Neurobiol Dis 2021 Jun 24;153:105313. Epub 2021 Feb 24.
Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, 308433, Singapore; Neuroscience and Behavioral Disorders Program, DUKE-NUS Graduate Medical School, 169857, Singapore; Lee Kong Chian School of Medicine, Nanyang Technology University, Novena Campus, 11 Mandalay Road, 308232, Singapore. Electronic address:
Vacuolar protein sorting protein 35 (VPS35) is a core component of the retromer complex involved in regulating protein trafficking and retrieval. Recently, a missense mutation, Asp620Asn (D620N), in VPS35 (PARK17) has been identified as a pathogenic mutation for late-onset autosomal dominant Parkinson's disease (PD). Although PD is characterized by a range of motor symptoms associated with loss of dopaminergic neurons in the substantial nigra, non-motor symptoms such as impaired hippocampal neurogenesis were observed in both PD patients and animal models of PD caused by multiple PD-linked pathogenic genes such as alpha-synuclein and leucine-rich repeat kinase 2 (LRRK2). Read More