101,195 results match your criteria massive

Embryonic exposure to low concentrations of aflatoxin B1 triggers global transcriptomic changes, defective yolk lipid mobilization, abnormal gastrointestinal tract development and inflammation in zebrafish.

J Hazard Mater 2021 Apr 2;416:125788. Epub 2021 Apr 2.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary. Electronic address:

Aflatoxin B1-contaminated feeds and foods induce various health problems in domesticated animals and humans, including tumor development and hepatotoxicity. Aflatoxin B1 also has embryotoxic effects in different livestock species and humans. However, it is difficult to distinguish between the indirect, maternally-mediated toxic effects and the direct embryotoxicity of aflatoxin B1 in mammals. Read More

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Development and clinical validation of loop-mediated isothermal amplification (LAMP) assay to diagnose high HBV DNA levels in resource-limited settings.

Clin Microbiol Infect 2021 Apr 7. Epub 2021 Apr 7.

Unité d'Epidémiologie des Maladies Émergentes, Institut Pasteur, Paris, France. Electronic address:

Objectives: A massive scale-up of testing and treatment is indicated to globally eliminate hepatitis B virus (HBV) infection. However, access to a polymerase chain reaction (PCR), a key test to quantify HBV DNA levels and determine treatment eligibility, is limited in resource-limited countries. We developed and evaluated loop-mediated isothermal amplification (LAMP) assay to diagnose clinically important HBV DNA thresholds defined by WHO (≥20,000 and ≥200,000 IU/mL). Read More

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Current capsid assembly models of icosahedral nucleocytoviricota viruses.

Adv Virus Res 2020 5;108:275-313. Epub 2020 Oct 5.

Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas, United States. Electronic address:

Nucleocytoviricota viruses (NCVs) belong to a newly established phylum originally grouped as Nucleocytoplasmic large DNA viruses. NCVs are unique because of their large and complicated genomes that contain cellular genes with homologs from all kingdoms of life, raising intensive debates on their evolutional origins. Many NCVs pack their genomes inside massive icosahedral capsids assembled from thousands of proteins. Read More

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October 2020

Endovascular repair and open repair surgery of thoraco-abdominal aortic aneurysms cause drastically different types of spinal cord injury.

Sci Rep 2021 Apr 9;11(1):7834. Epub 2021 Apr 9.

Department of Surgery, Division of Vascular and Endovascular Surgery, Eastern Virginia Medical School, 600 Gresham Dr, Norfolk, VA, 23507, USA.

Both endovascular repair (EVR) and open repair (OR) surgery of thoraco-abdominal aortic aneurysms cause spinal cord (SC) injury that can lead to paraparesis or paraplegia. It has been assumed that mechanisms responsible for SC damage after EVR are similar to those after OR. This pilot study compared the pathophysiology of SC injury after EVR versus OR using a newly developed EVR dog model. Read More

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Six-fold increase of atmospheric pCO during the Permian-Triassic mass extinction.

Nat Commun 2021 Apr 9;12(1):2137. Epub 2021 Apr 9.

Department of Earth and Environmental Studies, Montclair State University, Montclair, NJ, USA.

The Permian-Triassic mass extinction was marked by a massive release of carbon into the ocean-atmosphere system, evidenced by a sharp negative carbon isotope excursion. Large carbon emissions would have increased atmospheric pCO and caused global warming. However, the magnitude of pCO changes during the PTME has not yet been estimated. Read More

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Stellar feedback and triggered star formation in the prototypical bubble RCW 120.

Sci Adv 2021 Apr 9;7(15). Epub 2021 Apr 9.

Department of Astronomy, University of Maryland, College Park, MD 20742, USA.

Radiative and mechanical feedback of massive stars regulates star formation and galaxy evolution. Positive feedback triggers the creation of new stars by collecting dense shells of gas, while negative feedback disrupts star formation by shredding molecular clouds. Although key to understanding star formation, their relative importance is unknown. Read More

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Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry.

Scand J Trauma Resusc Emerg Med 2021 Apr 9;29(1):57. Epub 2021 Apr 9.

Hematopathology, Pathology Department, CDB, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain.

Background: Colloid fluids supplemented with adequate combinations of coagulation factor concentrates with the capability to restore coagulation could be a desirable future treatment component in massive transfusion.

Methods: Starting from a coagulation factor and blood cell-free albumin solution we added Prothrombin Complex Concentrate, Fibrinogen Concentrate and Factor XIII in different combinations and concentrations to analyze their properties to restore thromboelastometry parameters without the use of plasma. Further analysis under the presence of platelets was performed for comparability to whole blood conditions. Read More

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Loss of Reproductive Ability due to Late Application of Young Refugee with Choriocarcinoma During the COVID-19 Pandemic.

J Adolesc Young Adult Oncol 2021 Apr 9. Epub 2021 Apr 9.

Department of Gynecologic Oncology, Adana City Training and Research Hospital, Adana, Turkey.

Choriocarcinoma is an aggressive malignant trophoblastic neoplasm. The rapid growth of neoplastic tissue and myometrial invasion can cause uterine perforation. It is important to quickly diagnose the disease and plan treatment because these tumors are nearly always curable, and fertility can be preserved in most cases with proper management. Read More

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A simple x-ray scoring system for the diagnosis of Chronic Pulmonary Aspergillosis.

Mycoses 2021 Apr 9. Epub 2021 Apr 9.

Department of Pulmonary Medicine and Dean, St. John's Medical college Hospital, Bengaluru, India.

Background: Chronic pulmonary aspergillosis (CPA) is a severe form of post tuberculosis lung disease (PTBLD). Considering the high burden of TB in India, it can be concluded that the prevalence of CPA is also high. Chest x-ray though most feasible, interpretation is subjective. Read More

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Databases for RNA Editing Collections.

Methods Mol Biol 2021 ;2284:467-480

Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari, Bari, Italy.

A-to-I RNA editing in humans plays a relevant role since it can influence gene expression and increase proteome diversity. In addition, its deregulation has been linked to a variety of human diseases, including neurological disorders and cancer.In the last decade, massive transcriptome sequencing through the RNAseq technology has dramatically improved the investigation of RNA editing at single nucleotide resolution. Read More

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January 2021

iDEP Web Application for RNA-Seq Data Analysis.

Xijin Ge

Methods Mol Biol 2021 ;2284:417-443

Department of Mathematics and Statistics, South Dakota State University, Brookings, SD, USA.

RNA sequencing (RNA-seq) has become a routine method for transcriptomic profiling. We developed a user-friendly web app called iDEP (integrated differential expression and pathway analysis) to help biologists interpret read counts or other types of expression matrices derived from read mapping. With iDEP, users can easily conduct exploratory data analysis, identify differentially expressed genes, and perform pathway analysis. Read More

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January 2021

A case of black esophagus with duodenal involvement.

Clin J Gastroenterol 2021 Apr 9. Epub 2021 Apr 9.

Department of Emergency Medicine, Nagayama Hospital, 1-1-10 Okubohigashi, Kumatori, Osaka, 590-0406, Japan.

Black esophagus is a rare condition referred from acute necrosis of the esophagus, with characteristic endoscopic finings of circumferential black appearance of the mucosa. Black esophagus is associated with systemic dysfunction, such as massive bleeding, or severe dehydration. Although the duodenal mucosa is also susceptible to ischemia, reports of black esophagus with duodenal involvement, such as bleeding or perforation, are limited. Read More

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Distribution of genetic elements associated with antibiotic resistance in treated and untreated animal husbandry waste and wastewater.

Environ Sci Pollut Res Int 2021 Apr 9. Epub 2021 Apr 9.

Department of Biological Sciences, Federal University of Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, State of Minas Gerais, CEP: 35.400-000, Brazil.

Animal breeding for meat production based on swine, cattle, poultry, and aquaculture is an activity that generates several impacts on the environment, among them the spread of antibiotic resistance. There is a worldwide concern related to the massive use of antibiotics, which causes selective pressure on the microbial community, triggering bacteria that contain "antibiotic resistance genes." According to the survey here presented, antibiotic resistance-related genes such as tetracyclines (tet), erythromycin (erm), and sulfonamides (sul), as well as the genetic mobile element interferon (int), are the most reported genetic elements in qualitative and quantitative studies of swine, cattle, poultry, and aquaculture manure/wastewater. Read More

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Perforator-Based Intercostal Artery Muscle Flap: A Novel Approach for the Treatment of Tracheoesophageal or Bronchoesophageal Fistulas.

Plast Reconstr Surg 2021 Apr 7. Epub 2021 Apr 7.

From the Department of Plastic, Reconstructive, and Aesthetic Surgery, Hospital Sud, INSERM U1236, and the Department of Hepatobiliary and Digestive Surgery, University of Rennes 1; SITI Laboratory, Etablissement Français du Sang Bretagne, Rennes University Hospital; and the Department of Plastic, Reconstructive, and Aesthetic Surgery, Cliniques Universitaires Saint-Luc.

Summary: Postoperative tracheoesophageal or bronchoesophageal fistulas represent a major surgical challenge. The authors report the description of an original perforator-based intercostal artery muscle flap, aiming to cover all types of intrathoracic fistulas, from any location, in difficult cases such as postoperative fistulas after esophagectomy in an irradiated field. Between June of 2016 and January of 2019, eight male patients were treated with a perforator-based intercostal artery muscle flap. Read More

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An Automatic Ontology-Based Approach to Support Logical Representation of Observable and Measurable Data for Healthy Lifestyle Management: Proof-of-Concept Study.

J Med Internet Res 2021 Apr 9;23(4):e24656. Epub 2021 Apr 9.

Department of Health and Nursing Science, Centre for e-Health, University of Agder, Grimstad, Norway.

Background: Lifestyle diseases, because of adverse health behavior, are the foremost cause of death worldwide. An eCoach system may encourage individuals to lead a healthy lifestyle with early health risk prediction, personalized recommendation generation, and goal evaluation. Such an eCoach system needs to collect and transform distributed heterogenous health and wellness data into meaningful information to train an artificially intelligent health risk prediction model. Read More

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[Analysis of risk factors of acute respiratory distress syndrome secondary to severe multiple trauma].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):299-304

Trauma Center, Zhenjiang First People's Hospital, Zhenjiang 212000, Jiangsu, China. Corresponding author: Wang Peng, Email:

Objective: To explore the risk factors of acute respiratory distress syndrome (ARDS) secondary to severe multiple trauma and the role of clinical guidance.

Methods: The clinical data of 115 patients with severe multiple trauma admitted to the trauma center of Zhenjiang First People's Hospital from December 2017 to September 2020 were retrospectively analyzed. According to whether ARDS occurred within 1 week of the disease course, the patients were divided into ARDS group and non-ARDS group. Read More

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Signatures of Chaos in Nonintegrable Models of Quantum Field Theories.

Phys Rev Lett 2021 Mar;126(12):121602

Faculty of Mathematics and Physics, University of Ljubljana, Ljubljana SI 1000, Slovenia.

We study signatures of quantum chaos in (1+1)D quantum field theory (QFT) models. Our analysis is based on the method of Hamiltonian truncation, a numerical approach for the construction of low-energy spectra and eigenstates of QFTs that can be considered as perturbations of exactly solvable models. We focus on the double sine-Gordon, also studying the massive sine-Gordon and ϕ^{4} model, all of which are nonintegrable and can be studied by this method with sufficiently high precision from small to intermediate perturbation strength. Read More

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A hybrid multi-objective whale optimization algorithm for analyzing microarray data based on Apache Spark.

PeerJ Comput Sci 2021 25;7:e416. Epub 2021 Mar 25.

Faculty of Computers and Information, Assiut University, Egypt.

A microarray is a revolutionary tool that generates vast volumes of data that describe the expression profiles of genes under investigation that can be qualified as Big Data. Hadoop and Spark are efficient frameworks, developed to store and analyze Big Data. Analyzing microarray data helps researchers to identify correlated genes. Read More

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Case Report: Successful revascularization in massive pulmonary embolism with a large protruding thrombus and dilated cardiomyopathy.

F1000Res 2021 11;10:13. Epub 2021 Jan 11.

Department of Physiology and Medical Biochemistry, Airlangga University, Surabaya, Indonesia.

Pulmonary embolism is a potentially life-threatening condition. Despite advances in diagnostics, lack of consensus and delays in determining the diagnosis of pulmonary embolism are still important problems. We report the diagnosis and management of a 37-year-old man suffering from massive pulmonary embolism, a large protruding thrombus, and dilated cardiomyopathy. Read More

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January 2021

COVID-19: Mental Health Prevention and Care for Healthcare Professionals.

Front Psychiatry 2021 23;12:566740. Epub 2021 Mar 23.

Regional Center for Psychotraumatism Great East, Strasbourg University Hospital, Strasbourg, France.

The Coronavirus Disease 2019 (COVID-19) pandemic exposed health professionals to high stress levels inducing significant psychological impact. Our region, , was the most impacted French region during the first COVID-19 wave. In this context, we created CoviPsyHUS, local mental health prevention and care system dedicated explicitly to healthcare workers affected by the COVID-19 pandemic in one of this region's tertiary hospitals. Read More

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Management of Patient with Simultaneous Overt Gastrointestinal Bleeding and Myocardial Infarction with ST-Segment Elevation - Priority Endoscopy.

Vasc Health Risk Manag 2021 31;17:123-133. Epub 2021 Mar 31.

Faculty of Medicine, Department of Psychiatry, Medical University of Gdansk, Gdansk, Poland.

Background: The current ERC guidelines are the source of many positive changes, reduction of mortality, length of hospitalization and improvement of prognosis of STEMI patients. However, there is a small group of patients whose slight modification in guidelines would further reduce in-hospital mortality and hospitalization costs. These are patients with concomitant STEMI infarction and gastrointestinal bleeding. Read More

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Factors influencing the short-term and long-term survival of hepatocellular carcinoma patients with portal vein tumor thrombosis who underwent chemoembolization.

Ke-Li Chen Jian Gao

World J Gastroenterol 2021 Apr;27(13):1330-1340

Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

Background: The factors affecting the short-term and long-term prognosis of hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) receiving transarterial chemoembolization (TACE) are still unclear.

Aim: To clarify the predictors correlated with the short-term and long-term survival of HCC patients with PVTT who underwent TACE.

Methods: The medical records of 181 HCC patients with PVTT who underwent TACE at the Second Affiliated Hospital of Chongqing Medical University from January 2015 to July 2019 were retrospectively analyzed. Read More

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Conformational Dynamics of Sclerostin-LRP6 Complex Analyzed by HDX-MS.

Biomol Ther (Seoul) 2021 Apr 9. Epub 2021 Apr 9.

School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.

Sclerostin (SOST), a regulator of bone formation in osteocytes, inhibits the canonical Wnt signaling by interacting with low-density lipoprotein receptor-related protein 5/6 (LRP5/6) to prevent Wnt binding. Loss-of-function mutations of the gene caused massive bone outgrowth and SOST-null mouse exhibited a high bone density phenotype. Therefore, SOST has been suggested as a promising therapeutic target for osteoporosis. Read More

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Management of Acute Pulmonary Embolism With a Pulmonary Embolism Response Team.

J Am Board Fam Med 2021 Mar-Apr;34(2):402-408

From the Division of Cardiology, Yale University, New Haven, CT (JC); Division of Cardiology, Medical College of Georgia at the Augusta University Medical Center (VA); and the Department of Family Medicine, Medical College of Georgia at the Augusta University Medical Center, Augusta (TW).

Despite recent advances in the assessment, risk stratification, and treatment of acute pulmonary embolism (PE), it remains a leading cause of cardiovascular morbidity and mortality in the United States each year. Patient presentation and prognosis are heterogeneous, and a variety of diagnostic and therapeutic instruments have arisen to assist in providing patients with the appropriate level of care and aggressiveness of approach. Fortunately, a growing number of institutions now have pulmonary embolism response teams (PERT) that urgently assist with risk assessment and management of patients with massive and sub-massive PE. Read More

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ECMO (extra corporeal membrane oxygenation) in major trauma: A 10 year single centre experience.

Injury 2021 Apr 2. Epub 2021 Apr 2.

National Trauma Research Institute, Australia; Trauma Services, The Alfred, Australia.

Aim To review the indications, complications and outcomes of extracorporeal membrane oxygenation (ECMO) in major trauma patients. Methods Single centre, retrospective, cohort study. Results Over a ten year period, from 13,420 major trauma patients, 11 were identified from our institutional trauma registry as having received ECMO. Read More

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Carnosine functionalized magnetic metal-organic framework nanocomposites for synergistic enrichment of phosphopeptides.

Anal Chim Acta 2021 May 12;1157:338383. Epub 2021 Mar 12.

College of Chemistry, Jilin University, Changchun, 130012, China; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Sciences, Jilin University, Changchun, 130012, China. Electronic address:

Protein phosphorylation regulates the conformations and function of proteins, which plays an important part in organisms. However, systematic and in-depth analysis of phosphorylation often hinders on account of the low abundance and suppressed ionization of phosphopeptides. Various materials based on single enrichment mechanism show potential in phosphopeptides enrichment, but the enrichment performance is typically not satisfactory. Read More

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State predictive information bottleneck.

J Chem Phys 2021 Apr;154(13):134111

Department of Chemistry and Biochemistry and Institute for Physical Science and Technology, University of Maryland, College Park, Maryland 20742, USA.

The ability to make sense of the massive amounts of high-dimensional data generated from molecular dynamics simulations is heavily dependent on the knowledge of a low-dimensional manifold (parameterized by a reaction coordinate or RC) that typically distinguishes between relevant metastable states, and which captures the relevant slow dynamics of interest. Methods based on machine learning and artificial intelligence have been proposed over the years to deal with learning such low-dimensional manifolds, but they are often criticized for a disconnect from more traditional and physically interpretable approaches. To deal with such concerns, in this work we propose a deep learning based state predictive information bottleneck approach to learn the RC from high-dimensional molecular simulation trajectories. Read More

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The complete spectrum of pentalogy of Cantrell in one of a set of dizygotic twins: A case report of a rare congenital anomaly.

Medicine (Baltimore) 2021 Apr;100(14):e25470

College of Medicine.

Rationale: Pentalogy of Cantrell (POC) is an extremely rare syndrome with an estimated incidence of 1:65,000 to 200,000 live births. Its complete form includes a midline epigastric abdominal wall defect, defects affecting the lower sternum, anterior diaphragm, diaphragmatic pericardium, and various intracardiac defects.

Patient Concerns: We report a case of complete POC affecting only the first-born of a set of premature dizygotic twins. Read More

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Treatment challenges in patients with early acute massive pulmonary thrombosis embolism (PTE) after lung cancer surgery: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25371

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Introduction: Early acute massive pulmonary thrombosis embolism (PTE) after lung cancer surgery is one of the most fatal surgical complications. It is often accompanied by shock and hypotension, with high mortality rate. Due to surgical wounds, patients with early acute massive PTE after lung cancer surgery have a high risk of thrombolytic bleeding, which renders treatment more challenging and there is currently no standard protocol on how to safely and effectively treat these patients in the clinic. Read More

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[Aortic Para-annular Abscess Following Infective Endocarditis Requiring Three Times of Operation:Report of a Case].

Kyobu Geka 2021 Mar;74(3):217-219

Department of Cardiovascular Surgery, Mito Saiseikai General Hospital, Mito, Japan.

A 45-year-old man was diagnosed with active aortic valve endocarditis accompanied by massive aortic regurgitation, complete atrioventricular block, para-annular abscess and a mobile large vegetation. He underwent emergency resection of the aortic valve, direct closure of the abscess with an autologous pericardium patch and mechanical valve replacement. Acquired communication between the left ventricle and the right atrium was closed simultaneously. Read More

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