19,397 results match your criteria maturation process


Canine parturition: what is known about the hormonal setting?

Authors:
J Fusi M C Veronesi

Domest Anim Endocrinol 2021 Sep 20;78:106687. Epub 2021 Sep 20.

Department of Veterinary Medicine, University of Milan, 26900, Lodi, Italy. Electronic address:

Parturition is a challenging physiological process with perfect timing dictated by the events leading to the end of pregnancy in the female, and by the maturation of the fetus(es). The process of parturition remains an intricate interaction of hormones in a fine-tuned timing that remains to be better elucidated in the dog. In the dog pregnancy is maintained by the progesterone production by the corpora lutea, in which some hormones play a luteotrophic action. Read More

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September 2021

An overview on the manufacturing of functional and mature cellular skin substitutes.

Tissue Eng Part B Rev 2021 Oct 15. Epub 2021 Oct 15.

University of Granada, humqn Anatomy and embriology, avd del conocimiento nº 11, Granada, Granada, Spain, 18016;

There are different types of skin diseases due to chronic injuries that impede the natural healing process of the skin. Tissue engineering (TE) has focused on the development of bioengineered skin or skin substitutes that cover the wound, providing the necessary care to restore the functionality of injured skin. There are two types of substitutes: acellular skin substitutes (ASSs), which offer a low response of the body, and cellular skin substitutes (CSSs), which incorporate living cells and appear as a great alternative in the treatment of skin injuries due to them presenting a greater interaction and integration with the rest of the body. Read More

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October 2021

How to enter the state of dormancy? A suggestion by Trichoderma atroviride conidia.

Fungal Biol 2021 11 3;125(11):934-949. Epub 2021 Jul 3.

Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37, Bratislava, Slovakia.

It is generally accepted that conidia, propagules of filamentous fungi, exist in the state of dormancy. This state is defined mostly phenomenologically, e.g. Read More

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November 2021

Fabricating Tissues In Situ with the Controlled Cellular Alignments.

Adv Healthc Mater 2021 Oct 14:e2100934. Epub 2021 Oct 14.

Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering, Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China.

Tissue engineering techniques have enabled to replicate the geometrical architecture of native tissues but usually fail to reproduce their exact cellular arrangements during the fabricating process, while it's critical for manufacturing physiologically relevant tissues. To address this problem, we here report a "sewing-like" method of controlling cellular alignment during the fabricating process. By integrating the stretching step into the fabricating process, we are able to create a static mechanical environment which, in turn, would regulate the subsequent cellular alignment, elongation, and differentiation in the generated tissues. Read More

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October 2021

Mapping Sphingolipid Metabolism Pathways during Phagosomal Maturation.

ACS Chem Biol 2021 Oct 14. Epub 2021 Oct 14.

Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pashan, Pune 411008, India.

Phagocytosis is an important physiological process, which, in higher organisms, is a means of fighting infections and clearing cellular debris. During phagocytosis, detrimental foreign particles (e.g. Read More

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October 2021

Global 3'-UTR landscape mediated by alternative polyadenylation during meiotic maturation of pig oocytes.

Reprod Domest Anim 2021 Oct 13. Epub 2021 Oct 13.

College of Animal Science, Yangtze University, Jingzhou, 434025, Hubei, China.

Alternative polyadenylation (APA) affects the length and composition of 3'-untranslated region (3'-UTR), and regulates mRNA stability or translational activity to affect important biological processes. However, global 3'-UTR landscape and its relationship with gamete maturation remain less studied. Here, we analyzed our previously reported single cell (sc)RNA-seq data of germinal vesicle (GV) and metaphase II (MII) stage oocytes in pigs, to systematically catalogue the 3'-UTR dynamics during oocyte maturation. Read More

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October 2021

Prefused lysosomes cluster on autophagosomes regulated by VAMP8.

Cell Death Dis 2021 Oct 13;12(10):939. Epub 2021 Oct 13.

Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.

Lysosome-autophagosome fusion is critical to autophagosome maturation. Although several proteins that regulate this fusion process have been identified, the prefusion architecture and its regulation remain unclear. Herein, we show that upon stimulation, multiple lysosomes form clusters around individual autophagosomes, setting the stage for membrane fusion. Read More

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October 2021

Body-fat sensor triggers ribosome maturation in the steroidogenic gland to initiate sexual maturation in Drosophila.

Cell Rep 2021 Oct;37(2):109830

Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas (CSIC), and Universidad Miguel Hernández (UMH), Campus de Sant Joan, Apartado 18, 03550 Sant Joan, Alicante, Spain. Electronic address:

Fat stores are critical for reproductive success and may govern maturation initiation. Here, we report that signaling and sensing fat sufficiency for sexual maturation commitment requires the lipid carrier apolipophorin in fat cells and Sema1a in the neuroendocrine prothoracic gland (PG). Larvae lacking apolpp or Sema1a fail to initiate maturation despite accruing sufficient fat stores, and they continue gaining weight until death. Read More

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October 2021

Regulatory association of long noncoding RNAs and chromatin accessibility facilitates erythroid differentiation.

Blood Adv 2021 Oct 13. Epub 2021 Oct 13.

CAS Key Laboratory of Genome Science & Information, Beijing Institute of Genomics, Chinese Academy of Sciences/ China National Center for Bioinformation, Beijing 100101, China, Beijing, China.

Erythroid differentiation is a dynamic process regulated by multiple factors, while the interaction between long non-coding RNAs and chromatin accessibility and its influence on erythroid differentiation remains unclear. To elucidate this interaction, we employed hematopoietic stem cells, multipotent progenitor cells, common myeloid progenitor cells, megakaryocyte-erythroid progenitor cells, and erythroblasts from human cord blood as an erythroid differentiation model to explore the coordinated regulatory functions of lncRNAs and chromatin accessibility by integrating RNA-Seq and ATAC-Seq data. We revealed that the integrated network of chromatin accessibility and lncRNAs exhibits stage-specific changes throughout the erythroid differentiation process, and that the changes at the EB stage of maturation are dramatic. Read More

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October 2021

Perturbing HIV-1 ribosomal frameshifting frequency reveals a preference for Gag-Pol incorporation into assembling virions.

J Virol 2021 Oct 13:JVI0134921. Epub 2021 Oct 13.

Department of Oncology (McArdle Laboratory for Cancer Research), Institute for Molecular Virology, and Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

HIV-1 virion production is driven by Gag and Gag-Pol (GP) proteins, with Gag forming the bulk of the capsid and driving budding while GP binds Gag to deliver the essential virion enzymes Protease, Reverse Transcriptase, and Integrase. Virion GP levels are traditionally thought to reflect the relative abundances of GP and Gag in cells (∼1:20), dictated by the frequency of a -1 programmed ribosomal frameshifting (PRF) event occurring in mRNAs. Herein we exploited a panel of PRF mutant viruses to show that mechanisms in addition to PRF regulate GP incorporation into virions. Read More

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October 2021

Wnt Modulation Enhances Otic Differentiation by Facilitating the Enucleation Process but Develops Unnecessary Cardiac Structures.

Int J Mol Sci 2021 Sep 24;22(19). Epub 2021 Sep 24.

Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.

Otic organoids have the potential to resolve current challenges in hearing loss research. The reproduction of the delicate and complex structure of the mammalian cochlea using organoids requires high efficiency and specificity. Recent attempts to strengthen otic organoids have focused on the effects of the Wnt signaling pathway on stem cell differentiation. Read More

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September 2021

Caput Ligation Renders Immature Mouse Sperm Motile and Capable to Undergo cAMP-Dependent Phosphorylation.

Int J Mol Sci 2021 Sep 23;22(19). Epub 2021 Sep 23.

Department of Veterinary and Animal Sciences, Integrated Science Building, University of Massachusetts, Amherst, MA 01003, USA.

Mammalian sperm must undergo two post-testicular processes to become fertilization-competent: maturation in the male epididymis and capacitation in the female reproductive tract. While caput epididymal sperm are unable to move and have not yet acquired fertilization potential, sperm in the cauda epididymis have completed their maturation, can move actively, and have gained the ability to undergo capacitation in the female tract or in vitro. Due to the impossibility of mimicking sperm maturation in vitro, the molecular pathways underlying this process remain largely unknown. Read More

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September 2021

QSAR Studies to Predict Activity of HSP90 Inhibitors.

Curr Top Med Chem 2021 Oct 10. Epub 2021 Oct 10.

Warren Family Research Center for Drug Discovery and Development, University of Notre Dame, IN. United States.

Heat shock protein 90 (HSP90) is a multichaperone complex that mediates the maturation and stability of a variety of oncogenic signaling proteins. HSP90 has emerged as a promising target for the development of anticancer agents. Heterocyclic chemical moieties with HSP90 inhibitory activity were studied continuously during the last decades, and resulting data were applied by medicinal chemists to design and develop new drugs. Read More

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October 2021

Synthetic amorphous silica nanoparticles promote human dendritic cell maturation and CD4 + T-lymphocyte activation.

Toxicol Sci 2021 Oct 11. Epub 2021 Oct 11.

Université Paris-Saclay, Inserm, Inflammation, Microbiome and Immunosurveillance, 92290, Châtenay-Malabry, France.

Innate immune cells such as dendritic cells (DCs) sense and engulf nanomaterials potentially leading to an adverse immune response. Indeed, as described for combustion-derived particles, nanomaterials could be sensed as danger signals, enabling DCs to undergo a maturation process, migrate to regional lymph nodes and activate naive T-lymphocytes. Synthetic amorphous silica nanoparticles (SAS-NPs) are widely used as food additives, cosmetics, and construction materials. Read More

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October 2021

Maturation of biomimetic hydroxyapatite in physiological fluids: a physicochemical and proteomic study.

Mater Today Bio 2021 Sep 15;12:100137. Epub 2021 Sep 15.

Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Av. Eduard Maristany 16, 08019, Barcelona, Spain.

Biomimetic calcium-deficient hydroxyapatite (CDHA) as a bioactive material exhibits exceptional intrinsic osteoinductive and osteogenic properties because of its nanostructure and composition, which promote a favorable microenvironment. Its high reactivity has been hypothesized to play a relevant role in the performance, mediated by the interaction with the biological fluids, which is amplified by its high specific surface area. Paradoxically, this high reactivity is also behind the cytotoxicity of this material, especially pronounced in static conditions. Read More

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September 2021

Multiple periapical dysplasias analyzed by cone-beam-computer tomography and Tcm-Scintigraphy.

Radiol Case Rep 2021 Dec 2;16(12):3757-3765. Epub 2021 Oct 2.

Department of Oral and Maxillofacial Surgery, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.

Periapical cemental dysplasia (PCD) is considered a non-neoplastic proliferation of fibrous tissues and cementum-like hard tissues, usually occurring in the periapical regions of teeth. PCD is characterized by the presence of vital pulp and is often accidentally discovered during a general radiographic survey. PCD may arise from the tissue of odontogenic origin or occur as a reactive process in the periapical tissue. Read More

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December 2021

A Bumpy Ride of Mycobacterial Phagosome Maturation: Roleplay of Coronin1 Through Cofilin1 and cAMP.

Front Immunol 2021 23;12:687044. Epub 2021 Sep 23.

Molecular Immunology and Cellular Microbiology Laboratory, Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, India.

Phagosome-lysosome fusion in innate immune cells like macrophages and neutrophils marshal an essential role in eliminating intracellular microorganisms. In microbe-challenged macrophages, phagosome-lysosome fusion occurs 4 to 6 h after the phagocytic uptake of the microbe. However, live pathogenic mycobacteria hinder the transfer of phagosomes to lysosomes, up to 20 h post-phagocytic uptake. Read More

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September 2021

6-Gingerol Alleviates Neonatal Hypoxic-Ischemic Cerebral and White Matter Injury and Contributes to Functional Recovery.

Front Pharmacol 2021 22;12:707772. Epub 2021 Sep 22.

Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Key Laboratory of Mental Disorders, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.

Hypoxic-ischemic encephalopathy (HIE) is one main cause of neonatal death and disability, causing substantial injury to white and gray matter, which can lead to severe neurobehavioral dysfunction, including intellectual disability and dyskinesia. Inflammation, nerve cell death, and white matter injury are important factors in the pathological process of HIE. 6-Gingerol is a ginger extract, which reduces inflammatory response and cell death. Read More

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September 2021

Circulating autoreactive proteinase 3+ B cells and tolerance checkpoints in ANCA-associated vasculitis.

JCI Insight 2021 Oct 7. Epub 2021 Oct 7.

Laboratory of Immunology, University of Brest, Brest, France.

Background: Little is known about the autoreactive B cells in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We aimed to investigate tolerance checkpoints of circulating antigen-specific proteinase 3 (PR3+) B cells.

Methods: Multicolor flow cytometry in combination with bioinformatics and functional in vitro studies were performed on baseline samples of peripheral blood mononuclear cells from 154 well-characterized participants of the RAVE trial (NCT00104299) with severely active PR3-AAV and myeloperoxidase (MPO)-AAV, and 27 healthy controls (HCs). Read More

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October 2021

Biological roles of l-carnitine in oocyte and early embryo development.

Mol Reprod Dev 2021 Oct 7. Epub 2021 Oct 7.

The New York Fertility Center, New York-Presbyterian Queens Affiliate with Weill Medical College of Cornell University, New York, New York, USA.

Poor oocyte quality is responsible for female infertility. Multiple studies have been carried out to find supplements to enhance oocyte quality and mitigate infertility problems. l-carnitine and its derivatives have diverse roles in developing oocytes and early embryos. Read More

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October 2021

Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV.

Bull Exp Biol Med 2021 Sep 7;171(5):651-655. Epub 2021 Oct 7.

Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.

We studied the effect of an experimental synthetic organoselenium compound 2,6-dipyridinium- 9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the cell composition of the red bone marrow and peripheral blood in white mice. Read More

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September 2021

Contribution of epididymal epithelial cell functions to sperm epigenetic changes and the health of progeny.

Hum Reprod Update 2021 Oct 7. Epub 2021 Oct 7.

Department of Obstetrics, Gynecology and Reproduction, Université Laval, Quebec, Canada.

Background: Spermatozoa acquire their motility and fertilizing abilities during their maturation through the epididymis. This process is controlled by epididymal epithelial cells that possess features adapted to sense and respond to their surrounding environment and to communicate with spermatozoa. During the past decade, new intercellular communication processes have been discovered, including the secretion and transport of molecules from the epithelium to spermatozoa via extracellular vesicles (EVs), as well as sensing of the intraluminal milieu by cellular extensions. Read More

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October 2021

System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation.

Front Immunol 2021 20;12:734282. Epub 2021 Sep 20.

Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.

Germinal center (GC) reactions are vital to the correct functioning of the adaptive immune system, through formation of high affinity, class switched antibodies. GCs are transient anatomical structures in secondary lymphoid organs where specific B cells, after recognition of antigen and with T cell help, undergo class switching. Subsequently, B cells cycle between zones of proliferation and somatic hypermutation and zones where renewed antigen acquisition and T cell help allows for selection of high affinity B cells (affinity maturation). Read More

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September 2021

Serum Prokineticin-2 in Prepubertal and Adult Klinefelter Individuals.

Can J Physiol Pharmacol 2021 Oct 6. Epub 2021 Oct 6.

IBCN CNR Roma, 70300, Roma, Italy;

The prokineticin-2 (PROK2) is a small peptide belonging to the prokineticin family. In humans and rodents this chemokine is primarily involved in the control of central and peripheral reproductive processes. Klinefelter's syndrome (KS) is the first cause of male genetic infertility, due to an extra X chromosome, which may occur with a classical karyotype (47, XXY) or mosaic forms (46, XY/47, XXY). Read More

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October 2021

Bioactive compounds of fruit parts of three Eugenia uniflora biotypes in four ripening stages.

Chem Biodivers 2021 Oct 5. Epub 2021 Oct 5.

Universidade Federal de Goias Instituto de Quimica, Instituto de Química, Campus Samambaia, Brasil, 74690-900, GOIÂNIA, BRAZIL.

Variability of secondary metabolites in edible (peel and pulp) and inedible (seeds) parts of three pitanga varieties, red, red-orange and purple, was investigated during the maturation process. Hydrolysable tannins, anthocyanins, and flavonoids were quantified by HPLC/DAD and carotenoids by absorbance. Peel/pulp showed greater complexity of constituents (carotenoids, anthocyanins, flavonoids, and hydrolysable tannins), while only tannins were identified in seeds, but in quantities of ten to one hundred times greater. Read More

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October 2021

Potential role of tea extract in oocyte development.

Food Funct 2021 Oct 5. Epub 2021 Oct 5.

College of Life Sciences, Institute of Reproductive Sciences, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao, P.R. China.

Tea is the second most popular beverage in the world and beneficial to health. It has been demonstrated that tea polyphenols can reduce the risk of diseases, such as cancers, diabetes, obesity, Alzheimer's disease, . But the knowledge of tea extract on the female germline is limited. Read More

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October 2021

Cloning, functional and regulation analysis of a novel male reproduction-related protein gene from the oriental river prawn Macrobrachium nipponense.

Anim Reprod Sci 2021 Sep 27;234:106867. Epub 2021 Sep 27.

Shandong Freshwater Fisheries Research Institute, Jinan 250013, PR China. Electronic address:

Gonadogenesis processes in crustaceans are complex. There, however, has been a large amount of research focused on regulation of female gonad (ovary) development in crustaceans, however, there has been little focus on the male gonad (testis). In the current study, a novel male reproduction-related protein gene (Mn-MRP) was identified from Macrobrachium nipponense. Read More

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September 2021

Postnatal myelination of the immature rat cingulum is regulated by GABAB receptor activity.

Dev Neurobiol 2021 Oct 3. Epub 2021 Oct 3.

Department of Neonatology, Charité University Hospital Berlin, Augustenburger Platz 1, Berlin, 13353, Germany.

Myelination of axons in the neonatal brain is a highly complex process primarily achieved by oligodendroglial cells (OLs). OLs express receptors for γ-aminobutyric acid (GABA) which is released from cortical interneurons on a basal level, while glial cells can be a source of GABA, too. We investigated GABA-induced oligodendroglial maturation, proliferation, apoptosis, and myelin production after pharmacological inhibition of GABA and GABA in the neonatal rat brain. Read More

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October 2021

Longitudinal monitoring and prediction of long-term outcome of scar stiffness on pediatric patients.

Burns Trauma 2021 30;9:tkab028. Epub 2021 Sep 30.

Burn Center, Division of Plastic and Reconstructive Surgery, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zürich, Switzerland.

Background: Hypertrophic scarring after burn injury is one of the greatest unmet challenges in patients with burn injuries. A better understanding of the characteristics of scar maturation and early prediction of the long-term outcome of scarring are prerequisites for improving targeted therapies and pivotal for patient counselling.

Methods: Repeated measurements of scar stiffness in 11 pediatric patients were performed over the course of 1 year using 2 suction devices, the Cutometer and the Nimble. Read More

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September 2021

Tracing Eukaryotic Ribosome Biogenesis Factors Into the Archaeal Domain Sheds Light on the Evolution of Functional Complexity.

Front Microbiol 2021 16;12:739000. Epub 2021 Sep 16.

Applied Bioinformatics Group, Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Frankfurt, Germany.

Ribosome assembly is an essential and carefully choreographed cellular process. In eukaryotes, several 100 proteins, distributed across the nucleolus, nucleus, and cytoplasm, co-ordinate the step-wise assembly of four ribosomal RNAs (rRNAs) and approximately 80 ribosomal proteins (RPs) into the mature ribosomal subunits. Due to the inherent complexity of the assembly process, functional studies identifying ribosome biogenesis factors and, more importantly, their precise functions and interplay are confined to a few and very well-established model organisms. Read More

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September 2021