Curr Genet 2021 Apr 8. Epub 2021 Apr 8.
GQE-Le Moulon, Université Paris-Saclay, INRAE, CNRS, AgroParisTech, Ferme du Moulon, 91190, Gif-sur-Yvette, France.
This short paper aims to review what our recent studies in the Nakaseomyces yeasts, principally Candida glabrata, reveal about the evolution of the mating-type switching system and its components, as well as about the repair of chromosomal double-strand breaks in this clade. In the model yeast Saccharomyces cerevisiae, the study of mating-type switching has, over the years, led to major discoveries in how cells process chromosomal breaks. Indeed, in this species, switching, which allows every haploid cell to produce cells of opposite mating types that can mate together, is initiated by the Ho endonuclease, linking sexual reproduction to a programmed chromosomal cut. Read More