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Trimetazidine Protects from Mercury-Induced Kidney Injury.

Pharmacology 2021 Apr 13:1-9. Epub 2021 Apr 13.

Pharmacology, Faculty of Biochemical and Pharmaceutical Sciences. National University of Rosario, CONICET, Rosario, Argentina.

Introduction: The presence of mercury in the environment is a worldwide concern. Inorganic mercury is present in industrial materials, is employed in medical devices, is widely used in batteries, is a component of fluorescent light bulbs, and it has been associated with human poisoning in gold mining areas. The nephrotoxicity induced by inorganic mercury is a relevant health problem mainly in developing countries. Read More

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Effect of "Residents as Teachers" Workshop on Learner Perception of Trainee Teaching Skill.

J Surg Res 2021 Apr 10;264:418-424. Epub 2021 Apr 10.

University Hospitals Cleveland Medical Center, Department of General Surgery, Cleveland Ohio; University Hospitals Research in Surgical Outcomes & Effectiveness Center (UH-RISES), Cleveland Ohio. Electronic address:

Background: Surgical residencies use variable structures for formal training in education. We hypothesized that a one-day workshop intervention would improve resident teaching ability measured by self-assessment and learner evaluation.

Materials And Methods: Faculty educators delivered a Residents as Teachers (RAT) workshop to general surgery residents on setting expectations, positive learning environment, difficult feedback and the 1-min preceptor model. Read More

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Evolution of the gross tumour volume extent during radiotherapy for glioblastomas.

Radiother Oncol 2021 Apr 10. Epub 2021 Apr 10.

Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Department of Oncology, Odense University Hospital, Odense, Denmark.

Background And Purpose: Tumour growth during radiotherapy may lead to geographical misses of the target volume. This study investigates the evolution of the tumour extent and evaluates the need for plan adaptation to ensure dose coverage of the target in glioblastoma patients.

Materials And Methods: The prospective study included 29 patients referred for 59. Read More

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Organic Nanoparticles-Assisted Low-Power STED Nanoscopy.

Nano Lett 2021 Apr 13. Epub 2021 Apr 13.

Beijing Key Laboratory for Optical Materials and Photonic Devices, Capital Normal University, Beijing 100048, China.

Stimulated emission depletion (STED) nanoscopy plays a key role in achieving sub-50 nm high spatial resolution for subcellular live-cell imaging. To avoid re-excitation, the STED wavelength has to be tuned at the red tail of the emission spectrum of fluorescent probes, leading to high depletion laser power that might damage the cell viability and functionality. Herein, with the highly emissive silica-coated core-shell organic nanoparticles (CSONPs) enabling a giant Stokes shift of 150 nm, ultralow power STED is achieved by shifting the STED wavelength to the emission maximum at 660 nm. Read More

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Quercetin as a nephroprotector after warm ischemia: histomorphometric evaluation in a rodent model.

Int Braz J Urol 2021 Jul-Aug;47(4):796-802

Unidade de Pesquisa Urogenital, Universidade do Estado do Rio de Janeiro - UERJ, Rio de Janeiro, RJ, Brasil.

Purpose: To quantitatively evaluate the possible long-term protective effects of quercetin during renal warm ischemia.

Materials And Methods: Male rats were allocated into 4 groups: sham (S), sham quercetin (SQ), ischemia (I), and ischemia quercetin (IQ). Groups SQ and IQ received quercetin (50mg/kg) before and after surgery. Read More

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Determination of minor isotope ratios of individual uranium particles by accelerator mass spectrometry.

J Mass Spectrom 2021 May;56(5):e4719

Department of Radiochemistry, China Institute of Atomic Energy, Beijing, China.

The determination of uranium isotope ratios in uranium particle is an essential technique in the analysis of environmental samples for nuclear safeguards. At present, mass spectrometry has been widely used to measure isotope ratios of uranium particles. We developed a new analytical method for measuring minor isotope ratios of individual uranium particles directly. Read More

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Evaluation of Interfacial pH Using Surface Forces Apparatus Fluorescence Spectroscopy.

Langmuir 2021 Apr 13. Epub 2021 Apr 13.

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980-8577, Japan.

The fluorescence spectrum measurement of a fluorescence pH probe, C. SNARF-4F, was performed for monitoring the interfacial pH of aqueous electrolytes between mica or silica surfaces while varying the surface separation () using surface force apparatus (SFA) fluorescence spectroscopy. The pH of the aqueous CsCl between mica exponentially decreased with decreasing . Read More

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Nitrogen isotope effects can be used to diagnose N transformations in wastewater anammox systems.

Sci Rep 2021 Apr 12;11(1):7850. Epub 2021 Apr 12.

Aquatic and Isotope Biogeochemistry, Department of Environmental Sciences, University of Basel, Basel, 4056, Switzerland.

Anaerobic ammonium oxidation (anammox) plays an important role in aquatic systems as a sink of bioavailable nitrogen (N), and in engineered processes by removing ammonium from wastewater. The isotope effects anammox imparts in the N isotope signatures (N/N) of ammonium, nitrite, and nitrate can be used to estimate its role in environmental settings, to describe physiological and ecological variations in the anammox process, and possibly to optimize anammox-based wastewater treatment. We measured the stable N-isotope composition of ammonium, nitrite, and nitrate in wastewater cultivations of anammox bacteria. Read More

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Patient preferences regarding use of contrast-enhanced imaging for breast cancer screening.

Acad Radiol 2021 Apr 9. Epub 2021 Apr 9.

Division of Breast Imaging, Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 USA. Electronic address:

Rationale And Objectives: Our purpose is to understand patient preferences towards contrast-enhanced imaging such as CEM or MRI for breast cancer screening.

Methods And Materials: An anonymous survey was offered to all patients having screening mammography at a single academic institution from December 27 th 2019 to March 6 th 2020. Survey questions related to: (1) patients' background experiences (2) patients' concern for aspects of MRI and CEM measured using a 5-point Likert scale, and (3) financial considerations. Read More

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Characterization and toxicity evaluation of air-borne particles released by grinding from two dental resin composites in vitro.

Dent Mater 2021 Apr 9. Epub 2021 Apr 9.

National Institute of Occupational Health, Oslo, Norway. Electronic address:

Objective: The project aims to evaluate whether inhalation of particles released upon grinding of dental composites may pose a health hazard to dentists. The main objective of the study was to characterize the dust from polymer-based dental composites ground with different grain sized burs and investigate particle uptake and the potential cytotoxic effects in human bronchial cells.

Methods: Polymerized blocks of two dental composites, Filtek™ Z250 and Filtek™ Z500 from 3M™ ESPE, were ground with super coarse (black) and fine (red) burs inside a glass chamber. Read More

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Effect of commercial wearables and digital behaviour change resources on the physical activity of adolescents attending schools in socio-economically disadvantaged areas: the RAW-PA cluster-randomised controlled trial.

Int J Behav Nutr Phys Act 2021 Apr 12;18(1):52. Epub 2021 Apr 12.

Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.

Background: There has been increasing interest in using wearable activity trackers to promote physical activity in youth. This study examined the short- and longer-term effects of a wearable activity tracker combined with digital behaviour change resources on the physical activity of adolescents attending schools in socio-economically disadvantaged areas.

Methods: The Raising Awareness of Physical Activity (RAW-PA) Study was a 12-week, multicomponent intervention that combined a Fitbit Flex (and accompanying app), and online digital behaviour change resources and weekly challenges delivered via Facebook. Read More

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Augmented cerclage wire improves the fixation strength of a two-screw construct for humerus split type greater tuberosity fracture: a biomechanical study.

BMC Musculoskelet Disord 2021 Apr 12;22(1):350. Epub 2021 Apr 12.

Department of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background: Poor functional outcome can result from humeral greater tuberosity (GT) fracture if not treated appropriately. A two-screw construct is commonly used for the surgical treatment of such injury. However, loss of reduction is still a major concern after surgery. Read More

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Capsular closure versus unrepaired interportal capsulotomy after hip arthroscopy in patients with femoroacetabular impingement, results of a patient-blinded randomised controlled trial.

Hip Int 2021 Apr 12:11207000211005762. Epub 2021 Apr 12.

Specialized Center of Orthopaedic Research & Education (SCORE), Department of Orthopaedic Surgery, Xpert Orthopaedic Surgery Clinic, Amsterdam, The Netherlands.

Background: Hip capsular management after hip arthroscopy remains a topic of debate. Most available current literature is of poor quality and are retrospective or cohort studies. As of today, no clear consensus exists on capsular management after hip arthroscopy. Read More

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