105,674 results match your criteria marrow patients


Therapeutic roles of antibody drug conjugates (ADCs) in relapsed/refractory lymphomas.

Hematol Oncol Stem Cell Ther 2021 Jul 28. Epub 2021 Jul 28.

Department of Blood & Marrow Transplant and Cellular Immunotherapy (BMT CI), Moffitt Cancer Center, United States. Electronic address:

Relapsed or refractory lymphoma is commonly treated with combination chemoimmunotherapy and cellular immunotherapy. Modest response rates and associated toxicities are obstacles to achieving durable remission using traditional cytotoxic chemotherapy, especially in frail patients with advanced disease. Antibody drug conjugates represent a new class of novel targeted agents with significant improvement in therapeutic efficacy in the treatment of lymphomas. Read More

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Impact of cholesterol on proinflammatory monocyte production by the bone marrow.

Eur Heart J 2021 Aug 3. Epub 2021 Aug 3.

Department of Experimental Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.

Aim: Preclinical work indicates that low-density lipoprotein cholesterol (LDL-C) not only drives atherosclerosis by directing the innate immune response at plaque level but also augments proinflammatory monocyte production in the bone marrow (BM) compartment. In this study, we aim to unravel the impact of LDL-C on monocyte production in the BM compartment in human subjects.

Methods And Results: A multivariable linear regression analysis in 12 304 individuals of the EPIC-Norfolk prospective population study showed that LDL-C is associated with monocyte percentage (β = 0. Read More

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Assessment of Clonotypic Rearrangements and Minimal Residual Disease in Lymphoid Malignancies: A Large Cancer Center Experience Using clonoSEQ.

Arch Pathol Lab Med 2021 Aug 3. Epub 2021 Aug 3.

Malignant Hematology (Shah, Pinilla-Ibarz, Shain), Moffitt Cancer Center, Tampa, Florida.

Context.—: Measurable (minimal) residual disease (MRD) is an independent prognostic factor for survival outcomes in patients with lymphoid and plasma cell malignancies and has been incorporated into consensus criteria regarding treatment response, strategy, and clinical trial endpoints. clonoSEQ (a next-generation sequencing [NGS]-MRD assay) uses multiplex polymerase chain reaction and NGS to identify clonotypic rearrangements at the immunoglobulin (Ig) H, IgK, IgL, T-cell receptor (TCR)-β, and TCR-γ loci, and translocated B-cell lymphoma 1/IgH and 2/IgH sequences for MRD assessment. Read More

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Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium.

Am J Hematol 2021 Aug 3. Epub 2021 Aug 3.

Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, USA.

The North American Pediatric Aplastic Anemia Consortium (NAPAAC) is a group of pediatric hematologist-oncologists, hematopathologists, and bone marrow transplant physicians from 46 institutions in North America with interest and expertise in aplastic anemia, inherited bone marrow failure syndromes, and myelodysplastic syndromes. The NAPAAC Bone Marrow Failure Diagnosis and Care Guidelines Working Group was established with the charge of harmonizing the approach to the diagnostic workup of aplastic anemia in an effort to standardize best practices in the field. This document outlines the rationale for initial evaluations in pediatric patients presenting with signs and symptoms concerning for severe aplastic anemia. Read More

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Preliminary evaluation of anticancer efficacy of pioglitazone combined with celecoxib for the treatment of non-small cell lung cancer.

Invest New Drugs 2021 Aug 2. Epub 2021 Aug 2.

Department of Pharmacology, JSS College of Pharmacy (JSS Academy of Higher Education & Research) Rocklands, Ooty, The Nilgiris, Tamil Nadu, 643001, India.

Purpose: Among the lung cancer types, non-small cell lung cancer (NSCLC) is prominent and less responsive to chemotherapy. The current chemotherapeutics for NSCLC are associated with several dose-limiting side effects like bone-marrow suppression, neurotoxicity, nephrotoxicity, and ototoxicity, etc. which are causing non-compliance in patients. Read More

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Quantitative whole-body MR imaging for assessment of tumor burden in patients with multiple myeloma: correlation with prognostic biomarkers.

Quant Imaging Med Surg 2021 Aug;11(8):3767-3780

Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: To assess the quantification of tumor burden in multiple myeloma (MM) patients using whole-body magnetic resonance imaging (MRI) and to identify the correlation between MRI parameters and prognostic biomarkers.

Methods: We retrospectively analyzed 95 newly diagnosed MM patients treated at our hospital from June 2018 to March 2020. All patients underwent whole-body MRI examination, including diffusion-weighted whole-body imaging with background body signal suppression (DWIBS), modified Dixon chemical-shift imaging (mDIXON), and short TI inversion recovery (STIR) sequences. Read More

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Vertebral bone marrow T2* mapping using chemical shift encoding-based water-fat separation in the quantitative analysis of lumbar osteoporosis and osteoporotic fractures.

Quant Imaging Med Surg 2021 Aug;11(8):3715-3725

Department of Radiology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.

Background: Chemical shift encoding-based water-fat separation techniques have been used for fat quantification [proton density fat fraction (PDFF)], but they also enable the assessment of bone marrow T2*, which has previously been reported to be a potential biomarker for osteoporosis and may give insight into the cause of vertebral fractures (i.e., osteoporotic traumatic) and the microstructure of the bone when applied to vertebral bone marrow. Read More

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Systematic Review of Studies on Telomere Length in Patients with Multiple Sclerosis.

Aging Dis 2021 Aug 1;12(5):1272-1286. Epub 2021 Aug 1.

Rostock University Medical Center, Department of Neurology, Division of Neuroimmunology, Rostock, Germany.

Telomeres are protective cap structures at the end of chromosomes that are essential for maintaining genomic stability. Accelerated telomere shortening is related to premature cellular senescence. Shortened telomere lengths (TL) have been implicated in the pathogenesis of various chronic immune-mediated and neurological diseases. Read More

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CD34 progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients.

Atherosclerosis 2021 Jul 10. Epub 2021 Jul 10.

School of Applied Sciences, Edinburgh Napier University, Edinburgh, United Kingdom. Electronic address:

Background And Aims: Circulating progenitor cells (CPCs) play an important role in vascular repair and can influence cardiovascular (CV) health and longevity. Exercise is known to modulate these cells via mobilization from the bone marrow. The primary aims of this study were to evaluate the association of CPCs with mortality and explore the association between physical activity (PA) and CPCs. Read More

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MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1.

J Nanobiotechnology 2021 Jul 30;19(1):226. Epub 2021 Jul 30.

Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430072, Hubei, China.

Background: Patients with diabetes have an increased risk of nonunion and delayed union of fractures. Macrophages have been shown as a key player in diabetic complications. However, it remains obscure how diabetic milieu affects macrophage-derived exosomes and its implications on osteogenic differentiation of BMSCs. Read More

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Comparison of the clinical features and outcome of children with hemophagocytic lymphohistiocytosis (HLH) secondary to visceral leishmaniasis and primary HLH: a single-center study.

BMC Infect Dis 2021 Aug 2;21(1):732. Epub 2021 Aug 2.

Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive inflammation. We aimed to describe the clinical and laboratory findings of HLH patients secondary to Visceral leishmaniasis (VL) and their treatment outcome during a 4-year follow-up period compared to primary HLH.

Method: Forty children with primary HLH confirmed by genetic study and 20 children with HLH secondary to VL confirmed by a blood or bone marrow polymerase chain reaction from 2014 to 2018 in Shiraz, Fars province, Southern Iran, were enrolled. Read More

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Phase II study of azacitidine with pembrolizumab in patients with intermediate-1 or higher-risk myelodysplastic syndrome.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Programmed cell death protein 1 (PD-1) and PD-ligand 1 (PD-L1) expression is upregulated in cluster of differentiation 34 (CD34) bone marrow cells from patients with myelodysplastic syndromes (MDS). Hypomethylating agent (HMA) treatment results in further increased expression of these immune checkpoints. We hypothesised that combining an anti-PD-1 antibody with HMAs may have efficacy in patients with MDS. Read More

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Proton beam therapy in rectal cancer: A systematic review and meta-analysis.

Surg Oncol 2021 Jul 27;38:101638. Epub 2021 Jul 27.

Department of Colorectal Surgery, Countess of Chester NHS Foundation Trust, UK; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, 200 London Road, Liverpool, L3 9TA, UK. Electronic address:

Introduction: Locally advanced rectal cancer is often treated with neoadjuvant chemoradiotherapy and surgery. Radiotherapy carries significant risk of toxicity to organs at risk (OAR). Proton beam therapy (PBT) has demonstrated to be effective in other cancers, delivering equivalent dosimetric radiation but with the benefit of improved sparing of OAR. Read More

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Characterization of Pericarditis Following Allogeneic Hematopoietic Cell Transplant.

Transplant Cell Ther 2021 Jul 30. Epub 2021 Jul 30.

Blood and Marrow Transplant and Cellular Therapy Program, Abramson Cancer Center and the Division of Hematology and Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA.

Background: Pericarditis is an uncommon cardiac complication following allogeneic hematopoietic transplant (alloHCT) with limited data characterizing incidence, presentation, and management. The etiology of pericarditis in this setting is poorly understood, and may include conditioning-related toxicity, infection, or graft-versus-host disease (GVHD).

Objective: The objective of this study was to characterize the clinical presentation, management and outcomes of post alloHCT pericarditis observed at a single center. Read More

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HLA genetic polymorphism in patients with Coronavirus Disease 2019 in Midwestern United States.

HLA 2021 Aug 2. Epub 2021 Aug 2.

Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

The experience of individuals with Coronavirus Disease 2019 (COVID-19) ranges from asymptomatic to life threatening multi-organ dysfunction. Specific HLA alleles may affect the predisposition to severe COVID-19 due to their role in presenting viral peptides to launch the adaptive immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this population-based case-control study in the midwestern United States, we performed high-resolution HLA typing of 234 cases hospitalized for COVID-19 in the St. Read More

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Bone marrow adiposity inversely correlates with bone turnover in pediatric renal osteodystrophy.

Bone Rep 2021 Dec 8;15:101104. Epub 2021 Jul 8.

Department of Pediatrics, David Geffen School of Medicine at UCLA, United States of America.

Bone marrow adiposity is associated with bone disease in the general population. Although chronic kidney disease (CKD) is associated with increased bone fragility, the correlation between marrow adiposity and bone health in CKD is unknown. We evaluated the relationship between bone marrow adipocytes and bone histomorphometry in 32 pediatric patients. Read More

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December 2021

Selective Retention of Bone Marrow Stromal Cells with Gelatin Sponge for Repair of Intervertebral Disc Defects after Microendoscopic Discectomy: A Prospective Controlled Study and 2-Year Follow-Up.

Biomed Res Int 2021 13;2021:4822383. Epub 2021 Jul 13.

Department of Minimally Invasive Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin 300211, China.

Objective: Discectomy remains the classic procedure for treating lumbar intervertebral disc (IVD) herniation, but the occurrence of defects after discectomy is thought to be an important cause generating recurrent and accelerated IVD degeneration. Previous studies attempted suture of the annulus fissure, but the validity of this technique on restraining the degenerative process is controversial. On the other hand, cell therapies have been shown in multiple clinical and basic studies. Read More

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Prediction Model for Cereblon Expression in Bone Marrow Plasma Cells Based on Blood Markers in Multiple Myeloma Patients.

Front Oncol 2021 14;11:687361. Epub 2021 Jul 14.

Department of Internal Medicine, Korea University College of Medicine, Anam Hospital, Seoul, South Korea.

Background: Cereblon (CRBN) is a direct target of immunomodulatory drugs (IMiDs) and is known to be sensitive and responsive to IMiD therapy. We evaluated CRBN expression in bone marrow plasma cells and analyzed whether CRBN expression was associated with multiple myeloma prognosis. Lastly, we developed a nomogram model for predicting high CRBN expression based on clinically significant blood markers. Read More

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An unusual case of T-cell acute lymphoblastic leukemia in a patient with BCR-ABL positive chronic myeloid leukemia and Gaucher disease.

Ann Med Surg (Lond) 2021 Aug 14;68:102565. Epub 2021 Jul 14.

Al-Quds University Faculty of Medicine, Jerusalem, Palestine.

Background: Chronic myelogenous leukemia (CML) is a chronic myeloproliferative disease characterized by a massive overproduction of myeloid cells. It is associated with the Philadelphia chromosome [Ph1, t (9; 22) (q34; q11)] or BCR-ABL fusion gene. CML usually undergoes a triphasic clinical course ending in a blast crisis, an accelerated phase of blasts and promyelocyte production. Read More

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MicroRNA-107 promotes apoptosis of acute myelocytic leukemia cells by targeting RAD51.

Arch Med Sci 2021 4;17(4):1044-1055. Epub 2020 Feb 4.

Department of Laboratory Medicine, North Sichuan Medical College, Nanchong, Sichuan, China.

Introduction: This study aimed to investigate the role of microRNA (miRNA) that affects acute myelocytic leukemia (AML) and its potential molecular mechanism by constructing a miRNA-mRNA interaction network using bioinformatics methods.

Material And Methods: MicroRNA expression data of AML were retrieved from Gene Expression Omnibus (GEO) and analyzed by microarray analysis. Expression levels of miR-107 and RAD51 mRNA were detected by quantitative real time polymerase chain reaction (qRT-PCR). Read More

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February 2020

Imbalance of Chemokines and Cytokines in the Bone Marrow Microenvironment of Children with B-Cell Acute Lymphoblastic Leukemia.

J Oncol 2021 22;2021:5530650. Epub 2021 Jul 22.

Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas (UFAM), Manaus, Brazil.

In the hematopoietic microenvironment, leukemic cells secrete factors that imbalanced chemokine and cytokine production. However, the network of soluble immunological molecules in the bone marrow microenvironment of acute lymphoblastic leukemia (ALL) remains underexplored. Herein, we evaluated the levels of the immunological molecules (CXCL8, CCL2, CXCL9, CCL5, CXCL10, IL-6, TNF, IFN-, IL-17A, IL-4, IL-10, and IL-2) in the bone marrow plasma of 47 recently diagnosed B-cell acute lymphoblastic leukemia (B-ALL) patients during induction therapy using cytometric beads arrays. Read More

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Abnormal Macrophage Polarization in Patients with Myelodysplastic Syndrome.

Mediators Inflamm 2021 9;2021:9913382. Epub 2021 Jul 9.

Department of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.

Background: This study is aimed at assessing the subsets of bone marrow macrophages in patients with myelodysplastic syndrome (MDS) and exploring the role of macrophages in the pathogenesis of MDS.

Methods: Thirty-eight newly diagnosed MDS patients were enrolled in the Department of Hematology of General Hospital of Tianjin Medical University from June 2015 to June 2016. Bone marrow monocytes and macrophage subsets (M1/M2) were detected in patients with MDS and normal controls by flow cytometry. Read More

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Progressive Cytopenia Developing during Treatment of Cryptococcosis in a Patient with HIV Infection and Bone Marrow Cryptococcal Infection.

Intern Med 2021 Jul 30. Epub 2021 Jul 30.

AIDS Clinical Center of the National Center for Global Health and Medicine, Japan.

Cytopenia is a common complication in patients with human immunodeficiency virus (HIV) infection. Identifying the cause is demanding because of the wide range of possible diagnoses. We herein report an HIV-infected patient with disseminated cryptococcosis involving multiple organs including the blood, brain, lungs, and bone marrow, who developed progressive pancytopenia after initiation of anti-fungal treatment with liposomal amphotericin-B (L-AMB) and flucytosine (5FC). Read More

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Development of Advanced Cell-Based Therapy by Regulating Cell-Cell Interactions.

Authors:
Kosuke Kusamori

Biol Pharm Bull 2021 ;44(8):1029-1036

Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science.

Cell-based therapy for disease treatment involves the transplantation of cells obtained either from self or others into relevant patients. While cells constituting the body tissues maintain homeostasis by performing remarkable functions through complicated cell-cell interactions, transplanted cells, which are generally cultured as a monolayer, are unable to recapitulate similar interactions in vivo. The regulation of cell-cell interactions can immensely increase the function and therapeutic effect of transplanted cells. Read More

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January 2021

CD26 expression on donor harvest as a risk predictive biomarker for developing Graft-versus-Host Disease post-Allogeneic Hematopoietic Stem Cell Transplantation: A tenyear followup study.

Cancer Biomark 2021 Jul 15. Epub 2021 Jul 15.

Tumor Immunology and Immunotherapy Group, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India.

Background: Allogeneic hematopoietic stem cell transplantation (ASCT) is the preferred treatment option for patients with several hematologic disorders and immunodeficiency syndromes. Graft versus host disease (GVHD) is an immune mediated post-transplant complication which has a major impact on long term transplant outcomes.

Objective: Current efforts are focused on identification of new markers that serve as potential predictors of GVHD and other post-transplant clinical outcomes. Read More

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A panel of epigenetically dysregulated Wnt signaling pathway genes for non-invasive diagnosis of pediatric acute lymphoblastic leukemia.

Cancer Biomark 2021 Jul 16. Epub 2021 Jul 16.

Biopharmaceuticals and Biomarkers Discovery Lab., Institute of Biochemistry and Biotechnology, University of the Punjab, Lahore, Pakistan.

Background: Genetic and epigenetic dysregulation of Wnt signaling pathway is widely linked up with abnormal proliferation and/or epithelial-to-mesenchymal transition, in different cancer cell types.

Objective: In the present research, we have tested whether promoter DNA methylation of a set of Wnt/non-Wnt genes such as [cadherin-2 (CDH2)], "present in circulation", could serve as "bone-marrow biopsy surrogate" and help in diagnosing the status, sub-type or treatment outcome in pediatric acute lymphoblastic leukemia (ALL) patients.

Methods: Promoter DNA methylation was quantified in the bisulfite modified blood from the pediatric ALL patients (n= 86) in comparison with age-matched cancer-free subjects (n= 28), using real-time methylation specific PCR followed by rigorous statistical validations. Read More

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Chest CT Has Higher Yield for Infection than CT Sinus in Febrile Neutropenic Patients.

Curr Probl Diagn Radiol 2021 Jul 3. Epub 2021 Jul 3.

Johns Hopkins Hospital: Johns Hopkins Medicine, 600 N. Wolfe Street, Phipps B-100, Baltimore, MD.. Electronic address:

Objective: Chest and sinus CT imaging among cancer patients undergoing chemotherapy and bone marrow transplant in the setting of neutropenic fever is not uncommon, yet the utility of routine imaging surveillance remains unclear. We aim to compare the rates of acute infection detected on CT chest and CT sinus exams performed in this clinical setting.

Methods: Reports of 1059 consecutive CT chest and sinus examinations for the clinical indication of neutropenic fever on 262 patients performed between January through June 2017 were retrospectively reviewed. Read More

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Positron emission tomography/computed tomography hypermetabolism of Kikuchi-Fujimoto disease mimicking malignant lymphoma: a case report and literature review.

J Int Med Res 2021 Jul;49(7):3000605211032859

Department of Nuclear Medicine, 159407The First Hospital of China Medical University, The First Hospital of China Medical University, Shenyang, P.R. China.

Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting inflammatory disorder of unknown etiology and pathogenesis. This report presents a rare case involving a man with F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) hypermetabolism caused by KFD mimicking malignant lymphoma. The PET/CT maximum intensity projection showed multiple hypermetabolic lymphadenopathies and homogeneous FDG uptake in the bone marrow and spleen. Read More

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[Clinical study on the effect of etoposide-containing induction regimen for adult-onset Still's disease associated hemophagocytic syndrome].

Zhonghua Yi Xue Za Zhi 2021 Aug;101(29):2322-2327

Department of Hematology, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China.

To investigate the efficacy of an etoposide-containing regimen in the treatment of adult-onset Still's disease related hemophagocytic syndrome(AOSD-HLH). This study adopted the method of retrospective analysis to collect clinical data of 43 AOSD-HLH patients, including the clinical characteristics, laboratory indexes, treatment regimen and prognosis. There were 7 males and 36 females, aged 24-40 years, with a median age of 30. Read More

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A novel ITGB2 variant with long survival in patients with leukocyte adhesion defect type-I.

Immunol Res 2021 Aug 1. Epub 2021 Aug 1.

Department of Immunology, Medical Faculty, Erciyes University, Kayseri, Turkey.

Leukocyte adhesion deficiency is an autosomal recessive primary immunodeficiency that has been divided into three types: LAD1 (beta-2 integrin (CD18) family deficiency/defect), LAD2 (absence of fucosylated carbonhydrate ligands for selectins) and LAD3 (defective activation of all beta integrins). However, recently LAD4 has been described in cystic fibrosis patients, with a defect in integrin activation reported in monocytes. LAD-I is the most common type and prevalence of 1 in 1,000,000 live births. Read More

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