J Biol Chem 2021 Jun 19:100905. Epub 2021 Jun 19.
Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3010, Australia; Immunology Laboratory, Guangzhou Institute of Paediatrics, Guangzhou Women and Children's Medical Centre, Guangzhou, Guangdong, 510623, China. Electronic address:
PLCγ2 is a critical signalling molecule activated downstream from a variety of cell surface receptors that contain an intracellular immunoreceptor tyrosine-based activation motif (ITAM). These receptors recruit kinases such as Syk, BTK and BLNK to phosphorylate and activate PLCγ2, which then generates 1D-myo-inositol 1,4,5-trisphosphate (IP) and diacylglycerol (DAG). These well known second messengers are required for diverse membrane functionality including cellular proliferation, endocytosis and calcium flux. Read More