547,346 results match your criteria markers 3βhsd


Autophagic defects observed in fibroblasts from a patient with β-propeller protein-associated neurodegeneration.

Am J Med Genet A 2021 Jul 29. Epub 2021 Jul 29.

Neural Circuit Research Group, Korea Brain Research Institute, Daegu, South Korea.

Beta-propeller protein-associated neurodegeneration (BPAN) is associated with mutations in the autophagy gene WDR45. The aim of this study was to demonstrate autophagic defects in a patient with BPAN. We assayed autophagic markers using western blot analysis and immunocytochemistry and applied transmission electron microscopy (TEM) to visualize the autophagic structures in fibroblasts from a 7-year-old Korean female with WDR45 splice-site mutation (c. Read More

View Article and Full-Text PDF

Measuring Proximal Tibial Metaphyseal Width and Lateral Epiphyseal Height Improves Determination of Remaining Growth in Children.

J Pediatr Orthop 2021 Jul 29. Epub 2021 Jul 29.

Departments of Orthopaedics and Rehabilitation Cell Biology, Yale School of Medicine, New Haven, CT Division of Orthopedics, Texas Children's Hospital, Houston, TX University of Pittsburgh, Pittsburgh, PA.

Background: Accurate assessments of skeletal maturity is of critical importance to guide type and timing of orthopaedic surgical interventions. Several quantitative markers of the proximal tibia were recently developed using historical knee radiographs. The purpose of the present study was to determine which marker would be most effective in assessment of full-length radiographs in a modern pediatric patient population. Read More

View Article and Full-Text PDF

NUDCD1 knockdown inhibits the proliferation, migration, and invasion of pancreatic cancer via the EMT process.

Aging (Albany NY) 2021 Jul 29;13(undefined). Epub 2021 Jul 29.

School of Stomatology, Wenzhou Medical University, Wenzhou 110013, China.

NudC domain containing 1 (NUDCD1) is an oncoprotein frequently activated or upregulated in various human cancers, but its role in pancreatic cancer (PC) remains unknown. Thus, we aimed to determine the function and mechanism of NUDCD1 in PC. We employed Western blot and quantitative real-time polymerase chain reaction to assess NUDCD1 expression in cells and PC tissues. Read More

View Article and Full-Text PDF

Integrating single-cell transcriptomics and microcircuit computer modeling.

Curr Opin Pharmacol 2021 Jul 26;60:34-39. Epub 2021 Jul 26.

Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States. Electronic address:

Biophysically realistic computer modeling of neuronal microcircuitry has served as a testing ground for hypotheses related to the structure and function of different brain microcircuits. Recent advances in single-cell transcriptomics provide snapshots of a neuron's molecular state and have demonstrated that cell-specific genetic markers engineer the electrophysiological properties of a neuron. Integrating these molecular details with biophysical modeling can allow unprecedented mechanistic insights. Read More

View Article and Full-Text PDF

Neonatal streptozotocin treatment rapidly causes different subtype of hepatocellular carcinoma without persistent hyperglycemia in 4CS mice fed on a normal diet.

Pathol Res Pract 2021 Jul 21;225:153559. Epub 2021 Jul 21.

Department of Pathology and Laboratory Medicine and Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan; Molecular Pathology and Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. Electronic address:

Although diabetes mellitus (DM) is a well-known risk factor for hepatocellular carcinoma (HCC), the underlying mechanisms have not yet to be defined. We previously reported that DIAR mice fed with standard murine diet developed type 1 diabetes and HCC at age of 16 weeks old with a neonatal streptozotocin treatment (n-STZ). Because DIAR mice did not manifest obesity nor develop steatohepatitis, hyperglycemia with streptozotocin trigger or streptozotocin alone might turn on the hepato-carcinogenesis. Read More

View Article and Full-Text PDF

An untargeted metabolomics approach to identify markers to distinguish duck eggs that come from different poultry breeding systems by ultra high performance liquid chromatography-high resolution mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jul 3;1179:122820. Epub 2021 Jul 3.

Institute of Food Safety, Chinese Academy of Inspection & Quarantine, Beijing 100176, China. Electronic address:

Untargeted metabolomics approach based on ultra high performance liquid chromatography coupled with high resolution mass spectrometry (UHPLC-HRMS) was used to investigate the differences in cage duck eggs and sea duck eggs that from different poultry breeding system, which could help to combat fraud within the egg industry. High dimensions and complex data collected by UHPLC-HRMS were analyzed by multivariate statistical analysis. Identification model of sea duck eggs based on was established. Read More

View Article and Full-Text PDF

Predictive protein markers for depression severity in mood disorders: A preliminary trans-diagnostic approach study.

J Psychiatr Res 2021 Jul 24;142:63-72. Epub 2021 Jul 24.

Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea. Electronic address:

Depression is a common symptom of many mental disorders, especially major depressive disorder (MDD) and bipolar disorder (BD). Previous studies have reported that these diseases share common pathophysiological pathways; therefore, this study elucidated whether the plasma levels of protein markers related to common depressive symptoms differed between patients with BD and those with MDD. Plasma samples of 71 patients with mood disorders and clinical manifestations were analyzed in this study. Read More

View Article and Full-Text PDF

Cross-diagnostic evaluation of minor physical anomalies in psychiatric disorders.

J Psychiatr Res 2021 Jul 20;142:54-62. Epub 2021 Jul 20.

Department of Psychiatry, National Institute for Mental Health and Neurosciences (NIMHANS), Bangalore, India. Electronic address:

Background: Minor physical anomalies (MPA) are markers of impaired neurodevelopment during the prenatal stage. Assessing MPA across psychiatric disorders may help understand their shared nature. In addition, MPA in family members would indicate a shared liability and endophenotype potential. Read More

View Article and Full-Text PDF

Both a single sacral marker and the whole-body center of mass accurately estimate peak vertical ground reaction force in running.

Gait Posture 2021 Jul 24;89:186-192. Epub 2021 Jul 24.

Institute of Sport Sciences, University of Lausanne, Lausanne, 1015, Switzerland.

Background: While running, the human body absorbs repetitive shocks with every step. These shocks can be quantified by the peak vertical ground reaction force (F). To measure so, using a force plate is the gold standard method (GSM), but not always at hand. Read More

View Article and Full-Text PDF

Phenotypical characterization of regulatory T cells in acute Zika infection.

Cytokine 2021 Jul 26;146:155651. Epub 2021 Jul 26.

Immunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Paraíba 58051-900, Brazil. Electronic address:

Zika virus (ZIKV), alongside Dengue virus (DENV), Chikungunya virus (CHIKV), and Yellow Fever Virus (YFV) are prevalent arboviruses in the Americas. Each of these infections is associated with the development of associated disease immunopathology. Immunopathological processes are an outcome of counter-balancing impacts between effector and regulatory immune mechanisms. Read More

View Article and Full-Text PDF

Behavioral and Magnetoencephalographic Correlates of Fear Generalization are Associated with Responses to Later Virtual Reality Exposure Therapy in Spider Phobia.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 Jul 26. Epub 2021 Jul 26.

Institute for Biomagnetism and Biosignalanalysis, University of Münster, Germany.

Background: As overgeneralization of fear is a pathogenic marker of anxiety disorders, we investigated whether pre-treatment levels of fear generalization in spider-phobic patients are related to their response to exposure-based treatment, in order to identify pre-treatment moderators of treatment success.

Methods: Ninety patients with spider phobia completed pre-treatment clinical and magnetoencephalography (MEG) assessments, one session of virtual reality exposure therapy, and a post-treatment clinical assessment. Based on the primary outcome (30% symptom reduction in self-reported symptoms) they were categorized as responders or non-responders. Read More

View Article and Full-Text PDF

Prolonged anesthesia and decreased toxicity of enantiomeric-excess Bupivacaine loaded in Ionic gradient liposomes.

Int J Pharm 2021 Jul 26:120944. Epub 2021 Jul 26.

Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, Brazil. Electronic address:

Bupivacaine is the most employed local anesthetic in surgical procedures, worldwide. Its systemic toxicity has directed the synthesis of the less toxic, S(-) enantiomer. This work describes a formulation of ionic gradient liposomes (IGL) containing BVC, an enantiomeric excess mixture of 75% S(-) and 25% R(+) bupivacaine. Read More

View Article and Full-Text PDF

Plastid phylogenomics improves resolution of phylogenetic relationship in the Cheirostylis and Goodyera clades of Goodyerinae (Orchidoideae, Orchidaceae).

Mol Phylogenet Evol 2021 Jul 26:107269. Epub 2021 Jul 26.

Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Fujian Colleges and Universities Engineering Research Institute of Conservation and Utilization of Natural Bioresources, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address:

Goodyerinae are one of phylogenetically unresolved groups of Orchidaceae. The lack of resolution achieved through the analyses of previous molecular sequences from one or a few markers has long confounded phylogenetic estimation and generic delimitation. Here, we present large-scale phylogenomic data to compare the plastome structure of the two main clades (Goodyera and Cheirostylis) in this subtribe and further adopt two strategies, combining plastid coding sequences and the whole plastome, to investigate phylogenetic relationships. Read More

View Article and Full-Text PDF

Strain echocardiography improves prediction of arrhythmic events in ischemic and non-ischemic dilated cardiomyopathy.

Int J Cardiol 2021 Jul 26. Epub 2021 Jul 26.

ProCardio Center for Innovation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address:

Background: Recent evidence suggests that an implantable cardioverter defibrillator (ICD) in non-ischemic cardiomyopathy (NICM) may not offer mortality benefit. We aimed to investigate if etiology of heart failure and strain echocardiography can improve risk stratification of life threatening ventricular arrhythmia (VA) in heart failure patients.

Methods: This prospective multi-center follow-up study consecutively included NICM and ischemic cardiomyopathy (ICM) patients with left ventricular ejection fraction (LVEF) <40%. Read More

View Article and Full-Text PDF

Management of Oral Potentially Malignant Disorders.

Oral Dis 2021 Jul 29. Epub 2021 Jul 29.

Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Milano, Italia.

Patients with oral potentially malignant disorders (OPMDs), including oral leukoplakia and erythroplakia, proliferative verrucous leukoplakia, oral submucous fibrosis, and oral lichen planus/lichenoid lesions can be challenging to manage. A small proportion will undergo cancer development and determining a patient's cancer risk is key to making management decisions. Yet, our understanding of the natural history of OPMDs has not been fully elucidated, and a precision approach based on the integration of numerous predictive markers has not been validated by prospective studies. Read More

View Article and Full-Text PDF

The role of neutral and adaptive genomic variation in population diversification and speciation in two ground squirrel species of conservation concern.

Mol Ecol 2021 Jul 29. Epub 2021 Jul 29.

Department of Fish and Wildlife Sciences, College of Natural Resources, University of Idaho, 875 Perimeter Drive, Moscow, ID, 83844-1136, USA.

Understanding the neutral (demographic) and adaptive processes leading to the differentiation of species and populations is a critical component of evolutionary and conservation biology. In this context, recently diverged taxa represent a unique opportunity to study the process of genetic differentiation. Northern and southern Idaho ground squirrels (Urocitellus brunneus - NIDGS, and U. Read More

View Article and Full-Text PDF

A rohitukine derivative IIIM-290 induces p53 dependent mitochondrial apoptosis in acute lymphoblastic leukemia cells.

Mol Carcinog 2021 Jul 29. Epub 2021 Jul 29.

Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.

Rohitukine, a chromone alkaloid extracted from Dysoxylum binectariferum, has a propitious anticancer activity. Our previous study shows that a new Rohitukine derivative IIIM-290 restricts the growth of pancreatic cancer in vivo and in vitro. In the present findings, we report the mechanism of cell death induced by IIIM-290 in MOLT-4 cells (acute lymphoblastic leukemia) and its anticancer potential against various murine leukemic tumor models in vivo. Read More

View Article and Full-Text PDF

Higher strength gain after hypoxic vs normoxic resistance training despite no changes in muscle thickness and fractional protein synthetic rate.

FASEB J 2021 Aug;35(8):e21773

Institute of Neuroscience, UCLouvain, Louvain-la-Neuve, Belgium.

Acute hypoxia has previously been suggested to potentiate resistance training-induced hypertrophy by activating satellite cell-dependent myogenesis rather than an improvement in protein balance in human. Here, we tested this hypothesis after a 4-week hypoxic vs normoxic resistance training protocol. For that purpose, 19 physically active male subjects were recruited to perform 6 sets of 10 repetitions of a one-leg knee extension exercise at 80% 1-RM 3 times/week for 4 weeks in normoxia (FiO : 0. Read More

View Article and Full-Text PDF

Engineering a safe monoclonal anti-human IL-2 that is effective in a murine model of food allergy and asthma.

Allergy 2021 Jul 29. Epub 2021 Jul 29.

INRAE, Biopolymères Intéractions Assemblages (BIA), Nantes, France.

Regulatory T cells (Tregs) are known to protect against allergies. Moreover, the decrease in the frequency and efficiency of Tregs amplifies allergic symptoms. This study investigated whether expanding Tregs in vivo with an IL-2/IL-2 antibody complex could be safe, well tolerated and efficient in a therapeutic setting in allergies. Read More

View Article and Full-Text PDF

Lactate based Scoring System in the diagnosis of necrotizing fasciitis.

J Burn Care Res 2021 Jul 29. Epub 2021 Jul 29.

Department of Plastic, Reconstructive, Hand and Burn Surgery, Cologne Merheim Medical Center, University of Witten-Herdecke, Cologne, Germany.

Introduction: Necrotizing fasciitis (NF) is a rare and quickly progressing infection and leads to 100% mortality if untreated. Quick diagnosis and an early and radical surgical treatment are essential for stopping bacterial progression. Unfortunately, the absence of clear clinical signs makes the diagnosis often challenging. Read More

View Article and Full-Text PDF

Assessment of genetic diversity and population structure of oil palm (Elaeis guineensis Jacq.) field genebank: A step towards molecular-assisted germplasm conservation.

PLoS One 2021 29;16(7):e0255418. Epub 2021 Jul 29.

Plant Breeding Section, Advanced Agriecological Research Sdn. Bhd. (AAR), Paloh, Johor, Malaysia.

Oil palm (Elaeis guineensis) germplasm is exclusively maintained as ex situ living collections in the field for genetic conservation and evaluation. However, this is not for long term and the maintenance of field genebanks is expensive and challenging. Large area of land is required and the germplasms are exposed to extreme weather conditions and casualty from pests and diseases. Read More

View Article and Full-Text PDF

Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system.

PLoS One 2021 29;16(7):e0255380. Epub 2021 Jul 29.

Pavlov Institute of Physiology, Russian Academy of Sciences, Saint- Petersburg, Russia.

Patients with post-stress pathologies display the signs of inflammation in the peripheral blood as well as in the brain. The mechanisms of such post-stress neuroimmune changes, their contribution to the behavior, the relationship of the intensity of inflammation with genetically determined features have not been clarified. The goal of this work was to evaluate the dynamics of post-stress inflammation in the blood and hippocampus of rats which differ in level of excitability of the nervous system. Read More

View Article and Full-Text PDF

Aging increases senescence, calcium signaling, and extracellular matrix deposition in human airway smooth muscle.

PLoS One 2021 29;16(7):e0254710. Epub 2021 Jul 29.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States of America.

Lung function declines as people age and their lungs become stiffer. With an increasing elderly population, understanding mechanisms that contribute to these structural and functional changes in the aging lung is important. Part of the aging process is characterized by thicker, more fibrotic airways, and senile emphysema caused by changes in lung parenchyma. Read More

View Article and Full-Text PDF

The role of procalcitonin and presepsin in the septic febrile neutropenia in acute leukemia patients.

PLoS One 2021 29;16(7):e0253842. Epub 2021 Jul 29.

Department of Internal Medicine (Hematology), Faculty of Medicine, Damascus University, Damascus, Syria.

Background: The source of bacterial infection in neutropenic acute leukemia patients is detected in about 20-30% of cases. Bacterial cultures may require a long incubation period and risk false-positive and false- negative results. Therefore, biomarkers distinguishing septic febrile neutropenia from other etiologies in acute leukemia patients play the important role in patient assessment and treatment planning. Read More

View Article and Full-Text PDF

Mexican consensus on Hodgkin's lymphoma.

Gac Med Mex 2021 ;157(Suppl 2):S1-S16

Servicio de Hematología, Centro Médico Nacional 20 de noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Ciudad de México, México.

El linfoma de Hodgkin (LH) se debe a la transformación clonal de células originadas en los linfocitos B, lo que genera las células binucleadas patognomónicas de Reed-Sternberg. El LH es una enfermedad de células B con una distribución bimodal, con mayor incidencia en la adolescencia y la tercera década de la vida y un segundo pico en personas mayores de 55 años. Las células del LH clásico habitualmente sufren una reprogramación de la expresión génica, ya que pierden la expresión de la mayoría de los genes típicos de las células B y han adquirido la expresión de múltiples genes que son típicos de otros tipos de células del sistema inmunitario. Read More

View Article and Full-Text PDF
January 2021

Cold Water Immersion Offers No Functional or Perceptual Benefit Compared to a Sham Intervention During a Resistance Training Program.

J Strength Cond Res 2021 Jul 28. Epub 2021 Jul 28.

London Sports Institute, Middlesex University, Allianz Park, London, United Kingdom; Department of Natural Sciences, Middlesex University, London, United Kingdom; Biomarker Research Group, Department of Natural Sciences, Middlesex University, London, United Kingdom; Sports and Exercise Medicine, Queen Mary University of London, London, United Kingdom; and School of Biomedical, Nutritional and Sport Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

Abstract: Wilson, LJ, Dimitriou, L, Hills, FA, Gondek, MB, van Wyk, A, Turek, V, Rivkin, T, Villiere, A, Jarvis, P, Miller, S, Turner, A, and Cockburn, E. Cold water immersion offers no functional or perceptual benefit compared to a sham intervention during a resistance training program. J Strength Cond Res XX(X): 000-000, 2021-Cold water immersion (CWI) is regularly used by athletes as a postexercise recovery strategy, but relatively little is understood about potential training adaptations associated with habitual use. Read More

View Article and Full-Text PDF

Wnt Family Member 9b (Wnt9b) Is a New Sensitive and Specific Marker for Breast Cancer.

Am J Surg Pathol 2021 Jul 29. Epub 2021 Jul 29.

Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI.

Confirming the tumor origin is often a diagnostic challenge in pathology and carries significant therapeutic impacts. Cytokeratin 7, estrogen receptor, and GATA binding protein 3 (GATA3) are well-established diagnostic markers frequently used to support a tumor's breast origin. However, their specificities still have room to improve. Read More

View Article and Full-Text PDF

Postoperative Zoledronic Acid for Osteoporosis in Primary Hyperparathyroidism: a Randomized Placebo-controlled Study.

Eur J Endocrinol 2021 Jul 1. Epub 2021 Jul 1.

C Schalin-Jantti, Division of Endocrinology, Abdominal Center, Helsinki University Central Hospital, Helsinki, Finland.

Objective: In primary hyperparathyroidism (PHPT) with osteoporosis, bone mineral density (BMD) improves after parathyroidectomy. It is unclear whether combining surgery with postoperative bisphosphonate treatment can further improve bone health.

Design: This randomized, placebo-controlled study compared the effects of surgery alone and surgery combined with zoledronic acid on bone metabolism in PHPT with osteoporosis. Read More

View Article and Full-Text PDF

Structural Markers of the Frenkel Line in the Proximity of Widom Lines.

J Phys Chem B 2021 Jul 29. Epub 2021 Jul 29.

SUPA, School of Physics and Astronomy and Centre for Science at Extreme Conditions, The University of Edinburgh, Edinburgh EH9 3JZ, United Kingdom.

We have performed a neutron scattering experiment on supercritical fluid nitrogen at 160 K (1.27 ) over a wide pressure range (7.8 MPa/0. Read More

View Article and Full-Text PDF

Insulin-like growth factor 1 gene transfer for sporadic Alzheimer's disease: New evidence for trophic factor mediated hippocampal neuronal and synaptic recovery-based behavior improvement.

Hippocampus 2021 Jul 29. Epub 2021 Jul 29.

Institute for Biochemical Research (INIBIOLP)-National Scientific and Technical Research Council (CONICET)-School of Medical Sciences, National University of La Plata (UNLP), La Plata, Argentina.

Sporadic Alzheimer's disease (sAD) is the most prevalent neurodegenerative disorder with no cure. Patients typically suffer from cognitive impairment imprinted by irreversible neocortex and hippocampal degeneration with overt synaptic and neuron dysfunction. Insulin-like growth factor 1 (IGF1) has proven to be a potent neuroprotective molecule in animal models of age-related neurodegeneration. Read More

View Article and Full-Text PDF