139,978 results match your criteria markers genetic


Identification and molecular characterization of H9N2 viruses carrying multiple mammalian adaptation markers in resident birds in central-western wetlands in India.

Infect Genet Evol 2021 Jul 19:105005. Epub 2021 Jul 19.

ICAR- National Institute of High Security Animal Diseases, Bhopal 462022, India.

We report here a targeted risk-based study to investigate the presence of influenza A viruses at the migratory-wild-domestic bird interface across the major wetlands of central India's Maharashtra state during the winter migration season. The H9N2 viruses have been isolated and confirmed in 3.86% (33/854) of the fecal samples of resident birds. Read More

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Effect of Early Feeding on Intestinal Permeability and Inflammation Markers in Infants with Genetic Susceptibility to Type 1 Diabetes: A Randomized Clinical Trial.

J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland. Electronic address:

Objectives: To assess whether weaning to an extensively hydrolyzed formula (EHF) decreases gut permeability and/or markers of intestinal inflammation in infants with HLA-conferred diabetes susceptibility, when compared with conventional formula.

Study Design: By analyzing 1468 expecting biological parent pairs for HLA-conferred susceptibility for type 1 diabetes, 465 couples (32%) potentially eligible for the study were identified. After further parental consent, 332 babies to be born were randomized at 35 gestational week. Read More

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Anti-microbial antibody response is associated with future onset of Crohn's disease independent of biomarkers of altered gut barrier function, subclinical inflammation, and genetic risk.

Gastroenterology 2021 Jul 19. Epub 2021 Jul 19.

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: /Aim: Altered host immune reactivity to microbial antigens is hypothesized to trigger the onset of Crohn's disease (CD). We aimed to assess whether increased serum anti-microbial antibody response in asymptomatic first-degree relatives (FDR) of CD patients is an independent risk factor for future CD development.

Methods: We measured host serum antibody response to six microbial antigens at enrollment (Prometheus ELISA test: ASCA IgA/IgG, anti-OmpC, anti-A4-Fla2, anti-FlaX, anti-CBir1) and derived the sum of positive antibodies (AS). Read More

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Molecular and physiological characterization of Fusarium strains associated with different diseases in date palm.

PLoS One 2021 22;16(7):e0254170. Epub 2021 Jul 22.

Department of Plant Protection, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.

Several species of Fusarium cause serious diseases in date palm worldwide. In the present work, 14 SSR markers were used to assess the genetic variation of Fusarium strains isolated from diseased trees in Saudi Arabia. We also studied the effect of different temperatures on mycelial growth of these strains. Read More

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Genetic portrait of 23 Y-STR loci in the Naga tribes of Nagaland, India.

Int J Legal Med 2021 Jul 22. Epub 2021 Jul 22.

DNA Fingerprinting Unit, State Forensic Science Laboratory, Department of Home (Police), Govt. of MP, Sagar, 470001, India.

To explore the genomic diversity and forensic characterization of Naga tribes, Nagaland, haplotypes for 23 Y-STR markers have been analyzed. In this study, 203 unrelated male individuals residing in the Northeast Indian state of Nagaland were selected. A total of 203 unique haplotypes were observed. Read More

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N-3 Long Chain Fatty Acids Supplementation, Fatty Acids Desaturase Activity, and Colorectal Cancer Risk: A Randomized Controlled Trial.

Nutr Cancer 2021 Jul 22:1-11. Epub 2021 Jul 22.

Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Introduction: n-3 long-chain polyunsaturated fatty acids (LCPUFA) have anti-inflammatory effects and may reduce colorectal cancer risk. The purpose of this study was to evaluate the effects of n-3 LCPUFA supplementation on markers of rectal cell proliferation and apoptosis and examine how genetic variation in desaturase enzymes might modify this effect.

Methods: We conducted a randomized, double-blind, control six-month trial of 2. Read More

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Type O blood group associates with higher anti-JC polyomavirus antibody levels.

Brain Behav 2021 Jul 21. Epub 2021 Jul 21.

Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.

Background: Patients with multiple sclerosis (MS) and high anti-JC polyomavirus (JCPyV) antibodies in blood have an increased risk for the development of progressive multifocal leukoencephalopathy (PML) when treated for MS. To test the hypothesis that type O blood group associates with anti-JCPyV antibody levels and the risk of developing PML, we characterized ABO blood group antigen on blood samples of 62 patients with PML, and 64 MS controls without PML.

Methods: Monocentric retrospective cohort study. Read More

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Genetic variation and relationships between Azerbaijani and Turkish olive genetic resources.

Mol Biol Rep 2021 Jul 21. Epub 2021 Jul 21.

Department of Crop and Animal Production, Organic Agriculture Programme, Karacabey Vocational School, Bursa Uludağ University, Bursa, Turkey.

Olive (Olea europaea L.) is one of the most economically important crop from east to the west around the world. The aim of this research was to investigate the genetic relationship among 41 olive genotypes, including 11 well-known Turkish cultivars and 30 Azerbaijani olive genotypes using simple sequence repeat (SSR) markers. Read More

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Mitochondrial- sequence polymorphism reflects spatial genetic clustering of sibling species E in Sri Lanka.

J Vector Borne Dis 2020 Apr-Jun;57(2):139-146

Center for Biotechnology, Department of Zoology; Genetics and Molecular Biology Unit, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Sri Lanka.

Background & Objectives: Malaria infects around 216 million people annually with estimated 445,000 deaths globally. Anopheles culicifacies is the vector of malaria in Sri Lanka, a complex of five morphologically identical sibling species of which precise identification using DNA-based methods is still under experimentation. This study was carried out in Sri Lanka to observe the utility of BCE-PCR assay based on mitochondrial Cytochrome Oxidase II (COII) developed in India, in sibling species B and E identification in Sri Lanka, to characterize nucleotide and corresponding amino acid sequences of COII region in major vector sibling species E in Sri Lanka and to analyze the spatial distribution pattern of sibling species E in Sri Lanka using microsatellite markers. Read More

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Phlebotomine sand fly survey in the Republic of Moldova: species composition, distribution and host preferences.

Parasit Vectors 2021 Jul 21;14(1):371. Epub 2021 Jul 21.

Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic.

Background: Phlebotomine sand flies (Diptera: Psychodiae) in the Republic of Moldova have been understudied for decades. Our study provides a first update on their occurrence, species composition and bloodmeal sources after 50 years.

Methods: During 5 seasons (2013-2017), 58 localities from 20 regions were surveyed for presence of sand flies using CDC light traps and manual aspirators. Read More

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Genetic basis of maize kernel oil-related traits revealed by high-density SNP markers in a recombinant inbred line population.

BMC Plant Biol 2021 Jul 21;21(1):344. Epub 2021 Jul 21.

Ministry of Agricultural Scientific Observing and Experimental Station of Maize in Plain Area of Southern Region, School of Life Sciences, Nantong University, Nantong, 226019, People's Republic of China.

Background: Maize (Zea mays ssp. mays) is the most abundantly cultivated and highly valued food commodity in the world. Oil from maize kernels is highly nutritious and important for the diet and health of humans, and it can be used as a source of bioenergy. Read More

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Comparative analysis of the genetic diversity of the neutral microsatellite loci and second exon of the goat MHC-DQB1 gene.

Anim Biotechnol 2021 Jul 21:1-8. Epub 2021 Jul 21.

College of Animal Science and Technology, Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.

This study compared and analyzed the genetic diversity and population structure of exon 2 of the gene and 13 autosomal neutral microsatellite markers from 14 Chinese goat breeds to explore the potential evolutionary mechanism of the major histocompatibility complex (MHC). A total of 287 haplotypes were constructed from MHC-DQB1 exon 2 from 14 populations, and 82 nucleotide polymorphic sites (SNPs, 31.78%) and 172 heterozygous individuals (79. Read More

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Pathotype Complexity and Genetic Characterization of Populations in Illinois, Indiana, Kentucky, and Ohio.

Phytopathology 2021 Jul 21. Epub 2021 Jul 21.

The Ohio State University, Plant Pathology, 1680 Madison Ave., Wooster, Ohio, United States, 44691;

, the causal agent of Phytophthora root and stem rot of soybean, has been managed with single genes since the 1960's, but has subsequently adapted to many of these resistance genes, rendering them ineffective. The objective of this study was to examine the pathotype and genetic diversity of from soil samples across Illinois, Indiana, Kentucky, and Ohio by assessing which gene(s) were still effective and identifying possible population clusters. There were 218 pathotypes identified from 473 isolates with an average of 6. Read More

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Improving mobilization of foreign DNA into ZM4 by removal of multiple restriction systems.

Appl Environ Microbiol 2021 Jul 21:AEM0080821. Epub 2021 Jul 21.

DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, USA.

has emerged as a promising candidate for production of high value bioproducts from plant biomass. However, a major limitation in equipping with novel pathways to achieve this goal is restriction of heterologous DNA. Here, we characterized the contribution of several defense systems of strain ZM4 to impeding heterologous gene transfer from an donor. Read More

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Robust and efficient software for reference-free genomic diversity analysis of GBS data on diploid and polyploid species.

Mol Ecol Resour 2021 Jul 20. Epub 2021 Jul 20.

Department of Systems and Computing Engineering, Universidad de los Andes, Bogotá, Colombia.

Genotyping-by-Sequencing (GBS) is a widely used and cost-effective technique for obtaining large numbers of genetic markers from populations by sequencing regions adjacent to restriction cut sites. Although a standard reference-based pipeline can be followed to analyze GBS reads, a reference genome is still not available for a large number of species. Hence, reference-free approaches are required to generate the genetic variability information that can be obtained from a GBS experiment. Read More

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Is neutral genetic diversity related to quantitative variation in semen traits in bulls?

Reprod Domest Anim 2021 Jul 20. Epub 2021 Jul 20.

Germplasm and Reproductive Technology Laboratory, Department of Animal Production & Technology, Chinhoyi University of Technology, Private Bag, 7724, Chinhoyi, Zimbabwe.

Conservation decisions based on neutral genetic diversity have been observed to promote retention of useful quantitative variation in biological populations. An experiment was undertaken to determine the association between microsatellite marker polymorphisms and phenotypic variation in semen production and cryosurvival traits in bulls. Thirty-five ejaculates were collected from ten bulls of two breeds and evaluated before and after cryopreservation for several semen traits. Read More

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Genetic diversity of the carp oedema virus in France.

J Fish Dis 2021 Jul 19. Epub 2021 Jul 19.

ANSES, Laboratory Ploufragan-Plouzané-Niort, Plouzané, Ploufragan, France.

The koi sleepy disease of carp caused by the carp oedema virus (CEV) was observed on farms and in ponds in France since the 2010s. Samples of CEV collected in France over a period of eight years were characterized at the molecular level by sequencing the partial p4a gene. All the sequences, except one, fell into two well-defined genogroups. Read More

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Uncoupling protein 2 and dynamin-related protein 1 mRNA expressions as genetic markers for plaque psoriasis.

Int J Dermatol 2021 Jul 20. Epub 2021 Jul 20.

Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.

Background: Psoriasis is a long-lasting, inflammatory disease of the skin with not fully understood pathogenesis. Uncoupling protein 2 (UCP2) and dynamin-related protein 1 (Drp1) are the main mitochondrial regulatory proteins implicated in various inflammatory conditions. This work aimed to evaluate the role of UCP2 and Drp1 messenger RNA (mRNA) expressions in diagnosing plaque psoriasis and to correlate their expression levels with the available clinical data. Read More

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No effect of Parkinson's disease-polygenic load on striatal density of dopaminergic neuron in healthy subjects.

Ann Nucl Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, 49241, Republic of Korea.

Objective: There has been increasing evidence to support the role of genetic factors in Parkinson's disease (PD). I-FP-CIT single-photon emission computed tomography (SPECT) enables in vivo visualization of the striatal density of dopaminergic neuron.

Methods: We investigated the association between PD-associated polygenic load and striatal density of dopaminergic neuron in healthy subjects. Read More

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Canine Oncopanel: a capture-based, NGS platform for evaluating the mutational landscape and detecting putative driver mutations in canine cancers.

Vet Comp Oncol 2021 Jul 19. Epub 2021 Jul 19.

Department of Pathology and Laboratory Medicine, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, US.

Canine cancer, a significant cause of mortality in domestic dogs, is a powerful comparative model for human cancers. Revealing genetic alterations driving the oncogenesis of canine cancers holds great potential to deepen our understanding of the cancer biology, guide therapeutic development, and improve cancer management in both dogs and people. Next generation sequencing (NGS) based-diagnostic panels have been routinely used in human oncology for the identification of clinically-actionable mutations, enabling tailored treatments based on the individual's unique mutation profiles. Read More

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Transcriptome-wide association study for inflammatory bowel disease reveals novel candidate susceptibility genes in specific colon subsites and tissue categories.

J Crohns Colitis 2021 Jul 21. Epub 2021 Jul 21.

Oncology Data Analytics Program, Catalan Institute of Oncology (ICO). L'Hospitalet de Llobregat, Barcelona, Spain.

Background & Aims: Genome-wide association studies [GWAS] for inflammatory bowel disease [IBD] have identified 240 risk variants. However, the benefit of understanding the genetic architecture of IBD remains to be exploited. Transcriptome-wide association studies [TWAS] associate gene expression with genetic susceptibility to disease, providing functional insight into risk loci. Read More

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Machine learning identifies novel markers predicting functional decline in older adults.

Brain Commun 2021 Jul 26;3(3):fcab140. Epub 2021 Jun 26.

Department of Psychology, The Ohio State University, Columbus, OH 43210, USA.

The ability to carry out instrumental activities of daily living, such as paying bills, remembering appointments and shopping alone decreases with age, yet there are remarkable individual differences in the rate of decline among older adults. Understanding variables associated with a decline in instrumental activities of daily living is critical to providing appropriate intervention to prolong independence. Prior research suggests that cognitive measures, neuroimaging and fluid-based biomarkers predict functional decline. Read More

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Flatfoot in Africa, the cirripede in the west Indian Ocean.

PeerJ 2021 8;9:e11710. Epub 2021 Jul 8.

The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

Barnacles of the genus are commonly encountered rocky intertidal shores. The phylogeography of the different species in the Western Indian Ocean is unclear. Using morphological characteristics as well as the molecular markers mitochondrial cytochrome oxygenase subunit I (COI) and the nuclear sodium-potassium ATPase (NaKA), we identified four clades representing four species in the Western Indian Ocean and its adjacent seas. Read More

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Genetic differentiation in the genus : implications for conservation and taxonomy.

PeerJ 2021 8;9:e11492. Epub 2021 Jul 8.

Laboratorio de Biología Acuática, Facultad de Biología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, México.

The subfamily Goodeinae is a group of fishes endemic to the Mexican highlands. Most of the species are restricted to small and isolated streams or springs. Within this subfamily, the genus is the earliest diverging lineage of which three species have been described: , , and , with the latter, considered extinct. Read More

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-Synuclein E46K Mutation and Involvement of Oxidative Stress in a Model of Parkinson's Disease.

Parkinsons Dis 2021 3;2021:6621507. Epub 2021 Jul 3.

Department of Biology, Faculty of Science, University of Zabol, Zabol, Iran.

Parkinson's disease (PD) is an age-associated neurodegenerative condition in which some genetic variants are known to increase disease susceptibility on interaction with environmental factors inducing oxidative stress. Different mutations in the gene are reported as the major genetic contributors to PD. E46K mutation pathogenicity has not been investigated as intensive as other gene mutations including and . Read More

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PRENATAL IDENTIFICATION OF ABERRANT RIGHT SUBCLAVIAN ARTERY IN ISOLATION: THE NEED FOR FURTHER GENETIC WORK-UP?

Acta Clin Croat 2020 Dec;59(4):582-589

1Division of Perinatology, Istanbul Medeniyet University, Faculty of Medicine, Istanbul, Turkey; 2Division of Genetic Disease, Van Regional Training and Research Hospital, Van, Turkey; 3Division of Obstetrics & Gynecology, Van Regional Trainingand Research Hospital, Van, Turkey; 4Bahceci Infertility and IVF Center, Fulya, Istanbul, Turkey.

The objective of this study was to evaluate the association between aberrant right subclavian artery (ARSA) and chromosomal abnormalities. The study included 5211 women having attended our unit for fetal anatomic screening and fetal echocardiography from August 2016 until February 2019. After diagnosing ARSA, prenatal invasive testing was discussed with the patients. Read More

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December 2020

Interleukin 6 (rs1800795) and pentraxin 3 (rs2305619) polymorphisms-association with inflammation and all-cause mortality in end-stage-renal disease patients on dialysis.

Sci Rep 2021 Jul 20;11(1):14768. Epub 2021 Jul 20.

UCIBIO, REQUIMTE, Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.

Chronic inflammation plays an important role in the progression and outcome of chronic kidney disease (CKD). The circulating levels of the inflammatory biomarkers interleukin 6 (IL6) and pentraxin 3 (PTX3) are enhanced in CKD patients, and are associated with the progression of the disease and with higher risk for cardiovascular events, the major cause of death in CKD patients. Our aim was to study how specific polymorphisms of IL6 and PTX3 encoding genes affect the inflammatory response and outcome of end-stage renal disease (ESRD) patients on dialysis. Read More

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Do aspermic (parthenogenetic) forms have the ability to reproduce their progeny via parthenogenesis?

J Helminthol 2021 Jul 21;95:e36. Epub 2021 Jul 21.

Laboratory of Veterinary Parasitology, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka020-8550, Japan.

Across Far East Asia, aspermic Fasciola forms are found endemically. They have abnormal spermatogenesis and oogenesis, and it is presumed that their progeny are produced parthenogenetically and clonally. Because of this, they are also termed parthenogenic Fasciola forms. Read More

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A comparative study of single Theileria lestoquardi and mixed infections with Theileria ovis.

Parasit Vectors 2021 Jul 20;14(1):370. Epub 2021 Jul 20.

Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, AlKhoud 123, PO Box 35, Muscat, Oman.

Background: Epidemiological surveys in Oman have revealed a high prevalence of the co-occurrence of the pathogenic Theileria lestoquardi and the non-pathogenic Theileria ovis among sheep in the Barka region, Oman. Our most recent data illustrated an interaction and reduced mortality risk in animals co-infected with T. lestoquardi and T. Read More

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