166,153 results match your criteria maturation


Vastus lateralis muscle volume prediction in early-adolescent boys.

J Biomech 2021 Sep 6;128:110735. Epub 2021 Sep 6.

Department of Training and Movement Sciences, Humboldt-Universität zu Berlin, Berlin, Germany; Berlin School of Movement Science, Berlin, Germany. Electronic address:

The applicability of a simplified approach for muscle volume assessment, based on multiplying muscle length, maximum anatomical cross-sectional area (ACSA) and a muscle-specific shape factor, was investigated in the present study for the vastus lateralis muscle of early-adolescent boys. Muscle length, ACSA and volume were calculated from magnetic resonance image muscle reconstructions of early-adolescent athletes (n = 14) and untrained peers (n = 10). A cohort-specific shape factor was obtained from the ratio of the measured volume and the product of ACSA and muscle length, which did not differ significantly between trained and untrained adolescents despite significant differences in anthropometry and muscle dimensions. Read More

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September 2021

Polydopamine-based nanoplatform for photothermal ablation with long-term immune activation against melanoma and its recurrence.

Acta Biomater 2021 Sep 15. Epub 2021 Sep 15.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China. Electronic address:

The high risk of tumor recurrence presents a big challenge in melanoma therapy. Photothermal therapy (PTT) has merged as a powerful weapon against tumor in recent years, which produces tumor-associated antigens (TAA) and recruits dendritic cells (DCs) to tumor sites through immunogenic cell death (ICD) for immune activation. However, due to the lack of activation signals of DCs, the immune effect induced by PTT is not sufficient to inhibit the recurrence and proliferation of tumor. Read More

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September 2021

Serine/threonine kinase 17b (STK17B) signaling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias.

Eur J Neurosci 2021 Sep 18. Epub 2021 Sep 18.

Institute of Anatomy, Department of Biomedicine, University of Basel, Basel, Switzerland.

Serine/threonine kinase 17b (STK17B, also known as DRAK2) is known to be a downstream effector of Protein Kinase C (PKC) in the immune system, in particular T-lymphocytes. PKC activity also plays a critical role for dendritic development and synaptic maturation and plasticity in cerebellar Purkinje cells. We present evidence that STK17B is strongly expressed in mouse cerebellar Purkinje cells starting in the early postnatal period and remaining highly expressed throughout adult stages and that STK17B is a target of PKC phosphorylation in the cerebellum. Read More

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September 2021

Evoglow-Pp1 and mCherry proteins: a dual fluorescent labeling system for lactic acid bacteria.

Appl Microbiol Biotechnol 2021 Sep 18. Epub 2021 Sep 18.

Departamento de Tecnología de Alimentos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Carretera de La Coruña Km 7.5, 28040, Madrid, Spain.

Fluorescent proteins are widely used for cell and protein tracking. Most of these proteins show a high signal and need the presence of oxygen to emit fluorescence. Among them, the fluorescent protein mCherry stands up because of its bright signal and fast maturation. Read More

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September 2021

Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts.

Sci Rep 2021 Sep 17;11(1):18551. Epub 2021 Sep 17.

Department of Molecular Life Sciences, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

The liver is an important metabolic organ that controls homeostasis in the body. Moreover, it functions as a hematopoietic organ, while its metabolic function is low during development. Hepatocytes, which are parenchymal cells of the liver, acquire various metabolic functions by the maturation of hepatic progenitor cells during the fetal period; however, this molecular mechanism is still unclear. Read More

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September 2021

Extracellular vesicles cargo from head and neck cancer cell lines disrupt dendritic cells function and match plasma microRNAs.

Sci Rep 2021 Sep 17;11(1):18534. Epub 2021 Sep 17.

Centro de Pesquisa Experimental, Albert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

Extracellular vesicles (EVs) are mediators of the immune system response. Encapsulated in EVs, microRNAs can be transferred between cancer and immune cells. To define the potential effects of EVs originated from squamous cell carcinoma cells on immune system response, we performed microRNA profiling of EVs released from two distinct cell lines and treated dendritic cells derived from circulating monocytes (mono-DCs) with these EVs. Read More

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September 2021

The study of Dominican amber-bearing sediments from Siete Cañadas and La Cumbre with a discussion on their origin.

Sci Rep 2021 Sep 17;11(1):18556. Epub 2021 Sep 17.

Residencial Rosmil, Los restauradores Calle 3 casa #7, Altos Distrito Nacional, Dominican Republic.

The paper presents comprehensive mineralogical and geochemical characteristics of Dominican amber-bearing sediments from Siete Cañadas, Hato Mayor Province of the Eastern Mining District (EMD) in the Cordillera Oriental. The characteristics of rocks collected from the borehole in Siete Cañadas area (EMD) were compared with petrography of coaly shales from La Cumbre in the Northern Mining District (NMD). The mineralogy of the rocks was determined using transmitted and reflected light microscopy, scanning electron microscopy, Powder X-ray diffraction and Fourier Transform Raman Spectroscopy. Read More

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September 2021

A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies.

Nat Commun 2021 Sep 17;12(1):5506. Epub 2021 Sep 17.

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Antibody engineering technologies face increasing demands for speed, reliability and scale. We develop CeVICA, a cell-free nanobody engineering platform that uses ribosome display for in vitro selection of nanobodies from a library of 10 randomized sequences. We apply CeVICA to engineer nanobodies against the Receptor Binding Domain (RBD) of SARS-CoV-2 spike protein and identify >800 binder families using a computational pipeline based on CDR-directed clustering. Read More

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September 2021

Association of the Degree of Erythroid Expansion and Maturation Arrest with the Clinical Severity of β0-Thalassemia/Hemoglobin E Patients.

Acta Haematol 2021 Sep 14:1-12. Epub 2021 Sep 14.

Institute of Molecular Biosciences, Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom, Thailand.

Introduction: β-Thalassemia/hemoglobin E represents one-half of all the clinically severe β-thalassemias worldwide. Despite similar genetic backgrounds, patients show clinical heterogeneity ranging from nearly asymptomatic to transfusion-dependent thalassemia. The underlying disease modifying factors remain largely obscure. Read More

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September 2021

Assessment of thyroid function in the preterm and/or very low birth weight newborn.

An Pediatr (Engl Ed) 2021 Sep 14. Epub 2021 Sep 14.

Sección de Endocrinología Pediátrica, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain.

The screening program or early detection of congenital hypothyroidism is one of the greatest advances achieved in Pediatrics. Thyroid hormones are essential for brain development and maturation, which continue into the neonatal stage. Alterations in thyroid function in premature and underweight children in the first months of life causes irreversible damage to the central nervous system and is one of the most frequent and avoidable causes of mental retardation. Read More

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September 2021

Focused Ultrasound of the Fetus, Female and Male Reproductive Tracts, Pregnancy, and Dystocia in Dogs and Cats.

Authors:
Robert M Fulton

Vet Clin North Am Small Anim Pract 2021 Sep 14. Epub 2021 Sep 14.

Clarividus Veterinary Ultrasound and Education, 2500 East Cary Street, Richmond, VA 23223, USA. Electronic address:

Add "in dogs and cats"? This article covers image acquisition of the fetus and the reproductive organs of the female (cervix, gravid and nongravid uterus, and ovaries) and male (testicles and prostate) reproductive tracts. This article is a brief overview of normal sonographic anatomy and important clinical conditions for each sex using point-of-care ultrasound as a screening test. In addition to normal sonographic appearance and common conditions of the scrotum and testes, prostate, uterus, and ovaries, this article discusses the use of ultrasound for diagnosis of and evaluating pregnancy, fetal maturation, and fetal stress during dystocia. Read More

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September 2021

Cellular and Molecular Mechanisms Linking Human Cortical Development and Evolution.

Annu Rev Genet 2021 Sep 17. Epub 2021 Sep 17.

VIB-KU Leuven Center for Brain & Disease Research, KU Leuven Department of Neurosciences, Leuven Brain Institute, 3000 Leuven, Belgium; email:

The cerebral cortex is at the core of brain functions that are thought to be particularly developed in the human species. Human cortex specificities stem from divergent features of corticogenesis, leading to increased cortical size and complexity. Underlying cellular mechanisms include prolonged patterns of neuronal generation and maturation, as well as the amplification of specific types of stem/progenitor cells. Read More

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September 2021

Maturation of the anterior petrous apex: surgical relevance for performance of the middle fossa transpetrosal approach in pediatric patients.

J Neurosurg 2021 Sep 17:1-7. Epub 2021 Sep 17.

2Department of Neurosciences and Pediatrics, University of California, San Diego, San Diego.

Objective: The middle fossa transpetrosal approach to the petroclival and posterior cavernous sinus regions includes removal of the anterior petrous apex (APA), an area well studied in adults but not in children. To this end, the authors performed a morphometric analysis of the APA region during pediatric maturation.

Methods: Measurements of the distance from the clivus to the internal auditory canal (IAC; C-IAC), the distance of the petrous segment of the internal carotid artery (petrous carotid; PC) to the mesial petrous bone (MPB; PC-MPB), the distance of the PC to the mesial petrous apex (MPA; PC-MPA), and the IAC depth from the middle fossa floor (IAC-D) were made on thin-cut CT scans from 60 patients (distributed across ages 0-3, 4-7, 8-11, 12-15, 16-18, and > 18 years). Read More

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September 2021

Microrna analysis of human decidua mesenchymal stromal cells from preeclampsia patients.

Placenta 2021 Sep 10;115:12-19. Epub 2021 Sep 10.

Istanbul University, Faculty of Science, Department of Molecular Biology and Genetics, Istanbul, Turkey. Electronic address:

Introduction: In preeclampsia (PE), human decidua mesenchymal stromal cells (hDMSCs) are exposed to abnormally high levels of oxidative stress and inflammatory factors circulating in the maternal blood. MicroRNAs (miRNAs) have been shown to have a significant impact on the differentiation, maturation and function of mesenchymal stromal cells (MSCs). Our aim in the present study is firstly to investigate differentially expressed miRNA levels to be used as a biomarker in the early detection of PE and secondly to investigate whether those differentially expressed miRNAs in hDMSCs have an effect on the pathogenesis of PE. Read More

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September 2021

Pertussis antibody levels in infants and their mothers receiving combined tetanus-diphtheria toxoid and acellular pertussis vaccine during pregnancy in Turkey.

Eur J Obstet Gynecol Reprod Biol 2021 Sep 2;265:212-216. Epub 2021 Sep 2.

Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Neonatology, Istanbul, Turkey.

Objective: Pertussis is an important cause of morbidity and mortality in infants under two months of age and these high risk babies are dependent on maternally derived antibodies until completion of their first immunization series. This study aimed to evaluate the vaccine response of late preterm and term newborns as well as their mothers who underwent combined tetanus-diphtheria toxoid and acellular pertussis (Tdap) vaccination during pregnancy.

Study Design: A total of 70 pregnant women were administered Tdap vaccine (Boostrix®, GSK) between 27 and 33 gestational weeks of pregnancy. Read More

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September 2021

Hybrid biofabrication of 3D osteoconductive constructs comprising Mg-based nanocomposites and cell-laden bioinks for bone repair.

Bone 2021 Sep 14:116198. Epub 2021 Sep 14.

Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group, Department of Orthopaedics Surgery and Musculoskeletal Medicine, University of Otago Christchurch, Christchurch, New Zealand; Centre of Research Excellence in Medical Technologies (MedTech CoRE), Auckland, New Zealand. Electronic address:

Tissue engineering approaches for bone repair have rapidly evolved due to the development of novel biofabrication technologies, providing an opportunity to fabricate anatomically-accurate living implants with precise placement of specific cell types. However, limited availability of biomaterial inks, that can be 3D-printed with high resolution, while providing high structural support and the potential to direct cell differentiation and maturation towards the osteogenic phenotype, remains an ongoing challenge. Aiming towards a multifunctional biomaterial ink with high physical stability and biological functionality, this work describes the development of a nanocomposite biomaterial ink (Mg-PCL) comprising of magnesium hydroxide nanoparticles (Mg) and polycaprolactone (PCL) thermoplastic for 3D printing of strong and bioactive bone regenerative scaffolds. Read More

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September 2021

Endocannabinoid system contributions to sex-specific adolescent neurodevelopment.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Sep 14:110438. Epub 2021 Sep 14.

Department of Biological Sciences, 1812 Sir Isaac Brock Way, Brock University, St. Catharines, ON L2S 3A1, Canada; Centre for Neuroscience, 1812 Sir Isaac Brock Way, Brock University, St. Catharines, ON L2S 3A1, Canada; Department of Psychology, 1812 Sir Isaac Brock Way, Brock University, St. Catharines, ON L2S 3A1, Canada. Electronic address:

With an increasing number of countries and states adopting legislation permitting the use of cannabis for medical purposes, there is a growing interest among health and research professionals into the system through which cannabinoids principally act, the endocannabinoid system (ECS). Much of the seminal research into the ECS dates back only 30 years and, although there has been tremendous development within the field during this time, many questions remain. More recently, investigations have emerged examining the contributions of the ECS to normative development and the effect of altering this system during important critical periods. Read More

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September 2021

Human epididymis protein 4 and fetal lung maturity.

J Perinat Med 2021 Sep 20. Epub 2021 Sep 20.

Department of Obstetrics and Gynecology, Ufuk University School of Medicine, Ankara, Turkey.

Objectives: To document the maternal and fetal cord blood levels of human epididymis protein 4 (HE-4) in term and preterm newborns in order to investigate the possible physiological role of HE-4 in fetal lung development.

Methods: This cross-sectional study was conducted in a university-affiliated hospital between April 2018 and September 2018. The study population consisted of cesarean section (C-section) deliveries after 24 weeks of pregnancy. Read More

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September 2021

Approaches to oocyte meiotic arrest in vitro and impact on oocyte developmental competence.

Biol Reprod 2021 Sep 17. Epub 2021 Sep 17.

Fertility & Research Centre, School of Women's & Children's Health, University of New South Wales Sydney, NSW 2052, Australia.

Oocytes are maintained in a state of meiotic arrest following the first meiotic division until ovulation is triggered. Within the antral follicle, meiotic arrest is actively suppressed in a process facilitated by the cyclic nucleotides cGMP and cAMP. If removed from this inhibitory follicular environment and cultured in vitro, mammalian oocytes undergo spontaneous meiotic resumption in the absence of the usual stimulatory follicular stimuli, leading to asynchronicity with oocyte cytoplasmic maturation and lower developmental competence. Read More

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September 2021

Sensitive timing of undifferentiation in oligodendrocyte progenitor cells and their enhanced maturation in primary visual cortex of binocularly enucleated mice.

PLoS One 2021 17;16(9):e0257395. Epub 2021 Sep 17.

Department of Bioinformatics, Graduate School of Engineering, Soka University, Hachioji, Tokyo, Japan.

Sensory experience modulates proliferation, differentiation, and migration of oligodendrocyte progenitor cells (OPCs). In the mouse primary visual cortex (V1), visual deprivation-dependent modulation of OPCs has not been demonstrated. Here, we demonstrate that undifferentiated OPCs developmentally peaked around postnatal day (P) 25, and binocular enucleation (BE) from the time of eye opening (P14-15) elevated symmetrically-divided undifferentiated OPCs in a reversible G0/G1 state even more at the bottom lamina of the cortex by reducing maturing oligodendrocyte (OL) lineage cells. Read More

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September 2021

Transcriptomic entropy benchmarks stem cell-derived cardiomyocyte maturation against endogenous tissue at single cell level.

PLoS Comput Biol 2021 Sep 17;17(9):e1009305. Epub 2021 Sep 17.

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine; Baltimore, Maryland, United States of America.

The immaturity of pluripotent stem cell (PSC)-derived tissues has emerged as a universal problem for their biomedical applications. While efforts have been made to generate adult-like cells from PSCs, direct benchmarking of PSC-derived tissues against in vivo development has not been established. Thus, maturation status is often assessed on an ad-hoc basis. Read More

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September 2021

Flunarizine suppresses Mycobacterium tuberculosis growth via calmodulin-dependent phagosome maturation.

J Leukoc Biol 2021 Sep 17. Epub 2021 Sep 17.

Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Pathogen Biology, School of Medicine, Shenzhen University, Shenzhen, China.

Tuberculosis (TB), an infectious bacterial disease caused by Mycobacterium tuberculosis (Mtb), is a major cause of death worldwide. Multidrug-resistant TB remains a public health crisis and thus novel effective treatments, such as host-directed therapies (HDTs), are urgently required to overcome the challenges of TB infection. In this study, we evaluated 4 calcium modulators for their effects on Mtb growth in macrophages. Read More

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September 2021

Neutrophil mediated postoperative photoimmunotherapy against melanoma skin cancer.

Nanoscale 2021 Sep 17;13(35):14825-14836. Epub 2021 Sep 17.

Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, 130022, China.

Surgery is the primary treatment option for most melanoma; however, high tumor recurrence rate after surgical resection becomes the main cause of death in cancer patients. The development of efficient drug delivery nanosystems to inhibit postoperative tumor recurrence becomes very necessary. In the present study, IR780 molecules and TRP-2 peptide were encapsulated in the hydrophobic shell and hydrophilic interior of TAT peptide functionalized liposomes to form LipIT NPs, which were further internalized into neutrophils (NEs) to achieve LipIT/NEs. Read More

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September 2021

FSH levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia.

J Assist Reprod Genet 2021 Sep 17. Epub 2021 Sep 17.

Austin Fertility & Reproductive Medicine/Westlake IVF, 300 Beardsley Lane, Building B, Suite 200, Austin, TX, 78746, USA.

Purpose: The purpose of this study is to assess a potential association between FSH levels and testicular volumes with the severity of testicular histopathology on testicular biopsy in men with non-obstructive azoospermia (NOA) undergoing microdissection testicular sperm extraction (microTESE).

Methods: A retrospective chart review was performed from the electronic health records of men who underwent microTESE with NOA.

Results: Eighty-six men with NOA underwent microTESE with concomitant testicular biopsy for permanent section to assess the testicular cellular architecture. Read More

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September 2021

Comparison of in vitro maturation and in vitro fertilization for polycystic ovary syndrome patients: a systematic review and meta-analysis.

Authors:
Yalan Xu Jie Qiao

Ann Transl Med 2021 Aug;9(15):1235

Centre for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Background: There are two common treatments for polycystic ovary syndrome (PCOS): in vitro fertilization (IVF) and in vitro maturation (IVM). Our study aimed to assess the clinical effects and safety of IVM versus IVF for PCOS.

Methods: We searched randomized controlled trials and retrospective cohort studies comparing IVM versus IVF for PCOS. Read More

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Effects of L-carnitine combined with pancreatic kininogenase on thioredoxin 2, thioredoxin reductase 1, and sperm quality in patients with oligoasthenospermia.

Transl Androl Urol 2021 Aug;10(8):3515-3523

Department of Laboratory Medicine, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

Background: To study the effects of L-carnitine (LC) combined with pancreatic kininogenase on thioredoxin 2 (Trx 2), thioredoxin reductase 1 (TrxR 1), and sperm quality in patients with oligoasthenospermia.

Methods: A total of 300 male infertility patients with oligoasthenospermia who were treated in the andrology clinic of our hospital from December 2019 to December 2020 were randomly divided into an LC group and combined treatment group, and 50 males with normal semen were selected as a control group. The computer-assisted semen analysis system (CASA) was used to detect the total number, vitality, and forward motility of the sperm before and after treatment, and sperm morphology was detected by the Diff-Quik method of the sperm staining kit. Read More

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Impact of early hypothalamic-pituitary-gonadal axis maturation on prostate cancer: cross-sectional analysis of a Veterans affairs cohort.

Transl Androl Urol 2021 Aug;10(8):3368-3374

Charlie Norwood VA Medical Center, Augusta, GA, USA.

Background: It has been hypothesized that earlier onset of puberty, and thus a more prolonged exposure to high androgen levels, increases risk of prostate cancer development. Our objective was to determine whether earlier age of first shave and height, as surrogates of pubertal onset, were associated with risk of prostate cancer diagnosis.

Methods: A prospectively collected outcomes registry of patients presenting for a prostate biopsy at the Charlie Norwood Veterans Affair Medical Center in Augusta, GA between July 1995 and June 2016 was utilized. Read More

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The expression of Beclin-1 in testicular tissues of non-obstructive azoospermia patients and its predictive value in sperm retrieval rate.

Transl Androl Urol 2021 Aug;10(8):3267-3274

Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, China.

Background: Beclin-1 is an autophagy gene and higher levels suggest mammalian testicular damage. Our study aims at exploring the role of Beclin-1 in non-obstructive azoospermia (NOA) patients and clarifying the predictive value of Beclin-1for sperm retrieval in microdissection testicular sperm extraction (micro-TESE).

Methods: In the present study, 62 NOA patients were finally recruited. Read More

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Development of brain behavior integration systems related to criminal culpability from childhood to young adulthood: Does it stop at 18 years?

Authors:
Ruben C Gur

J Pediatr Neuropsychol 2021 Jun 21;7(1-2):55-65. Epub 2021 Apr 21.

Brain Behavior Laboratory and the Penn-CHOP Lifespan Brain Institute, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 5th Floor Richards Bldg. Pod B, 3700 Hamilton Walk, Philadelphia, Pennsylvania, United States 19104.

The rate at which the brain develops from conception to adulthood, and how that maturational process relates to brain's product, behavior, has been a major topic for the neurosciences with implications to legal practice, most dramatically in the case of the death penalty. Based partly on neuroscience evidence for protracted maturation of executive brain systems, the US Supreme Court ruled in 2005 that capital punishment is unconstitutional for crimes committed while under the age of 18. Much more data have since been acquired on multiple indices of brain development and behavior, and a question now facing the courts is whether the cutoff age of 18 has a scientific basis or, from the developmental neuroscience evidence, it is arbitrary and in need for re-evaluation. Read More

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