18,757 results match your criteria martens

Jiyuan Oridonin A Overcomes Differentiation Blockade in Acute Myeloid Leukemia Cells With MLL Rearrangements Multiple Signaling Pathways.

Front Oncol 2021 26;11:659720. Epub 2021 Mar 26.

Laboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, China.

Differentiation therapy with all-trans-retinoic acid (ATRA) in acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), has been extremely successful in inducing clinical remission in APL patients. However, the differentiation therapy of ATRA-based treatment has not been effective in other subtypes of AML. In this study, we evaluated a small molecule of -kaurene diterpenoid, Jiyuan oridonin A (JOA), on the differentiation blockade in AML cells with the mixed lineage leukemia (MLL) gene rearrangements (MLLr) in MV4-11, MOLM-13 and THP-1 cells. Read More

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Comparative Metabolite and Gene Expression Analyses in Combination With Gene Characterization Revealed the Patterns of Flavonoid Accumulation During subsp. Fruit Development.

Front Plant Sci 2021 26;12:619634. Epub 2021 Mar 26.

Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

L. subsp. (rockrose) is a shrub widespread in Greece and the Mediterranean basin and has been used in traditional medicine as herb tea for colds, for healing and digestive hitches, for the treatment of maladies, as perfumes, and for other purposes. Read More

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Resective epilepsy surgery in patients aged 50years and older - a retrospective study regarding seizure outcome, memory performance, and psychopathology.

Epilepsy Behav 2021 Apr 8;118:107933. Epub 2021 Apr 8.

Protestant Hospital Alsterdorf, Epilepsy Center Hamburg, Elisabeth-Flügge-Str. 1, 22337 Hamburg, Germany. Electronic address:

Purpose: To assess clinical and demographic characteristics in two cohorts of elderly patients with drug-resistant focal epilepsy, undergoing resective epilepsy surgery (RES). Further, to determine seizure, neuropsychological, and mental health outcomes after RES and evaluate possible influencing factors.

Methods: Consecutive patients aged ≥50 years with temporal lobe epilepsy (TLE) who underwent curative RES in the Hamburg epilepsy surgery program (2004-2017) were identified. Read More

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Iron deficiency is associated with impaired biventricular reserve and reduced exercise capacity in patients with unexplained dyspnea.

J Card Fail 2021 Apr 7. Epub 2021 Apr 7.

Department of Cardiology, Hartcentrum, Jessa Hospital, Hasselt, Belgium; Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.

Background: Iron deficiency (ID) is frequent and associated with diminished exercise capacity in heart failure (HF), but its contribution to unexplained dyspnea without a HF diagnosis at rest remains unclear.

Methods: Consecutive patients with unexplained dyspnea and normal echocardiography and pulmonary function tests at rest underwent prospective standardized cardiopulmonary exercise testing with echocardiography (CPETecho) in a tertiary care dyspnea clinic. ID was defined as ferritin <300µg/l and transferrin saturation (TSAT)<20% and its impact on peak oxygen uptake (peakVO), biventricular response to exercise, and peripheral oxygen extraction was assessed. Read More

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Bioassessment of the ecological integrity of freshwater ecosystems using aquatic macroinvertebrates: the case of Sable Island National Park Reserve, Canada.

Environ Monit Assess 2021 Apr 9;193(5):257. Epub 2021 Apr 9.

School for Resource and Environmental Studies, Faculty of Management, Dalhousie University, Halifax, Canada.

Due to ubiquitous distribution of taxa, relatively low-cost and efficient sampling procedure, and known responses to environmental gradients, macroinvertebrate indicators are often a central component of biological monitoring of freshwater resources. This study examined establishing a baseline reference of benthic macroinvertebrate indicators in a biomonitoring approach as a means for monitoring the freshwater ponds of Sable Island National Park Reserve (SINPR), Canada. We compared water quality parameters monitored from 2015 to 2019 to a biomonitoring approach deployed in May, June, and August of 2019. Read More

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Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well: results from the MR CLEAN Registry.

Stroke Vasc Neurol 2021 Apr 7. Epub 2021 Apr 7.

Neurology, Leiden University Medical Centre, Leiden, The Netherlands.

Background: Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment (EVT) for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen well. However, outcomes after EVT in these late window patients without perfusion imaging are largely unknown. We assessed their characteristics and outcomes in routine clinical practice. Read More

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Spectral prediction features as a solution for the search space size problem in proteogenomics.

Mol Cell Proteomics 2021 Apr 3:100076. Epub 2021 Apr 3.

BioBix, Lab of Bioinformatics and Computational Genomics, Department of Mathematical Modeling, Statistics and Bioinformatics, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium; OHMX.bio, Ghent, Belgium. Electronic address:

Proteogenomics approaches often struggle with the distinction between true and false peptide-to-spectrum matches as the database size enlarges. However, features extracted from tandem mass spectrometry intensity predictors can enhance the peptide identification rate and can provide extra confidence for peptide-to-spectrum matching in a proteogenomics context. To that end, features from the spectral intensity pattern predictors MSPIP and Prosit were combined with the canonical scores from MaxQuant in the Percolator post-processing tool for protein sequence databases constructed out of ribosome profiling and nanopore RNA-seq analyses. Read More

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ACARPA, a rare case of ALCAPA.

J Card Surg 2021 Apr 6. Epub 2021 Apr 6.

Department of Cardiac Surgery, Ghent University Hospital, Ghent, Belgium.

An anomalous circumflex coronary artery arising from the right pulmonary artery is very rare. Clinical presentation varies from absence of symptoms to arrhythmia and sudden cardiac death. Since prevalence is very low, no definite therapy has been delineated yet. Read More

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AON-based degradation of c.151C>T mutant transcripts associated with dominantly inherited hearing impairment DFNA9.

Mol Ther Nucleic Acids 2021 Jun 1;24:274-283. Epub 2021 Mar 1.

Department of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.

The c.151C>T founder mutation in is a frequent cause of late-onset, dominantly inherited hearing impairment and vestibular dysfunction (DFNA9) in the Dutch/Belgian population. The initial clinical symptoms only manifest between the 3rd and 5th decade of life, which leaves ample time for therapeutic intervention. Read More

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The association between number of children and weight loss outcomes among individuals undergoing bariatric surgery.

Surg Obes Relat Dis 2021 Feb 13. Epub 2021 Feb 13.

Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Michigan; Behavioral Health Department, Henry Ford Health System, Detroit, Michigan.

Background: Existing research demonstrates that parity is associated with risk for obesity. The majority of those who undergo bariatric surgery are women, yet little is known about whether having children before bariatric surgery is associated with pre- and postsurgical weight outcomes.

Objectives: We aim to evaluate presurgical body mass index (BMI) and postsurgical weight loss among a racially diverse sample of women with and without children. Read More

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February 2021

Characteristics and Outcomes of COVID-19 in Patients on Left Ventricular Assist Device Support.

Circ Heart Fail 2021 Apr 5:CIRCHEARTFAILURE120007957. Epub 2021 Apr 5.

Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia. (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.).

Background: The coronavirus disease 2019 (COVID-19) pandemic continues to afflict millions of people worldwide. Patients with end-stage heart failure and left ventricular assist devices (LVADs) may be at risk for severe COVID-19 given a high prevalence of complex comorbidities and functional impaired immunity. The objective of this study is to describe the clinical characteristics and outcomes of COVID-19 in patients with end-stage heart failure and durable LVADs. Read More

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The Successful Elimination of Sylvatic Rabies Using Oral Vaccination of Foxes in Slovenia.

Viruses 2021 Mar 4;13(3). Epub 2021 Mar 4.

Institute of Microbiology and Parasitology, Virology Unit, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.

Sylvatic rabies was present in Slovenia between 1973 and 2013, with the red fox as the main reservoir of the rabies virus. The first oral rabies vaccination (ORV) control program in foxes started in 1988, using the manual distribution of baits. Significant improvement of fox vaccination was achieved with the aerial distribution of baits, starting in 1995 and successfully finished with the final, fifty-ninth vaccination campaign in 2019. Read More

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Characterization of Methacrylate-Based Resins Containing Methacryl-Polyhedral Oligomeric Silsesquioxanes (MA-POSS-8).

Materials (Basel) 2021 Mar 29;14(7). Epub 2021 Mar 29.

Department of Preventive Dentistry, Periodontology and Cariology, University Medical Center Göttingen, 37075 Göttingen, Germany.

The use of functionalized dental adhesives that might prevent degradation of the dentin hybrid layer has been proposed. The aim of the study was to characterize the physicochemical properties and the potential to induce mineral precipitation of methacrylate-based resins containing methacryl-functionalized polyhedral oligomeric silsesquioxane (MA-POSS-8). In total, six different compositions of resins based on bisphenol A glycerolate dimethacrylate (BisGMA, 40 to 60 wt. Read More

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First Discovery of du Buysson (Hymenoptera: Vespidae), an Invasive Hornet in the Feces of the Yellow-Throated Marten in South Korea.

Insects 2021 Mar 29;12(4). Epub 2021 Mar 29.

School of Applied Biosciences, College of Agriculture & Life Sciences, Kyungpook National University, Daegu 41566, Korea.

Yellow-throated martens (YTMs) are omnivores that often prey on wasps in late autumn in Korea. However, to the best of our knowledge, predation of the invasive alien species (VVN) has not previously been investigated. In this study, YTM feces were collected and analyzed from Mt. Read More

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The Role of Mustelids in the Transmission of spp. Using Cattle as Intermediate Hosts.

Animals (Basel) 2021 Mar 15;11(3). Epub 2021 Mar 15.

Nature Research Centre, Akademijos Str. 2, LT-08412 Vilnius, Lithuania.

There is a lack of research on the role of mustelids in the transmission of various spp. In the present study we tested the hypothesis that widespread mustelids in Lithuania could be involved in the transmission of spp. using cattle as intermediate hosts. Read More

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Habitat Elevation Shapes Microbial Community Composition and Alter the Metabolic Functions in Wild Sable () Guts.

Animals (Basel) 2021 Mar 18;11(3). Epub 2021 Mar 18.

Faculty of Biological and Environmental Science, University of Helsinki, Niemenkatu 73, 15140 Lahti, Finland.

In recent decades, wild sable (Carnivora Mustelidae ) habitats, which are often natural forests, have been squeezed by anthropogenic disturbances such as clear-cutting, tilling and grazing. Sables tend to live in sloped areas with relatively harsh conditions. Here, we determine effects of environmental factors on wild sable gut microbial communities between high and low altitude habitats using Illumina Miseq sequencing of bacterial 16S rRNA genes. Read More

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24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer's Disease.

Mar Drugs 2021 Mar 27;19(4). Epub 2021 Mar 27.

Department of Internal Medicine, Section Pharmacology and Vascular Medicine, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.

We recently found that dietary supplementation with the seaweed , containing the preferential LXRβ-agonist 24(S)-saringosterol, prevented memory decline and reduced amyloid-β (Aβ) deposition in an Alzheimer's disease (AD) mouse model without inducing hepatic steatosis. Here, we examined the effects of 24(S)-saringosterol as a food additive on cognition and neuropathology in AD mice. Six-month-old male APPswePS1ΔE9 mice and wildtype C57BL/6J littermates received 24(S)-saringosterol (0. Read More

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A Survey of Transposon Landscapes in the Putative Ancient Asexual Ostracod .

Genes (Basel) 2021 Mar 11;12(3). Epub 2021 Mar 11.

Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA.

How asexual reproduction shapes transposable element (TE) content and diversity in eukaryotic genomes remains debated. We performed an initial survey of TE load and diversity in the putative ancient asexual ostracod . We examined long contiguous stretches of DNA in clones from a genomic fosmid library, totaling about 2. Read More

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Optimal Design Parameters for a Phased Array Based Ultrasonic Polar Scan.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Apr 2;PP. Epub 2021 Apr 2.

In the context of designing a next-generation Ultrasonic Polar Scan (UPS) measurement system for visco-elastic material characterisation, a novel approach is proposed that draws on a set of cylindrically focused emitters in conjunction with a Circular Phased Array (C-PA) receiver in order to create a portable measurement system, while improving the data quality and ease the data interpretation. To explore the potential of the new approach and determine its optimal design parameters, a three-dimensional analytical model is presented to numerically simulate UPS experiments with the proposed system. Furthermore, a post-processing procedure is worked out to treat the acquired raw data with the aim to deal with the integrating effect of finite size transducers and to directly reconstruct the angle dependent plane wave reflection coefficients of the sample under study. Read More

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First mitochondrial genome of the marbled polecat (Carnivora, Mustelidae).

Mitochondrial DNA B Resour 2021 Mar 18;6(3):1009-1011. Epub 2021 Mar 18.

Laboratoire Biodiversité et Génomique Fonctionnelle, Faculté des Sciences, Université Saint-Joseph, Beirut, Lebanon.

The marbled polecat, , is one of the least studied species in the Mustelidae family, especially with regard to phylogeography and genetic diversity. In this study, we determined the mitochondrial genome sequence of and investigated its position within the Mustelidae phylogeny. The generated mitogenome is 15,982 bp in length; it consists of 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes, and a control region. Read More

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Long- and short-ranged chiral interactions in DNA-assembled plasmonic chains.

Nat Commun 2021 04 1;12(1):2025. Epub 2021 Apr 1.

Faculty of Physics, Ludwig-Maximilians-University, Munich, Germany.

Circular dichroism (CD) has long been used to trace chiral molecular states and changes of protein configurations. In recent years, chiral plasmonic nanostructures have shown potential for applications ranging from pathogen sensing to novel optical materials. The plasmonic coupling of the individual elements of such metallic structures is a crucial prerequisite to obtain sizeable CD signals. Read More

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Protocol for personal RF-EMF exposure measurement studies in 5th generation telecommunication networks.

Environ Health 2021 Apr 1;20(1):36. Epub 2021 Apr 1.

Department of Information Technology, Ghent University / IMEC, Technologiepark-Zwijnaarde, 126, Ghent, Belgium.

Background: The general population is exposed to Radio-Frequency Electromagnetic Fields (RF-EMFs) used by telecommunication networks. Previous studies developed methods to assess this exposure. These methods will be inadequate to accurately assess exposure in 5G technologies or other wireless technologies using adaptive antennas. Read More

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Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy.

Sci Rep 2021 Mar 31;11(1):7259. Epub 2021 Mar 31.

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, 2300 RA, Leiden, The Netherlands.

Screening for effective candidate drugs for breast cancer has shifted from two-dimensional (2D) to three-dimensional (3D) cultures. Here we systematically compared the transcriptomes of these different culture conditions by RNAseq of 14 BC cell lines cultured in both 2D and 3D conditions. All 3D BC cell cultures demonstrated increased mitochondrial metabolism and downregulated cell cycle programs. Read More

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