131 results match your criteria maternal age-based


Thyroid Function Tests in the First Trimester of Pregnancy According to Maternal Age in Asia.

Clin Lab 2021 Feb;67(2)

Background: The American Thyroid Association suggested selective performance of the thyroid function test (TFT) in pregnant women with risk factors such as age over 30 years. We evaluated the limited indication of TFT based on age by analyzing our institution's retrospective data about TFT in pregnant women.

Methods: We retrospectively analyzed the results of thyroid stimulating hormone (TSH) and free thyroxine (FT4) with the antithyroid autoantibody test using the Cobas 8000 e801 module (Roche Diagnostics, Mannheim, Germany) performed during the first trimester of pregnancy. Read More

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February 2021

The division and transfer of care responsibilities in paediatric type 1 diabetes: A qualitative study on parental perspectives.

J Adv Nurs 2021 Apr 16;77(4):1968-1979. Epub 2021 Feb 16.

Department of Medical and Clinical Psychology, Center of Research on Psychological and Somatic disorders [CoRPS], Tilburg University, Tilburg, The Netherlands.

Aim: To determine which factors other than child age play a role in the division and transfer of diabetes care responsibilities between parents and children with type 1 diabetes.

Design: Qualitative focus group study.

Methods: Across four sites in the Netherlands, 18 parents (13 mothers) of children (9-14 years) with type 1 diabetes participated in four focus groups in 2015-2016, as part of the research project 'Whose diabetes is it anyway?'. Read More

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Sonographic growth curves versus neonatal birthweight growth curves for the identification of fetal growth restriction.

J Matern Fetal Neonatal Med 2020 Dec 1:1-8. Epub 2020 Dec 1.

Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, affiliated with the Hebrew University Hadassah Medical School, Jerusalem, Israel.

Objective: Fetal growth restriction is suspected when the estimated fetal weight is <10th percentile for gestational age. Using a regional sonographic estimated fetal weight growth curve to diagnose fetal growth restriction has no known benefits; however, the traditional approach of using birthweight curves is misleading, since a large proportion of preterm births arise from pathological pregnancies. Our aim was to compare the diagnostic accuracies of sonographic versus birthweight curves in diagnosing fetal growth restriction. Read More

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December 2020

Reduced fetal growth velocity precedes antepartum fetal death.

Ultrasound Obstet Gynecol 2020 Sep 16. Epub 2020 Sep 16.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Bethesda, Maryland, and Detroit, Michigan, USA.

Objectives: 1) To determine whether decreased fetal growth velocity precedes antepartum fetal death, and 2) Evaluate if fetal growth velocity predicts better antepartum fetal death compared to a single, last available, ultrasound examination prior to diagnosis.

Methods: We conducted a retrospective, longitudinal study of 4,285 singleton pregnancies in African-American women who underwent at least two fetal ultrasound examinations between 14 and 32 weeks of gestation and delivered a live born neonate (controls; n=4,262) or experienced antepartum fetal death (cases; n=23). Fetal death was defined as the death of a fetus ≥ 20 weeks of gestation and confirmed by ultrasound examination. Read More

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September 2020

Individualized sex-specific birth weight percentiles for gestational age based on maternal height and weight.

J Perinat Med 2020 Aug 31;49(1):94-103. Epub 2020 Aug 31.

Department of Pediatrics and Adolescent Medicine, Division of Neonatology/Intensive Care Medicine, University Hospital, Freiburg, Germany.

Objectives: The maternal body size affects birth weight. The impact on birth weight percentiles is unknown. The objective of the study was to develop birth weight percentiles based on maternal height and weight. Read More

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An analysis of clinical predictive values for radiographic pneumonia in children.

BMJ Glob Health 2020 08;5(8)

Division of Emergency Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA

Introduction: Healthcare providers in resource-limited settings rely on the presence of tachypnoea and chest indrawing to establish a diagnosis of pneumonia in children. We aimed to determine the test characteristics of commonly assessed signs and symptoms for the radiographic diagnosis of pneumonia in children 0-59 months of age.

Methods: We conducted an analysis using patient-level pooled data from 41 shared datasets of paediatric pneumonia. Read More

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Predicting the Impact of COVID-19 and the Potential Impact of the Public Health Response on Disease Burden in Uganda.

Am J Trop Med Hyg 2020 09;103(3):1191-1197

School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.

The COVID-19 pandemic and public health "lockdown" responses in sub-Saharan Africa, including Uganda, are now widely reported. Although the impact of COVID-19 on African populations has been relatively light, it is feared that redirecting focus and prioritization of health systems to fight COVID-19 may have an impact on access to non-COVID-19 diseases. We applied age-based COVID-19 mortality data from China to the population structures of Uganda and non-African countries with previously established outbreaks, comparing theoretical mortality and disability-adjusted life years (DALYs) lost. Read More

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September 2020

Prolonged maternal investment in northern bottlenose whales alters our understanding of beaked whale reproductive life history.

PLoS One 2020 23;15(6):e0235114. Epub 2020 Jun 23.

Arctic Aquatic Research Division, Fisheries and Oceans Canada, Winnipeg, Canada.

Nursing and weaning periods are poorly understood in cetaceans due to the difficulty of assessing underwater behaviour in the wild. However, the onset and completion of weaning are critical turning points for individual development and survival, with implications for a species' life history including reproductive potential. δ15N and δ13C deposited in odontocete teeth annuli provide a lifetime record of diet, offering an opportunity to investigate variation and trends in fundamental biology. Read More

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September 2020

Normal reference ranges for fetal cardiac function: Assessed by modified Doppler myocardial performance index (Mod MPI) in the Egyptian population.

Eur J Obstet Gynecol Reprod Biol 2020 Aug 21;251:66-72. Epub 2020 May 21.

Department of Paediatrics, Cairo University, Egypt.

Aim: To develop gestational age-based reference ranges for the modified Doppler myocardial performance index (Mod MPI) and to examine the maternal characteristics that affect this measurement.

Methods: This was a cross-sectional study, comprised of 1021 healthy pregnancies between 20+0 to 35+6 weeks' gestation. They were all undergoing ultrasound examination in Cairo Fetal Medicine Unit (CAIFM) in Cairo University, Egypt from 1st April 2017 till 1st April 2019. Read More

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Likelihood of achieving a 50%, 60%, or 70% estimated live birth rate threshold with 1 or 2 cycles of planned oocyte cryopreservation.

J Assist Reprod Genet 2020 Jul 16;37(7):1637-1643. Epub 2020 May 16.

Extend Fertility Medical Practice - Center for Fertility Research and Education, 200 West 57th Street - Suite 1101, New York, NY, 10019, USA.

Purpose: To characterize the likelihood of cryopreserving enough oocytes for 50%, 60%, or 70% estimated live birth rate (eLBR) with 1-2 planned oocyte cryopreservation (Pl-OC) cycles.

Methods: We performed a retrospective cohort study utilizing all patients completing ≥ 1 Pl-OC cycle from 2016 to 2018 at a large single-center OC program. Subjects were categorized by age at retrieval and number of cycles. Read More

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Decreasing Admissions to the NICU: An Official Transition Bed for Neonates.

Adv Neonatal Care 2021 Feb;21(1):87-91

Department of Pediatrics, Division of Neonatology, University of Florida Jacksonville, Jacksonville, Florida (Drs Baker and Alissa); and College of Nursing, University of Florida, Gainesville, Florida (Dr Parker).

Background: Evidence supports the need to decrease healthcare costs. One approach may be minimizing use of low-value care by reducing the number of unnecessary neonatal intensive care unit (NICU) admissions through the use of official neonatal transition beds.

Purpose: To evaluate whether transition beds decrease unnecessary NICU admissions and estimate the cost savings of this practice change. Read More

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February 2021

Non-invasive prediction of fetal growth restriction by whole-genome promoter profiling of maternal plasma DNA: a nested case-control study.

BJOG 2021 Jan 2;128(2):458-466. Epub 2020 Jun 2.

Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Objective: To predict fetal growth restriction (FGR) by whole-genome promoter profiling of maternal plasma.

Design: Nested case-control study.

Setting: Hospital-based. Read More

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January 2021

Sperm Ribosomal DNA Promoter Methylation Levels Are Correlated With Paternal Aging and May Relate With Fertilization Outcomes.

Front Genet 2020 3;11:319. Epub 2020 Apr 3.

Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University School of Medicine, Hangzhou, China.

The impact of aging on reproductive outcomes has received considerable critical attention; however, there is much less information available on the effects of paternal age compared to the effects of maternal age. In this study, methylation levels of sperm rDNA promoter regions and Long Interspersed Nucleotide Element 1 (LINE-1) were measured using pyrosequencing and fertilization, day 3 good-quality embryo, pregnancies, and implantation results were assessed. We observed significantly increasing levels of DNA methylation in the sperm rDNA promoter regions with age based on stratifying the samples by age alone ( = 0. Read More

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Obstetric and perinatal risks in 4601 singletons and 884 twins conceived after fresh blastocyst transfers: a Nordic study from the CoNARTaS group.

Hum Reprod 2020 04;35(4):805-815

Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Study Question: Are obstetric and perinatal outcomes in pregnancies after fresh blastocyst transfer (BT) comparable with those born after fresh cleavage stage transfer (CT) and spontaneous conception (SC)?

Summary Answer: Fresh BT is associated with a higher risk of placental and perinatal complications.

What Is Known Already: BT optimizes the selection of top-quality embryos and increases pregnancy and live birth rates per transfer compared to CT. However, concerns have been raised as extended culture duration may increase obstetric complications and impair perinatal outcomes. Read More

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Maternal plasma endocan levels in intrauterine growth restriction.

J Matern Fetal Neonatal Med 2020 Apr 14:1-6. Epub 2020 Apr 14.

Department of Perinatology, Zekai Tahir Burak Women's Research and Tertiary Hospital, Ankara, Turkey.

Intrauterine growth restriction (IUGR) is diagnosed when the estimated fetal weight remains below the 10th percentile of gestational age based on pathological restriction of growth and/or accompanying Doppler abnormalities. Endothelial dysfunction is a common pathogenetic pathway underlying IUGR etiology. Endocan (ESM-1) is a novel marker of endothelial dysfunction and inflammation found in the maternal circulation. Read More

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Associations between growth from birth to 18 years, intelligence, and schooling in a Brazilian cohort.

Am J Clin Nutr 2020 07;112(1):187-194

Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.

Background: Growth faltering in the first 1000 d is associated with lower human capital among adults. The existence of a second window of opportunity for nutritional interventions during adolescence has been postulated.

Objectives: We aimed to verify the associations between growth from birth to 18 y and intelligence and schooling in a cohort. Read More

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Food insecurity and housing instability during early childhood as predictors of adolescent mental health.

J Fam Psychol 2020 Sep 19;34(6):721-730. Epub 2020 Mar 19.

Department of Research.

This study examined the effects of food insecurity and housing instability experiences during early childhood on adolescent anxiety and depressive symptoms through maternal depression and parenting stress. This longitudinal study included 4 waves of data from the Fragile Families and Child Well-Being Study ( = 2,626). Food insecurity was measured when the child was 5 years of age using the U. Read More

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September 2020

Do developmental and temperamental characteristics mediate the association between preterm birth and the quality of mother-child interaction?

Infant Behav Dev 2020 02 2;58:101421. Epub 2020 Mar 2.

Department of Psychology, the Hebrew University of Jerusalem, Mount Scopus, Jerusalem, 91905, Israel. Electronic address:

Background: The current study aims to evaluate the association between preterm birth and the quality of mother-child interaction of very preterm-, moderate preterm-, and full-term-born children at 18 and 36 months and to determine whether developmental and behavioral characteristics mediate the association between preterm birth and the quality of mother-child interaction.

Method: Participants included 110 preterm-born children and 39 full-term-born children assessed at ages 18 and 36 months. Mother-child free play interactions, the Mullen Scales of Early Learning, the Infant Behavior Questionnaire, and the Early Childhood Behavior Questionnaire were administered. Read More

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February 2020

Neurodevelopmental Abnormalities in Children With In Utero Zika Virus Exposure Without Congenital Zika Syndrome.

JAMA Pediatr 2020 03;174(3):269-276

BIOMELAB, Barranquilla, Colombia.

Importance: The number of children who were born to mothers with Zika virus (ZIKV) infection during pregnancy but who did not have apparent disability at birth is large, warranting the study of the risk for neurodevelopmental impairment in this population without congenital Zika syndrome (CZS).

Objective: To investigate whether infants without CZS but who were exposed to ZIKV in utero have normal neurodevelopmental outcomes until 18 months of age.

Design, Setting, And Participants: This cohort study prospectively enrolled a group of pregnant women with ZIKV in Atlántico Department, Colombia, and in Washington, DC. Read More

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Cell-free DNA fetal fraction in twin gestations in single-nucleotide polymorphism-based noninvasive prenatal screening.

Prenat Diagn 2020 01 21;40(2):179-184. Epub 2019 Nov 21.

Department of Genetics and Genome Sciences, UConn Health, Farmington, CT.

Objectives: The performance of noninvasive prenatal screening (NIPS) for fetal aneuploidy in twin pregnancies is dependent on the amount of placentally derived cell-free DNA, the "fetal fraction (FF)," present in maternal plasma. We report FF values in monozygotic (MZ) and dizygotic (DZ) pregnancies.

Methods: We reviewed FF in pregnancies at 10 to 20 completed weeks gestational age based on single-nucleotide polymorphism (SNP)-based NIPS where zygosity was routinely established in twin pregnancies. Read More

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January 2020

Timing of Elective Cesarean Section and Growth and Psychomotor Developmental Indices in 6-Month-Old Infants.

Arch Iran Med 2019 08 1;22(8):420-428. Epub 2019 Aug 1.

IVF Unit, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: In the present study, we evaluated post-natal growth and psychomotor development status of infants at 6 months of age based on their gestational age at elective cesarean sections.

Methods: This is a prospective cohort study performed in 2014-2015 in Iran. The study population consisted of 6-month-old infants with gestational ages of 38-40 weeks delivered by elective cesarean section. Read More

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Testing the theoretical similarities between food and water insecurity: Buffering hypothesis and effects on mental wellbeing.

Authors:
Amanda Maxfield

Soc Sci Med 2020 01 12;244:112412. Epub 2019 Jul 12.

Department of Anthropology, Emory University. 1557 Dickey Drive Atlanta, GA 30322, USA. Electronic address:

Theoretical analyses by anthropologists suggest that food and water insecurity exhibit multiple conceptual parallels, hold similar consequences for wellbeing, and lead to analogous coping strategies aimed at mitigating those consequences. However, these deductions largely originate from studies conducted separately on either food or water insecurity. Thus, these similarities may not bear out when examined in populations facing high rates of both. Read More

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January 2020

Fission-fusion dynamics of a megaherbivore are driven by ecological, anthropogenic, temporal, and social factors.

Oecologia 2019 Oct 27;191(2):335-347. Epub 2019 Aug 27.

Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.

Fission-fusion dynamics hypothetically enable animals to exploit dispersed and ephemeral food resources while minimizing predation risk. Disentangling factors affecting group size and composition of fission-fusion species facilitates their management and conservation. We used a 6-year data set of 2888 group formations of Masai giraffes in Tanzania to investigate determinants of social group size and structure. Read More

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October 2019

Predictors of Severe Neurologic Injury on Ultrasound Scan of the Head and Risk Factor-based Screening for Infants Born Preterm.

J Pediatr 2019 11 31;214:27-33.e3. Epub 2019 Jul 31.

Department of Paediatrics, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada; Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada.

Objective: To identify risk factors for severe neurologic injury (intraventricular hemorrhage grade 3 or greater and/or periventricular leukomalacia) diagnosed by ultrasound scan of the head among infants born at 30-32 weeks of gestation and compare different screening strategies.

Study Design: This was a retrospective cohort study of infants born at 30-32 weeks or >32 weeks of gestation with a birth weight <1500 g admitted to neonatal intensive care units in the Canadian Neonatal Network from 2011 to 2016. Stepwise logistic regression analysis was used to identify significant risk factors and calculate aORs and 95% CIs. Read More

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November 2019

Identifying fetal growth disorders using ultrasound in obese nulliparous women.

J Matern Fetal Neonatal Med 2021 Jun 1;34(11):1768-1773. Epub 2019 Aug 1.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Objective: We evaluated the ability of third trimester ultrasound to diagnose fetal growth disorders among obese women.

Methods: This is a retrospective cohort study of obese nulliparous women who delivered term singleton neonates who had an ultrasound within 5 weeks of delivery. We characterized the sensitivity, specificity, positive predictive value and negative predictive value of ultrasound to detect large-for-gestational age (LGA) and small-for-gestational age (SGA) infants. Read More

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Advanced paternal age and the risk of spontaneous abortion: an analysis of the combined 2011-2013 and 2013-2015 National Survey of Family Growth.

Am J Obstet Gynecol 2019 11 22;221(5):476.e1-476.e7. Epub 2019 May 22.

Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, CA.

Background: Maternal and paternal age at first birth are increasing across the global population. Spontaneous abortion, one of the most common abnormal pregnancy outcomes, is known to occur more frequently with increasing maternal age. However, the relationship of advanced paternal age and spontaneous abortion is poorly understood, and previous results have yielded conflicting results. Read More

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November 2019

[Exploration of the process of prenatal screening and diagnosis for women with advanced maternal age based on results of 351 cases of fetal chromosomal abnormalities].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2019 Jun;36(6):538-542

Prenatal Diagnosis Center, Bejing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China. Email:

Objective: To explore the suitable process for prenatal screening and diagnosis for women with advanced maternal age.

Methods: From January 2014 to November 2017, the indications and distributions of prenatal diagnosis for women with advanced maternal age only or accompanying with positive maternal serum test screening and non-invasive prenatal testing (NIPT), abnormal fetal ultrasound, one harboring chromosomal abnormalities or anomalous reproductive history were analyzed. The rate of fetal chromosomal abnormalities was compared between different groups. Read More

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Prevalence trends of overweight, obesity, diabetes and hypertension among Brazilian women of reproductive age based on sociodemographic characteristics.

Health Care Women Int 2019 04 15;40(4):386-406. Epub 2019 Apr 15.

b Departamento de Enfermagem Materno-Infantil e Saúde Pública, Escola de Enfermagem , Universidade Federal de Minas Gerais , Belo Horizonte, Minas , Brazil.

The authors estimated the prevalence and trends of overweight, obesity, diabetes and hypertension among Brazilian women of reproductive age. A time series was constructed with Vigitel data from 2008 to 2015 and we analyzed trends of the prevalence of these conditions, considering sociodemographic characteristics. We observed an increasing trend in prevalence of overweight, obesity, and diabetes (for some sociodemographic characteristics), and stationary trends for hypertension. Read More

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Effects of adding psychosocial stimulation for children of lactating mothers using an unconditional cash transfer platform on neurocognitive behavior of children in rural Bangladesh: protocol for a cluster randomized controlled trial.

BMC Psychol 2019 Mar 5;7(1):13. Epub 2019 Mar 5.

Maternal and Child Health Division (MCHD), Internationational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka, 1212, Bangladesh.

Background: There is sufficient evidence that psychosocial stimulation (PS) benefits children's neurocognitive behavior, however, there is no information on how it works when delivered through an Unconditional Cash Transfer (UCT) platform for poor rural population in developing countries. The objective of this study is to measure effects of adding PS for children of lactating mothers enrolled to receive UCT with health education (HE) on neurocognitive behavior of children in rural Bangladesh.

Methods: The study will be conducted at 11 unions of Ullapara sub-district in Bangladesh. Read More

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Management of Chorioamnionitis-Exposed Infants in the Newborn Nursery Using a Clinical Examination-Based Approach.

Hosp Pediatr 2019 04 4;9(4):227-233. Epub 2019 Mar 4.

Department of Pediatrics, Stanford University, Stanford, California; and

Background: Antibiotic use in well-appearing late preterm and term chorioamnionitis-exposed (CE) infants was reduced by 88% after the adoption of a care approach that was focused on clinical monitoring in the intensive care nursery to determine the need for antibiotics. However, this approach continued to separate mothers and infants. We aimed to reduce maternal-infant separation while continuing to use a clinical examination-based approach to identify early-onset sepsis (EOS) in CE infants. Read More

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