light) was recorded psychophysically in four human participants at 17 locations concentric within a 0. Read More

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Development of a novel formulation method to prepare liposomal Epacadostat.

Eur J Pharm Sci 2021 Jul 18:105954. Epub 2021 Jul 18.

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: One of the important metabolic pathways in cancer progression is tryptophan catabolism by the indoleamin-2,3-dioxygenase (IDO) enzyme, which suppresses the immune system and induces tolerance. Inhibition of IDO1 is an important therapeutic goal for immunotherapy in many cancers such as metastatic melanoma. Epacadostat (EPA) is a very strong inhibitor of IDO1, and its clinical studies are being performed in a higher clinical phase than other inhibitors. Read More

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Perception versus reality: A National Cohort Analysis of the surgery-first approach for resectable pancreatic cancer.

Cancer Med 2021 Jul 21. Epub 2021 Jul 21.

Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic Rochester, Rochester, Minnesota, USA.

Introduction: Although surgical resection is necessary, it is not sufficient for long-term survival in pancreatic ductal adenocarcinoma (PDAC). We sought to evaluate survival after up-front surgery (UFS) in anatomically resectable PDAC in the context of three critical factors: (A) margin status; (B) CA19-9; and (C) receipt of adjuvant chemotherapy.

Methods: The National Cancer Data Base (2010-2015) was reviewed for clinically resectable (stage 0/I/II) PDAC patients. Read More

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Estimating Hepatotoxic Doses Using High-Content Imaging in Primary Hepatocytes.

Toxicol Sci 2021 Jul 21. Epub 2021 Jul 21.

Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.

Using in vitro data to estimate point of departure (POD) values is an essential component of new approach methodologies (NAM)-based chemical risk assessments. In this case study, we evaluated a NAM for hepatotoxicity based on rat primary hepatocytes, high-content imaging (HCI), and toxicokinetic modeling. First, we treated rat primary hepatocytes with 10 concentrations (0. Read More

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Phenotypic differences between highlanders and lowlanders in Papua New Guinea.

PLoS One 2021 21;16(7):e0253921. Epub 2021 Jul 21.

Laboratoire Évolution and Diversité Biologique (EDB UMR5174), Université de Toulouse Midi-Pyrénées, CNRS, IRD, UPS, Toulouse, France.

Objectives: Altitude is one of the most demanding environmental pressures for human populations. Highlanders from Asia, America and Africa have been shown to exhibit different biological adaptations, but Oceanian populations remain understudied [Woolcock et al., 1972; Cotes et al. Read More

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Kinematic gait characteristics of straight line walk in clinically sound dairy cows.

PLoS One 2021 21;16(7):e0253479. Epub 2021 Jul 21.

Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.

The aim of this study is to describe the kinematic gait characteristics of straight line walk in clinically sound dairy cows using body mounted Inertial Measurement Units (IMUs) at multiple anatomical locations. The temporal parameters used are speed and non-speed normalized stance duration, bipedal and tripedal support durations, maximal protraction and retraction angles of the distal limbs and vertical displacement curves of the upper body. Gait analysis was performed by letting 17 dairy cows walk in a straight line at their own chosen pace while equipped with IMU sensors on tubera sacrale, left and right tuber coxae (LTC and RTC), back, withers, head, neck and all four lower limbs. Read More

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Circular RNA FAT atypical cadherin 1 (circFAT1)/microRNA-525-5p/spindle and kinetochore-associated complex subunit 1 (SKA1) axis regulates oxaliplatin resistance in breast cancer by activating the notch and Wnt signaling pathway.

Bioengineered 2021 Dec;12(1):4032-4043

Department of Ultrasonography, Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.

Increasing evidence has confirmed the vital roles of circular RNAs (CircRNAs) in the drug resistance of breast cancer (BC). Herein, we intended to study the effect of circular RNA FAT atypical cadherin 1 (circFAT1) on BC oxaliplatin (OX) resistance and find out the potential molecular mechanism in it. In this study, mRNA and protein levels of genes were measured by RT-qPCR and western blotting, respectively. Read More

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December 2021

W' reconstitution rate at different intensities above critical torque: The role of muscle size and maximal strength.

Exp Physiol 2021 Jul 20. Epub 2021 Jul 20.

Human Performance Laboratory, UNESP, Rio Claro, SP, Brazil.

New Findings: What is the central question of this study? Does muscle size, maximal force and exercise intensity influence the recovery time constant for the finite impulse above critical torque (τIET')? What is the main finding and its importance? This study showed that muscle size and maximal strength have different influences on the parameters of the hyperbolic torque - T relationship. Greater muscle size and maximal strength, as well as exercise at an intensity of 60% MVC, prolong τIET' during intermittent isometric exercise.

Abstract: Muscle perfusion and O delivery limitations through muscle force generation appear to play a major role in defining the hyperbolic torque - T relationship. Read More

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Teucrium polium extract-loaded solid lipid nanoparticles: A design and in vitro anticancer study.

J Food Biochem 2021 Jul 19:e13868. Epub 2021 Jul 19.

Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.

Teucrium polium extract (TPE) is a natural product with potent anticancer activity because of its terpenoid and flavonoid content. The aim of this study was to synthesize solid lipid nanoparticles (SLN) containing T. polium extract (TPE-SLNs) and to evaluate its anti-cancer effect. Read More

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Competitive blocking of salivary gland [F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study.

EJNMMI Res 2021 Jul 21;11(1):66. Epub 2021 Jul 21.

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, NCI/NIH, Building 10, Room # B3B69F, Bethesda, MD, 20892, USA.

Background: PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radionuclides. With [F]DCFPyL as a surrogate for PSMA-TRT, we report a novel method to selectively reduce salivary gland (SG) uptake of systemically administered [F]DCFPyL by immediate prior infusion of non-radioactive standard of [F]DCFPyL (DCFPyL) directly into the SG via retrograde cannulation.

Methods: A dose-finding cohort using athymic nude mice demonstrated proof of principle that SG uptake can be selectively blocked by DCFPyL administered either locally via cannulation (CAN group) or systemically (SYS group). Read More

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Exercise Capacity in Young Adults Born Small for Gestational Age.

JAMA Cardiol 2021 Jul 21. Epub 2021 Jul 21.

Fetal Medicine Research Center, BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, Universitat de Barcelona, Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.

Importance: Being born small for gestational age (SGA), approximately 10% of all births, is associated with increased risk of cardiovascular mortality in adulthood, but mechanistic pathways are unclear. Cardiac remodeling and dysfunction occur in fetuses SGA and children born SGA, but it is uncertain whether and how these changes persist into adulthood.

Objective: To evaluate baseline cardiac function and structure and exercise capacity in young adults born SGA. Read More

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Pattern of the Heart Rate Performance Curve in Subjects with Beta-Blocker Treatment and Healthy Controls.

J Funct Morphol Kinesiol 2021 Jul 13;6(3). Epub 2021 Jul 13.

Institute of Human Movement Science, Sport & Health, University of Graz, 8010 Graz, Austria.

(1): Heart rate performance curve (HRPC) in incremental exercise was shown to be not uniform, causing false intensity estimation applying percentages of maximal heart rate (HR). HRPC variations are mediated by β-adrenergic receptor sensitivity. The aim was to study age and sex dependent differences in HRPC patterns in adults with β-blocker treatment (BB) and healthy controls (C). Read More

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The Effects of High-Intensity Interval Exercise on Skeletal Muscle and Cerebral Oxygenation during Cycling and Isokinetic Concentric and Eccentric Exercise.

J Funct Morphol Kinesiol 2021 Jul 16;6(3). Epub 2021 Jul 16.

School of Physical Education and Sport Science, National and Kapodistrian University of Athens, 17237 Athens, Greece.

The aim of the present study was to study the effects of cycling and pure concentric and pure eccentric high-intensity interval exercise (HIIE) on skeletal muscle (i.e., vastus lateralis) and cerebral oxygenation. Read More

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